TY - JOUR A1 - Ciuchi, Sergio A1 - Di Sante, Domenico A1 - Dobrosavljević, Vladimir A1 - Fratini, Simone T1 - The origin of Mooij correlations in disordered metals JF - npj Quantum Materials N2 - Sufficiently disordered metals display systematic deviations from the behavior predicted by semi-classical Boltzmann transport theory. Here the scattering events from impurities or thermal excitations can no longer be considered as additive-independent processes, as asserted by Matthiessen’s rule following from this picture. In the intermediate region between the regime of good conduction and that of insulation, one typically finds a change of sign of the temperature coefficient of resistivity, even at elevated temperature spanning ambient conditions, a phenomenology that was first identified by Mooij in 1973. Traditional weak coupling approaches to identify relevant corrections to the Boltzmann picture focused on long-distance interference effects such as “weak localization”, which are especially important in low dimensions (1D and 2D) and close to the zero-temperature limit. Here we formulate a strong-coupling approach to tackle the interplay of strong disorder and lattice deformations (phonons) in bulk three-dimensional metals at high temperatures. We identify a polaronic mechanism of strong disorder renormalization, which describes how a lattice locally responds to the relevant impurity potential. This mechanism, which quantitatively captures the Mooij regime, is physically distinct and unrelated to Anderson localization, but realizes early seminal ideas of Anderson himself, concerning the interplay of disorder and lattice deformations. KW - electronic properties and materials KW - phase transitions and critical phenomena KW - theory and computation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223148 VL - 3 ER - TY - JOUR A1 - China, Swarup A1 - Burrows, Susannah M. A1 - Wang, Bingbing A1 - Harder, Tristan H. A1 - Weis, Johannes A1 - Tanarhte, Meryem A1 - Rizzo, Luciana V. A1 - Brito, Joel A1 - Cirino, Glauber G. A1 - Ma, Po-Lun A1 - Cliff, John A1 - Artaxo, Paulo A1 - Gilles, Mary K. A1 - Laskin, Alexander T1 - Fungal spores as a source of sodium salt particles in the Amazon basin JF - Nature Communications N2 - In the Amazon basin, particles containing mixed sodium salts are routinely observed and are attributed to marine aerosols transported from the Atlantic Ocean. Using chemical imaging analysis, we show that, during the wet season, fungal spores emitted by the forest biosphere contribute at least 30% (by number) to sodium salt particles in the central Amazon basin. Hydration experiments indicate that sodium content in fungal spores governs their growth factors. Modeling results suggest that fungal spores account for ~69% (31–95%) of the total sodium mass during the wet season and that their fractional contribution increases during nighttime. Contrary to common assumptions that sodium-containing aerosols originate primarily from marine sources, our results suggest that locally-emitted fungal spores contribute substantially to the number and mass of coarse particles containing sodium. Hence, their role in cloud formation and contribution to salt cycles and the terrestrial ecosystem in the Amazon basin warrant further consideration. KW - atmospheric chemistry KW - biogeochemistry KW - environmental sciences Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222492 VL - 9 ER - TY - JOUR A1 - Castilho, Miguel A1 - Hochleitner, Gernot A1 - Wilson, Wouter A1 - van Rietbergen, Bert A1 - Dalton, Paul D. A1 - Groll, Jürgen A1 - Malda, Jos A1 - Ito, Keita T1 - Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds JF - Scientific Reports N2 - Reinforcing hydrogels with micro-fibre scaffolds obtained by a Melt-Electrospinning Writing (MEW) process has demonstrated great promise for developing tissue engineered (TE) constructs with mechanical properties compatible to native tissues. However, the mechanical performance and reinforcement mechanism of the micro-fibre reinforced hydrogels is not yet fully understood. In this study, FE models, implementing material properties measured experimentally, were used to explore the reinforcement mechanism of fibre-hydrogel composites. First, a continuum FE model based on idealized scaffold geometry was used to capture reinforcement effects related to the suppression of lateral gel expansion by the scaffold, while a second micro-FE model based on micro-CT images of the real construct geometry during compaction captured the effects of load transfer through the scaffold interconnections. Results demonstrate that the reinforcement mechanism at higher scaffold volume fractions was dominated by the load carrying-ability of the fibre scaffold interconnections, which was much higher than expected based on testing scaffolds alone because the hydrogel provides resistance against buckling of the scaffold. We propose that the theoretical understanding presented in this work will assist the design of more effective composite constructs with potential applications in a wide range of TE conditions. KW - biomedical engineering KW - biomedical materials KW - gels and hydrogels Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222280 VL - 8 ER - TY - JOUR A1 - Carradec, Quentin A1 - Pelletier, Eric A1 - Da Silva, Corinne A1 - Alberti, Adriana A1 - Seeleuthner, Yoann A1 - Blanc-Mathieu, Romain A1 - Lima-Mendez, Gipsi A1 - Rocha, Fabio A1 - Tirichine, Leila A1 - Labadie, Karine A1 - Kirilovsky, Amos A1 - Bertrand, Alexis A1 - Engelen, Stefan A1 - Madoui, Mohammed-Amin A1 - Méheust, Raphaël A1 - Poulain, Julie A1 - Romac, Sarah A1 - Richter, Daniel J. A1 - Yoshikawa, Genki A1 - Dimier, Céline A1 - Kandels-Lewis, Stefanie A1 - Picheral, Marc A1 - Searson, Sarah A1 - Jaillon, Olivier A1 - Aury, Jean-Marc A1 - Karsenti, Eric A1 - Sullivan, Matthew B. A1 - Sunagawa, Shinichi A1 - Bork, Peer A1 - Not, Fabrice A1 - Hingamp, Pascal A1 - Raes, Jeroen A1 - Guidi, Lionel A1 - Ogata, Hiroyuki A1 - de Vargas, Colomban A1 - Iudicone, Daniele A1 - Bowler, Chris A1 - Wincker, Patrick T1 - A global ocean atlas of eukaryotic gene JF - Nature Communications N2 - While our knowledge about the roles of microbes and viruses in the ocean has increased tremendously due to recent advances in genomics and metagenomics, research on marine microbial eukaryotes and zooplankton has benefited much less from these new technologies because of their larger genomes, their enormous diversity, and largely unexplored physiologies. Here, we use a metatranscriptomics approach to capture expressed genes in open ocean Tara Oceans stations across four organismal size fractions. The individual sequence reads cluster into 116 million unigenes representing the largest reference collection of eukaryotic transcripts from any single biome. The catalog is used to unveil functions expressed by eukaryotic marine plankton, and to assess their functional biogeography. Almost half of the sequences have no similarity with known proteins, and a great number belong to new gene families with a restricted distribution in the ocean. Overall, the resource provides the foundations for exploring the roles of marine eukaryotes in ocean ecology and biogeochemistry. KW - genomics KW - marine biology KW - microbial ecology KW - water microbiology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222250 VL - 9 ER - TY - JOUR A1 - Brunk, Michael A1 - Sputh, Sebastian A1 - Doose, Sören A1 - van de Linde, Sebastian A1 - Terpitz, Ulrich T1 - HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi JF - Scientific Reports N2 - The dynamics of early fungal development and its interference with physiological signals and environmental factors is yet poorly understood. Especially computational analysis tools for the evaluation of the process of early spore germination and germ tube formation are still lacking. For the time-resolved analysis of conidia germination of the filamentous ascomycete Fusarium fujikuroi we developed a straightforward toolbox implemented in ImageJ. It allows for processing of microscopic acquisitions (movies) of conidial germination starting with drift correction and data reduction prior to germling analysis. From the image time series germling related region of interests (ROIs) are extracted, which are analysed for their area, circularity, and timing. ROIs originating from germlings crossing other hyphae or the image boundaries are omitted during analysis. Each conidium/hypha is identified and related to its origin, thus allowing subsequent categorization. The efficiency of HyphaTracker was proofed and the accuracy was tested on simulated germlings at different signal-to-noise ratios. Bright-field microscopic images of conidial germination of rhodopsin-deficient F. fujikuroi mutants and their respective control strains were analysed with HyphaTracker. Consistent with our observation in earlier studies the CarO deficient mutant germinated earlier and grew faster than other, CarO expressing strains. KW - bioinformatics KW - cell growth KW - fungal biology KW - microscopy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221691 VL - 8 ER - TY - JOUR A1 - Bruchhagen, Christin A1 - Jarick, Marcel A1 - Mewis, Carolin A1 - Hertlein, Tobias A1 - Niemann, Silke A1 - Ohlsen, Knut A1 - Peters, Georg A1 - Planz, Oliver A1 - Ludwig, Stephan A1 - Ehrhardt, Christina T1 - Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound JF - Scientific Reports N2 - Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral target. Inhibitors of MEK, such as CI-1040, showed potent antiviral activity. However, it remained unclear if this inhibitor and its active form, ATR-002, might sensitize host cells to either IV or secondary bacterial infections. To address these questions, we studied the anti-pathogen activity of ATR-002 in comparison to CI-1040, particularly, its impact on Staphylococcus aureus (S. aureus), which is a major cause of IV super-infections. We analysed IV and S. aureus titres in vitro during super-infection in the presence and absence of the drugs and characterized the direct impact of ATR-002 on bacterial growth and phenotypic changes. Importantly, neither CI-1040 nor ATR-002 treatment led to increased bacterial titres during super-infection, indicating that the drug does not sensitize cells for bacterial infection. In contrast, we rather observed reduced bacterial titres in presence of ATR-002. Surprisingly, ATR-002 also led to reduced bacterial growth in suspension cultures, reduced stress- and antibiotic tolerance without resistance induction. Our data identified for the first time that a particular MEK-inhibitor metabolite exhibits direct antibacterial activity, which is likely due to interference with the bacterial PknB kinase/Stp phosphatase signalling system. KW - antimicrobials KW - pathogens Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221648 VL - 8 ER - TY - JOUR A1 - Anany, Mohamed A. A1 - Kreckel, Jennifer A1 - Füllsack, Simone A1 - Rosenthal, Alevtina A1 - Otto, Christoph A1 - Siegmund, Daniela A1 - Wajant, Harald T1 - Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis JF - Cell Death & Disease N2 - TNF-like weak inducer of apoptosis (TWEAK) and inhibition of protein synthesis with cycloheximide (CHX) sensitize for poly(I:C)-induced cell death. Notably, although CHX preferentially enhanced poly(I:C)-induced apoptosis, TWEAK enhanced primarily poly(I:C)-induced necroptosis. Both sensitizers of poly(I:C)-induced cell death, however, showed no major effect on proinflammatory poly(I:C) signaling. Analysis of a panel of HeLa-RIPK3 variants lacking TRADD, RIPK1, FADD, or caspase-8 expression revealed furthermore similarities and differences in the way how poly(I:C)/TWEAK, TNF, and TRAIL utilize these molecules for signaling. RIPK1 turned out to be essential for poly(I:C)/TWEAK-induced caspase-8-mediated apoptosis but was dispensable for this response in TNF and TRAIL signaling. TRADD-RIPK1-double deficiency differentially affected poly(I:C)-triggered gene induction but abrogated gene induction by TNF completely. FADD deficiency abrogated TRAIL- but not TNF- and poly(I:C)-induced necroptosis, whereas TRADD elicited protective activity against all three death inducers. A general protective activity against poly(I:C)-, TRAIL-, and TNF-induced cell death was also observed in FLIPL and FLIPS transfectrants. Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221104 VL - 9 ER - TY - JOUR A1 - Albrecht, Jörg A1 - Classen, Alice A1 - Vollstädt, Maximilian G.R. A1 - Mayr, Antonia A1 - Mollel, Neduvoto P. A1 - Schellenberger Costa, David A1 - Dulle, Hamadi I. A1 - Fischer, Markus A1 - Hemp, Andreas A1 - Howell, Kim M. A1 - Kleyer, Michael A1 - Nauss, Thomas A1 - Peters, Marcell K. A1 - Tschapka, Marco A1 - Steffan-Dewenter, Ingolf A1 - Böhning-Gaese, Katrin A1 - Schleuning, Matthias T1 - Plant and animal functional diversity drive mutualistic network assembly across an elevational gradient JF - Nature Communications N2 - Species' functional traits set the blueprint for pair-wise interactions in ecological networks. Yet, it is unknown to what extent the functional diversity of plant and animal communities controls network assembly along environmental gradients in real-world ecosystems. Here we address this question with a unique dataset of mutualistic bird-fruit, bird-flower and insect-flower interaction networks and associated functional traits of 200 plant and 282 animal species sampled along broad climate and land-use gradients on Mt. Kilimanjaro. We show that plant functional diversity is mainly limited by precipitation, while animal functional diversity is primarily limited by temperature. Furthermore, shifts in plant and animal functional diversity along the elevational gradient control the niche breadth and partitioning of the respective other trophic level. These findings reveal that climatic constraints on the functional diversity of either plants or animals determine the relative importance of bottom-up and top-down control in plant-animal interaction networks. KW - Traits-Environment Relationships KW - Species Traits KW - Ecological Networks KW - 4TH-Corner Problem KW - Multiple Traits KW - Bottom-up KW - Biodiversity KW - Community ecology KW - Ecological networks KW - Ecology KW - Ecosystem ecology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221056 VL - 9 ER - TY - JOUR T1 - Long-term monitoring of the ANTARES optical module efficiencies using \(^{40}\)K decays in sea water JF - European Physical Journal C N2 - Cherenkov light induced by radioactive decay products is one of the major sources of background light for deep-sea neutrino telescopes such as ANTARES. These decays are at the same time a powerful calibration source. Using data collected by the ANTARES neutrino telescope from mid 2008 to 2017, the time evolution of the photon detection efficiency of optical modules is studied. A modest loss of only 20% in 9 years is observed. The relative time calibration between adjacent modules is derived as well. KW - Neutrino Telescope KW - Dark-Matter KW - Calibration KW - System KW - Light Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227815 VL - 78 ER - TY - JOUR T1 - Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials JF - Lancet Oncology N2 - Background Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials. Methods We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality). Findings Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5-14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21.4% for NACT versus 15.9% for adjuvant chemotherapy (5.5% increase [95% CI 2.4-8.6]; rate ratio 1.37 [95% CI 1.17-1.61]; p = 0.0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38.2% for NACT vs 38.0% for adjuvant chemotherapy; rate ratio 1.02 [95% CI 0.92-1.14]; p = 0.66), breast cancer mortality (34.4% vs 33.7%; 1.06 [0.95-1.18]; p = 0.31), or death from any cause (40.9% vs 41.2%; 1.04 [0.94-1.15]; p = 0.45). Interpretation Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered-eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy. Copyright (c) The Author(s). Published by Elsevier Ltd. KW - Stimulating factor KW - Therapy KW - Methotrexate KW - Radiotherapy KW - Survival KW - Surgery Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227782 VL - 19 IS - 1 ER - TY - JOUR T1 - Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope