TY  - JOUR
A1  - Brinkmann, R.
A1  - Schwinn, A.
A1  - Müller, J.
A1  - Stahl-Hennig, C.
A1  - Coulibaly, C.
A1  - Hunsmann, G.
A1  - Czub, S.
A1  - Rethwilm, Axel
A1  - Dörries, R.
A1  - ter Meulen, Volker
T1  - In vitro and in vivo infection of rhesus monkey microglial cells by simian immunodeficiency virus
N2  - The observation that microglial cells in brain tissue are probably a major target for human immunodeficiency virus (HIV) infection has raised interest in the pathogenic role of this cell population for the development of neuro-AIOS. Since it is very difficult to obtain microglia from normal or diseased human brain we studied microglial cells isolated from fresh brain tissue of uninfected and simian immunodeficiency virus (SIV) infected rhesus monkeys (Macacca mulatta) in comparison to peripheral blood macrophages. Besides the characterization of the phenotypes of these two cell populations, we examined the replication of SIV in the cells in addition to the effect of viral infection on the expression of cell surface molecules. We found that microglia and macrophages support replication of the wild-type SIV\(_{mac25}\), strain as well as the infectious clone (SIV\(_239\)). Infectious viruswas produced and a CPE developed. Isolated microglial cells from SIV-infected monkeys were latently infected independent of the presence of neuropathological lesions and produced infectious virus after 20-25 days in culture. In situ hybridization revealed that only a small percentage of isolated microglial cells are productively infected in vivo, yet the majority of these expressed MHC class II molecules. This indicated a state of activation that is acquired in vivo. These findings indicate that microglia are a prime target cell for SIV infection in CNS tissue.
KW  - Virologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61415
ER  - 
TY  - JOUR
A1  - Erlwein, Otto
A1  - Rethwilm, Axel
T1  - BEL-1 transactivator responsive sequences in the long terminal repeat of human foamy virus
N2  - No abstract available
KW  - Virologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61402
ER  - 
TY  - JOUR
A1  - Baunach, Gerald
A1  - Maurer, Bernd
A1  - Hahn, Heidi
A1  - Kranz, Manuela
A1  - Rethwilm, Axel
T1  - Functional analysis of human foamy virus accessory reading frames
N2  - No abstract available
KW  - Virologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61398
ER  - 
TY  - JOUR
A1  - Hong, Liu
A1  - Bräutigam, Sandra
A1  - Rethwilm, Axel
T1  - Expression of the human foamy virus bel-1 transactivator in insect cells
N2  - The human foamy virus (HFV) bel-l transactivator protein was expressed in insect cells by a recombinant baculovirus. For the generation of the recombinant baculovirus, Acbel-1, the bel-l gene of an HFV mutant was used, that bears truncations in the bel-l overlapping bel-2 open reading frame. Acbel-1 infected Sf9 cells produced high amounts of recombinant protein of the same electrophoretic mobility (36 kD) as bel-l expressed in mammalian cells. The baculovirus expressed bel-l proteinwas readily identified by a polyclonal rabbit serum directed against bel-1 in immunoblot assay. As in mammalian cells, bel-l was predominantly localized to the nucleus of Acbel-1 infected insect cells. The baculovirus expressed bel-1 proteinwill be of use to determine the action of this novel viral transactivator more precisely.
KW  - Virologie
KW  - Human foamy virus bel-l transactivator; Expression in insect cells
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61383
ER  - 
TY  - JOUR
A1  - Bentley, T. W.
A1  - Norman, S. J.
A1  - Gerstner, E.
A1  - Kemmer, R.
A1  - Christl, Manfred
T1  - Solvolysis of Tricyclo[3.1.0.0\(^{2,6}\)]hex-3-yl and Bicyclo[2.1.1]hex-2-yl Sulfonates
N2  - No abstract available
KW  - Organische Chemie
KW  - Bicyclo[1.1.0]butylcarbinyl sulfonates
KW  - solvolysis of
KW  - Cyclobutylcarbinyl sulfonates
KW  - Anchimeric assistance in solvolysis
KW  - Rearrangement of carbocations
KW  - Electron demand in ditosylates
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58689
ER  - 
TY  - JOUR
A1  - Feineis, E.
A1  - Schwarz, H.
A1  - Hegmann, J.
A1  - Christl, Manfred
A1  - Peters, K.
A1  - Peters, E.-M.
A1  - Schnering, H. G. von
T1  - Cycloadditionen von 6H-1,3,4-0xadiazin-6-onen (4,5-Diaza-α-pyronen), 13 - Diels-Alder-Reaktionen mit 6H-1,3,4-Oxadiazin-6-onen als Dienophil
T1  - Cycloaddltions of 6H-1,3,4-0xadiazin-6-ones (4,5-Diaza-α-pyrones), 13 - Diels-Alder Reactions wtth 6H-1,3,4-0xadiazin-6-ones as Dienophile
N2  - No abstract available
KW  - Organische Chemie
KW  - 6H-1
KW  - 3
KW  - 4-0xadiazin-6-ones
KW  - 1
KW  - 2-Bismethylenecyclohexane
KW  - Diels-Alder reactions
KW  - [1
KW  - 3
KW  - 4]0xadiazino[4
KW  - 5-b]isoquinolin-1-one derivatives
KW  - Bicyclo[2.1.l]hexan-5-one
KW  - highly substituted
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58673
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Lanzendörfer, U.
A1  - Grötsch, M. M.
A1  - Hegmann, J.
A1  - Ditterich, E.
A1  - Hüttner, G.
A1  - Peters, K.
A1  - Peters, E.-M.
A1  - Schnering, H. G. von
T1  - Cycloadditionen von 6H-1,3,4-0xadiazin-6-onen (4,5-Diaza-α-pyronen), 12 - Dieckmann-Kondensationen ohne Basen
T1  - Cycloadditions of 6H-1,3,4-0xadiazin-6-ones (4,5-Diaza-α-pyrones), 12 - Dieckmann Condensations without Bases
N2  - No abstract available
KW  - Organische Chemie
KW  - 1
KW  - 3
KW  - 4-0xadiazine-2-carboxylate
KW  - methyl 6-oxo-5-phenyl-
KW  - Diels-Alder reactions
KW  - Ketenes
KW  - y-oxo-
KW  - 1
KW  - 2-Cyclopentanedione derivatives
KW  - Adipic acid
KW  - substituted 2-oxo- dimethyl esters
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58665
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Müller, H.
T1  - Induktiver Effekt, negative Hyperkonjugation und Gegenion sind nicht die Ursache der besonderen Eigenschaften des Bicyclo[3.2.1]octa-3,6-dien-2-yl-Anions. - Eine NMR-Studie mit phenylsubstituierten Modellen
T1  - Inductive Effect, Negative Hyperconjugation, and Gegenion do not Cause the Unusual Properties of the Bicyclo[3.2.1]octa-3,6-dien-2-yl Anion. An NMR Study with Phenyl-Substituted Models
N2  - No abstract available
KW  - Organische Chemie
KW  - Tricyclo[3.3.1.0 2
KW  - 4]non-7-en-6-ylpotassium
KW  - 6-phenyl
KW  - Homoaromaticity in carbanions
KW  - Bicyclo[3.2.1]oct-3-en-2-yl anions
KW  - phenyl-substituted
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58655
ER  - 
TY  - JOUR
A1  - Stöber, Gerald
A1  - Franzek, E.
A1  - Beckmann, H.
T1  - Schwangerschafts- und Geburtskomplikationen - ihr Stellenwert in der Entstehung schizophrener Psychosen
N2  - In a retrospective study of 80 chronic DSM 111-R schizophrenics and 80 controls, the occurrence of obstetric complications (OCs) into the development of chronic schizophrenias was investigated using Leonhard s distinction in systematic schizophrenia (no obvious familial loading) and unsystematic schizophrenia (mainly genetically determined according to Leonhard). The Lewis & Murray and Fuchs scales were used for evaluation. In both scales, unsystematic schizophrenias did not differ from controls, but those with OCs were significantly (p < 0.01) earlier hospitalized (20.5 years) than those without OCs (25.6 years). Systematic schizophrenics had an increased frequency, severity and total score of OCs compared to controls in the Fuchs scale (p < 0.0 I). Likewise, in the Lewis & Murray scale systematic schizophrenia showed an increased presence ofOCs compared to controls (p < 0.05) and to unsystematic schizophrenia (p < 0.1 ). Systematic schizophrenias were significantly allocated to matemal infectious diseases during mid-gestation. Patients with matemal infections showed moreadditional OCs than those without (p < 0.05; Lewis & Murray scale). In systematic schizophrenia, a history of OC was not associated with an early onset of the disease. In the genetic determined schizophrenias prenatal and perinatal disturbanccs Iead to an early onset of the disease, however, in systematic schizophrenias they seem to be of causal importance for the development of the disease.
N2  - Auf der Grundlage von Leonhards Unterteilung in systematische Schizophrenien (niedriges genetisches Risiko) und unsystematische Schizophrenien (nach Leonhardr Befunden hauptsächlich genetisch determiniert) wurden in einer retrospektiven Studie bei 80 Patienten mit chronischen DSM 111-R Schizophrenien und 80 Kontrollen die Häufigkeit von Schwangerschafts- und Geburtskomplikationen untersucht. Zur Auswertung wurden die Skalen von Lewis & Murray sowie von Fuchs verwandt. Unsystematische Schizophrenien unterschieden sich in beiden Skalen nicht von den Kontrollen. Diejenigen mit Komplikationen wurden jedoch signifikant früher als diejenigen ohne Komplikationen ersthospitalisiert (p < 0,01 ). Bei systematischen Schizophrenen waren in ; der Skala von Fuchs Häufigkeit, Schweregrad sowie der Summenwert der Komplikationen gegenüber den Kontrollen erhöht (p < 0,0 I). Auch in der Skala von Lewis & Murray traten häufiger obstetrische Komplikationen auf als bei Kontrollen (p < 0,05) und unsystematischen Schizophrenen (p < 0,1 ). Systematische Schizophrenien waren auch assoziiert mit Schwangerschaftsinfektionen im zweiten Trimenon. Mütter mit Schwangerschaftsinfektionen zeigten gehäuft weitere perinatala Komplikationen (p < 0,05). Geburtskomplikationen hatten bei systematischen Schizophrenen jedoch keinen Einfluß auf den Zeitpunkt des Krankheitsbeginns. Während pdi und perinatale Störungen bei genetisch determinierten Schizophrenien lediglich einen frühen Krankheitsbeginn bewirken, scheinen sie bei den systematischen Schizophrenien von ursächlicher Bedeutung fiir die Krankheitsentstehung zu sein.
