TY  - JOUR
A1  - Magliocca, Giorgia
A1  - Mone, Pasquale
A1  - Di Iorio, Biagio Raffaele
A1  - Heidland, August
A1  - Marzocco, Stefania
T1  - Short-chain fatty acids in Chronic Kidney Disease: focus on inflammation and oxidative stress regulation
JF  - International Journal of Molecular Sciences
N2  - Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.
KW  - chronic kidney disease
KW  - short-chain fatty acids
KW  - oxidative stress
KW  - inflammation
KW  - uremic toxins
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284587
SN  - 1422-0067
VL  - 23
IS  - 10
ER  -