JF - Journal of Instrumentation N2 - The Hamamatsu R12199-023-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum efficiency, the gain and the peak-to-valley ratio have also been measured for a sub-sample in order to determine parameter values needed as input to numerical simulations of the detector. KW - Cherenkov detectors KW - Large detector systems for particle and astroparticle physics KW - Neutrino detectors KW - Photon detectors for UV, visible and IR photons (vacuum) KW - Prototype Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227744 VL - 13 ER - TY - JOUR A1 - Abt, Raimond A1 - Erdmenger, Johanna T1 - Properties of modular Hamiltonians on entanglement plateaux JF - Journal of High Energy Physics N2 - The modular Hamiltonian of reduced states, given essentially by the logarithm of the reduced density matrix, plays an important role within the AdS/CFT correspondence in view of its relation to quantum information. In particular, it is an essential ingredient for quantum information measures of distances between states, such as the relative entropy and the Fisher information metric. However, the modular Hamiltonian is known explicitly only for a few examples. For a family of states rho(lambda) that is parametrized by a scalar lambda, the first order contribution in (lambda) over tilde = lambda-lambda(0) of the modular Hamiltonian to the relative entropy between rho(lambda) and a reference state rho(lambda 0) is completely determined by the entanglement entropy, via the first law of entanglement. For several examples, e.g. for ball-shaped regions in the ground state of CFTs, higher order contributions are known to vanish. In these cases the modular Hamiltonian contributes to the Fisher information metric in a trivial way. We investigate under which conditions the modular Hamiltonian provides a non-trivial contribution to the Fisher information metric, i.e. when the contribution of the modular Hamiltonian to the relative entropy is of higher order in (lambda) over tilde. We consider one-parameter families of reduced states on two entangling regions that form an entanglement plateau, i.e. the entanglement entropies of the two regions saturate the Araki-Lieb inequality. We show that in general, at least one of the relative entropies of the two entangling regions is expected to involve (lambda) over tilde contributions of higher order from the modular Hamiltonian. Furthermore, we consider the implications of this observation for prominent AdS/CFT examples that form entanglement plateaux in the large N limit. KW - AdS-CFT Correspondence KW - Gauge-gravity correspondence KW - Conformal Field Theory KW - Relative Entropy KW - Complexity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227693 VL - 11 IS - 2 ER - TY - JOUR A1 - Klenke, Daniela A1 - Quast, Anja A1 - Prelog, Martina A1 - Holl-Wieden, Annette A1 - Riekert, Maximilian A1 - Stellzig-Eisenhauer, Angelika A1 - Meyer-Marcotty, Philipp T1 - TMJ pathomorphology in patients with JIA-radiographic parameters for early diagnosis- JF - Head & Face Medicine N2 - Background Juvenile idiopathic arthritis (JIA) is often accompanied by pathomorphological changes to the temporomandibular joint (TMJ). By analyzing orthodontical orthopantomograms of JIA patients the aims of the study were a) classification of condyle changes, b) quantification of bony asymmetries of condylar destruction and c) detection of relationships between disease duration and TMJ-involvement. Patients/Methods 46 caucasian JIA-patients (28 female; 18 male; < 16.0 years) were enrolled, each joint (n = 92) was morphologically assessed by means of orthopantomogram, quantitatively analysed and compared with duration of general disease. Condyle morphology was assessed using the Billiau scale for severity of destruction [1]. The quantitative analysis was based on ratios of condyle, ramus and mandible height. Results Patients were divided into groups (Group I – slightly affected, n = 36; Billiau severity 0–2; condyle findings: X-ray normal, condyle erosions, condylar flattening; Group II – severely affected, N = 10; Billiau severity 3–4; condyle findings: condylar flattenings and erosions, unilateral/bilateral complete loss of condyles), based on morphological analysis of condylar destruction. Duration of disease was significantly longer in Group II (8.9 ± 5.2 years) than in Group I (4.6 ± 4.7 years). Asymmetries of condyle, ramus and mandible height, quantitatively analysed by contralateral comparison, were significantly more marked in patients of Group II than of Group I. Conclusions Orthopantomogram imaging can be used in orthodontics clinical routine to detect TMJ-pathologies and is an important reference for monitoring progression of JIA. Classification into severe and slightly affected TMJ is possible by analysis of condylar pathomorphology. An association between degree of destruction, extent of lower jaw asymmetry and disease duration is suggested by the results. KW - juvenile idiopathic arthritis KW - TMJ KW - OPT KW - asymmetry KW - condyle pathomorphology Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-325882 VL - 14 ER - TY - JOUR A1 - Semler, Elisa A1 - Anderl-Straub, Sarah A1 - Uttner, Ingo A1 - Diehl-Schmid, Janine A1 - Danek, Adrian A1 - Einsiedler, Beate A1 - Fassbender, Klaus A1 - Fliessbach, Klaus A1 - Huppertz, Hans-Jürgen A1 - Jahn, Holger A1 - Kornhuber, Johannes A1 - Landwehrmeyer, Bernhard A1 - Lauer, Martin A1 - Muche, Rainer A1 - Prudlo, Johannes A1 - Schneider, Anja A1 - Schroeter, Matthias L. A1 - Ludolph, Albert C. A1 - Otto, Markus T1 - A language-based sum score for the course and therapeutic intervention in primary progressive aphasia JF - Alzheimer's Research & Therapy N2 - Background With upcoming therapeutic interventions for patients with primary progressive aphasia (PPA), instruments for the follow-up of patients are needed to describe disease progression and to evaluate potential therapeutic effects. So far, volumetric brain changes have been proposed as clinical endpoints in the literature, but cognitive scores are still lacking. This study followed disease progression predominantly in language-based performance within 1 year and defined a PPA sum score which can be used in therapeutic interventions. Methods We assessed 28 patients with nonfluent variant PPA, 17 with semantic variant PPA, 13 with logopenic variant PPA, and 28 healthy controls in detail for 1 year. The most informative neuropsychological assessments were combined to a sum score, and associations between brain atrophy were investigated followed by a sample size calculation for clinical trials. Results Significant absolute changes up to 20% in cognitive tests were found after 1 year. Semantic and phonemic word fluency, Boston Naming Test, Digit Span, Token Test, AAT Written language, and Cookie Test were identified as the best markers for disease progression. These tasks provide the basis of a new PPA sum score. Assuming a therapeutic effect of 50% reduction in cognitive decline for sample size calculations, a number of 56 cases is needed to find a significant treatment effect. Correlations between cognitive decline and atrophy showed a correlation up to r = 0.7 between the sum score and frontal structures, namely the superior and inferior frontal gyrus, as well as with left-sided subcortical structures. Conclusion Our findings support the high performance of the proposed sum score in the follow-up of PPA and recommend it as an outcome measure in intervention studies. KW - frontotemporal dementia KW - cognitive neuropsychology in dementia KW - assessment of cognitive disorders/dementia KW - volumetric MRI KW - aphasia Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-236277 VL - 10 ER - TY - JOUR A1 - Andratschke, N. A1 - Alheid, H. A1 - Allgäuer, M. A1 - Becker, G. A1 - Blanck, O. A1 - Boda-Heggemann, J. A1 - Brunner, T. A1 - Duma, M. A1 - Gerum, S. A1 - Guckenberger, M. A1 - Hildebrandt, G. A1 - Klement, R. J. A1 - Lewitzki, V. A1 - Ostheimer, C. A1 - Papachristofilou, A. A1 - Petersen, C. A1 - Schneider, T. A1 - Semrau, R. A1 - Wachter, S. A1 - Habermehl, D. T1 - The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases JF - BMC Cancer N2 - Background The intent of this pooled analysis as part of the German society for radiation oncology (DEGRO) stereotactic body radiotherapy (SBRT) initiative was to analyze the patterns of care of SBRT for liver oligometastases and to derive factors influencing treated metastases control and overall survival in a large patient cohort. Methods From 17 German and Swiss centers, data on all patients treated for liver oligometastases with SBRT since its introduction in 1997 has been collected and entered into a centralized database. In addition to patient and tumor characteristics, data on immobilization, image guidance and motion management as well as dose prescription and fractionation has been gathered. Besides dose response and survival statistics, time trends of the aforementioned variables have been investigated. Results In total, 474 patients with 623 liver oligometastases (median 1 lesion/patient; range 1–4) have been collected from 1997 until 2015. Predominant histologies were colorectal cancer (n = 213 pts.; 300 lesions) and breast cancer (n = 57; 81 lesions). All centers employed an SBRT specific setup. Initially, stereotactic coordinates and CT simulation were used for treatment set-up (55%), but eventually were replaced by CBCT guidance (28%) or more recently robotic tracking (17%). High variance in fraction (fx) number (median 1 fx; range 1–13) and dose per fraction (median: 18.5 Gy; range 3–37.5 Gy) was observed, although median BED remained consistently high after an initial learning curve. Median follow-up time was 15 months; median overall survival after SBRT was 24 months. One- and 2-year treated metastases control rate of treated lesions was 77% and 64%; if maximum isocenter biological equivalent dose (BED) was greater than 150 Gy EQD2Gy, it increased to 83% and 70%, respectively. Besides radiation dose colorectal and breast histology and motion management methods were associated with improved treated metastases control. Conclusion After an initial learning curve with regards to total cumulative doses, consistently high biologically effective doses have been employed translating into high local tumor control at 1 and 2 years. The true impact of histology and motion management method on treated metastases control deserve deeper analysis. Overall survival is mainly influenced by histology and metastatic tumor burden. KW - stereotactic body radiotherapy KW - liver oligometastases KW - outcome KW - treated metastases control KW - oligometastases KW - oligo-recurrence KW - sync-oligometastases Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-221116 VL - 18 ER - TY - JOUR A1 - Breuer, René A1 - Mattheisen, Manuel A1 - Frank, Josef A1 - Krumm, Bertram A1 - Treutlein, Jens A1 - Kassem, Layla A1 - Strohmaier, Jana A1 - Herms, Stefan A1 - Mühleisen, Thomas W. A1 - Degenhardt, Franziska A1 - Cichon, Sven A1 - Nöthen, Markus M. A1 - Karypis, George A1 - Kelsoe, John A1 - Greenwood, Tiffany A1 - Nievergelt, Caroline A1 - Shilling, Paul A1 - Shekhtman, Tatyana A1 - Edenberg, Howard A1 - Craig, David A1 - Szelinger, Szabolcs A1 - Nurnberger, John A1 - Gershon, Elliot A1 - Alliey-Rodriguez, Ney A1 - Zandi, Peter A1 - Goes, Fernando A1 - Schork, Nicholas A1 - Smith, Erin A1 - Koller, Daniel A1 - Zhang, Peng A1 - Badner, Judith A1 - Berrettini, Wade A1 - Bloss, Cinnamon A1 - Byerley, William A1 - Coryell, William A1 - Foroud, Tatiana A1 - Guo, Yirin A1 - Hipolito, Maria A1 - Keating, Brendan A1 - Lawson, William A1 - Liu, Chunyu A1 - Mahon, Pamela A1 - McInnis, Melvin A1 - Murray, Sarah A1 - Nwulia, Evaristus A1 - Potash, James A1 - Rice, John A1 - Scheftner, William A1 - Zöllner, Sebastian A1 - McMahon, Francis J. A1 - Rietschel, Marcella A1 - Schulze, Thomas G. T1 - Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics JF - International Journal of Bipolar Disorders N2 - Background Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in explaining the high heritability of BD through GWAS have remained elusive. To overcome this dilemma, genetic research into BD, has embraced a variety of strategies such as the formation of large consortia to increase sample size and sequencing approaches. Here we advocate a complementary approach making use of already existing GWAS data: a novel data mining procedure to identify yet undetected genotype–phenotype relationships. We adapted association rule mining, a data mining technique traditionally used in retail market research, to identify frequent and characteristic genotype patterns showing strong associations to phenotype clusters. We applied this strategy to three independent GWAS datasets from 2835 phenotypically characterized patients with BD. In a discovery step, 20,882 candidate association rules were extracted. Results Two of these rules—one associated with eating disorder and the other with anxiety—remained significant in an independent dataset after robust correction for multiple testing. Both showed considerable effect sizes (odds ratio ~ 3.4 and 3.0, respectively) and support previously reported molecular biological findings. Conclusion Our approach detected novel specific genotype–phenotype relationships in BD that were missed by standard analyses like GWAS. While we developed and applied our method within the context of BD gene discovery, it may facilitate identifying highly specific genotype–phenotype relationships in subsets of genome-wide data sets of other complex phenotype with similar epidemiological properties and challenges to gene discovery efforts. KW - bipolar disorder KW - subphenotypes KW - rule discovery KW - data mining KW - genotype-phenotype patterns Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220509 VL - 6 ER - TY - JOUR A1 - Coelho, Luis Pedro A1 - Kultima, Jens Roat A1 - Costea, Paul Igor A1 - Fournier, Coralie A1 - Pan, Yuanlong A1 - Czarnecki-Maulden, Gail A1 - Hayward, Matthew Robert A1 - Forslund, Sofia K. A1 - Schmidt, Thomas Sebastian Benedikt A1 - Descombes, Patrick A1 - Jackson, Janet R. A1 - Li, Qinghong A1 - Bork, Peer T1 - Similarity of the dog and human gut microbiomes in gene content and response to diet JF - Microbiome N2 - Background Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs. Results We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data). Based on this catalog and taxonomic abundance profiling, we show that the dog microbiome is closer to the human microbiome than the microbiome of either pigs or mice. To investigate this similarity in terms of response to dietary changes, we report on a randomized intervention with two diets (high-protein/low-carbohydrate vs. lower protein/higher carbohydrate). We show that diet has a large and reproducible effect on the dog microbiome, independent of breed or sex. Moreover, the responses were in agreement with those observed in previous human studies. Conclusions We conclude that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high-protein diet. KW - microbiome KW - diet KW - metagenomics KW - dog microbiome KW - human microbiome KW - mouse microbiome KW - pig microbiome Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-223177 VL - 6 ER - TY - JOUR A1 - Wevrett, Jill A1 - Fenwick, Andrew A1 - Scuffham, James A1 - Johansson, Lena A1 - Gear, Jonathan A1 - Schlögl, Susanne A1 - Segbers, Marcel A1 - Sjögreen-Gleisner, Katarina A1 - Solný, Pavel A1 - Lassmann, Michael A1 - Tipping, Jill A1 - Nisbet, Andrew T1 - Inter-comparison of quantitative imaging of lutetium-177 (\(^{177}\)Lu) in European hospitals JF - EJNMMI Physics N2 - Background This inter-comparison exercise was performed to demonstrate the variability of quantitative SPECT/CT imaging for lutetium-177 (\(^{177}\)Lu) in current clinical practice. Our aim was to assess the feasibility of using international inter-comparison exercises as a means to ensure consistency between clinical sites whilst enabling the sites to use their own choice of quantitative imaging protocols, specific to their systems. Dual-compartment concentric spherical sources of accurately known activity concentrations were prepared and sent to seven European clinical sites. The site staff were not aware of the true volumes or activity within