KW  - Schwangerschaft
KW  - Schizophrenie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63343
ER  - 
TY  - JOUR
A1  - Sponholz, Barbara
A1  - Baumhauer, Roland
A1  - Felix-Hennignsen, P.
T1  - Fulgurites in the southern central Sahara, Republic of Niger and their palaeoenvironmental significance
N2  - The mineralogical and chemical characteristics of fulgurites ( = natural glasses forrned by lightning strikes to the ground) from the southern Centrat Sahara (Niger) are presented. The fulgurites are indicators of thunderstorms. The northernmost important fulgurite formation in the study area reached up to about l8°N, with decreasing fulgurite concentration from south to north. Their distribution pattern and the relative dating of their formation in relation to Iandscape history from the Late Pleistocene onwards (e.g., palaeolakes, palaeosols), and to Neolithic settlement reveals their value as palaeoenvironmental indicators. They indicate: (1) local palaeoenvironmental conditions depending on the topographical situation in a complex dune relief; (2) climatic change during the mid-Holocene from northerly rains to southerly rains; and (3) the northernmost Iimit of important thunderstorrns and rainfall activity since this time in the southern Centrat Sahara.
KW  - Sahara
KW  - Niger
KW  - Fulgurite
KW  - fulgurites
KW  - lightning
KW  - thunderstorms
KW  - Sahara
KW  - Holocene
KW  - climatic change
KW  - palaeosols
KW  - Neolithic
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63337
ER  - 
TY  - JOUR
A1  - Poulat, F.
A1  - Morin, D.
A1  - Konig, A.
A1  - Brun, P.
A1  - Giltay, J.
A1  - Sultan, C.
A1  - Dumas, R.
A1  - Gessler, Manfred
A1  - Berta, P.
T1  - Distinct molecular origins for Denys-Drash and Frasier syndromes
N2  - The direct involvment of the Wilm's tumor suppressor gene (WTl) in Denys-Drash syndrome through mutations within exons 8 or 9 has recently been established. The absence of such alterations in three patients with Frasier syndrome provides a molecular basis for distinguishing these two syndromes that are associated with streak gonads, pseudohermaphroditism and renal failure.
KW  - Biochemie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59172
ER  - 
TY  - JOUR
A1  - Konig, Anja
A1  - Jakubiczka, Sybille
A1  - Wieacker, Peter
A1  - Schlösser, Hans W.
A1  - Gessler, Manfred
T1  - Further evidence that imbalance of WT1 isoforms may be involved in Denys-Drash syndrome
N2  - No abstract available
KW  - Biochemie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59167
ER  - 
TY  - JOUR
A1  - Henry, Isabelle
A1  - Hoovers, Jan
A1  - Barichard, Fernande
A1  - Berthéas, Marie-Francoise
A1  - Puech, Anne
A1  - Prieur, Fabienne
A1  - Gessler, Manfred
A1  - Bruns, Gail
A1  - Mannens, Marcel
A1  - Junien, Claudine
T1  - Pericentric intrachromosomal insertion responsible for recurrence of del(11)(p13p14) in a family
N2  - The combined use of qualitative and quantitative analysis of I I p I 3 polymorphic markers tagether with chromosomal in situ suppression hybridization (CISS) with biotin labeled probes mapping to I I p allowed us to characterize a complex rearrangement segregating in a family. We detected a pericentric intrachromosomal insertion responsible (or recurrence of del( I I )(p 13p 14) in the family: an insertion of band I I p 13-p 14 carrying the genes for predisposition to Wilms' tumor, WT I, and for aniridia, AN2, into the long arm of chromosome I I in II q 13-q 1<4. Asymptomatic balanced carriers were observed over three generations. Classical cytogenetics had failed to detect this anomaly in the balanced carriers, who were first considered to be somatic mosaics for del( II )(p 13). Two of these women gave birth to children carrying a deleted chromosome II. most likely resulting from the loss of the I I p 13 band inserted in I I q. Although in both cases the deletion encompassed exactly the same maternally inherited markers, there was a wide Variation in clinical expression. One child, with the karyotype 46,XY,del(ll)(pllpl4), presented the full-blown WAGR syndrome with anlridia, mental retardation, Wilms' tumor, and pseudohermaphroditism, but also had proteinuria and glomerular sclerosis reminiscent of Drash syndrome. In contrast, the other one, a girl with the karyotype 46,XX,del( I I )(p I 3), only had aniridia. Although a specific set of mutational sites has been observed in Drash patients, these findings suggest that the loss of one copy of the WTI gene can result in similar genital and kidney abnormalities.
KW  - Biochemie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59157
ER  - 
TY  - JOUR
A1  - Gessler, Manfred
A1  - Konig, Anja
A1  - Moore, Jay
A1  - Qualman, Steven
A1  - Arden, Karen
A1  - Cavenee, Webster
A1  - Bruns, Gail
T1  - Homozygous inactivation of WTI in a Wilms' tumor associated with the WAGR syndrome
N2  - Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two-hit mechanism. A candidate II p 13 Wilms' tumor gene, WTI, has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilms' tumor, aniridia, genitourinary abnormalities, and mental retardation) have a high risk of developing Wilms' tumor and they carry constitutional deletions of one chromosome II allele encompassing the WTI gene. Analysis of the remaining WTI allele in a Wilms' tumor from a WAGR patient revealed the deletion of a single nucleotide in exon 7. This mutation likely played a key role in tumor formation, as it prevents translation of the DNA-binding zinc finger domain that is essential for the function of the WTI polypeptide as a transcriptional regulator.
KW  - Biochemie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59146
ER  - 
TY  - JOUR
A1  - Gorboulev, Valentin
A1  - Büchner, Hubert
A1  - Akhundova, Aida
A1  - Fahrenholz, Falk
T1  - Molecular cloning and functional characterization of V<sub>2</sub> [8-Iysine] vasopressin and oxytocin receptors from a pig kidney cell line (LLC-PK1)
N2  - No abstract available
KW  - Biologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59311
ER  - 
TY  - CHAP
A1  - Sponholz, Barbara
T1  - Holocene fulgurite formation in the southern Central Sahara (Niger)
N2  - Fulgurites (= natural glasses formed by lightning strikes to the ground) are indicators of thunderstorms (e.g. Julien 1901). The distribution pattern of fulgurites in the study area (Grand Erg de Bilma and Erg de Tenere between 11.5°E and 16.5° and 18.5°N) shows decreasing fulgurite concentration from south to north. The fulgurite sites are concentrated in the area of fossil dune complexes, where they occur topographically above palaeolimnic deposits in mid-slope position of interdune depressions.
KW  - Geographie
KW  - Niger
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-56584
ER  - 
TY  - GEN
A1  - Macht, Michael
T1  - Psychophysiological effects of a short-term reduction of energy supply
N2  - No abstract available
KW  - Psychologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55269
ER  - 
TY  - JOUR
A1  - Archelos, JJ
A1  - Roggenbuck, K.
A1  - Schneider-Schaulies, Jürgen
A1  - Linington, C.
A1  - Toyka, KV
A1  - Hartung, H.-P.
T1  - Production and characterization of monoclonal antibodies to the extracellular domain of PO
N2  - Seven monoclonal antibodies were raised against the immunoglobulin-like extracellular domain of PO (POED), the major protein of peripheral nervous system myelin. Mice were immunized with purified recombinant rat PO-ED. After fusion, 7 clones (POI-P07) recognizing either recombinant, rat, mouse, or human PO-ED were selected by ELlS A and were characterized by Western blot, immunohistochemistry, and a competition assay. Antibodies belonged to the IgG or IgM class, and P04-P07, reacted with PO in fresh-frozen and paraffin-embedded sections of human or rat peripheral nerve, but not with myelin proteins of the central nervous system of either species. Epitope specificity of the antibodies was determined by a competition enzyme-linked immunosorbent assay (ELISA) and a direct ELlS A using short synthetic peptides spanning the entire extracellular domain of PO. These assays showed that POl and P02 exhibiting the same reaction pattern in Western blot and immunohistochemistry reacted with different distant epitopes of PO. Furthermore, the monoclonal antibodies P05 and P06 recognized 2 different epitopes in close proximity within the neuritogenic extracellular sequence of PO. This panel of monoclonal antibodies, each binding to a different epitope of the extracellular domain of PO, will be useful for in vitro and in vivo studies designed to explore the role of PO during myelination and in demyelinating diseases of the peripheral nervous system.
KW  - Immunologie
KW  - peripheral nervous system
KW  - myelin
KW  - epitope specificity
KW  - demyelination
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54889
ER  - 
TY  - BOOK
A1  - Kleinhans, Martha
T1  - "Lucidere vault tant a dire comme donnant lumiere" : Untersuchung und Edition der Prosaversionen 2, 4 und 5 des Elucidarium
N2  - No abstract available
KW  - Romanistik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54488
N1  - Zugl.: Würzburg, Univ., Diss., 1991
ER  - 
TY  - CHAP
A1  - Kleinhans, Martha
T1  - Die Schöpfung des Ich: Rachid Boudjedras Romane L'Escargot entêté und La pluie
N2  - No abstract available
KW  - Romanistik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54229
ER  - 
TY  - CHAP
A1  - Kleinhans, Martha
T1  - Zwischen Orthodoxie und Häresie: Die englischsprachige Rezeption des Elucidarium
N2  - No abstract available
KW  - Honorius <Augustodunensis>
KW  - Elucidarium
KW  - Rezeption
KW  - Altfranzösisch
KW  - Predigt
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54214
ER  - 
TY  - JOUR
A1  - Liu, T.
