TY  - CHAP
A1  - Lohse, Martin J.
A1  - Klotz, Karl-Norbert
A1  - Maurer, K.
A1  - Ott, I.
A1  - Schwabe, Ulrich
T1  - Effects of adenosine on mast cells
N2  - No abstract available
KW  - Adenosin
KW  - Mastzelle
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86101
ER  - 
TY  - JOUR
A1  - Lohse, M. J.
A1  - Maurer, K.
A1  - Klotz, Karl-Norbert
A1  - Schwabe, U.
T1  - Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells
N2  - 1 Adenosine and its metabolically stable analogue N.etbyl-carboxamidoadenosine (NECA) enhance histamine release from rat peritoneal mast cells when tbese are stimulated by calciummobilizing agents. NECA and adenosine shift the concentration-response curve of tbe calcium ionophore A23187 to lower concentrations. 2 The potencies of NECA or adenosinein enhancing A23187-induced histamine release are dependent on the Ievel of stimulated release in tbe absence of adenosine analogues. At high Ievels of release their potencies are up to 20 times higher than at low Ievels. Consequently, averaged concentration-response curves of adenosine and NECA for enhancing bistamine release are shallow. 3 The adenosine transport blocker S-(p-nitrobenzyl)-6-thioinosine (NBTI) has no effect by itself at low Ievels of stimulated histamine release, but abolishes the enhancing effect of adenosine. At high Ievels of release, however, NBTI alone enhances the release of histamine. 4 lt is concluded that adenosine and calcium reciprocally enhance the sensitivity of the secretory processes to the effects of the other agent. The Ievels of intracellular adenosine obtained by trapping adenosine inside stimulated mast cells are sufficient to enhance histamine release substantially, suggesting that this effect may play a physiological and pathophysiological role.
KW  - Toxikologie
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60346
ER  -