TY  - JOUR
A1  - Van Baelen, Anthony
A1  - Mottet, Nicolas
A1  - Spahn, Martin
A1  - Briganti, Alberto
A1  - Gontero, Paolo
A1  - Joniau, Steven
T1  - Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer
JF  - Advances in Urology
N2  - Lymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were drawn. Only recently, improved survival due to completion of radical prostatectomy (RP) (compared to abandoning RP) in known or presumed lymph-node-positive patients has been shown. Lymph node sampling can only be considered representative if an adequate number of nodes is removed. While several authors have suggested that a therapeutic benefit in patients undergoing RP is not provided by PLND, the reliability of these studies is uncertain. Contrary to this, several studies have indicated the possibility of long-term survival even in the presence of limited lymph node metastases. The role and timing of initiation of adjuvant androgen deprivation therapy (ADT) in patients who have node-positive disease after RP is controversial. Recent studies suggest that delaying ADT may not adversely impact survival.
KW  - Prostatakrebs
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-123990
VL  - 2012
IS  - 983058
ER  -