A1  - McDonnell, PC
A1  - Young, PR
A1  - White, RF
A1  - Sirèn, Anna-Leena
A1  - Hallenbeck, JM
A1  - Barone, FC
A1  - Feuerstein, Giora
T1  - Interleukin-1ß mRNA expression in ischemic rat cortex
N2  - Background and Pur pose: Interleukin-1ß is a proinftammatory cytokine produced by blood-borne and resident brain inftammatory cells. The present study was conducted to determine if interleukin-1ß mRNA was produced in the brain of rats subjected to permanent focal ischemia. Methods: Rat interleukin-1ß cDNA, synthesized from stimulated rat peritoneal macrophage RNA by reverse transcription and polymerase chain reaction and c10ned in plasmid Bluescript KS+, was used to evaluate the expression of interleukin-1ß mRNA in cerebral cortex from spontaneously hypertensive rats and normotensive rats subjected to permanent middle cerebral artery occlusion. Interleukin-1ß mRNA was quantified by Northern blot analysis and compared with rat macrophage RNA standard. To correct for gel loading, blots were also analyzed with cyclophilin cDNA, which encodes an abundant, conserved protein that was unchanged by the experimental conditions. Results: Interleukin-1ß mRNA produced in the ischemic zone was significantly increased from 6 hours to 120 hours, with a maximum of211±24% ofinterleukin-1ß reference standard, ie, 0.2 ng stimulated rat macrophage RNA, mRNA compared with the level in nonischemic cortices (4±2%) at 12 hours after ischemia (P<.OI; n=6). Interleukin-1ß mRNA at 12 hours after ischemia was markedly elevated in hypertensive rats over levels found in two normotensive rat strains. Neurological deficits were also apparent only in the hypertensive rats. Conclusions: Brain interleukin-1ß mRNA is elevated acutely after permanent focal ischemia and especially in hypertensive rats. These data suggest that this potent proinflammatory and procoagulant cytokine might have a role in brain damage following ischemia.
KW  - Gehirn
KW  - Durchblutung
KW  - cerebraI ischemia
KW  - cytokines
KW  - neuronal damage
KW  - rats
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47442
ER  - 
TY  - JOUR
A1  - Sirèn, Anna-Leena
A1  - Liu, Y.
A1  - Feuerstein, G.
A1  - Hallenbeck, JM
T1  - Increased release of tumor necrosis factor alpha into the cerebrospinal fluid and peripheral circulation  of aged rats
N2  - Background and Purpose: We earlier reported that risk factors for stroke prepare brain stem tissue for a modified Shwartzman reaction, incIuding the development of ischemia and hemorrhage and the production of tumor necrosis factor-a, after a provocative dose of lipopolysaccharide. In the present study, we sought to determine whether blood and central nervous system cells of rats with the stroke risk factor of advanced age produce more proinflammatory and prothrombotic media tors than do those of young rats of the same strain. Methods: Levels of tumor necrosis factor-a and platelet activating factor in the cerebrospinal fluid and tumor necrosis factor-a in the serum of 2-year-old and 16-week-old Sprague-Dawley rats were monitored before and after challenge with lipopolysaccharide. Results: No consistent tumor necrosis factor-a activity was found in the cerebrospinal fluid or blood of control animals. Intravenous administration of lipopolysaccharide (1.8 mg/kg) increased serum tumor necrosis factor-a levels but had no effect on tumor necrosis factor-a in the cerebrospinal fluid. Serum tumor necrosis factor-a increased much more in aged rats than in young rats. When lipopolysaccharide was injected intracerebroventricularly, tumor necrosis factor-a activity in cerebrospinal fluid increased significantly more in old rats than in young rats. Baseline levels of platelet activating factor in cerebrospinal fluid were significantly higher in old rats than in young rats, and the levels increased to a greater degree in aged rats on stimulation. Conclusions: Rats with the stroke risk factor of advanced age respond to lipopolysaccharide with a more exuberant production of tumor necrosis factor-a and platelet activating factor than young rats of the same strain. These findings are consistent with our working hypothesis that perivascular cells are capable of exaggerated signaling of endothelium through cytokines such as tumor necrosis factor-a in animals with stroke risk factors. The effect of such signaling might be to prepare the endothelium of the local vascular segment for thrombosis or hemorrhage in accord with the local Shwartzman reaction paradigm.
KW  - Gehirn
KW  - Durchblutung
KW  - lipopolysaccharides
KW  - platelet activating factor
KW  - tumor necrosis factor
KW  - rats
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47997
ER  - 
TY  - JOUR
A1  - Glaser, Rüdiger
A1  - Sponholz, Barbara
T1  - Erste Untersuchungen von Hangrutschungen an der Frankenhöhe
N2  - Der vorliegende Beitrag faßt den derzeitigen Stand der Untersuchungen von Hangrutschungen im Bereich der Frankenhöhe, die im Rahmen des EPOCH-Programmes durchgeführt wurden, zusammen. Nach einer Inventarisierung der regionalen Rutschungsereignisse wird die Rutschung bei Obergailnau in einer geomorphologischen Detailkartierung vorgestellt. Für die Auslösung der Rutschung kommen mehrere Faktoren in Betracht: neben einer erhöhten Rutschungsanfälligkeit aufgrund der geologisch-tektonischen Verhältnisse muß v.a. auch eine Einflußnahme durch die Landnutzung mit berücksichtigt werden. Dazu zählen Steinbrucharbeiten in unmittelbarer Nähe der Rutschung, aber auch Wasserbaumaßnahmen am Schloßberg. In diesem potentielllabilisierten Gebiet kam es nach überdurchschnittlichen Niederschlägen Anfang 1958 zu einer Überschreitung der Belastungsgrenze des Hanges, die sich in einer großflächigen Rutschung äußerte. Die weiteren Untersuchungen sollen zeigen, ob sich die für Obergailnau herausgestellten Faktorenkomplexe im regionalen Rahmen verifizieren lassen.
N2  - The paper summarizes the present status of investigations on landslides at a section of the Frankenhöhe escarpment of northem Bavaria, conducted within the context of an EPOCH program. Following an overview of landslide events in the region a recent landslide near the village of Obergailnau is presented in a detailed geomorphological map. Several factors may have contributed to triggering the landslide: an increased susceptibility to landsliding because of the geological and tectonical setting of the area may have been compounded with the landuse there, such as quarrying in the immediate vicinity and hydraulic engineering works at the Schloß mtn. upslope of the landslide area. Unusually high precipitation at the beginning of 1958 sufficiently lowered the load limit of this potentially unstable area, thus causing a major landslide. Further studies are planned in order to fmd out weiher Ihe complex of faclors identified at Obergailnau is of regional significance.
KW  - Geographie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-53615
ER  - 
TY  - JOUR
A1  - Aguzzi, A.
A1  - Wagner, E. F.
A1  - Netzer, K. O.
A1  - Bothe, K.
A1  - Anhauser, I.
A1  - Rethwilm, Axel
T1  - Human foamy virus proteins accumulate in neurons and induce multinucleated giant cells in the brain of transgenic mice
N2  - Humanfoamy virus (HFV) is a retrovirus encoding structural genes and, like human immunodeficiency virus and human T ceU leukemia virus I, several anciUary reading frames collectively termed the belgenes. We have previously shown that HFV transgenic mice develop an encephalopathy with neuronal loss in hippocampus and cerebral cortex. We have now raised and characterized rabbit antisera to various recombinant portions of gag, pot, env, and bel-I, the viraltransactivator. Immunoreactivity for gag and bel-I was observed in nuclei and processes of hippocampal and cortical neurons before the onset of morphological lesions and correlated with the appearance of HFV mRNA. Astrocyte-derived multinucleated giant ceUs containing HFV proteins were present in the brain oftransgenic mice coexpressingfuU- length HFV genes but not in mice expressing truncated gag and env, suggesting that these genes contain afusogenic domain. Expression of fuU-length structural genes decreased the life expectancy oftransgenic mice, implying an a4Juvant rolefor these proteins in HFV-induced brain damage. (Am] Pathol 1993, 142:1061-1072)
KW  - Molekularpathologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47356
ER  - 
TY  - CHAP
A1  - Klawitter, Jörg
A1  - Dornhauser, Karin
A1  - Irrgang, Bernhard
A1  - Kunz, Matthias
T1  - Editorial [zu Krankenhauspsychiatrie und Ethik]
N2  - No abstract available
KW  - Ethik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44266
ER  - 
TY  - JOUR
A1  - Burschka, Christian
T1  - Erfahrungen mit einem Modelling-Paket
T1  - Experience with a program package for molecular modeling
N2  - Als Newcomer im Kreise der Anwender IIOn Molecular Modelling Software sieht man sich mit einer verwirrenden und ständig wachsenden Vielfalt von einschlägigen Programmen konfrontiert. die alle viel versprechen. Oie meisten bieten Grafik 110m Feinsten und eine beeindruckende Benutzeroberfläche. Unterschiede gibt es in der Funlctionalität, der Fehlerhäufigkeit, beim Support und natürlich im Preis. Seit ca. einem Jahr haben wir MOLEK 9000 auf einer IRIS 40351G im Einsatz. Hier ein erster Erfahrungsbericht.
KW  - Chemie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47169
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Bös, Klaus
A1  - Rieder, H.
