TY  - JOUR
A1  - Fareed, Muhammad Mazhar
A1  - Qasmi, Maryam
A1  - Aziz, Shaan
A1  - Völker, Elisabeth
A1  - Förster, Carola Yvette
A1  - Shityakov, Sergey
T1  - The role of clusterin transporter in the pathogenesis of Alzheimer’s disease at the blood–brain barrier interface: a systematic review
JF  - Biomolecules
N2  - Alzheimer’s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (Aβ) peptide, which is the major pathogenic factor of AD. On the other hand, this transporter is also active at the blood–brain barrier (BBB), a barrier that prevents harmful substances from entering and exiting the brain. Therefore, in this review, we discuss and emphasize the role of the CLU transporter and CLU-linked molecular mechanisms at the BBB interface in the pathogenesis of AD.
KW  - clusterin transporter
KW  - Wnt signaling
KW  - Alzheimer’s disease
KW  - AD pathogenesis
KW  - blood–brain barrier
KW  - apolipoprotein J
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-290279
SN  - 2218-273X
VL  - 12
IS  - 10
ER  -