the sources—they performed SPECT/CT imaging of the source, positioned within a water-filled phantom, using their own choice of parameters and reported their estimate of the activities within the source. Results The volumes reported by the participants for the inner section of the source were all within 29% of the true value and within 60% of the true value for the outer section. The activities reported by the participants for the inner section of the source were all within 20% of the true value, whilst those reported for the outer section were up to 83% different to the true value. Conclusions A variety of calibration and segmentation methods were used by the participants for this exercise which demonstrated the variability of quantitative imaging across clinical sites. This paper presents a method to assess consistency between sites using different calibration and segmentation methods. KW - Lutetium KW - Lu-177 KW - SPECT/CT KW - quantitative imaging KW - PRRT KW - molecular radiotherapy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-233658 VL - 5 ER - TY - JOUR A1 - Zeiner, P. S. A1 - Zinke, J. A1 - Kowalewski, D. J. A1 - Bernatz, S. A1 - Tichy, J. A1 - Ronellenfitsch, M. W. A1 - Thorsen, F. A1 - Berger, A. A1 - Forster, M. T. A1 - Muller, A. A1 - Steinbach, J. P. A1 - Beschorner, R. A1 - Wischhusen, J. A1 - Kvasnicka, H. M. A1 - Plate, K. H. A1 - Stefanović, S. A1 - Weide, B. A1 - Mittelbronn, M. A1 - Harter, P. N. T1 - CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival JF - Acta Neuropathologica Communications N2 - Abstract Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Human Leukocyte Antigen (HLA) machinery of antigen presentation is still unclear. We present data on the HLA class II-chaperone molecule CD74 in brain metastases and its impact on the HLA peptidome complexity. We analyzed CD74 and HLA class II expression on tumor cells in a subset of 236 human brain metastases, primary tumors and peripheral metastases of different entities in association with clinical data including overall survival. Additionally, we assessed whole DNA methylome profiles including CD74 promoter methylation and differential methylation in 21 brain metastases. We analyzed the effects of a siRNA mediated CD74 knockdown on HLA-expression and HLA peptidome composition in a brain metastatic melanoma cell line. We observed that CD74 expression on tumor cells is a strong positive prognostic marker in brain metastasis patients and positively associated with tumor-infiltrating T-lymphocytes (TILs). Whole DNA methylome analysis suggested that CD74 tumor cell expression might be regulated epigenetically via CD74 promoter methylation. CD74\(^{high}\) and TIL\(^{high}\) tumors displayed a differential DNA methylation pattern with highest enrichment scores for antigen processing and presentation. Furthermore, CD74 knockdown in vitro lead to a reduction of HLA class II peptidome complexity, while HLA class I peptidome remained unaffected. In summary, our results demonstrate that a functional HLA class II processing machinery in brain metastatic tumor cells, reflected by a high expression of CD74 and a complex tumor cell HLA peptidome, seems to be crucial for better patient prognosis. KW - CD74 KW - HLA class II KW - brain metastasis KW - HLA peptidome KW - tumor infiltrating lymphocytes Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-233882 VL - 6 ER - TY - JOUR T1 - Measurement of differential cross sections of isolated-photon plus heavy-flavour jet production in \(pp\) collisions at √\(s\) = 8 TeV using the ATLAS detector JF - Physics Letters B N2 - This Letter presents the measurement of differential cross sections of isolated prompt photons produced in association with a b-jet or a c-jet. These final states provide sensitivity to the heavy-flavour content of the proton and aspects related to the modelling of heavy-flavour quarks in perturbative QCD. The measurement uses proton–proton collision data at a centre-of-mass energy of 8 TeV recorded by the ATLAS detector at the LHC in 2012 corresponding to an integrated luminosity of up to 20.2 fb−1 . The differential cross sections are measured for each jet flavour with respect to the transverse energy of the leading photon in two photon pseudorapidity regions: |η γ | < 1.37 and 1.56 < |η γ | < 2.37. The measurement covers photon transverse energies 25 < Eγ T < 400 GeV and 25 < Eγ T < 350 GeV respectively for the two |η γ | regions. For each jet flavour, the ratio of the cross sections in the two |η γ | regions is also measured. The measurement is corrected for detector effects and compared to leading-order and next- to-leading-order perturbative QCD calculations, based on various treatments and assumptions about the heavy-flavour content of the proton. Overall, the predictions agree well with the measurement, but some deviations are observed at high photon transverse energies. The total uncertainty in the measurement ranges between 13% and 66%, while the central γ + b measurement exhibits the smallest uncertainty, ranging from 13% to 27%, which is comparable to the precision of the theoretical predictions. KW - Intrinsic charm KW - Showers Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-347841 VL - 776 ER - TY - JOUR T1 - Direct top-quark decay width measurement in the t(t)over-bar lepton+jets channel at root \(s\)=8 TeV with the ATLAS experiment JF - European Physical Journal C N2 - This paper presents a direct measurement of the decay width of the top quark using t (t) over bar events in the lepton+jets final state. The data sample was collected by the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of 8 TeV and corresponds to an integrated luminosity of 20.2 fb(-1). The decay width of the top quark is measured using a template fit to distributions of kinematic observables associated with the hadronically and semileptonically decaying top quarks. The result, Gamma(t) = 1.76 +/- 0.33 (stat.) (+0.79)(-0.68) (syst.) GeV for a top-quark mass of 172.5 GeV, is consistent with the prediction of the Standard Model. KW - Parton Distributions KW - Hadron Colliders KW - Pair Production KW - Cross-Section KW - pp Collisions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226805 VL - 78 IS - 129 ER - TY - JOUR T1 - Measurement of τ polarisation in \(Z/\)γ* -> τ τ decays in proton-proton collisions at root \(s\)=8 TeV with the ATLAS detector JF - European Physical Journal C N2 - This paper presents a measurement of the polarisation of tau leptons produced in Z/gamma* -> tau tau decays which is performed with a dataset of proton-proton collisions at root s = 8 TeV, corresponding to an integrated luminosity of 20.2 fb(-1) recorded with the ATLAS detector at the LHC in 2012. The Z/gamma* -> tau tau decays are reconstructed from a hadronically decaying tau lepton with a single charged particle in the final state, accompanied by a tau lepton that decays leptonically. The tau polarisation is inferred from the relative fraction of energy carried by charged and neutral hadrons in the hadronic tau decays. The polarisation is measured in a fiducial region that corresponds to the kinematic region accessible to this analysis. The tau polarisation extracted over the full phase space within the Z/gamma* mass range of 66 < mZ/gamma* < 116GeVis found to be P-tau = -0.14 +/- 0.02(stat)+/- 0.04(syst). It is in agreement with the Standard Model prediction of Pt = -0.1517 +/- 0.0019, which is obtained from the ALP-GEN event generator interfaced with the PYTHIA 6 parton shower modelling and the TAUOLA tau decay library. KW - Monte-Carlo KW - pp Collisions KW - Simulation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226794 VL - 78 IS - 163 ER - TY - JOUR T1 - Constraints on off-shell Higgs boson production and the Higgs boson total width in \(ZZ\) → 4l and \(ZZ\) → 2l2ν final states with the ATLAS detector JF - Physics Letters B N2 - A measurement of off-shell Higgs boson production in the ZZ -> 4l and ZZ -> 2l2v decay channels, where stands for either an electron or a muon, is performed using data from proton-proton collisions at a centre-of-mass energy of root s = 13 TeV. The data were collected by the ATLAS experiment in 2015 and 2016 at the Large Hadron Collider, and they correspond to an integrated luminosity of 36.1 fb(-1). An observed (expected) upper limit on the off-shell Higgs signal strength, defined as the event yield normalised to the Standard Model prediction, of 3.8 (3.4) is obtained at 95% confidence level (CL). Assuming the ratio of the Higgs boson couplings to the Standard Model predictions is independent of the momentum transfer of the Higgs production mechanism considered in the analysis, a combination with the on-shell signal-strength measurements yields an observed (expected) 95% CL upper limit on the Higgs boson total width of 14.4 (15.2) MeV. KW - Parton Distributions KW - Search KW - Decay KW - Mass Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-346791 VL - 786 ER - TY - JOUR T1 - Search for \({WW/WZ}\) resonance production in \(lvqq\) final states in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - A search is conducted for new resonances decaying into a WW or WZ boson pair, where one W boson decays leptonically and the other W or Z boson decays hadronically. It is based on proton-proton collision data with an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of root s = 13 TeV in 2015 and 2016. The search is sensitive to diboson resonance production via vector-boson fusion as well as quark-antiquark annihilation and gluon-gluon fusion mechanisms. No significant excess of events is observed with respect to the Standard Model backgrounds. Several benchmark models are used to interpret the results. Limits on the production cross section are set for a new narrow scalar resonance, a new heavy vector-boson and a spin-2 Kaluza-Klein graviton. KW - Hadron-Hadron scattering (experiments) KW - ++ KW - HIGGS Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226787 VL - 42 ER - TY - JOUR T1 - Measurements of Higgs boson properties in the diphoton decay channel with 36 fb\(^{-1}\) of \(pp\) collision data at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - Properties of the Higgs boson are measured in the two-photon final state using 36.1 fb(-1) of proton-proton collision data recorded at root s = 13 TeV by the ATLAS experiment at the Large Hadron Collider. Cross-section measurements for the production of a Higgs boson through gluon-gluon fusion, vector-boson fusion, and in association with a vector boson or a top-quark pair are reported. The signal strength, defined as the ratio of the observed to the expected signal yield, is measured for each of these production processes as well as inclusively. The global signal strength measurement of 0.99 +/- 0.14 improves on the precision of the ATLAS measurement at root s = 7 and 8 TeV by a factor of two. Measurements of gluon-gluon fusion and vector-boson fusion productions yield signal strengths compatible with the Standard Model prediction. Measurements of simplified template cross sections, designed to quantify the different Higgs boson production processes in specific regions of phase space, are reported. The cross section for the production of the Higgs boson decaying to two isolated photons in a fiducial region closely matching the experimental selection of the photons is measured to be 55 +/- 10 fb, which is in good agreement with the Standard Model prediction of 64 +/- 2 fb. Furthermore, cross sections in fiducial regions enriched in Higgs boson production in vector-boson fusion or in association with large missing transverse momentum, leptons or top-quark pairs are reported. Differential and double-differential measurements are performed for several variables related to the diphoton kinematics as well as the kinematics and multiplicity of the jets produced in association with a Higgs boson. These differential cross sections are sensitive to higher order QCD corrections and properties of the Higgs boson, such as its spin and CP quantum numbers. No significant deviations from a wide array of Standard Model predictions are observed. Finally, the strength and tensor structure of the Higgs boson interactions are investigated using an effective Lagrangian, which introduces additional CP-even and CP-odd interactions. No significant new physics contributions are observed. KW - Differential Cross-Sections KW - QCD Corrections KW - Search KW - Model KW - NNLO KW - Particle data analysis KW - Particle properties KW - Photons KW - Higgs bosons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226733 VL - 98 ER - TY - JOUR T1 - Measurements of t(t)over-bar differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in \(pp\) collisions at root \(s\)=13 Te V using the ATLAS detector JF - Physical Review D N2 - Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and t (t) over bar system kinematic observables using proton-proton collisions at a center-of-mass energy of root s = 13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb(-1), recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two large-radius jets in the final state, one with transverse momentum p(T) > 500 GeV and a second with p(T) > 350 GeV, are used for the measurement. The top-quark candidates are separated from the multijet background using jet substructure information and association with a b-tagged jet. The measured spectra are corrected for detector effects to a particle-level fiducial phase space and a parton-level limited phase space, and are compared to several Monte Carlo simulations by means of calculated chi(2) values. The cross-section for t (t) over bar production in the fiducial phase-space region is 292 +/- 7(stat) +/- 71(syst) tb, to be compared to the theoretical prediction of 384 +/- 36 fb. KW - Parton Distributions KW - Particle data analysis KW - Bayesian methods KW - Top quark KW - Quarks KW - Strong interaction KW - Quantum chromodynamics KW - Perturbative QCD Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226771 VL - 98 ER - TY - JOUR T1 - Search for supersymmetry in final states with charm jets and missing transverse momentum in 13 TeV \(pp\) collisions with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for supersymmetric partners of top quarks decaying as (t) over tilde (1) -> c (chi) over tilde (0)(1)and supersymmetric partners of charm quarks decaying as (c) over tilde (1) -> c (chi) over tilde (0)(1) where (chi) over tilde (0)(1) is the lightest neutralino, is presented. The search uses 36.1 fb(-1) pp collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS experiment at the Large Hadron Collider and is performed in final states with jets identified as containing charm hadrons. Assuming a 100% branching ratio to c (chi) over tilde (0)(1), top and charm squarks with masses up to 850 GeV are excluded at 95% confidence level for a massless lightest neutralino. For m (t) over tilde (1,(c) over tilde1) - m((chi) over tilde 10)< 100 GeV, top and charm squark masses up to 500 GeV are excluded. KW - Hadron-Hadron scattering (experiments) KW - Parton Distributions KW - Extension KW - Squark KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226752 VL - 09 ER - TY - JOUR T1 - Search for Low-Mass Dijet Resonances Using Trigger-Level Jets with the ATLAS Detector in \(pp\) Collisions at root \(s\)=13 TeV JF - Physical Review Letters N2 - Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from standard model multijet production. This Letter describes a new search for dijet resonances where this limitation is overcome by recording only the event information calculated by the jet trigger algorithms, thereby allowing much higher event rates with reduced storage needs. The search targets low-mass dijet resonances in the range 450-1800 GeV. The analyzed data set has an integrated luminosity of up to 29.3 fb(-1) and was recorded at a center-of-mass energy of 13 TeV. No excesses are found; limits are set on Gaussian-shaped contributions to the dijet mass distribution from new particles and on a model of dark-matter particles with axial-vector couplings to quarks. KW - Distributions KW - Hadron colliders KW - Weakly interacting massive particles KW - Quark & gluon jets KW - Particle dark matter Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226725 VL - 121 ER - TY - JOUR T1 - Measurement of colour flow using