T1  - Leistungsprognose bei jugendlichen Spitzensportlern
N2  - Im vorliegenden Beitrag wird der Versuch gemacht, neuere Befunde der kognitiven Psychologie, insbesondere der Expertiseforschung, zur Entwicklung außergewöhnlicher Fertigkeiten und Kenntnisse auf den Bereich des Sports zu übertragen und damit deren Generalisierungsmöglichkeiten zu prüfen. In einem ersten Schritt werden dabei die Grundannahmen der traditionellen fähigkeitsorientierten Leistungsprognose mit denen der neueren Expertiseforschung verglichen und im Hinblick auf ihre empirische Bewährung untersucht. Der zweite Schritt besteht darin, daß mögliche Parallelen zwischen der Entwicklung kognitiver und sportlicher Expertise aufgezeigt und an Fallbeispielen demonstriert werden. Dies leitet zum Schwerpunkt des vorliegenden Beitrags über, der in einer Reanalyse von Daten besteht, die im Rahmen einer fünfjährigen Längsschnittstudie an jugendlichen deutschen Tennistalenten gewonnen wurden (vgl. Rieder, Krahl, Sommer, Weicker & Weiss, 1983). Da in dieser Untersuchung sowohl Daten zur Entwicklung allgemeiner motorischer Basisfähigkeiten wie auch zur Entwicklung sportartspezifischer Fertigkeiten erhoben worden waren, ließ sich die Bedeutsamkeit dieser beiden Komponenten für den sportlichen Erfolg relativ genau bestimmen. Weiterhin waren Informationen zu Hintergrundmerkmalen wie z.B. der elterlichen Unterstützung, der Trainingsintensität sowie Merkmalen der Motivation und Konzentration verfügbar, von denen anzunehmen war, daß sie zusätzlich dazu geeignet sein sollten, individuelle Unterschiede in den beobachteten Entwicklungsverläufen zu erklären.
KW  - Aufmerksamkeit
KW  - Leistung
KW  - Sportpsychologie
KW  - Kongress
KW  - Ringberg <Tegernsee
KW  - 1990>
KW  - Kognitive Psychologie
KW  - Aufsatzsammlung
KW  - Leistungssport
KW  - Psychologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50556
ER  - 
TY  - CHAP
A1  - Näslung, J. C.
A1  - Schneider, Wolfgang
T1  - Emerging literacy from kindergarten to second grade: Evidence from the Munich Longitudinal Study on the Genesis of Individual Competencies
N2  - No abstract available
KW  - Psychologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50513
ER  - 
TY  - JOUR
A1  - Becker, Charles, R.
A1  - Latussek, V.
A1  - Heinke, H.
A1  - Regnet, M. M.
A1  - Goschenhofer, F.
A1  - Einfeldt, S.
A1  - He, L.
A1  - Bangert, E.
A1  - Kraus, M. M.
A1  - Landwehr, G.
T1  - Molecular beam epitaxial growth and characterization of (001) Hg\(_{1-x}\) Cd\(_x\) Te-HgTe superlattices
N2  - The molecular beam epitaxially growth of (001) Hg\(_{1-x}\) Cd\(_z\) Te-HgTe superlattices has been systematically investigated. The well width as well as the period were determined directly by X-ray diffraction. This was accomphshed for the well width by exploiting the high reflectivity from HgTe and the low reflectivity from CdTe for the (002) Bragg reflection. Knowing the well and barrier thicknesses we have been able to set an upper limit on the aver~ge composition of the barriers, Xl, by annealing the superlattice and then measuring the composition of the. resultmg alloy. Xb was shown to decrease exponentially with decreasing barrier width. Xb is appreciably smaller m. narrow barriers due to the increased significance of interdiffusion in the Hg\(_{1-x}\)Cd\(_x\) Te/HgTe interface in narrow barriers. The experimentally determined optical absorption coefficient for these superlattices is compared WIth theoretical calculations. The absorption coefficient was determined from transmission and reflection spectra at 300, 77 and 5 K. Using the thickness and composition of the barriers and wells, and an interface width due to interdiffusion, the complex refractive index is calculated and compared with the experimental absorption coefficient. The envelope function method based on an 8 x 8 second order k . p band model was used to calculate the superlattice states. These results when inserted into Kubo's formula, yield the dynamic conductivity for interband transitions. The experimental and theoretical values for the absorption coefficient using no adjustable parameters are in good agreement for most of the investigated superlattices. Furthermore the agreement for the higher energetic interband transitions is much worse if values for the barrier composition, which are appreciably different than the experimentally determined values, are used. The infrared photoluminescence was investigated at temperatures from 4.2 to 300 K. Pronounced photoluminescence was observed for all superlattices in this temperature range.
KW  - Physik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50959
ER  - 
TY  - JOUR
A1  - Becker, Charles R.
A1  - He, L.
A1  - Einfeldt, S.
A1  - Wu, Y. S.
A1  - Lérondel, G.
A1  - Heinke, H.
A1  - Oehling, S.
A1  - Bicknell-Tassius, R. N.
A1  - Landwehr, G.
T1  - Molecular beam epitaxial growth and characterization of (100) HgSe on GaAs
N2  - In this paper, we present results on the first MBE growth of HgSe. The influence of the GaAs substrate temperature as well as the Hg and Se fluxes on the growth and the electrical properties has been investigated. It has been found that the growth rate is very low at substrate temperatures above 120°C. At 120°C and at lower temperatures, the growth rate is appreciably higher. The sticking coefficient of Se seems to depend inversely on the Hg/Se flux ratio. Epitaxial growth could be maintained at 70°C with Hg/Se flux ratios between lOO and ISO, and at 160°C between 280 and 450. The electron mobilities of these HgSe epilayers at room temperature decrease from a maximum value of 8.2 x 10^3 cm2 /V' s with increasing electron concentration. The concentration was found to be between 6xlO^17 and 1.6x10^19 cm- 3 at room temperature. Rocking curves from X-ray diffraction measurements of the better epilayers have a full width at half maximum of 5S0 arc sec.
KW  - Physik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50947
ER  - 
TY  - JOUR
T1  - Blick - das Magazin der Julius-Maximilians-Universität Würzburg. Ausgabe 2/1993. Schwerpunktthema: Wissensorganisierende und wissensvermittelnde Literatur im Mittelalter
N2  - Inhaltsübersicht zum Schwerpunktthema: - Die Vorbereitung der Neuzeit - Gattungen der Wissensliteratur: Allgemeines - Zur mittelhochdeutschen Weltchronistik: Gattungen - Das Publikum spätmittelalterlicher Zeitgeschichtschroniken - Zur Sprache der Wissensliteratur - Das schulgeschichtliche Projekt - Scientia und sapientia u.a.
KW  - Würzburg
KW  - Universität
KW  - Zeitschrift
KW  - Mittelalter
KW  - Wissensliteratur
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44884
VL  - 2/1993
ER  - 
TY  - JOUR
T1  - Blick - das Magazin der Julius-Maximilians-Universität Würzburg. Ausgabe 1/1993. Schwerpunktthema: Infektionen
N2  - Inhaltsübersicht zum Schwerpunktthema: - Zentrum zur Erforschung von Infektionskrankheiten - "Virulenzgene" von Bakterien - Molekulare Grundlagen zum Verständnis bakterieller Infektionen - Der Darm des Menschen: Eintrittspforte und Quelle für Infektionserreger - Unser Immunsystem: Antwort auf die mikrobielle Herausforderung - Neurologische Klinik: Im Zentrum des Interesses stehen Autoimmunerkrankungen - Entstehung und Abwehr von viralen Infektionskrankheiten - Infektionen bei neuropenischen Patienten: Neue Entwicklungen in der Therapie und bei der Erregertypisierung - Probleme bei Therapie und Prophylaxe an Patienten mit HIV –Infektion u. a.
KW  - Würzburg
KW  - Universität
KW  - Zeitschrift
KW  - Infektion
KW  - Infektionskrankheit
KW  - Infektionserreger
KW  - Darm
KW  - Immunsystem
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44876
VL  - 1/1993
ER  - 
TY  - JOUR
A1  - Breitkreuz, A.
A1  - Ulrichs, Karin
A1  - Eckstein, V.
A1  - Müller-Ruchholz, W.
T1  - Long-term suppression of natural and graft-induced xenophile antibodies by short-term antigen-cyclophosphamide treatment
N2  - No abstract available
KW  - Chirurgie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45262
ER  - 
TY  - JOUR
A1  - Waaga, AM
A1  - Krzymanski, M.
A1  - Ulrichs, Karin
A1  - Wierusz-Wysocka, Bogna
A1  - Müller-Buchholtz, Wolfgang
T1  - Hematological effects of the new immunosuppressive drug 15-deoxyspergualin
N2  - Since systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of banc marrow regeneration. DOS induced lymphocytopenia, granUlocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependent and bone marrow as well as blood changes were observed in animals treated with doses from 0.5 to 10.0 mg/kg DOS. Within 14 days after termination of the treatment, rapid recovery with normalization of all hematological parameters was observed. In the light of our data, these hematological side effects may not be a major disadvantage, if DOS is used in doses below 2.5 mg/kg, and for a course of therapy which is limited to 7 to 14 days.
KW  - Chirurgie
KW  - 15-Deoxyspergualin
KW  - hematology
KW  - immunosuppression
KW  - bone marrow
KW  - regeneration
KW  - experimental therapy
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44701
ER  - 
TY  - CHAP
A1  - Fackler, Guido
T1  - Not macht erfinderisch: Der Spinnaufsatz
N2  - No abstract available
KW  - Frauenarbeit
KW  - Baden
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41831
ER  - 
TY  - JOUR
A1  - Heck, Brigitte
A1  - Fackler, Guido
T1  - Zwischen Schule und Fabrik - Textile Frauenarbeit in Baden : Eine volkskundliche Sonderausstellung in Baden
N2  - No abstract available
KW  - Frauenarbeit
KW  - Baden
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41844
ER  - 
TY  - CHAP
A1  - Wang, HY
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation
N2  - No abstract available
KW  - Immunbiologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45669
ER  - 
TY  - CHAP
A1  - Ulrichs, Karin
A1  - Eckstein, V.
A1  - Korsgren, O.
A1  - Müller-Ruchholtz, W.
T1  - Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA)
N2  - No abstract available
KW  - Immunbiologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45655
ER  - 
TY  - CHAP
A1  - Hedke, K.
A1  - Eckstein, V.
A1  - May, G.
A1  - Kaden, J.
A1  - Müller-Ruchholtz, W.
A1  - Ulrichs, Karin
T1  - Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45642
ER  - 
TY  - JOUR
A1  - Kaupp, Martin
A1  - Zyubin, A. S.
A1  - Charkin, O. P.
