TY  - JOUR
A1  - Haring, Bernhard
A1  - Reiner, Alexander P.
A1  - Liu, Jungmin
A1  - Tobias, Deirdre K.
A1  - Whitsel, Eric
A1  - Berger, Jeffrey S.
A1  - Desai, Pinkal
A1  - Wassertheil-Smoller, Sylvia
A1  - LaMonte, Michael J.
A1  - Hayden, Kathleen
A1  - Bick, Alexander G.
A1  - Natarajan, Pradeep
A1  - Weinstock, Joshua S.
A1  - Nguyen, Patricia K.
A1  - Stefanick, Marcia
A1  - Simon, Michael S.
A1  - Eaton, Charles
A1  - Kooperberg, Charles
A1  - Manson, JoAnn E.
T1  - Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential. Results from the Women’s Health Initiative
JF  - Journal of the American Heart Association
N2  - Background
Presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality. The relationship between a healthy lifestyle and CHIP is unknown.

Methods and Results
This analysis included 8709 postmenopausal women (mean age, 66.5 years) enrolled in the WHI (Women's Health Initiative), free of cancer or cardiovascular disease, with deep‐coverage whole genome sequencing data available. Information on lifestyle factors (body mass index, smoking, physical activity, and diet quality) was obtained, and a healthy lifestyle score was created on the basis of healthy criteria met (0 point [least healthy] to 4 points [most healthy]). CHIP was derived on the basis of a prespecified list of leukemogenic driver mutations. The prevalence of CHIP was 8.6%. A higher healthy lifestyle score was not associated with CHIP (multivariable‐adjusted odds ratio [OR] [95% CI], 0.99 [0.80–1.23] and 1.13 [0.93–1.37]) for the upper (3 or 4 points) and middle category (2 points), respectively, versus referent (0 or 1 point). Across score components, a normal and overweight body mass index compared with obese was significantly associated with a lower odds for CHIP (OR, 0.71 [95% CI, 0.57–0.88] and 0.83 [95% CI, 0.68–1.01], respectively; P‐trend 0.0015). Having never smoked compared with being a current smoker tended to be associated with lower odds for CHIP.

Conclusions
A healthy lifestyle, based on a composite score, was not related to CHIP among postmenopausal women. However, across individual lifestyle factors, having a normal body mass index was strongly associated with a lower prevalence of CHIP. These findings support the idea that certain healthy lifestyle factors are associated with a lower frequency of CHIP.
KW  - body mass index
KW  - clonal hematopoiesis of indeterminate potential
KW  - diet
KW  - lifestyle
KW  - physical activity
KW  - smoking
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-236146
VL  - 10
IS  - 5
ER  - 
TY  - JOUR
A1  - Verrua, Elisa
A1  - Ferrante, Emanuele
A1  - Filopanti, Marcello
A1  - Malchiodi, Elena
A1  - Sala, Elisa
A1  - Giavoli, Claudia
A1  - Arosio, Maura
A1  - Lania, Andrea Gerardo
A1  - Ronchi, Christina Lucia
A1  - Mantovani, Giovanna
A1  - Beck-Peccoz, Paolo
A1  - Spada, Anna
T1  - Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease
JF  - International Journal of Endocrinology
N2  - Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management. This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, and comorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria. At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 mu g/L in 11 patients (Group A) and below 0.4 mu g/L in 29 patients (Group B); moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only. No differences in other evaluated parameters were found. These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be too low for the currently used GH assay.
KW  - IGF-I
KW  - glucose tolerance test
KW  - growth hormone deficiency
KW  - body mass index
KW  - oral glucose
KW  - GH response
KW  - mortality
KW  - immunoassays
KW  - statement
KW  - diagnosis
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117790
SN  - 1687-8345
ER  -