jet-pull observables in t(t)over-bar events with the ATLAS experiment at root \(s\)=13TeV JF - European Physical Journal C N2 - Previous studies have shown that weighted angular moments derived from jet constituents encode the colour connections between partons that seed the jets. This paper presents measurements of two such distributions, the jet-pull angle and jet-pull magnitude, both of which are derived from the jet-pull angular moment. The measurement is performed in delivered by the Large Hadron Collider. The observables are measured for two dijet systems, corresponding to the colour-connected daughters of the Wboson and the two b-jets from the top-quark decays, which are not expected to be colour connected. To allow the comparison of the measured distributions to colour model predictions, the measured distributions are unfolded to particle level, after correcting for experimental effects introduced by the detector. While good agreement can be found for some combinations of predictions and observables, none of the predictions describes the data well across all observables. KW - Quark pair procuction KW - Parton distributions KW - Hadron colliders KW - Cross-section Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226039 VL - 78 ER - TY - JOUR T1 - Prompt and non-prompt \(J\)/\(ψ\) and \(ψ\)(2S) suppression at high transverse momentum in 5.02 TeV Pb+Pb collisions with the ATLAS experiment JF - European Physical Journal C N2 - A measurement of J/psi and psi(2S) production is presented. It is based on a data sample from Pb+Pb collisions at root s(NN) = 5.02 TeV and pp collisions at root s = 5.02 TeV recorded by the ATLAS detector at the LHC in 2015, corresponding to an integrated luminosity of 0.42 nb(-1) and 25 pb(-1) in Pb+Pb and pp, respectively. The measurements of per-event yields, nuclear modification factors, and non-prompt fractions are performed in the dimuon decay channel for 9 < p(T)(mu mu) < 40 GeV in dimuon transverse momentum, and -2 < y(mu mu) < 2 in rapidity. Strong suppression is found in Pb+Pb collisions for both prompt and non-prompt J/psi, increasing with event centrality. The suppression of prompt psi(2S) is observed to be stronger than that of J/psi, while the suppression of non-prompt psi(2S) is equal to that of the non-prompt J/psi within uncertainties, consistent with the expectation that both arise from b-quarks propagating through the medium. Despite prompt and non-prompt J/psi arising from different mechanisms, the dependence of their nuclear modification factors on centrality is found to be quite similar. KW - PB-PB Collisions KW - Quarkonium Production KW - Monte-Carlo KW - Nuclear KW - Charmonia KW - Rapidity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226056 VL - 78 ER - TY - JOUR T1 - Search for new phenomena using the invariant mass distribution of same-flavour opposite-sign dilepton pairs in events with missing transverse momentum in root \(s\)=13 TeV \(pp\) collisions with the ATLAS detector JF - European Physical Journal C N2 - A search for new phenomena in final states containing an e(+)e(-) or m(+)m(-) pair, jets, and large missing transverse momentum is presented. This analysis makes use of proton-proton collision data with an integrated luminosity of 36.1 fb(-1), collected during 2015 and 2016 at a centre of-mass energy Os = 13 TeV with the ATLAS detector at the Large Hadron Collider. The search targets the pair production of supersymmetric coloured particles (squarks or gluinos) and their decays into final states containing an e(+)e(-) or m(+)m(-) pair and the lightest neutralino ((c) over tilde (0)(1)) via one of two next-to-lightest neutralino ((c) over tilde (0)(2)) decay mechanisms: (c) over tilde (0)(2) Z (c) over tilde (0)(1), where the Z boson decays leptonically leading to a peak in the dilepton invariant mass distribution around the Z boson mass; and (c) over tilde (0)(2) l(+)1(-) (c) over tilde (0)(1) with no intermediate l(+)l(-) resonance, yielding a kinematic endpoint in the dilepton invariant mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted using simplified models, and exclude gluinos and squarks with masses as large as 1.85 and 1.3 TeV at 95% confidence level, respectively. KW - Parton Distributions KW - Gluino Production KW - ++ KW - Extension KW - Energy KW - Squark KW - Supersymmetry KW - Physics KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226109 VL - 78 ER - TY - JOUR T1 - Measurement of differential cross-sections of a single top quark produced in association with a \(W\) boson at root \(s\)=13TeV with ATLAS JF - European Physical Journal C N2 - The differential cross-section for the production of a W boson in association with a top quark is measured for several particle-level observables. The measurements are performed using 36.1 fb(-1) of pp collision data collected with the ATLAS detector at the LHC in 2015 and 2016. Differential cross-sections are measured in a fiducial phase space defined by the presence of two charged leptons and exactly one jet matched to a b-hadron, and are normalised with the fiducial cross-section. Results are found to be in good agreement with predictions from several Monte Carlo event generators. KW - Parton Distributions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226718 VL - 78 ER - TY - JOUR T1 - Search for the Decay of the Higgs Boson to Charm Quarks with the ATLAS Experiment JF - Physical Review Letters N2 - A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH -> l(+)l(-) cc is studied. A data set with an integrated luminosity of 36.1 fb(-1) of pp collisions at root s = 13TeV recorded by the ATLAS experiment at the LHC is used. The H -> cc signature is identified using charm-tagging algorithms. The observed (expected) upper limit on sigma(pp -> ZH) x B(H -> cc) is 2.7 (3.9(-2.1)(+2.1) ) pb at the 95% confidence level for a Higgs boson mass of 125 GeV, while the standard model value is 26 fb. KW - Programm KW - Spontaneous symmetry breaking KW - Higgs bosons KW - Charm quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226523 VL - 120 ER - TY - JOUR T1 - Search for a Structure in the B-s(0) π\(^{±}\) Invariant Mass Spectrum with the ATLAS Experiment JF - Physical Review Letters N2 - A search for the narrow structure, X(5568), reported by the DO Collaboration in the decay sequence X -> B-s(0) pi +/-, B-s(0) -> J/psi phi, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb(-1) of pp collisions at 7 TeV and 19.5 fb(-1)at 8 TeV. No significant signal was found. Upper limits on the number of signal events, with properties corresponding to those reported by DO, and on the A production rate relative to B-s(0) mesons, rho x, were determined at 95% confidence level. The results are N(X) < 382 and rho x <0.015 for B-s(0) mesons with transverse momenta above 10 GeV and N(X) < 356 and rho(x) < 0.016 for transverse momenta above 15 GeV. Limits are also set for potential B-s(0) pi(+) resonances in the mass range 5550 to 5700 MeV. KW - Mass Spectrum KW - Parton Distributions KW - Decay sequence KW - Analysis KW - MASS KW - Hadron colliders KW - Exotic mesons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226539 VL - 120 ER - TY - JOUR T1 - Search for High-Mass Resonances Decaying to τν in \(pp\) Collisions at root \(s\)=13 TeV with the ATLAS Detector JF - Physical Review Letters N2 - A search for high-mass resonances decaying to tau nu using proton-proton collisions at root s = 13 TeV produced by the Large Hadron Collider is presented. Only tau-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb(-1). No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible tau nu production cross section. Heavy W' bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2-3.8 TeV depending on the coupling in the nonuniversal Go(221) model are excluded at the 95% credibility level. KW - Proton-Proton Collisions KW - Parton Ditributions KW - Cross-Section KW - ++ KW - Lepton KW - Hadron colliders KW - Hypothetical gauge bosons KW - Particle production KW - Extensions of gauge sector Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226556 VL - 120 ER - TY - JOUR T1 - Search for pair production of Higgsinos in final states with at least three \(b\)-tagged jets in root \(s\)=13 TeV \(pp\) collisions using the ATLAS detector JF - Physical Review D N2 - A search for pair production of the supersymmetric partners of the Higgs boson (higgsinos (H) over tilde) in gaugemediated scenarios is reported. Each higgsino is assumed to decay to a Higgs boson and a gravitino. Two complementary analyses, targeting high- and low-mass signals, are performed to maximize sensitivity. The two analyses utilize LHC pp collision data at a center-of-mass energy root s = 13 TeV, the former with an integrated luminosity of 36.1 fb(-1) and the latter with 24.3 fb(-1), collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing missing transverse momentum and several energetic jets, at least three of which must be identified as b-quark jets. No significant excess is found above the predicted background. Limits on the cross section are set as a function of the mass of the <(Hover tilde> in simplified models assuming production via mass-degenerate higgsinos decaying to a Higgs boson and a gravitino. Higgsinos with masses between 130 and 230 GeV and between 290 and 880 GeV are excluded at the 95% confidence level. Interpretations of the limits in terms of the branching ratio of the higgsino to a Z boson or a Higgs boson are also presented, and a 45% branching ratio to a Higgs boson is excluded for m(<(Hover tilde>) approximate to 400 GeV. KW - Gluino Production KW - Supersymmetry KW - Extension KW - Squark KW - Predictions KW - Supersymmetric models KW - Hierarchy problem KW - Extensions of Higgs sector Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226010 VL - 98 ER - TY - JOUR T1 - Search for heavy resonances decaying to a photon and a hadronically decaying \({Z/W/H}\) boson in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - Many extensions of the Standard Model predict new resonances decaying to a Z, W, or Higgs boson and a photon. This paper presents a search for such resonances produced in pp collisions at root s = 13 TeV using a data set with an integrated luminosity of 36.1 fb(-1) collected by the ATLAS detector at the LHC. The Z/W/H bosons are identified through their decays to hadrons. The data are found to be consistent with the Standard Model expectation in the entire investigated mass range. Upper limits are set on the production cross section times branching fraction for resonance decays to Z.W + gamma in the mass range from 1.0 to 6.8 TeV and for the first time into H + gamma in the mass range from 1.0 to 3.0 TeV. KW - Parton Distributions KW - Gamma KW - Electroweak interaction KW - Higgs bosons Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226079 VL - 98 ER - TY - JOUR T1 - Search for top squarks decaying to tau sleptons in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - A search for direct pair production of top squarks in final states with two tau leptons, b-jets, and missing transverse momentum is presented. The analysis is based on proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. Two exclusive channels with either two hadronically decaying tau leptons or one hadronically and one leptonically decaying tau lepton are considered. No significant deviation from the Standard Model predictions is observed in the data. The analysis results are interpreted in terms of model-independent limits and used to derive exclusion limits on the masses of the top squark (t) over tilde (1) and the tau slepton (tau) over tilde (1) in a simplified model of supersymmetry with a nearly massless gravitino. In this model, masses up to m((t) over tilde (1)) = 1.16 TeV and m ((tau) over tilde (1)) = 1.00 TeV are excluded at 95% confidence level. KW - Parton Distributions KW - Measuring Masses KW - Extension KW - Physics KW - Energy KW - Supersymmetric models KW - Superpartners KW - Tau leptons KW - Top quark KW - Particle data analysis Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226080 VL - 98 ER - TY - JOUR T1 - Search for photonic signatures of gauge-mediated supersymmetry in 13 TeV \(pp\) collisions with the ATLAS detector JF - Physical Review D N2 - A search is presented for photonic signatures, motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of proton-proton collision data at root s = 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) recorded by the ATLAS detector at the LHC, and it explores models dominated by both strong and electroweak production of supersymmetric partner states. Experimental signatures incorporating an isolated photon and significant missing transverse momentum are explored. These signatures include events with an additional photon or additional jet activity not associated with any specific underlying quark flavor. No significant excess of events is observed above the Standard Model prediction, and 95% confidence-level upper limits of between 0.083 and 0.32 fb are set on the visible cross section of contributions from physics beyond the Standard Model. These results are interpreted in terms of lower limits on the masses of gluinos, squarks, and gauginos in the context of generalized models of gauge-mediated supersymmetry, which reach as high as 2.3 TeV for strongly produced and 1.3 TeV for weakly produced supersymmetric partner pairs. KW - Gluino production KW - Supersymmetric models KW - Hypothetical particle physics models KW - Fortran code KW - Extension KW - Squark KW - Breaking KW - Decays KW - Model KW - Weak Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226510 VL - 97 ER - TY - JOUR T1 - Search for the standard model Higgs boson produced in association with top quarks and decaying into a b(b)overbar pair in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physical Review D N2 - A search for the standard model Higgs boson produced in association with a top-quark pair, t(t)overbarH, is presented. The analysis uses 36.1 fb(-1) of pp collision data at root s = 13 TeV collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search targets the H -> b(b)overbar decay mode. The selected events contain either one or two electrons or muons from the top-quark decays, and are then categorized according to the number of jets and how likely these are to contain b-hadrons. Multivariate techniques are used to discriminate between signal and background events, the latter being dominated by ft + jets production. For a Higgs boson mass of 125 GeV, the ratio of the measured t(t)overbarH signal cross-section to the standard model expectation is found to be mu = 0.84(-0.61)(+0.64). A value of mu greater than 2.0 is excluded at 95% confidence level (C.L.) while the expected upper limit is mu < 1.2 in the absence of a t(t)overbarH signal. KW - ++ KW - Symmetries KW - program KW - MASS KW - spontaneous symmetry breaking KW - Higgs bosons KW - Top quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226545 VL - 97 IS - 7 ER - TY - JOUR T1 - Evidence for the associated production of the Higgs boson and a top quark pair with the ATLAS detector JF - Physical Review D N2 - A search for the associated production of the Higgs boson with a top quark pair (tt (b) over barH) is reported. The search is performed in multilepton final states using a data set corresponding to an integrated luminosity of 36.1 fb(-1) of proton-proton collision data recorded by the ATLAS experiment at a center-of-mass energy root s = 13 TeV at the Large Hadron Collider. Higgs boson decays to WW*, tau tau, and ZZ* are targeted. Seven final states, categorized by the number and flavor of charged-lepton candidates, are examined for the presence of the Standard Model Higgs boson with a mass of 125 GeVand a pair of top quarks. An excess of events over the expected background from Standard Model processes is found with an observed significance of 4.1 standard deviations, compared to an expectation of 2.8 standard deviations. The best fit for the (tt (b) over barH) production cross section is sot (tt (b) over barH) = 790(-210)(+230) fb, in agreement with the Standard Model prediction of 507(-50)(+35) fb. The combination of this result with other tt (b) over barH searches from the ATLAS experiment using the Higgs boson decay modes to b (b) over bar, gamma gamma and ZZ* -> 4l, has an observed significance