A1  - Schleyer, P. v. R
T1  - Non-Empirical Calculation of the Structure and Stability of Borohydrides of Zinc, Cadmium and Mercury of the Types MBH4 and HMBH4
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46339
ER  - 
TY  - JOUR
A1  - Hommers, Wilfried
T1  - Zum Begriff der Rechtspsychologie unter professioneller Perspektive
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43383
ER  - 
TY  - JOUR
A1  - Gillitzer, Reinhard
A1  - Moll, Heidrun
T1  - Simultaneous demonstration of two antigens with immunogold-silver staining and immunoenzymatic labeling
N2  - A novel technique for independent and simultaneous labeling of two antigens expressed on individual cells (referred to as mixed labeling) is presented. The staining procedure combined three-step (streptavidin-biotin) immunogold-silver staining with three-step immunoenzymatic labeling. To ensure both high specificity and high sensitivity, particular emphasis was placed on designing a protocol that avoids immunological crossreactivity between the antibody reagents and overlapping of the final color products. Two examples for usage of this mixed labeling technique are described: lymphocyte subpopulations were identified in inflammatory lesions of human skin and infected host cells were characterized in the skin of mice infected with the obligatory intracellular parasite Leishmania major, a cause of human cutaneous leishmaniasis.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33019
ER  - 
TY  - JOUR
A1  - Moll, Heidrun
A1  - Fuchs, Harald
A1  - Blank, Christine
A1  - Röllinghoff, Martin
T1  - Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells
N2  - No abstract available
KW  - Immunologie
KW  - Langerhans cell
KW  - Leishmania major
KW  - T-cell
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46023
ER  - 
TY  - JOUR
A1  - Blank, Christine
A1  - Fuchs, Harald
A1  - Rappersberger, Klemens
A1  - Röllinghoff, Martin
A1  - Moll, Heidrun
T1  - Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major
N2  - Murine epidermal Langerhans cells (LC) have been demonstrated to stimulate a vigorous T cell response to Leishmania major, a cause of human cutaneous leishmaniasis. It was therefore of interest to analyze whether LC can take up viable parasites. Epidermal cells were obtained from mouse ear skin for incubation with L. major and subsequent detection of intracellular parasites by cytochemistry. Freshly isolated LC, but not cultured LC, phagocytosed L. major and the uptake was inhibited by antibodies to the complement receptor type 3. Electron microscopic studies revealed the presence of viable amastigotes within Le. Moreover, with double-Iabeling techniques, L. major-containing LC could also be detected in infected skin. The results demonstrate that LC can internalize L. major. Since the number of organisms per infected LC remained consistently low, the prime task of LC may not be the promotion of parasite spreading but the presentation of L. major antigen to T cells and, thus, the regulation of the cellular immunity during cutaneous leishmaniasis.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45850
ER  - 
TY  - JOUR
A1  - Berger, Susanne
A1  - Ellersiek, Ulrike
A1  - Westhoff, Peter
A1  - Steinmüller, Klaus
T1  - Studies on the expression of NDH-H, a subunit of the NAD(P)H-plastoquinone-oxidoreductase of higher-plant chloroplasts
N2  - The plastid genomes of higher plants contain eleven reading frames (ndhA-K) that are homologous to genes encoding subunits of the mitochondrial NADH-ubiquinone-oxidoreductase (complex I). The carboxyterminal end of the NDH-H subunit from rice (Oryza sativa L.) was expressed as a fusion protein in Escherichia coli and antibodies against the fusion protein were generated in rabbits. The antibody was used to study the expression of NDH-H, and the following results were obtained: (i) NDH-H is expressed in mono- and dicotyledonous plants, (ii) NDH-H is localized on the stroma lamellae of the thylakoid membrane and (iii) NDH-H is expressed in etioplasts. Together with the finding that two other ndh genes (ndhI and ndhK) are expressed in plastids, these results point to the existence of an NAD(P)H-plastoquinone-oxidoreductase on the thylakoid membrane. The possible function of the enzyme in plastids is discussed and it is suggested that it works in balancing the ATP/ADP and the NADPH/NADP ratios during changing external (i.e. light) or internal (i.e. ATP and NADPH demands of biosynthetic pathways of the plastid) conditions.
KW  - NAD(P)H-plastoquinone-oxidoreductase
KW  - ndhH gene
KW  - Plastid DNA
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31283
ER  - 
TY  - JOUR
A1  - Berger, Susanne
A1  - Ellersiek, Ulrike
A1  - Kinzelt, Dagmar
A1  - Steinmüller, Klaus
T1  - Immunopurification of a subcomplex of the NAD(P)H-plastoquinone-oxidoreductase from the cyanobacterium Synechocystis sp. PCC6803
N2  - An antibody against the NDH-K subunit of the NAD(P)H-dehydrogenase from the cyanobacterium Synechocystis sp. PCC6803 was used to isolate a subcomplex ofthe enzyme from Triton X-lOO solubilized total membranes by immunoaffinity chromatography. The isolated subcomplex consisted of seven major polypeptides with molecular masses of 43, 27, 24, 21, 18, 14 and 7 kDa. The amino-terminal amino acid sequences of the polypeptides were determined. By comparing the sequences with the amino acid sequences deduced from DNA. three proteins were identified as NDH-H (43 kDa). NDH-K (27 kDa) and NDH-J (24 kDa). A fourth subunit (NDH-J, 21 kDa) was identified by Western blot analysis with an NDH-J antibody.
KW  - NAD(P)H-dehydrogenase
KW  - Cyanobacteria
KW  - Synechocystis sp. PCC6803
KW  - NDH-H
KW  - NDH-I
KW  - NDH-J
KW  - NDH-K
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31249
ER  - 
TY  - JOUR
A1  - Falk, Michael
A1  - Marohn, Frank
T1  - Asymptotically optimal tests for conditional distributions
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45823
ER  - 
TY  - JOUR
A1  - Falk, Michael
A1  - Marohn, Frank
T1  - Von Mises condition revisited
N2  - It is shown that the rate of convergence in the von Mises conditions of extreme value theory determines the distance of the underlying distribution function F from a generalized Pareto distribution. The distance is measured in terms of the pertaining densities with the limit being ultimately attained if and only if F is ultimately a generalized Pareto distribution. Consequently, the rate of convergence of the extremes in an lid sample, whether in terms of the distribution of the largest order statistics or of corresponding empirical truncated point processes, is determined by the rate of convergence in the von Mises condition. We prove that the converse is also true.
KW  - Von Mises conditions
KW  - extreme value theory
KW  - extreme value distribution
KW  - extreme order statistics
KW  - generalized Pareto distribution
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45790
ER  - 
TY  - CHAP
A1  - Krüger, Hans-Peter
T1  - Zur Psychobiologie des Sprechens als zeitstrukturiertes Verhalten und ihre verhaltenstherapeutische Aussagekraft
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41274
ER  - 
TY  - JOUR
A1  - Krüger, Hans-Peter
A1  - Schöch, Heinz
T1  - Absenkung der Promillegrenze. Ein zweifelhafter Beitrag zur Verkehrssicherheit
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41911
ER  - 
TY  - JOUR
A1  - Arbuznikov, Alexey V.
A1  - Plakhutin, A. B.
T1  - Symmetric vector coupling coefficients for atomic non-Roothaan states in the d\(^N\) configuration
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47062
ER  - 
TY  - JOUR
A1  - Ellgring, Johann Heinrich
A1  - Schneider, E.
T1  - Parkinson und Demenz
N2  - Auf der Delegierten-Konferenz der dPV in Hannover waren eine Reihe von Fragen wr Demenz im Zusammenhang mit dem Morbus Parkinson gestellt worden, zu denen hier Stellung genommen werden soll. Die Fragen und Antworten sind jeweil mit einem ? für die Fragen und einem ! für die Antworten gekennzeichnet.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43047
ER  - 
TY  - JOUR
A1  - Ellgring, Johann Heinrich
T1  - Wohlbefinden - Subjective Wellbeing
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42000
ER  - 
TY  - CHAP
A1  - Ellgring, Johann Heinrich
T1  - Streßbewältigung
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43275
ER  - 
TY  - JOUR
A1  - Hock, Robert
A1  - Moormann, Antoon
A1  - Fischer, Dagmar
A1  - Scheer, Ulrich
T1  - Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis
N2  - Available data on the occurrence and expression of somatic histone HI during oogenesis and early embryogenesis of Xenopus laevis are contradictory. In particular the reported presence of a large storage pool of histone HIA in oocytes is difficult to reconcile with the high transcriptional activity of all gene classes in this specific cell type. In the present study we have used polyclonal antibodies raised against somatic Xenopus histone HI (HIA and HIA/B) for combined immunoblotting experiments to quantitate HI pools and immunolocalization studies to visualize chromosome- bound HI. Both approaches failed to detect soluble or chromosomal histone HI in vitellogenic oocytes, eggs, and cleavage-stage embryos up to early blastula. In addition, chromatin assembled in Xenopus egg extract was also negative for histone HI as revealed by immunofluorescence microscopy. Lampbrush chromosomes not only lacked histone HI but also the previously identified histone HI-like B4 protein (Smith et al., 1988, Genes Dev. 2,1284-1295). In contrast, chromosomes of eggs and early embryos fluoresced brightly with anti-B4 antibodies. Our results lend further support to the view that histone HI expression is developmentally regulated during Xenopus oogenesis and embryogenesis similar to what is known from other species.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41350
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Thoenen, Hans
A1  - Hughes, R. A.
T1  - Members of several gene families influence survival of rat motoneurons in vitro and in vivo
N2  - The survival and functional maintenance of spinal motoneurons, both during the period of developmental cell death and in adulthood, have been shown to be dependent on trophic factors. In vitro experiments have previously been used to identify several survival factors for motoneurons, including CNTF, UF, and members of the neurotrophin, FGF, and IGF gene families. Some of these factors have also been shown to be active in vivo, either on chick motoneurons during embryonic development or on lesioned facial and spinal motoneurons of the newborn rat. Here we demonstrate that lesioned newborn rat facial motoneurons can be rescued by NT-4/5, IGF-I, and UF. Furthermore, in contrast to chick motoneurons, the survival of isolated embryonic rat motoneurons can be maintained by the neurotrophins BDNF, NT-3, and NT-4/5. IGF-I and FGF-5 were also active in this system, each supporting more than 50% of the originally plated neurons. The responsiveness of motoneurons to multiple factors in vitro and in vivo suggests that motoneuron survival and function are regulated by the coordinated actions of members of different gene families.
