TY - JOUR A1 - Schneider-Schaulies, Sibylle A1 - Liebert, U. G. A1 - Baczko, K. A1 - Cattaneo, R. A1 - Billeter, M. A1 - ter Meulen, V. T1 - Restriction of measles virus gene expression in acute and subacute encephalitis in Lewis rats N2 - No abstract available KW - Virologie Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62266 ER - TY - JOUR A1 - Kerkau, Thomas A1 - Schmitt-Landgraf, Renate A1 - Schimpl, Anneliese A1 - Wecker, Eberhard T1 - Downregulation of HLA Class I Antigensin HIV-1-Infected Cells N2 - By means of indirect immunofluorescence analysis we investigated the effect of HIV -1 infection on HLA class I surface antigens. We report here that in CD4\(^+\) HeLa cells, in H9 cells, and in peripheral T Iymphocytes HLA class I antigens are down regulated following infection with HIV -1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-l in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced. Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47172 ER -