of 4.2 standard deviations, compared to an expectation of 3.8 standard deviations. This provides evidence for the tt (b) over barH production mode. KW - Production cross-section KW - spontaneous symmetry breaking KW - Higgs bosons KW - Top quark KW - Parton distributions KW - pp collisions KW - Monte-Carlo KW - 8 TEV KW - Root s=7 KW - search KW - decay KW - model KW - symmetries Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226569 VL - 97 ER - TY - JOUR T1 - Search for R-parity-violating supersymmetric particles in multi-jet final states produced in \({p-p}\) collisions at root \(s\)=13 TeV using the ATLAS detector at the LHC JF - Physics Letters B N2 - Results of a search for gluino pair production with subsequent R-parity-violating decays to quarks are presented. This search uses 36.1 fb(-1) of data collected by the ATLAS detector in proton-proton collisions with a centre-of-mass energy of root s = 13 TeV at the LHC. The analysis is performed using requirements on the number of jets and the number of jets tagged as containing a b-hadron as well as a topological observable formed by the scalar sum of masses of large-radius jets in the event. No significant excess above the expected Standard Model background is observed. Limits are set on the production of gluinos in models with the R-parity-violating decays of either the gluino itself (direct decay) or the neutralino produced in the R-parity-conserving gluino decay (cascade decay). In the gluino cascade decay model, gluino masses below 1850 GeV are excluded for 1000 GeV neutralino mass. For the gluino direct decay model, the 95% confidence level upper limit on the cross section times branching ratio varies between 0.80 fb at m((g) over tilde) = 900 GeV and 0.011 fb at m((g) over tilde) = 1800 GeV. (c) 2018 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license. KW - Gluino Production KW - Extension KW - Decay KW - Squark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226047 VL - 785 ER - TY - JOUR T1 - Measurement of the Higgs boson mass in the \(H\) -> \({ZZ}\)* -> 4l and \(H\) -> \({γγ}\) channels with root \(s\)=13 TeV \({pp}\) collisions using the ATLAS detector JF - Physics Letters B N2 - The mass of the Higgs boson is measured in the H -> ZZ* -> 4l and in the H -> gamma gamma decay channels with 36.1 fb(-1) of proton-proton collision data from the Large Hadron Collider at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector in 2015 and 2016. The measured value in the H -> ZZ* -> 4l channel is m(H)(ZZ*) = 124.79 +/- 0.37 GeV, while the measured value in the H -> gamma gamma channel is m(H)(gamma gamma) = 124.93 +/- 0.40 GeV. Combining these results with the ATLAS measurement based on 7 and 8 TeV proton-proton collision data yields a Higgs boson mass of m(H) = 124.97 +/- 0.24 GeV. (c) 2018 The Author. Published by Elsevier B.V. KW - proton-proton collision KW - Hadron Collider KW - Higgs boson mass KW - gamma gamma channel Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226065 VL - 784 ER - TY - JOUR T1 - Search for a heavy Higgs boson decaying into a \(Z\) boson and another heavy Higgs boson in the \({llbb}\) final state in \({pp}\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physics Letters B N2 - A search for a heavy neutral Higgs boson, A, decaying into a Z boson and another heavy Higgs boson, H, is performed using a data sample corresponding to an integrated luminosity of 36.1 fb(-1) from proton-proton collisions at root s = 13 TeV recorded in 2015 and 2016 by the ATLAS detector at the Large Hadron Collider. The search considers the Z boson decaying to electrons or muons and the H boson into a pair of b-quarks. No evidence for the production of an A boson is found. Considering each production process separately, the 95% confidence-level upper limits on the pp -> A -> ZH production cross-section times the branching ratio H -> bb are in the range of 14-830 fb for the gluon-gluon fusion process and 26-570 fb for the b-associated process for the mass ranges 130-700 GeV of the H boson and 230-800 GeV of the A boson. The results are interpreted in the context of two-Higgs-doublet models. (C) 2018 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP(3). KW - Hadron Colliders KW - Parton Distributions KW - MASS Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226098 VL - 783 ER - TY - JOUR T1 - Search for Higgs boson decays into pairs of light (pseudo)scalar particles in the \({γγ jj}\) final state in \({pp}\) collisions at root \(s\)=13 TeV with the ATLAS detector JF - Physics Letters B N2 - This Letter presents a search for exotic decays of the Higgs boson to a pair of new (pseudo) scalar particles, H -> aa, where the a particle has a mass in the range 20-60 GeV, and where one of the a bosons decays into a pair of photons and the other to a pair of gluons. The search is performed in event samples enhanced in vector-boson fusion Higgs boson production by requiring two jets with large invariant mass in addition to the Higgs boson candidate decay products. The analysis is based on the full dataset of pp collisions at root s = 13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 36.7 fb(-1). The data are in agreement with the Standard Model predictions and an upper limit at the 95% confidence level is placed on the production cross section times the branching ratio for the decay H -> aa -> gamma gamma gg. This limit ranges from 3.1 pb to 9.0 pb depending on the mass of the a boson. (C) 2018 The Author. Published by Elsevier B.V. KW - Parton Distributions KW - Higgs boson KW - DECAY KW - Higgs boson decays KW - GAMMA Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226147 VL - 782 ER - TY - JOUR T1 - Measurement of the production cross section of three isolated photons in \({pp}\) collisions at root \(s\)=8 TeV using the ATLAS detector JF - Physics Letters B N2 - A measurement of the production of three isolated photons in proton-proton collisions at a centre-of-mass energy root s = 8 TeV is reported. The results are based on an integrated luminosity of 20.2 fb(-1) collected with the ATLAS detector at the LHC. The differential cross sections are measured as functions of the transverse energy of each photon, the difference in azimuthal angle and in pseudorapidity between pairs of photons, the invariant mass of pairs of photons, and the invariant mass of the triphoton system. A measurement of the inclusive fiducial cross section is also reported. Next-to-leading-order perturbative QCD predictions are compared to the cross-section measurements. The predictions underestimate the measurement of the inclusive fiducial cross section and the differential measurements at low photon transverse energies and invariant masses. They provide adequate descriptions of the measurements at high values of the photon transverse energies, invariant mass of pairs of photons, and invariant mass of the triphoton system. (C) 2018 The Author. Published by Elsevier B.V. KW - Parton Distributions KW - Hierarchy KW - Quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226154 VL - 781 ER - TY - JOUR T1 - Measurements of differential cross sections of top quark pair production in association with jets in pp collisions at root s=13 TeV using the ATLAS detector JF - Journal of High Energy Physics N2 - Measurements of di ff erential cross sections of top quark pair production in association with jets by the ATLAS experiment at the LHC are presented. The measurements are performed as functions of the top quark transverse momentum, the transverse momentum of the top quark-antitop quark system and the out-of-plane transverse momentum using data from pp collisions at p s = 13TeV collected by the ATLAS detector at the LHC in 2015 and corresponding to an integrated luminosity of 3.2 fb. The top quark pair events are selected in the lepton (electron or muon) + jets channel. The measured cross sections, which are compared to several predictions, allow a detailed study of top quark production. KW - Hadron-Hadron scattering (experiments) KW - Jets KW - Top physics KW - Parton Distributions KW - ++ Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226023 VL - 159 IS - 10 ER - TY - JOUR T1 - Search for flavour-changing neutral current top-quark decays \(t\) -> \({qZ}\) in proton-proton collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of root s = 13TeV, corresponding to an integrated luminosity of 36.1 fb(-1), are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t -> qZ (q = u, c) flavour-changing neutral-current channel, and the other through the dominant Standard Model mode t -> bW. Only Z boson decays into charged leptons and leptonic W boson decays are considered as signal. Consequently, the final-state topology is characterized by the presence of three isolated charged leptons (electrons or muons), at least two jets, one of the jets originating from a b-quark, and missing transverse momentum from the undetected neutrino. The data are consistent with Standard Model background contributions, and at 95% confidence level the search sets observed (expected) upper limits of 1.7 x 10(-4) (2.4 x 10(-4)) on the t -> uZ branching ratio and 2.4 x 10(-4) (3.2 x 10(-4)) on the t -> cZ branching ratio, constituting the most stringent limits to date. KW - Hadron-Hadron scattering (experiments) KW - Parton Distributions KW - ++ KW - Pair-Production KW - Cross-Section KW - Physics KW - Models Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226114 VL - 176 IS - 7 ER - TY - JOUR T1 - Search for pair production of up-type vector-like quarks and for four-top-quark events in final states with multiple \(b\)-jets with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for pair production of up-type vector-like quarks (T) with a significant branching ratio into a top quark and either a Standard Model Higgs boson or a Z boson is presented. The same analysis is also used to search for four-top-quark production in several new physics scenarios. The search is based on a dataset of pp collisions at root s = 13TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb(-1). Data are analysed in the lepton+jets final state, characterised by an isolated electron or muon with high transverse momentum, large missing transverse momentum and multiple jets, as well as the jets+E-T(miss) final state, characterised by multiple jets and large missing transverse momentum. The search exploits the high multiplicity of jets identified as originating from b-quarks, and the presence of boosted, hadronically decaying top quarks and Higgs bosons reconstructed as large-radius jets, characteristic of signal events. No significant excess above the Standard Model expectation is observed, and 95% CL upper limits are set on the production cross sections for the different signal processes considered. These cross-section limits are used to derive lower limits on the mass of a vector-like T quark under several branching ratio hypotheses assuming contributions from T -> Wb, Zt, Ht decays. The 95% CL observed lower limits on the T quark mass range between 0.99TeV and 1.43TeV for all possible values of the branching ratios into the three decay modes considered, significantly extending the reach beyond that of previous searches. Additionally, upper limits on anomalous four-top-quark production are set in the context of an effective field theory model, as well as in an universal extra dimensions model. KW - Beyond Standard Model KW - Hadron-Hadron scattering (experiments) KW - vector-like quarks KW - Parton Distributions KW - ++ KW - Boson KW - Breaking KW - Program KW - Gluon Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226131 VL - 89 IS - 7 ER - TY - JOUR T1 - Search for pair production of Higgs bosons in the \({bb̅bb̅}\) final state using proton-proton collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for Higgs boson pair production in the bbbb final state is carried out with up to 36.1 fb(-1) of LHC proton-proton collision data collected at s=13 TeV with the ATLAS detector in 2015 and 2016. Three benchmark signals are studied: a spin-2 graviton decaying into a Higgs boson pair, a scalar resonance decaying into a Higgs boson pair, and Standard Model non-resonant Higgs boson pair production. Two analyses are carried out, each implementing a particular technique for the event reconstruction that targets Higgs bosons reconstructed as pairs of jets or single boosted jets. The resonance mass range covered is 260-3000 GeV. The analyses are statistically combined and upper limits on the production cross section of Higgs boson pairs times branching ratio to bbbb are set in each model. No significant excess is observed; the largest deviation of data over prediction is found at a mass of 280 GeV, corresponding to 2.3 standard deviations globally. The observed 95% confidence level upper limit on the non-resonant production is 13 times the Standard Model prediction. KW - Hadron-Hadron scattering (experiments) KW - ++ KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226001 VL - 30 ER - TY - JOUR T1 - Comparison between simulated and observed LHC beam backgrounds in the ATLAS experiment at \(E\)\(_{beam}\)=4 TeV JF - Journal of Instrumentation N2 - Results of dedicated Monte Carlo simulations of beam-induced background (BIB) in the ATLAS experiment at the Large Hadron Collider (LHC) are presented and compared with data recorded in 2012. During normal physics operation this background arises mainly from scattering of the 4 TeV protons on residual gas in the beam pipe. Methods of reconstructing the BIB signals in the ATLAS detector, developed and implemented in the simulation chain based on the FLUKA Monte Carlo simulation package, are described. The interaction rates are determined from the residual gas pressure distribution in the LHC ring in order to set an absolute scale on the predicted rates of BIB so that they can be compared quantitatively with data. Through these comparisons the origins of the BIB leading to different observables in the ATLAS detectors are analysed. The level of agreement between simulation results and BIB measurements by ATLAS in 2012 demonstrates that a good understanding of the origin of BIB has been reached. KW - Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics) KW - Radiation calculations KW - Simulation methods and programs KW - Single-Photon Detectors KW - Search Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225966 VL - 13 ER - TY - JOUR T1 - Search for W ' -> \({tb}\) decays in the hadronic final state using \({pp}\) collisions at root s=13 TeV with the ATLAS detector JF - Physics Letters B N2 - A search for W'-boson production in the W' -> t (b) over bar -> q (q) over bar 'b (b) over bar decay channel is presented using 36.1 fb(-1) of 13 TeV proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search is interpreted in terms of both a left-handed and a right-handed chiral W' boson within the mass range 1-5 TeV. Identification of the hadronically decaying top quark is performed using jet substructure tagging techniques based on a shower deconstruction algorithm. No significant deviation from the Standard Model prediction is observed and the results are expressed as upper limits on the W' -> t (b) over bar production cross-section times branching ratio as a function of the W'-boson mass. These limits exclude W' bosons with right-handed couplings with masses below 3.0 TeV and W' bosons with left-handed couplings with masses below 2.9 TeV, at the 95% confidence level. (C) 2018 The Author. Published by Elsevier B.V. KW - Symmetry-breaking KW - Pair production KW - ++ KW - Dynamics KW - Physics KW - Mass Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225987 VL - 781 ER - TY - JOUR T1 - Searches for heavy \({ZZ}\) and \({ZW}\) resonances in the \({llqq}\) and \({vvqq}\) final states in \({pp}\) collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - This paper reports searches for heavy resonances decaying into ZZ or ZW using data from proton-proton collisions at a centre-of-mass energy of root s - 13 TeV. The data, corresponding to an integrated luminosity of 36.1 fb(-1), were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The searches are performed in final states in which one Z boson decays into either a pair of light charged leptons (electrons and muons) or a pair of neutrinos, and the associated W boson or the other Z boson decays