KW  - Immunopanning
KW  - Facial Nerve Transection
KW  - Neurotrophin
KW  - Fibroblast Growth Factor
KW  - Insulinlike Growth Factor
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42652
ER  - 
TY  - JOUR
A1  - Barres, B. A.
A1  - Schmid, R.
A1  - Sendtner, Michael
A1  - Raff, Martin C.
T1  - Multiple extracellular signals are required for long-term oligodendrocyte survival
N2  - We showed previously that oligodendrocytes and their precursors require continuous signalling by protein trophic factors to avoid programmed cell death in culture. Here we show that three classes of such trophic factors promote oligodendrocyte survival in vitro: (1) insulin and insulin-like growth factors (IGFs), (2) neurotrophins, particularly neurotrophin-3 (NT -3), and (3) ciliary-neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and interleukin 6 (IL-6). A single factor, or combinations of factors within the same class, promote only short-term survival of oligodendrocytes and their precursors, while combinations of factors from different classes promote survival additively. Long-term survival of oligodendrocytes in vitro requires at least one factor from each class, suggesting that multiple signals may be required for long-term oligodendrocyte survival in vivo. We also show that CNTF promotes oligodendrocyte survival in vivo, that platelet-derived growth factor (PDGF) can promote the survival of oligodendrocyte precursors in vitro by acting on a novel, very high affinity PDGF receptor, and that, in addition to its effect on survival, NT-3 is a potent mitogen for oligodendrocyte precursor cells.
KW  - neurotrophins
KW  - programmed cell death
KW  - apoptosis
KW  - ciliary-neurotrophic factor
KW  - interleukin 6
KW  - insulin
KW  - insulin-likegrowth factor I
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42644
ER  - 
TY  - JOUR
A1  - Hughes, Richard A.
A1  - Sendtner, Michael
A1  - Goldfarb, Mitchell
A1  - Lindholm, Dan
A1  - Thoenen, Hans
T1  - Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons
N2  - We examined the potential role of fibroblast growth factor 5 (FGF-5) as a target-derived trophic factor for spinal motoneurons. Northern analysis of total RNA from rat skeletal muscle revealed an FGF-5 mRNA transcript both during the period of embryonic motoneuron death and in the adult. Recombinant human FGF-5 supported the survival of highly enriched cultures of embryonic chick motoneurons. Significant proportions of the motoneuron survival activity of rat skeletal muscle extracts could be immunoprecipitated using an antiserum to FGF-5. The immunoprecipitable activity was present in soluble and matrix-bound forms in embryonic muscle, but bound exclusively to the extracellular matrix in adult muscle. These results, along with the secretory nature of FGF-5, suggest that FGF-5 may act as a target-derived trophic factor for motoneurons.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42588
ER  - 
TY  - JOUR
A1  - Weisenberger, Dieter
A1  - Scheer, Ulrich
A1  - Benavente, Ricardo
T1  - The DNA topoisomerase I inhibitor camptothecin blocks postmitotic reformation of nucleoli in mammmalian cells
N2  - No abstract available
KW  - Cytologie
KW  - Nucleolus-DNA
KW  - opoisomerase I
KW  - camptothecin
KW  - mitosis
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41434
ER  - 
TY  - CHAP
A1  - Thoenen, Hans
A1  - Hughes, Richard A.
A1  - Sendtner, Michael
T1  - Towards a comprehensive understanding of the trophic support of motoneurons
N2  - Motoneurons played an essential role in establishing the concept of target-mediated support of innervating neurons. However, it took several decades until molecules were identined which trophically support motoneurons in vitro and in vivo. The most potent molecule identined so far is ciliary neurotrophic factor (CNTF). It is expressed as a cytosolic molecule in myelinating Schwann cells rather than in skeletal muscle in the postnatal period and therefore does not qualify as a target-derived neurotrophic factor regulating motoneuron survival during embryonic development. However, the inactivation of CNTF by gene targeting experiments results in progressive atrophy and degeneration of motoneurons, demonstrating that CNTF plays an essential role as a maintenance factor for motoneurons postnatally. Secretory molecules which are expressed in skeletal muscle during embryonic development and which support motoneurons in culture and partially also in vivo include members of the NGF gene family (BDNF, NT-3, NT-4/S) , FGF-S, IGF-I, and UF. The evaluation of the physiological importance of these molecules is under investigation.
KW  - neurotrophic molecules
KW  - CNTF
KW  - gene targeting
KW  - NGF gene family
KW  - FGF-5
KW  - lIF
KW  - IGF-I
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31117
ER  - 
TY  - JOUR
A1  - Harth-Peter, Waltraud
T1  - Vorwort (Das Kind (1993) 14)
N2  - No abstract available
KW  - Kind
KW  - Erziehung
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43293
ER  - 
TY  - JOUR
A1  - Harth-Peter, Waltraud
T1  - Vorwort (Das Kind (1993) 13)
N2  - No abstract available
KW  - Kind
KW  - Erziehung
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43288
ER  - 
TY  - GEN
T1  - Jahresbericht 1992
T1  - Annual Report 1992
N2  - Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1992.
N2  - Annual Report of the University Library of Würzburg, 1992.
T3  - Jahresbericht der Universitätsbibliothek Würzburg - 1992 
KW  - Würzburg
KW  - Universitätsbibliothek
KW  - Bericht
KW  - Jahresbericht
KW  - Würzburg
KW  - University Library
KW  - Report
KW  - Annual Report
KW  - Wuerzburg
KW  - Wurzburg
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42369
ER  - 
TY  - JOUR
A1  - Kleber, Eduard W.
A1  - Stein, Roland
T1  - Konzentrationsprobleme: Fehldiagnose oder Zeitkrankheit?
N2  - Konzentration ist ein psychologisches Konstrukt, das hochkomplexe Interaktions-Situations-Phänomene bezeichnet. Die hohe Komplexität läßt unmittelbare Folgerungen für therapeutische Maßnahmen nicht zu und enthält spezielle Probleme der Validität bei niedrigen Leistungswerten in Tests. Die Diagnose von Konzentrationsproblemen dient nicht selten Lehrern, Schülern und Eltern als Entlastung. Dabeiführen oberflächliche Analysen oft zu Mißverständnissen und Fehldiagnosen. Bei solchen Diagnosen werden dann Konzentration, Interesse, Motivation, Belastbarkeit, "aus dem Felde gehen" und "auswandern" konfundiert. Ohne eine sorgfältige und möglichst umfassende Analyse der Aufmerksamkeitssituation können Maßnahmen zur Beseitigung oder Reduktion der Schwierigkeiten nicht effektiv ausgewählt werden.
N2  - Concentration is a psychological construct characterizing highly complex phenomena of interaction-situation. This high complexity does not allow direct deductions to be used for therapeutical measures and contains special problems ofvalidity when low test ranges occur. Frequently the diagnosis of a weakness in concentration is used to relieve teachers, pupils and parents. Due to this superjicial analyses often lead to misunderstandings and wrong diagnoses. In such diagnoses concentration, interest, motivation, stress capacity, "leaving the field" and "emigration" are confused with one another. Measures for removal or reduction of concentration deficits cannot be chosen in an effective manner without an analysis of the situation in which attention is being payed - an analysis as careful and as extensive as possible.
KW  - Sonderpädagogik
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40116
ER  - 
TY  - JOUR
A1  - Kunin, Calvin M.
A1  - Hua, Tong Hua
A1  - Van Arsdale-White, Laura
A1  - Krishnan, Chandradekar
A1  - Hacker, Jörg
T1  - Isolation of a nicotinamide-requiring clone of Escherichia coli O18:K1:H7 from women with acute cystitis resembles strains found in neonatal meningitis
N2  - During a study of the nutritional requirements of clinical isolates of Escherichia coli, we found that 21 (7.0%) of 301 strains required nicotinamide to grow in minimal medium. The nicotinamide- requiring strains were present in 16 (15.8%) of 101 cultures of urine from young women with acute cystitis, in 5 (5.0%) of 100 stool specimens from healthy adults, and in none of 100 blood samples from adult patients with bacteremia. Most of the strains belonged to serogroup OI8:KI:H7, were hemolytic, possessed type I fimbriae, and exhibited similar patterns of antibiotic susceptibility. Two of the urinary isolates expressed S fimbriae, and all 16 urinary isolates contained the s/aS homologue gene on their chromosomes. One of the stool isolates contained the s/aS gene. The urinary isolates closely resembled a large clone of E. coli that is reportedly associated with neonatal meningitis and sepsis. It may be possible to detect this and related clones by their requirement for nicotinamide and to screen strains for S fimbriae by relatively inexpensive hemagglutination methods, including the use of avian PI antigens to detect mannose- resistant, non-P-fimbriated E. coli; the agglutination of bovine erythrocytes; and the use of bovine mucin to detect sialyl galactosides in S fimbriae.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40406
ER  - 
TY  - JOUR
A1  - Fischer, Dagmar
A1  - Hock, Robert
A1  - Scheer, Ulrich
T1  - DNA Topoisomerase II is not detectable on lampbrush chromosomes but enriched in the amplified nucleoli of xenopus oocytes
N2  - In somatic cells DNA topoisomerase II (topo II) is thought to be involved in the domain Organization of the genome by anchoring the basis of chromatin loops to a chromosomal scafFold. Lampbrush chromosomes of am-phibian oocytes directly display this radial loop Organization in cytological preparations. In order to find out whether topo II may play a role in the Organization of these meiotic chromosomes, we performed immunofluorescence studies using antibodies against Xenopus topo II. Our results indicate that topo II is apparently absent from lampbrush chromosomes and is hence unlikely to act as a "fastener" of the numerous lateral chromosomal loops. Topo II was, however, enriched in the amplified nucleoli of Xenopus oocytes.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32654
ER  - 
TY  - CHAP
A1  - Schüssler, Ullrich
T1  - Electron microprobe investigations on the copper seal from burial 10
N2  - No abstract available
KW  - Tell Khirbet Salih
KW  - Tell Jikan
KW  - Ausgrabung
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38856
ER  - 
TY  - CHAP
A1  - Held, Winfried
T1  - Heiligtum und Wohnhaus : ein Beitrag zur Topographie des klassischen Milet
N2  - No abstract available
KW  - Klassische Archäologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39133
ER  - 
TY  - JOUR
A1  - Heller, Eberhard
A1  - Herdeis, Claus
T1  - Synthesis of 2S,5S- and 2R,5S-5-Hydroxypipecolic Acid via Amide-Methylenation of S-5-Hydroxy-2-piperidone with Dimethyltitanocene
N2  - A route to 2S,5S-and 2R,5S-hydroxypipecolic acid is presented, starting with the enantiopure 5S-5-hydroxy-piperidone 7. The key step of this reaction sequence is the chemoselsctive methylenation of the amide carbonyl group of 8 with dimethyltitanocene 9 to 10. The transformation of the exocyclic enecarbamate double bond to the carboxylic acid group is best accomplished via hydroboration/oxidation to the alcohol 11a,b. Separation and oxidation of the dlastereomers 11a,b, to 148. and 14b, and hydrolysis furnishes the diastereomeric pipecolic acids 15a and 15b in enantiopure form.
