TY - JOUR A1 - Heinsen, Helmut A1 - Heinsen, Y. L. T1 - Cerebellar capillaries: qualitative and quantitative observations in young and senile rats N2 - Ultrastructural changes including reduced electron density, reduction in polysemes and cisternae of rough endoplasmic reticulum occur in the cytoplasrn of endothelial cells and pericytes in the cerebellar cortex of senile virgin female Han: WIST-rats in cornparison to 3-month old virgin rats. Processes of pericytes cover less of the capillary surface in the cerebellar cortex of senile rats; moreover, arithmetic and harmonic mean thickness of the endothelium and relative volume of mitochondria in endothelial cells and pericytes are reduced, w hereas the luminal diameter of the capillaries, harmonic and arithmetic mean thickness of pericytes and their processes and of the basal laminae between endothelial cells and astrocytes (abbreviated BAL 1), pericytes and astrocytes (BAL 2) and endothelial cells and pericytes (BAL 3) increase. The increase in harmonic mean thickness of the basal laminae is statistically significant (α<=0.05) and compensates for a decrease in thickness of capillary endothelium. Consequently, the total barrier mass and thickness of cerebellar cortical capillaries in senile animals is higher than in young individuals. KW - Medizin KW - Capillaries KW - Blood-brain barrier KW - Quantitative anatomy KW - Cerebellar cortex KW - Senile rats Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59924 ER - TY - JOUR A1 - Heinsen, Helmut A1 - Heinsen, Y. L. T1 - Quantitative studies on regional differences in Purkinje cell dendritic spines and parallel fiber synaptic density N2 - No abstact available KW - Medizin KW - Cerebellar cortex KW - Albino rats KW - Quantitative anatomy KW - Purkinje cells KW - Spines KW - Parallel fiber synapses KW - Regional differences Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59917 ER - TY - JOUR A1 - Heinsen, Helmut T1 - Quantitative anatomical studies on the postnatal development of the cerebellum of the albino rat N2 - The quantitative postnatal changes of the cerebella of 65 Wistar rats aged 2-120 days have been examined. The cerebellar volume increases in two phases: The first phase lasts from birth to the seventh postnatal week. The second phase begins ten weeks post parturn and lasts for a Ionger period than the first phase. The cerebellar surface increases continuously from birth to the end of the seventh week. The volume of the external granular layer is maximal when the organ grows rapidly. The external granular layer has nearly disappeared 24 days after birth; the volume of the interaal granular layer is maximal at this time. Later on, the volume and the width of the interaal granular layer decrease. Myelinization of the cerebellar fibers and growth of the molecular layer run parallel to this decrease. The second late, but protracted growth of the cerebellum, ten weeks after birth, is due to an increase of the molecular and medullary layer. These findings are in good accord with histological, histochemical, and ultrastructural observations of other authors. KW - Medizin KW - Cerebellum KW - Albino rat KW - Ontogeny KW - Quantitative anatomy Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59881 ER - TY - JOUR A1 - Heinsen, Helmut A1 - Heinsen, YL T1 - Strain-specific differences in the vermian granular layer of albino rats N2 - Foliation of the cerebella of Sprague-Dawley rats (strain Han:SPRD) is more advanced than in Wistar rats (strain Chbb:THOM). The differences expressed as length of the granular layer in median sections were significant in lobules VIa, VIII, IX and X. The length of the other vermian lobules is generally higher in the former strain. With regard to the volume of the granular layer, the situation is reversed, indicating that the lateral extent and thickness of vermian lobules in Wistar rats (strain Chbb:THOM) is generally larger. These quantitative differences may express differences in cerebellar microcircuitry and fibre connections in the cortex of Wistar and Sprague-Dawley rats. KW - Albino rats KW - Cerebellum KW - Granular layer KW - Quantitative anatomy KW - Strain differences Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45735 ER - TY - JOUR A1 - Heinsen, Helmut A1 - Heinsen, Y. L. T1 - Regionale Unterschiede der numerischen Purkinje-Zell-Dichte in Kleinhirnen von Albinoratten zweier Stämme N2 - The total number and the number of Purkinje cells per square millimeter of the surface of the cerebellar granular layer were measured in albino rats from two strains: Chbb-THOM-Wist and Han: SPRD. The total number of the Purkinje cells in the cerebellar vermian lobules L land L X with the exception of cells in the lobules VIb + c did not. differ significantly. Statistically significant differences were found between the individuals of the two rat strains and within single lobules of the cerebella concerning the cell density of Purkinje cells per square millimeter surface of the granular layer. The results suggest heterogeneity of the cerebellar cortex between cerebellar lobules and between albino rats derived from different strains. KW - Albinoratten KW - Purkinje-Zellen KW - Quantitative Anatomie KW - Albino rats KW - Purkinje cells KW - Quantitative anatomy Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45752 ER -