hadronically. No evidence of the production of heavy resonances is observed. Upper bounds on the production cross sections of heavy resonances times their decay branching ratios to ZZ or ZW are derived in the mass range 300-5000 GeV within the context of Standard Model extensions with additional Higgs bosons, a heavy vector triplet or warped extra dimensions. Production through gluon-gluon fusion, Drell-Yan or vector-boson fusion are considered, depending on the assumed model. KW - Beyond Standard Model KW - Hadron-Hadron scattering (experiments) KW - Boson KW - Distributions KW - Combination KW - Hierarchy KW - Mass Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225951 VL - 9 ER - TY - JOUR T1 - Search for electroweak production of supersymmetric states in scenarios with compressed mass spectra at root s=13 TeV with the ATLAS detector JF - Physical Review D N2 - A search for electroweak production of supersymmetric particles in scenarios with compressed mass spectra in final states with two low-momentum leptons and missing transverse momentum is presented. This search uses proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015-2016, corresponding to 36.1 tb(-1) of integrated luminosity at root s = 13 TeV. Events with same flavor pairs of electrons or muons with opposite electric charge are selected. The data are found to be consistent with the Standard Model prediction. Results are interpreted using simplified models of R-parity conserving supersymmetry in which there is a small mass difference between the masses of the produced supersymmetric particles and the lightest neutralino. Exclusion limits at 95% confidence level are set on next-to-lightest neutralino masses of up to 145 GeV for Higgsino production and 175 GeV for wino production, and slepton masses of up to 190 GeV for pair production of sleptons. In the compressed mass regime, the exclusion limits extend down to mass splittings of 2.5 GeV for Higgsino production, 2 GeV for wino production, and 1 GeV for slepton production. The results are also interpreted in the context of a radiatively-driven natural supersymmetry model with nonuniversal Higgs boson masses. KW - PP Collicions KW - Parton Distributions KW - Gluino Production KW - Measuring Masses KW - Cross-Section KW - ++ KW - Z Boson KW - Energy KW - Squark KW - Extension Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226707 VL - 97 IS - 5 ER - TY - JOUR T1 - Measurement of the inclusive and fiducial t(t)over-bar production cross-sections in the lepton+jets channel in \({pp}\) collisions at root s=8 TeV with the ATLAS detector JF - The European Physical Journal C N2 - The inclusive and fiducial t (t) over bar production cross sections are measured in the lepton+jets channel using 20.2 fb(-1) of proton proton collision data at a centre-of mass energy of 8 TeV recorded with the ATLAS detector at the LHC. Major systematic uncertainties due to the modelling of the jet energy scale and b-tagging efficiency are constrained by separating selected events into three disjoint regions. In order to reduce systematic uncertainties in the most important background, the W+jets process is modelled using Z+jets events in a data-driven approach. The inclusive t (t) over bar cross-section is measured with a precision of 5.7% to be (sigma(inc) (t (t) over bar) = 248.3 +/- 0.7 (stat.) +/- 13.4 (syst.) +/- 4.7 (lumi.) pb, assuming a top-quark mass of 172.5 GeV. The result is in agreement with the Standard Model prediction. The cross-section is also measured in a phase space close to that of the selected data. The fiducial cross-section is sigma(fid) (t (t) over bar) = 48.8 +/- 0.1 (stat.) +/- 2.0 (syst.) +/- 0.9 (lumi.) pb with a precision of 4.5%. KW - Parton Distributions KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220827 VL - 78 IS - 487 ER - TY - JOUR T1 - Search for a new heavy gauge-boson resonance decaying into a lepton and missing transverse momentum in 36 fb\(^{-1}\) of \({pp}\) collisions at root s=13 TeV with the ATLAS experiment JF - The European Physical Journal C N2 - The results of a search for new heavy W' bosons decaying to an electron or muon and a neutrino using proton-proton collision data at a centre-of-mass energy of root s = 13 TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb(-1). As no excess of events above the Standard Model prediction is observed, the results are used to set upper limits on the W' boson cross-section times branching ratio to an electron or muon and a neutrino as a function of the W' mass. Assuming a W' boson with the same couplings as the Standard Model W boson, W' masses below 5.1 TeV are excluded at the 95% confidence level. KW - Cross-Section KW - Symmetry KW - Events KW - QCD KW - EW Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220869 VL - 78 IS - 401 ER - TY - JOUR T1 - A search for pair-produced resonances in four-jet final states at root s=13 TeV with the ATLAS detector JF - The European Physical Journal C N2 - A search for massive coloured resonances which are pair-produced and decay into two jets is presented. The analysis uses 36.7 fb(-1) of root s = 13 TeV pp collision data recorded by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the background prediction is observed. Results are interpreted in a SUSY simplified model where the lightest supersymmetric particle is the top squark, (t) over tilde, which decays promptly into two quarks through R-parity-violating couplings. Top squarks with masses in the range 100 GeV < m((T) over tilde) < 410 GeV are excluded at 95% confidence level. If the decay is into a b-quark and a light quark, a dedicated selection requiring two b-tags is used to exclude masses in the ranges 100 GeV < m((t) over tilde) < 470 GeV and 480 GeV < m(<(t)over tilde>) < 610 GeV. Additional limits are set on the pair-production of massive colour-octet resonances. KW - Patron Distributions KW - Collicions KW - Extension KW - Squark KW - Supersymmetry KW - Color KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225465 VL - 78 IS - 250 ER - TY - JOUR T1 - Search for heavy \({ZZ}\) resonances in the l\(^+\)l\(^-\)l\(^+\)l\(^-\) and l\(^+\)l\(^-\) nu(nu)over-bar final states using proton-proton collisions at root s=13 TeV with the ATLAS detector JF - The European Physical Journal C N2 - A search for heavy resonances decaying into a pair of Z bosons leading to l(+) l(-) l(+) l(-) and l(+) l(-) nu(nu) over bar final states, where l stands for either an electron or a muon, is presented. The search uses proton-proton collision data at a centre-of-mass energy of 13 TeV corresponding to an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector during 2015 and 2016 at the Large Hadron Collider. Different mass ranges for the hypothetical resonances are considered, depending on the final state and model. The different ranges span between 200 and 2000 GeV. The results are interpreted as upper limits on the production cross section of a spin-0 or spin-2 resonance. The upper limits for the spin-0 resonance are translated to exclusion contours in the context of Type-I and Type-II two-Higgs-doublet models, while those for the spin-2 resonance are used to constrain the Randall-Sundrum model with an extra dimension giving rise to spin-2 graviton excitations. KW - Boson KW - Decay KW - Mass KW - Distributions KW - Tauola KW - Tool KW - WZ Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225421 VL - 78 IS - 293 ER - TY - JOUR T1 - Search for doubly charged Higgs boson production in multi-lepton final states with the ATLAS detector using proton-proton collisions at root s=13TeV JF - The European Physical Journal C N2 - A search for doubly charged Higgs bosons with pairs of prompt, isolated, highly energetic leptons with the same electric charge is presented. The search uses a proton-proton collision data sample at a centre-of-mass energy of 13 TeV corresponding to 36.1 fb(-1) of integrated luminosity recorded in 2015 and 2016 by the ATLAS detector at the LHC. This analysis focuses on the decays H-+/-+/- -> e(+/-)e(+/-), H-+/-+/- -> e(+/-)mu(+/-) and H-+/-+/- -> mu(+/-)mu(+/-), fitting the dilepton mass spectra in several exclusive signal regions. No significant evidence of a signal is observed and corresponding limits on the production cross-section and consequently a lower limit on m(H-+/-+/-) are derived at 95% confidence level. With l(+/-)l(+/-) = e(+/-)e(+/-)/mu(+/-)mu(+/-)/e(+/-)mu(+/-), the observed lower limit on the mass of a doubly charged Higgs boson only coupling to left-handed leptons varies from 770 to 870GeV (850GeV expected) for B(H-+/-+/- -> l(+/-)l(+/-)) = 100% and both the expected and observed mass limits are above 450GeV for B(H-+/-+/- -> l(+/-)l(+/-)) = 10% and any combination of partial branching ratios. KW - Cross-Section KW - Symmetry KW - Models KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225591 VL - 78 IS - 199 ER - TY - JOUR T1 - Measurement of longitudinal flow decorrelations in Pb plus Pb collisions at root s(NN)=2.76 and 5.02 TeV with the ATLAS detector JF - The European Physical Journal C N2 - Measurements of longitudinal flow correlations are presented for charged particles in the pseudorapidity range vertical bar eta vertical bar < 2.4 using 7 mu b(-1) and 470 mu b(-1) of Pb+Pb collisions at root s(NN) = 2.76 and 5.02 TeV, respectively, recorded by the ATLAS detector at the LHC. It is found that the correlation between the harmonic flow coefficients v(n) measured in two separated eta intervals does not factorise into the product of single-particle coefficients, and this breaking of factorisation, or flow decorrelation, increases linearly with the eta separation between the intervals. The flow decorrelation is stronger at 2.76 TeVthan at 5.02 TeV. Higher-order moments of the correlations are also measured, and the corresponding linear coefficients for the kth-moment of the v(n) are found to be proportional to k for v(3), but not for v(2). The decorrelation effect is separated into contributions from the magnitude of v(n) and the event-plane orientation, each as a function of eta. These two contributions are found to be comparable. The longitudinal flow correlations are also measured between v(n) of different order in n. The decorrelations of v(2) and v(3) are found to be independent of each other, while the decorrelations of v(4) and v(5) are found to be driven by the nonlinear contribution from v(2)(2) and v(2)v(3), respectively. KW - Charged-Particles KW - Pseudorapidity KW - Dependence KW - Viscosity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225610 VL - 78 IS - 142 ER - TY - JOUR T1 - Search for the direct production of charginos and neutralinos in final states with tau leptons in root s=13 TeV pp collisions with the ATLAS detector JF - The European Physical Journal C N2 - A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. No significant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of pair production and of and production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the state is set to be halfway between the masses of the and the (chi) over tilde (0.)(1) . Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of for a massless (chi) over tilde (0.)(1). Common and masses up to 760 GeV are excluded in the case of production of and assuming a massless . Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the and the are also studied by varying the mass between the masses of the and the (chi) over tilde (0.)(1) KW - Dynamical Supersymmetry Breaking KW - Parton Distributions KW - Measuring masses KW - Energy KW - Extension KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225602 VL - 78 IS - 154 ER - TY - JOUR T1 - Search for new phenomena in high-mass final states with a photon and a jet from \({pp}\) collisions at root s=13 TeV with the ATLAS detector JF - The European Physical Journal C N2 - A search is performed for new phenomena in events having a photon with high transverse momentum and a jet collected in 36.7 fb(-1) of proton-proton collisions at a centre-of-mass energy of root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider. The invariant mass distribution of the leading photon and jet is examined to look for the resonant production of new particles or the presence of new high-mass states beyond the Standard Model. No significant deviation from the background-only hypothesis is observed and cross-section limits for generic Gaussian-shaped resonances are extracted. Excited quarks hypothesized in quark compositeness models and high-mass states predicted in quantum black hole models with extra dimensions are also examined in the analysis. The observed data exclude, at 95% confidence level, the mass range below 5.3 TeV for excited quarks and 7.1 TeV (4.4 TeV) for quantum black holes in the Arkani-Hamed-Dimopoulos-Dvali (Randall-Sundrum) model with six (one) extra dimensions. KW - Parton distributions KW - Hierarchy Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225887 VL - 78 IS - 102 ER - TY - JOUR T1 - Search for heavy resonances decaying into \({WW}\) in the eνμν final state in \({pp}\) collisions at root s=13 TeV with the ATLAS detector JF - European Physical Journal C N2 - A search for neutral heavy resonances is performed in the WW -> e nu mu nu decay channel using pp collision data corresponding to an integrated luminosity of 36.1 fb(-1), collected at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. No evidence of such heavy resonances is found. In the search for production via the quark-antiquark annihilation or gluon-gluon fusion process, upper limits on sigma(X) x B(X -> WW) as a function of the resonance mass are obtained in the mass range between 200 GeV and up to 5 TeV for various benchmark models: a Higgs-like scalar in different width scenarios, a two-Higgs-doublet model, a heavy vector triplet model, and a warped extra dimensions model. In the vector-boson fusion process, constraints are also obtained on these resonances, as well as on a Higgs boson in the Georgi-Machacek model and a heavy tensor particle coupling only to gauge bosons. KW - Gluon Fusion KW - Higgs KW - Bosons KW - Mass Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225914 VL - 78 IS - 24 ER - TY - JOUR T1 - Search for dark matter produced in association with bottom or top quarks in root s=13 TeV \({pp}\) collisions with the ATLAS detector JF - European Physical Journal C N2 - A search for weakly interacting massive dark matter particles produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and missing transverse momentum are considered. The analysis uses 36.1 fb(-1) of proton proton collision data recorded by the ATLAS experiment at root s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are interpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour-neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross-section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour-charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements. KW - Production Cross-Section KW - Pair Prodution KW - Parton Distributions KW - Hadron Colliders KW - Measuring Masses KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225937 VL - C 78 IS - 18 ER - TY - JOUR T1 - Measurement of the Soft-Drop Jet Mass in \({pp}\) Collisions at root s=13 TeV with the ATLAS Detector JF - Physical Review Letters N2 - Jet substructure observables have significantly extended the search program for physics beyond the standard model at the Large Hadron Collider. The state-of-the-art tools have been motivated by theoretical calculations, but there has never been a direct comparison between data and calculations of jet substructure observables that are accurate beyond leading-logarithm approximation. Such observables are significant not only for probing the collinear regime of QCD that is largely unexplored at a hadron collider, but also for improving the understanding of jet substructure properties that are used in many studies at the Large Hadron Collider. This Letter documents a measurement of the first jet substructure quantity at a hadron collider to be calculated at next-to-next-to-leading-logarithm accuracy. The normalized, differential cross section is measured as a function of log(10)rho(2), where rho is the ratio of the soft-drop mass to the ungroomed jet transverse momentum. This quantity is measured in dijet events from 32.9 fb(-1) of root s = 13 TeV proton-proton