KW  - Chemie
KW  - Asymmetrie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38288
ER  - 
TY  - JOUR
A1  - Kraus, M. M.
A1  - Becker, Charles R.
A1  - Scholl, S.
A1  - Wu, Y. S.
A1  - Yuan, S.
A1  - Landwehr, G.
T1  - Infrared photoluminescence on molecular beam epitaxially  grown Hg\(_{1-x}\)Cd\(_x\)Te layers
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38053
ER  - 
TY  - JOUR
A1  - He, L.
A1  - Becker, Charles R.
A1  - Bicknell-Tassius, R. N.
A1  - Scholl, S.
A1  - Landwehr, G.
T1  - Molecular beam epitaxial growth of (100) Hg\(_{0.8}\)Cd\(_{0.2}\)Te on Cd\(_{0.96}\)Zn\(_{0.04}\)Te
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38044
ER  - 
TY  - JOUR
A1  - Wu, Y. S.
A1  - Becker, Charles R.
A1  - Waag, A.
A1  - von Schierstedt, K.
A1  - Bicknell-Tassius, R. N.
A1  - Landwehr, G.
T1  - Surface sublimation of zinc blende CdTe
N2  - The surface sublimation of Cd and Te atoms from the zinc blende (111)A CdTe surface has been investigated in detail by reflection high energy electron diffraction and x-ray photoelectron spectroscopy. These experiments verify that Te is much easier to evaporate than Cd. The experimental value for the Te activation energy from a Te stabilized (111)A CdTe surface is 1.41 ±0.1O eV, which is apparently inconsistent with recent theoretical results.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37829
ER  - 
TY  - JOUR
A1  - Qiu, Yueming
A1  - He, Li
A1  - Li, Jie
A1  - Yuan, Shixin
A1  - Becker, Charles R.
A1  - Landwehr, G.
T1  - Infrared photoconductor fabricated with HgTe/CdTe superlattice grown by molecular beam epitaxy
N2  - An infrared photoconductor fabricated with a HgTe/CdTe superlattice grown on a GaAs substrate by molecular beam epitaxy is described here for the first time. The growth procedure, device fabrication, and measurement results are described. The results show that the device has relatively high uniformity and 1000 K black-body detectivity 2.4 X 10\(^9\) cm Hz\(^{1/2}\) W\(^{-1}\) . The photoconductivity decay method was used for determining carrier lifetime of the HgTe/CdTe superlattice, the measured lifetime is 12\(\mu\)s at 77 K, which is the longest lifetime ever reported for HgTe/CdTe superlattices and we believe that the increase of lifetime is mainly due to the reduction of dimensions.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37772
ER  - 
TY  - JOUR
A1  - Becker, Charles R.
A1  - He, L.
A1  - Regnet, M. M.
A1  - Kraus, M.M.
A1  - Wu, Y. S.
A1  - Landwehr, G.
A1  - Zhang, X. F.
A1  - Zhang, H.
T1  - The growth and structure of short period (001) Hg\(_{1-x}\)Cd\(_x\)Te-HgTe superlattices
N2  - Molecular beam epitaxially grown short period (001) Hg\(_{1_x}\)Cd\(_x\)Te-HgTe superlattices have been systematically investigated. Several narrow well widths were chosen, e.g., 30, 35 and 40 Å, and the barrier widths were varied between 24 and 90 Å for a particular well width. Both the well width and the total period were determined directly by means of x-ray diffraction. The well width was determined by exploiting the high reflectivity from HgTe and the low reflectivity from CdTe for the (002) Bragg reflection. Knowing the well and barrier widths we have been able to set an upper limit on the average Cd concentration of the barriers, \(\overline x_b\), by annealing several superlattices and then measuring the composition of the resulting alloy. \(\overline x_b\) was shown to decrease exponentially with decreasing barrier width. The structure of a very short period superlattice, i.e., 31.4 Å, was also investigated by transmission electron microscopy, corroborating the x-ray diffraction results.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37858
ER  - 
TY  - JOUR
A1  - Wu, Y. S.
A1  - Becker, Charles R.
A1  - Waag, A.
A1  - Schmiedl, R.
A1  - Einfeldt, S.
A1  - Landwehr, G.
T1  - Oxygen on the (100) CdTe surface
N2  - We have investigated oxygen on CdTe substrates by means of x-ray photoelectron spectroscopy (XPS) and reflection high-energy electron diffraction (RHEED). A Te oxide layer that was at least 15 A thick was found on the surface of as-delivered CdTe substrates that were mechanically polished. This oxide is not easily evaporated at temperatures lower than 350°C. Furthermore, heating in air, which further oxidizes the CdTe layer, should be avoided. Etching with HCI acid (15% HCl) for at least 20 s and then rinsing with de-ionized water reduces the Te oxide layer on the surface down to 4% of a monoatomic layer. However, according to XPS measurements of the 0 Is peak, 20%-30% of a monoatomic layer of oxygen remains on the surface, which can be eliminated by heating at temperatures ranging between 300 and 340 cC. The RHEED patterns for a molecular beam epitaxially (MBE)-grown CdTe film on a (lOO) CdTe substrate with approximately one monoatomic layer of oxidized Te on the surface lose the characteristics of the normal RHEED pattems for a MBE-grown CdTe film on an oxygen-free CdTe substrate.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37869
ER  - 
TY  - JOUR
A1  - Herrmann, K. H.
A1  - Happ, M.
A1  - Möllmann, K.-P.
A1  - Tomm, J. W.
A1  - Becker, Charles R.
A1  - Kraus, M. M.
A1  - Yuan, S.
A1  - Landwehr, G.
T1  - A new model for the absorption coefficient of narrow gap (Hg,Cd)Te that simultaneously considers band tails and band filling
N2  - A semiempirical model is presented that correlates the broadening of the absorption edge with both transitions below the energy gap and with transitions by the Kane band model. This model correctly fits both the absorption and luminescence spectra of narrow-gap (Hg,Cd)Te samples that have been grown by the traveling heater method as well as by molecular-beam epitaxy. The accuracy of the band-gap determination is enhanced by this model.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37894
ER  - 
TY  - JOUR
A1  - Waag, A.
A1  - Heinke, H.
A1  - Scholl, S.
A1  - Becker, Charles R.
A1  - Landwehr, G.
T1  - Growth of MgTe and Cd\(_{1-x}\)Mg\(_x\)Te thin films by molecular beam epitaxy
N2  - We report on the growth of the compound semiconductor MgTe as weil as the ternary alloy Cd\(_{l-x}\)Mg, Te by molecular hcam cpitaxy. This is to our knowkdgc thc first time that this material has heen grown by any epitaxial technique. Bulk MgTe, which is hygroscopic, has a band gap of 3.0 eV and crystallizcs usually in thc wurtzite structure. Pseudomorphic films were grown on zincblende Cd Te suhstrates for a MgTe thickness helow a critical layer thickncss of approximately 500 nm. In addition, Cd\(_{l_x}\),Mg\(_x\)Te epilayers were grown with a Mg concentration between 0 and 68%, which corresponds to a band gap betwcen 1.5 and 2.5 eV at room temperature. The crystalline quality of thc layers is comparabk to CdTc thin films as long as they are fully strained. The lauice constant of zincblende MgTe is slightly smaller than that of CdTe, and the lattice mismatch is as low as O.7%. In addition highly n-type CdMgTe layers were fabricatcd by hromine doping. The tunability of the band gap as weil as the rather good laUice match with CdTc makes the matcrial interesting for optoelectronic device applications for the entire visible range.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37917
ER  - 
TY  - JOUR
A1  - Shanjia, Xu
A1  - Xinzhang, Wu
A1  - Boege, P.
A1  - Schäfer, H.
A1  - Becker, Charles R.
A1  - Geick, R.
T1  - Scattering characteristics of 3-D discontinuity consisting of semiconductor sample filled in waveguide with gaps
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37964
ER  - 
TY  - JOUR
A1  - He, L.
A1  - Becker, Charles R.
A1  - Bicknell-Tassius, R. N.
A1  - Scholl, S.
A1  - Landwehr, G.
T1  - Molecular beam epitaxial growth and evaluation of intrinsic and extrinsically doped (100) Hg\(_{0.8}\)Cd\(_{0.2}\)Te on (100) Cd\(_{0.96}\)Zn\(_{0.04}\)Te
N2  - No abstract available.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37885
ER  - 
TY  - JOUR
A1  - Wu, Y. S.
A1  - Becker, Charles R.
A1  - Waag, A.
A1  - Bicknell-Tassius, R. N.
A1  - Landwehr, G.
T1  - Removal of oxygen and reduction of carbon contamination on (100) Cd\(_{0.96}\)Zn\(_{0.04}\)Te
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38014
ER  - 
TY  - JOUR
A1  - Röder, G.
