TY  - JOUR
A1  - Raulf, Friedrich
A1  - Mäueler, Winfried
A1  - Robertson, Scott M.
A1  - Schartl, Manfred
T1  - Localization of cellular src mRNA during development and in the differentiated bipolar neurons of the adult neural retina in Xiphophorus
N2  - The expression of the c-src gene in embryonie and adult tissue of the teleost fish Xiphophorus helleri was analyzed by in-situ hybridization. The highly conserved fish c-src gene was found to be expressed at high levels in midterm embryos, where c-src mRNA was localized in developing neurons of the sensory layer of the differentiating retina and in the developing brain. In adult tissues the expression of c-src was found to persist in certain cell types of the brain and the neural retina, especially in the bipolar cells of the inner nuclear layer, which are postmitotic, fully differentiated mature neurons. Thus c-src in Xiphophorus appears to be a developmentally regulated proto-oncogene which is important for neuronal differentiation during organogenesis, but whose persistence of expression in certain terminally differentiated neurons strongly suggests a particular maintenance function for c-src in these cells as well.
KW  - Schwertkärpfling
KW  - Messenger-RNS
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86703
ER  - 
TY  - JOUR
A1  - Schartl, Manfred
A1  - Holstein, Thomas
A1  - Robertson, Scott M.
A1  - Barnekow, Angelika
T1  - Preferential expression of a pp60c-src related protein tyrosine kinase activity in nerve cells of the early metazoan Hydra (Coelenterates)
N2  - It has been suggested that the proto-oncogene c-src plays a functional role in developing neurons, and in the mature nerve cells of higher vertebrales. The coelenterate Hydra represents tbe most primitive known organism possessing nerve cells. With Southern blot hybridizations we have demonstrated src-related sequences in Hydra. Antisera specific for the c-src gene product (pp60 c-src) of birds and mammals precipitate a protein from Hydra cell extracts with a tyrosine-specific protein kinase activity. Studies of tissues and cells fractionated from a temperature sensitive mutant of Hydra which is depleted of interstitial (including nerve) cells at tbe non-permissive temperature, have indicated the src-like kinase of Hydra to be preferentially expressed in nerve cells. The high conservation of structural features and of the expression pattern indicates a basic function for pp60c-src in neurons.
KW  - Protein-Tyrosin-Kinasen
KW  - Nervenzelle
KW  - Süßwasserpolypen
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86179
ER  - 
TY  - CHAP
A1  - Schartl, Manfred
A1  - Mäueler, Winfried
A1  - Raulf, Friedrich
A1  - Robertson, Scott M.
T1  - Molecular aspects of melanoma formation in Xiphophorus
N2  - No abstract available.
KW  - Schwertkärpfling
KW  - Krebs <Medizin>
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72689
ER  -