collisions recorded by the ATLAS detector. The data are unfolded to correct for detector effects and compared to precise QCD calculations and leading-logarithm particle-level Monte Carlo simulations. KW - Algorithm Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220694 VL - 121 IS - 9 ER - TY - JOUR T1 - Measurement of dijet azimuthal decorrelations in \({pp}\) collisions at root s=8 TeV with the ATLAS detector and determination of the strong coupling JF - Physical Review D N2 - measurement of the rapidity and transverse momentum dependence of dijet azimuthal decorrelations is presented, using the quantity R-Delta phi. The quantity R-Delta phi specifies the fraction of the inclusive dijet events in which the azimuthal opening angle of the two jets with the highest transverse momenta is less than a given value of the parameter Delta phi(max). The quantity R-Delta phi is measured in proton-proton collisions at root s = 8 TeV as a function of the dijet rapidity interval, the event total scalar transverse momentum, and Delta phi(max). The measurement uses an event sample corresponding to an integrated luminosity of 20.2 fb(-1) collected with the ATLAS detector at the CERN Large Hadron Collider. Predictions of a perturbative QCD calculation at next-to-leading order in the strong coupling with corrections for nonperturbative effects are compared to the data. The theoretical predictions describe the data in the whole kinematic region. The data are used to determine the strong coupling alpha(S) and to study its running for momentum transfers from 260 GeV to above 1.6 TeV. Analysis that combines data at all momentum transfers results in alpha(S) (m(Z)) = 0.1127(- 0.0027) (+0.0063). KW - pp collisions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220665 VL - 98 IS - 9 ER - TY - JOUR T1 - Search for supersymmetry in events with four or more leptons in root s=13 TeV \({pp}\) collisions with ATLAS JF - Physical Review D N2 - Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb(-1) of proton-proton collisions delivered by the Large Hadron Collider at root s = 13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of general gauge mediated supersymmetry, where Higgsino masses are excluded up to 295 GeV. In R-parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46, 1.06, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively. KW - Gluino Production KW - Squark KW - Extension KW - Scale KW - Decay KW - Weak Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220705 VL - 98 IS - 3 ER - TY - JOUR T1 - Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb\(^{-1}\) of root s=13 TeV \({pp}\) collision data with the ATLAS detector JF - Physical Review D N2 - A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded in 2015 and 2016 by the ATLAS experiment in root s = 13 TeV proton-proton collisions at the Large Hadron Collider, corresponding to an integrated luminosity of 36.1 fb(-1). The results are interpreted in the context of various models where squarks and gluinos are pair produced and the neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.03 TeV for a simplified model incorporating only a gluino and the lightest neutralino, assuming the lightest neutralino is massless. For a simplified model involving the strong production of mass-degenerate first-and second-generation squarks, squark masses below 1.55 TeVare excluded if the lightest neutralino is massless. These limits substantially extend the region of supersymmetric parameter space previously excluded by searches with the ATLAS detector. KW - Parton Distributions KW - Decay KW - Weak Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220835 VL - 97 IS - 11 ER - TY - JOUR T1 - Search for long-lived, massive particles in events with displaced vertices and missing transverse momentum in root S=13 TeV \({pp}\) collisions with the ATLAS detector JF - Physical Review D N2 - A search for long-lived, massive particles predicted by many theories beyond the Standard Model is presented. The search targets final states with large missing transverse momentum and at least one highmass displaced vertex with five or more tracks, and uses 32.8 fb(-1) of root s = 13 TeV pp collision data collected by the ATLAS detector at the LHC. The observed yield is consistent with the expected background. The results are used to extract 95% C.L. exclusion limits on the production of long-lived gluinos with masses up to 2.37 TeV and lifetimes of O(10(-2)) - O(10) ns in a simplified model inspired by split supersymmetry. KW - Proton-Proton- Collisions KW - Parton Distributions KW - Gluino Production KW - Heavy-Particles KW - Breaking KW - Bosons KW - States KW - Squark KW - Decay KW - Jets Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225450 VL - 97 IS - 5 ER - TY - JOUR T1 - \({ZZ}\) -> l(+)l(-)l '(+)l '(-) cross-section measurements and search for anomalous triple gauge couplings in 13 TeV \({pp}\) collisions with the ATLAS detector JF - Physical Review D N2 - Measurements of ZZ production in the l(+)l(-)l'(+)l'(-) channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb(-1) of collisions collected by the ATLAS experiment in 2015 and 2016. Here l and l ' stand for electrons or muons. Integrated and differential ZZ -> l(+)l(-)l'(+)l'(-) cross sections with Z -> l(+)l(-) candidate masses in the range of 66 GeV to 116 GeV are measured in a fiducial phase space corresponding to the detector acceptance and corrected for detector effects. The differential cross sections are presented in bins of twenty observables, including several that describe the jet activity. The integrated cross section is also extrapolated to a total phase space and to all standard model decays of Z bosons with mass between 66 GeV and 116 GeV, resulting in a value of 17.3 +/- 0.9 [+/- 0.6(start) +/- 0.5 (syst) +/- 0.6 (lumi)] pb. The measurements are found to be in good agreement with the standard model. A search for neutral triple gauge couplings is performed using the transverse momentum distribution of the leading Z boson candidate. No evidence for such couplings is found and exclusion limits are set on their parameters. KW - Parton Distributions KW - Events Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225844 VL - 97 IS - 3 ER - TY - JOUR T1 - Search for \(B\) - \(L\) \(R\)-parity-violating top squarks in root s=13 TeV \({pp}\) collisions with the ATLAS experiment JF - Physical Review D N2 - A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb(-1) of proton-proton collisions at a center-of-mass energy of root s = 13 TeV, collected in 2015 and 2016 by the ATLAS detector at the LHC. No significant excess is observed over the Standard Model background, and exclusion limits are set on stop pair production at a 95% confidence level. Lower limits on the stop mass are set between 600 GeV and 1.5 TeV for branching ratios above 10% for decays to an electron or muon and a b-quark. KW - Parton Distributions KW - Breaking KW - Extension KW - Neutrino KW - Decay KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225863 VL - 97 IS - 3 ER - TY - JOUR T1 - Measurement of long-range multiparticle azimuthal correlations with the subevent cumulant method in \({pp}\) and \(p\)+Pb collisions with the ATLAS detector at the CERN Large Hadron Collider JF - Physical Review C N2 - A detailed study of multiparticle azimuthal correlations is presented using pp data at root s = 5.02 and 13 TeV, and p+Pb data at root s(NN) = 5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants c(n){4} and flow coefficients v(n){4} = (-c(n){4})(1/4) for n = 2 and 3, with the goal of extracting long-range multiparticle azimuthal correlation signals and suppressing the short-range correlations. The values of c(n){4} are obtained as a function of the average number of charged particles per event, < N-ch >, using the recently proposed two-subevent and three-subevent cumulant methods, and compared with results obtained with the standard cumulant method. The standard method is found to be strongly biased by short-range correlations, which originate mostly from jetswith a positive contribution to c(n){4}. The threesubevent method, on the other hand, is found to be least sensitive to short-range correlations. The three-subevent method gives a negative c(2){4}, and therefore a well-defined v(2){4}, nearly independent of < N-ch >, which implies that the long-range multiparticle azimuthal correlations persist to events with low multiplicity. Furthermore, v(2){4} is found to be smaller than the v(2){2} measured using the two-particle correlation method, as expected for long-range collective behavior. Finally, the measured values of v(2){4} and v(2){2} are used to estimate the number of sources relevant for the initial eccentricity in the collision geometry. The results based on the subevent cumulant technique provide direct evidence, in small collision systems, for a long-range collectivity involving many particles distributed across a broad rapidity interval. KW - Eccentricities Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225623 VL - 97 IS - 2 ER - TY - JOUR T1 - Measurement of the cross section for isolated-photon plus jet production in \({pp}\) collisions at root s=13 TeV using the ATLAS detector JF - Physics Letters B N2 - The dynamics of isolated-photon production in association with a jet in proton-proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb(-1). Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti-k(t) algorithm with radius parameter R = 0.4 and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon-jet invariant mass and the scattering angle in the photon-jet centre-of-mass system. Tree-level plus parton-shower predictions from SHERPA and PYTHIA as well as next-to-leading-order QCD predictions from JETPHOX and SHERPA are compared to the measurements. (C) 2018 The Author. Published by Elsevier B.V. KW - Fragmentation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225412 VL - 780 ER - TY - JOUR T1 - Measurement of the production cross-section of a single top quark in association with a \(Z\) boson in proton-proton collisions at 13 TeV with the ATLAS detector JF - Physics letters B N2 - The production of a top quark in association with a Z boson is investigated. The proton-proton collision data collected by the ATLAS experiment at the LHC in 2015 and 2016 at a centre-of-mass energy of root s = 13 TeV are used, corresponding to an integrated luminosity of 36.1 fb(-1). Events containing three identified leptons (electrons and/or muons) and two jets, one of which is identified as a b-quark jet are selected. The major backgrounds are diboson, tt($)over-bar and Z + jets production. A neural network is used to improve the background rejection and extract the signal. The resulting significance is 4.2 sigma in the data and the expected significance is 5.4 sigma. The measured cross-section for tZq production is 600 +/- 170(stat.)+/- 140(syst.)fb. (C) 2018 The Author(s). Published by Elsevier B.V. KW - ATLAS experiment KW - proton-proton collisions KW - single top quark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225406 VL - 780 ER - TY - JOUR T1 - A search for resonances decaying into a Higgs boson and a new particle \(X\) in the \({XH}\) -> \({qqbb}\) final state with the ATLAS detector JF - Physics letters B N2 - A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb(-1) of proton-proton collision data at root s = 13 TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle Xis assumed to decay to a pair of light quarks, and the fully hadronic final state XH -> q (q) over bar 'b (b) over bar is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the XH -> q (q) over bar 'b (b) over bar resonance. (c) 2018 The Author(s). Published by Elsevier B.V. KW - Proton-Proton Collisions KW - Root-S=13 TEV KW - MASS Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225435 VL - 779 ER - TY - JOUR T1 - Measurement of the exclusive gamma gamma -> mu\(^+\)mu\(^-\) process in proton-proton collisions at root s=13 TeV with the ATLAS detector JF - Physics Letters B N2 - The production of exclusive gamma gamma -> mu(+)mu(-) events in proton-proton collisions at a centre-of-mass energy of 13 TeV is measured with the ATLAS detector at the LHC, using data corresponding to an integrated luminosity of 3.2 fb(-1). The measurement is performed for a dimuon invariant mass of 12 GeV < m(mu+mu-) < 70 GeV. The integrated cross-section is determined within a fiducial acceptance region of the ATLAS detector and differential cross-sections are measured as a function of the dimuon invariant mass. The results are compared to theoretical predictions both with and without corrections for absorptive effects. (c) 2017 The Author(s). Published by Elsevier B.V. KW - Plus Plus KW - Physics Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225825 VL - 777 ER - TY - JOUR T1 - Search for diboson resonances with boson-tagged jets in \({pp}\) collisions at root S=13 TeV with the ATLAS detector JF - Physics Letters B N2 - Narrow resonances decaying into WW, WZ or ZZ boson pairs are searched for in 36.7 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The diboson system is reconstructed using pairs of large-radius jets with high transverse momentum and tagged as compatible with the hadronic decay of high-momentum Wor Zbosons, using jet mass and substructure properties. The search is sensitive to diboson resonances with masses in the range 1.2-5.0 TeV. No significant excess is observed in any signal region. Exclusion limits are set at the 95% confidence level on the production cross section times branching ratio to dibosons for a range of theories beyond the Standard Model. Model-dependent lower limits on the mass of new gauge bosons are set, with the highest limit set at 3.5 TeV in the context of mass-degenerate resonances that couple predominantly to bosons. (c) 2017 The Author(s). Published by Elsevier B.V. KW - Leptons KW - Physics KW - WZ Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225782 VL - 777 ER - TY - JOUR T1 - Search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a Z boson in \({pp}\) collisions at root s=13 TeV with the ATLAS detector JF - Physics Letters B N2 - A search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a leptonically decaying Z boson in proton-proton collisions at root s = 13 TeV is presented. This search uses 36.1 fb(-1) of data collected by the ATLAS experiment at the Large Hadron Collider. No significant deviation from the expectation of the Standard Model backgrounds is observed. Assuming the Standard Model ZH production cross-section, an observed (expected) upper limit of 67% (39%) at the 95% confidence level is set on the branching ratio of invisible decays of the Higgs boson with mass m(H) = 125 GeV. The corresponding limits on the production cross-section of the ZH process with the invisible Higgs boson decays are also presented. Furthermore, exclusion limits on the dark matter candidate and mediator masses are reported in the framework of simplified dark matter models. (c) 2017 The Author(s). Published by Elsevier B.V. KW - Distributions KW - Models Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225947 VL - 776 IS - 1 ER - TY - JOUR T1 - Angular analysis of B-d(0) -> K* µ\(^+\)μ\(^-\) decays in \({pp}\) collisions at root s=8 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - An angular analysis of the decay B-d(0) -> K*mu(+)mu(-) is presented, based on proton-proton collision data recorded by the ATLAS experiment at the LHC. The study is using 20.3 fb(-1) of integrated luminosity collected during 2012 at centre-of-mass energy of root s = 8TeV. Measurements of the K* longitudinal polarisation fraction and a set of angular parameters obtained for this decay are presented. The results are compatible with the Standard Model predictions. KW - Hadron-Hadron scattering (experiments) KW - K* µ+μ− KW - B-0 Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220670 VL - 47 ER - TY - JOUR T1 - Search for exclusive Higgs and Z boson decays to phi gamma and rho gamma with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for the exclusive decays of the Higgs and Z bosons to a phi or rho meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of up to 35.6 fb(-1) collected at root s = 13 TeV with the ATLAS detector at the CERN Large Hadron Collider. These decays have been suggested as a probe