A1  - Steinlein, C.
A1  - Schmid, M.
A1  - Linsenmair, Karl Eduard
T1  - Karyotype and chromosome banding in the Turkish desert woodlouse Desertellio elongatus (Crustacea, Isopoda, Oniscidea)
N2  - The karyotype of D. elongatus was investigated by means of C-banding, silver staining, and mithramycinand quinacrine fluorescent staining. The diploid chromosome number is 2n = 50. C-banding shows pericentromerically localized constitutive heterochromatin in every chromosome. Two of the chromosome pairs carry two telomeric nucleolus organizer regions each. No heteromorphic sex chromosomes were found.
KW  - Karyotype; chromosome banding; Desertellio elongatus; Crustacea; Isopoda; Oniscidea
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30989
ER  - 
TY  - CHAP
A1  - Moll, Heidrun
T1  - Experimental cutaneous leishmaniasis: Langerhans cells internalize Leishmania major and induce an antigen-specific T-cell response.
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30932
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
T1  - Neurotrophic factors and their action on motoneuron survival: Implications for neuromuscular disorders
N2  - Motoneuron diseases represent a m&jor challenge to modern neurology, yet their clinical manifestations ware first described more than hundred years ago, and despite many studies the etiology of these diseases ramd,ns obscure with no effective treatments having been reported. Although progress has been made in establishing genetic linkage in the rare inherited for.ms of these diseases such as familial amyotrophic lateral scleriosisl , spinal mDscular atrophy and X-linked bulbo-spinal-mDscular atrophy, this new information has not yet affected therapeutic techniques. During the last few years several important steps have been taken concerning the physiological mechanisms involved in motoneuron survival during development, after lesion and in animal models of degenerative diseases, the molecular clOning of several new neurotrophic factors (brain-derived neurotrophic factor (BDNP), neurotrophin-3 and-4 (NT-3 and NT-4) and ciliary neurotrophic factor (CNTP)); the identification of a gene family of receptor molecules for same of these factors, progress in the understanding of the effects of polypeptide growth factors on muscle cell differentiation, neuronal sprouting (insulin-like growth factor-I and -11 (IGF-I and IGF-II), and in vitro motoneuronal survival (CNTF, IGF-I and -II and basic FGF). These findings have raised new hopes in that they could lead to a better understanding of the pathophysiological processes underlying these diseases, and that the pharmacological use of same of these newly characterized neurotrophic factors could present new possibilities for the treatment of these diseases.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31149
ER  - 
TY  - JOUR
A1  - Carroll, Patrick
A1  - Sendtner, Michael
A1  - Meyer, Michael
A1  - Thoenen, Hans
T1  - Rat ciliary neurothrophic factor (CNTF): gene structure and regulation of mRNA levels in glial cell cultures.
N2  - The structure of the rat ciliary neurotrophic factor (CNTF) gene and the regulation ofCNTF mRNA levels in cultured glial cells were investigated. The rat mRNA is encoded by a simple two-exon transcription unit. Sequence analysis of the region upstream of the transcription start-site did not reveal a typical TATA-box consensus sequence. Low levels of CNTF mRNA were detected in cultured Schwann cells, and CNTF mRNA was not increased by a variety of treatments. Three-week-old astrocyteenriched cell cultures from new-born rat brain contained easily detectable CNTF mRNA. In astrocyte-enriched cultures, upregulation of CNTF mRNA levels was observed after treatment with IFN-gamma. CNTF mRNA levels were down-regulated in these cells by treatments that elevate intracellular cyclic AMP and by members of the fibroblast growth factor (FGF) family. The implications of these results for potential in vivo functions of CNTF are discussed.
KW  - Astrocytes ; Schwann cells ; Interferon-gamma ; Fibroblast growth factor ; Cyclic AMP
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31763
ER  - 
TY  - JOUR
A1  - Thoenen, Hans
A1  - Hughes, Richard A.
A1  - Sendtner, Michael
T1  - Trophic support of motoneurons: physiological, pathophysiological, and therapeutic implications.
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31746
ER  - 
TY  - JOUR
A1  - Masu, Yasuo
A1  - Wolf, Eckhard
A1  - Holtmann, Bettina
A1  - Sendtner, Michael
A1  - Brem, Gottfried
A1  - Thoenen, Hans
T1  - Disruption of the CNTF gene results in motor neuron degeneration
N2  - CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33038
ER  - 
TY  - JOUR
A1  - Bünemann, Moritz
A1  - Pott, Lutz
T1  - Membrane-delimited activation of muscarinic K current by an albumin-associated factor in guinea-pig atrial myocytes
N2  - No abstract available
KW  - cardiac myocyte ; muscarinic K current ; G-protein ; Albumin ; serum
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31300
ER  - 
TY  - CHAP
A1  - Fackler, Guido
A1  - Weinmann, M.
T1  - Musik und bildende Kunst in nationalsozialistischen Lagern: Eine kommentierte Bibliographie
N2  - No abstract available
KW  - Musik ; Nationalsozialismus ; Konzentrationslager
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33793
ER  - 
TY  - JOUR
A1  - Schüssler, Ulrich
A1  - Skinner, David N. B.
A1  - Roland, Norbert W.
T1  - Subduction-related Mafic to Intermediate Plutonism in the Northwestern Wilson Terrane, North Victoria Land and Oates Coast, Antarctica
N2  - No abstract available
KW  - Wilson Terrane ; intrusions ; mafic composition ; relative age ; petrographic analysis ; gabbroic composition ; subduction zones
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31805
ER  - 
TY  - JOUR
A1  - Schüssler, Ulrich
T1  - Zur geologischen Situation der Erzlagerstätte Kupferberg-Neufang in der Umrahmung der Münchberger Gneismasse
N2  - Die Kupfer-Zink-Lagerstätte von Kupferberg-Neufang im Bereich der Münchberger Deckenstruktur besteht aus einem etwa 4 km langen Zug einzelner stratiformer Vererzungslinsen, der in NW-SE-Richtung vom anchimetamorphen Paläozoikum "Bayerischer" Faziesentwicklung in die Prasinit-Phyllit-Serie hinüberzieht. Bisherige lagerstättenkundliche Untersuchimgen interpretierten die gesamte Lagerstätte als einheitliche, submarin-exhalativ entstandene stratiforme Bildung in Zusammenhang mit ordovizischem basischem Vulkanismus, der in den Rahmengesteinen der Lagerstätte durch die Diabase der anchimetamorphen Randschieferserie bzw. die Prasinite der Prasinit-Phyllit-Serie dokumentiert ist. Diese Vorstellung steht jedoch in deutlichem Widerspruch zu den Ergebnissen neuerer geochemischer und biostratigraphischer Untersuchungen, die für die Diabase und Prasinite eine völlig unterschiedliche Zusammensetzung ergaben und die zeigten, daß die Prasinit-Phyllit-Serie schon im Oberproterozoikum, die erzführenden Schichten im anchimetamorphen Paläozoikum aber erst im Unterdevon sedimentiert wurden. Für eine Klärung der Situation sind weitere Untersuchungen im Bereich der Lagerstätte erforderlich.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31791
ER  - 
TY  - CHAP
A1  - Zillober, Christian
T1  - Sequential convex programming in theory and praxis
N2  - In this paper, convex approximation methods, suclt as CONLIN, the method of moving asymptotes (MMA) and a stabilized version of MMA (Sequential Convex Programming), are discussed with respect to their convergence behaviour. In an extensive numerical study they are :finally compared with other well-known optimization methods at 72 examples of sizing problems.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-35513
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Wissensvermittlung in Frage und Antwort: Der enzyklopädische Lehrdialog "Le Livre de Sidrac".
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36823
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Praedicatio est translatio: Das Elucidarium in der altfranzösischen Predigt.
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36776
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Le poème tu aux blancs - retrouvé? A la nue accablante et les Poésies de Mallarmé
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36945
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - De Nedjma à Nedschma: Il y a trente ans, la critique allemande découvrait une nouvelle comète
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33857
ER  - 
TY  - JOUR
A1  - Plakhutin, B. N.
A1  - Arbuznikov, Alexei V.
A1  - Trofimov, A. B.
T1  - Coupling coefficients for systems with two open electronic shells: transition metal ions with p\(^M\)d\(^N\) configuration
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30736
ER  - 
TY  - JOUR
A1  - Moll, Heidrun
T1  - Development of helper T cell subsets: a central role for interleukin 12
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30975
ER  - 
TY  - JOUR
A1  - Wilken, Norbert
A1  - Kossner, Ursula
A1  - Senécal, Jean-Luc
A1  - Scheer, Ulrich
A1  - Dabauvalle, Marie-Christine
T1  - Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils
N2  - No abstract available
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32049
ER  - 
TY  - JOUR
A1  - Brabletz, Thomas
A1  - Pfeuffer, Isolde
A1  - Schorr, Elke
A1  - Siebelt, Friederike
A1  - Wirth, Thomas
A1  - Serfling, Edgar
T1  - Transforming growth factor \(\beta\) and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site
N2  - Transforming growth factor \(\beta\) (TGF-\(\beta\)) has a growth-inhibitory effect on numerous different cell types of the immune system, including T lymphocytes. We show in this study that the inhibitory action of TGF-\(\beta\) on T lymphocytes is accompanied by a block of interleukin 2 (IL-2) gene expression which is mediated, at least in part, by inhibition of IL-2 promoter/enhancer activity. The functional analysis of cis-regulatory (protoenhancer) elements of the IL-2 enhancer/promoter region showed that the most TGF-\(\beta\)-responsive element maps to its so-called upstream promoter site. The proto-enhancer activity of the upstream promoter site element is also inhibited by cyclosporin A. The upstream promoter site DNA harbors two noncanonical, closely linked binding sequences for octamer and AP-1-like factors. Both sites are involved in the establishment of IL-2 enhancer activity. Since the activity of genuine octamer sites but not that of AP-1-binding sites is also impaired by TGF-\(\beta\) and cyclosporin A in E14 T lymphoma cells, we conclude that both immunosuppressives interfere with the activity but not the DNA binding of octamer factors in T lymphocytes.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31199
ER  -