of the Higgs boson couplings to light quarks. No significant excess of events is observed above the background, as expected from the Standard Model. Upper limits at 95% confidence level were obtained on the branching fractions of the Higgs boson decays to phi gamma and rho gamma of 4.8 x 10(-4) and 8.8 x 10(-4), respectively. The corresponding 95% confidence level upper limits for the Z boson decays are 0.9 x 10(-6) and 25 x 10(-6) for phi gamma and rho gamma, respectively. KW - Hadron-Hadron scattering (experiments) KW - Mass KW - Hierarchy KW - QCD KW - Higgs physics Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220717 VL - 127 IS - 7 ER - TY - JOUR T1 - Search for Higgs boson decays to beyond-the-Standard-Model light bosons in four-lepton events with the ATLAS detector at root s=13 TeV JF - Journal of High Energy Physics N2 - A search is conducted for a beyond-the-Standard-Model boson using events where a Higgs boson with mass 125 GeV decays to four leptons (l = e or mu). This decay is presumed to occur via an intermediate state which contains one or two on-shell, promptly decaying bosons: H -> ZX/XX -> 4l , where X is a new vector boson Z(d) or pseudoscalar a with mass between 1 and 60 GeV. The search uses pp collision data collected with the ATLAS detector at the LHC with an integrated luminosity of 36.1 fb(-1) at a centre-of-mass energy root s = 13TeV. No significant excess of events above Standard Model background predictions is observed; therefore, upper limits at 95% confidence level are set on model-independent fiducial cross-sections, and on the Higgs boson decay branching ratios to vector and pseudoscalar bosons in two benchmark models. KW - Beyond Standard Model KW - Hadron-Hadron scattering (experiments) KW - Patron Distributions KW - Energies Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220721 VL - 166 IS - 6 ER - TY - JOUR T1 - Search for top-squark pair production in final states with one lepton, jets, and missing transverse momentum using 36 fb\(^{-1}\) of root s=13 TeV \({pp}\) collision data with the ATLAS detector JF - Journal of High Energy Physics N2 - The results of a search for the direct pair production of top squarks, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, several energetic jets, and missing transverse momentum are reported. The analysis also targets spin-0 mediator models, where the mediator decays into a pair of dark-matter particles and is produced in association with a pair of top quarks. The search uses data from proton-proton collisions delivered by the Large Hadron Collider in 2015 and 2016 at a centre-of-mass energy of root s = 13TeV and recorded by the ATLAS detector, corresponding to an integrated luminosity of 36 fb(-1). A wide range of signal scenarios with different mass-splittings between the top squark, the lightest neutralino and possible intermediate supersymmetric particles are considered, including cases where the W bosons or the top quarks produced in the decay chain are off-shell. No significant excess over the Standard Model prediction is observed. The null results are used to set exclusion limits at 95% confidence level in several supersymmetry benchmark models. For pair-produced top-squarks decaying into top quarks, top-squark masses up to 940 GeV are excluded. Stringent exclusion limits are also derived for all other considered top-squark decay scenarios. For the spin-0 mediator models, upper limits are set on the visible cross-section. KW - Hadron-Hadron scattering (experiments) KW - Dark-matter production KW - Symmetry-breaking KW - Plus plus KW - Model KW - Supersymmetry KW - Program KW - LHS KW - Mass KW - Extension KW - Physics Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220733 VL - 108 IS - 6 ER - TY - JOUR T1 - Search for supersymmetry in final states with missing transverse momentum and multiple b-jets in proton-proton collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks into the lightest neutralino ((chi) over tilde (0)(1)) is reported. It uses LHC proton-proton collision data at a centre-of-mass energy root s = 13TeV with an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing large missing transverse momentum and several energetic jets, at least three of which must be identified as originating from b-quarks. To increase the sensitivity, the sample is divided into subsamples based on the presence or absence of electrons or muons. No excess is found above the predicted background. For (chi) over tilde (0)(1) masses below approximately 300 GeV, gluino masses of less than 1.97 (1.92) TeV are excluded at 95% confidence level in simplified models involving the pair production of gluinos that decay via top (bottom) squarks. An interpretation of the limits in terms of the branching ratios of the gluinos into third-generation squarks is also provided. These results improve upon the exclusion limits obtained with the 3.2 fb(-1) of data collected in 2015. KW - Hadron-Hadron scattering (experiments) KW - Parton distributions KW - Gluino production KW - Plus plus KW - Squark KW - Extension KW - Decay Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220748 VL - 107 IS - 6 ER - TY - JOUR T1 - Search for long-lived charginos based on a disappearing-track signature in pp collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - This paper presents a search for direct electroweak gaugino or gluino pair production with a chargino nearly mass-degenerate with a stable neutralino. It is based on an integrated luminosity of 36.1 fb(-1) of pp collisions at root s = 13 TeV collected by the ATLAS experiment at the LHC. The final state of interest is a disappearing track accompanied by at least one jet with high transverse momentum from initial-state radiation or by four jets from the gluino decay chain. The use of short track segments reconstructed from the innermost tracking layers significantly improves the sensitivity to short chargino lifetimes. The results are found to be consistent with Standard Model predictions. Exclusion limits are set at 95% confidence level on the mass of charginos and gluinos for different chargino lifetimes. For a pure wino with a lifetime of about 0.2 ns, chargino masses up to 460 GeV are excluded. For the strong production channel, gluino masses up to 1.65 TeV are excluded assuming a chargino mass of 460 GeV and lifetime of 0.2 ns. KW - Hadron-Hadron scattering (experiments) KW - Extension KW - Squark Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220847 VL - 22 IS - 6 ER - TY - JOUR T1 - Measurement of inclusive jet and dijet cross-sections in proton-proton collisions at root s=13 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV. The measurement uses a dataset with an integrated luminosity of 3.2 fb(-1) recorded in 2015 with the ATLAS detector at the Large Hadron Collider. Jets are identified using the anti-lit algorithm with a radius parameter value of R = 0.4. The inclusive jet cross-sections are measured double-differentially as a function of the jet transverse momentum, covering the range from 100 GeV to 3.5 TeV, and the absolute jet rapidity up to vertical bar y vertical bar = 3. The double-differential dijet production cross-sections are presented as a function of the dijet mass, covering the range from 300 GeV to 9 TeV, and the half absolute rapidity separation between the two leading jets within vertical bar y vertical bar < 3, y*, up to y* = 3. Next-to-leading-order, and next-to-next-to-leading-order for the inclusive jet measurement, perturbative QCD calculations corrected for non-perturbative and electroweak effects are compared to the measured cross-sections. KW - Hadron-Hadron scattering (experiments) KW - Parton distributions Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220853 VL - 195 IS - 5 ER - TY - JOUR T1 - Measurement of differential cross sections and W\(^+\)/W\(^-\) cross-section ratios for W boson production in association with jets at root s=8 TeV with the ATLAS detector JF - Journal of High Energy Physics N2 - This paper presents a measurement of the W boson production cross section and the W+/W- cross-section ratio, both in association with jets, in proton-proton collisions at root s = 8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb(-1). Differential cross sections for events with at least one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W+/W- the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proton. KW - Hadron-Hadron scattering (experiments) KW - To-leading order KW - P(P)over-bar collicions KW - Parton distributions KW - Transverse-momentum KW - Pair production KW - Events KW - Decay KW - Plus KW - LHC Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220872 VL - 77 IS - 5 ER - TY - JOUR T1 - Search for heavy resonances decaying into a W or Z boson and a Higgs boson in final states with leptons and b-jets in 36 fb\(^{-1}\) of root s=13 TeV pp collisions with the ATLAS detector JF - Journal of High Energy Physics N2 - A search is conducted for new resonances decaying into a W or Z boson and a 125 GeV Higgs boson in the nu(nu) over barb (b) over bar, l(+/-)nu b (b) over bar, and l(+)l(-)b (b) over bar final states, where l(+/-) = e(+/-) or mu(+/-), in pp collisions at root s = 13 TeV. The data used correspond to a total integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector at the Large Hadron Collider during the 2015 and 2016 data-taking periods. The search is conducted by examining the reconstructed invariant or transverse mass distributions of Wh and Zh candidates for evidence of a localised excess in the mass range of 220 GeV up to 5 TeV. No significant excess is observed and the results are interpreted in terms of constraints on the production cross-section times branching fraction of heavy W' and Z' resonances in heavy-vector-triplet models and the CP-odd scalar boson A in two-Higgs-doublet models. Upper limits are placed at the 95% confidence level and range between 9.0 x 10(-4) pb and 7.3 x 10(-1) pb depending on the model and mass of the resonance. KW - Beyond Standard Model KW - Hadron-Hadron scattering (experiments) Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225446 VL - 174 IS - 3 ER - TY - JOUR A1 - Ranger, Christopher M. A1 - Biedermann, Peter HW A1 - Phuntumart, Vipaporn A1 - Beligala, Gayathri U. A1 - Ghosh, Satyaki A1 - Palmquist, Debra E. A1 - Mueller, Robert A1 - Barnett, Jenny A1 - Schultz, Peter B. A1 - Reding, Michael E. A1 - Benz, J. Philipp T1 - Symbiont selection via alcohol benefits fungus farming by ambrosia beetles JF - Proceedings of the National Academy of Sciences N2 - Animal-microbe mutualisms are typically maintained by vertical symbiont transmission or partner choice. A third mechanism, screening of high-quality symbionts, has been predicted in theory, but empirical examples are rare. Here we demonstrate that ambrosia beetles rely on ethanol within host trees for promoting gardens of their fungal symbiont and producing offspring. Ethanol has long been known as the main attractant for many of these fungus-farming beetles as they select host trees in which they excavate tunnels and cultivate fungal gardens. More than 300 attacks by Xylosandrus germanus and other species were triggered by baiting trees with ethanol lures, but none of the foundresses established fungal gardens or produced broods unless tree tissues contained in vivo ethanol resulting from irrigation with ethanol solutions. More X. germanus brood were also produced in a rearing substrate containing ethanol. These benefits are a result of increased food supply via the positive effects of ethanol on food-fungus biomass. Selected Ambrosiella and Raffaelea fungal isolates from ethanol-responsive ambrosia beetles profited directly and indirectly by (i) a higher biomass on medium containing ethanol, (ii) strong alcohol dehydrogenase enzymatic activity, and (iii) a competitive advantage over weedy fungal garden competitors (Aspergillus, Penicillium) that are inhibited by ethanol. As ambrosia fungi both detoxify and produce ethanol, they may maintain the selectivity of their alcohol-rich habitat for their own purpose and that of other ethanol-resistant/producing microbes. This resembles biological screening of beneficial symbionts and a potentially widespread, unstudied benefit of alcohol-producing symbionts (e.g., yeasts) in other microbial symbioses. KW - fungus-farming insects KW - plant-insect-microbe interactions KW - symbiosis KW - insect-fungus mutualism KW - host screening Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-224953 VL - 115 IS - 17 ER - TY - JOUR A1 - Saudek, František A1 - Cahová, Monika A1 - Havrdová, Terezie A1 - Zacharovová, Klára A1 - Daňková, Helena A1 - Voska, Luděk A1 - Lánská, Věra A1 - Üçeyler, Nurcan A1 - Sommer, Claudia T1 - Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation JF - Journal of Diabetes Research N2 - Diabetic peripheral neuropathy (DPN) is a common complication of diabetes with potential severe consequences. Its pathogenesis involves hyperglycemia-linked mechanisms, which may include changes in the expression of neurotrophic growth factors. We analyzed the expression of 29 factors potentially related to nerve degeneration and regeneration in skin biopsies from 13 type 1 diabetic pancreas and kidney recipients with severe DPN including severe depletion of intraepidermal nerve fibers (IENF) in lower limb skin biopsies (group Tx1 1st examination). The investigation was repeated after a median 28-month period of normoglycemia achieved by pancreas transplantation (group Tx1 2nd examination). The same tests were performed in 13 stable normoglycemic pancreas and kidney recipients 6-12 years posttransplantation (group Tx2), in 12 matched healthy controls (group HC), and in 12 type 1 diabetic subjects without severe DPN (group DM). Compared to DM and HC groups, we found a significantly higher (p < 0.05-0.001) expression of NGF (nerve growth factor), NGFR (NGF receptor), NTRK1 (neurotrophic receptor tyrosine kinase 1), GDNF (glial cell-derived neurotrophic factor), GFRA1 (GDNF family receptor alpha 1), and GFAP (glial fibrillary acidic protein) in both transplant groups (Tx1 and Tx2). Enhanced expression of these factors was not normalized following the median 28-month period of normoglycemia (Tx1 2nd examination) and negatively correlated with IENF density and with electrophysiological indices of DPN (vibration perception threshold, electromyography, and autonomic tests). In contrast to our expectation, the expression of most of 29 selected factors related to neural regeneration was comparable in subjects with severe peripheral nerve fiber depletion and healthy controls and the expression of six factors was significantly upregulated. These findings may be important for better understanding the pathophysiology of nerve regeneration and for the development of intervention strategies. KW - Nerve growth-factorcopy KW - Corneal confocal microscopy KW - Factor messenger-RNA KW - Schwann-cells KW - Gene-expression KW - Receptors KW - Identification KW - Innervation KW - Mechanisms KW - Gland Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227469 VL - 2018 IS - 2309108 ER - TY - JOUR A1 - Rietjens, Ivonne M. C. M. A1 - Dussort, P. A1 - Günther, Helmut A1 - Hanlon, Paul A1 - Honda, Hiroshi A1 - Mally, Angela A1 - O'Hagan, Sue A1 - Scholz, Gabriele A1 - Seidel, Albrecht A1 - Swenberg, James A1 - Teeguarden, Justin A1 - Eisenbrand, Gerhard T1 - Exposure assessment of process-related contaminants in food by biomarker monitoring JF - Archives of Toxicology N2 - Exposure assessment is a fundamental part of the risk assessment paradigm, but can often present a number of challenges and uncertainties. This is especially the case for process contaminants formed during the processing, e.g. heating of food, since they are in part highly reactive and/or volatile, thus making exposure assessment by analysing contents in food unreliable. New approaches are therefore required to accurately assess consumer exposure and thus better inform the risk assessment. Such novel approaches may include the use of biomarkers, physiologically based kinetic (PBK) modelling-facilitated reverse dosimetry, and/or duplicate diet studies. This review focuses on the state of the art with respect to the use of biomarkers of exposure for the process contaminants acrylamide, 3-MCPD esters, glycidyl esters, furan and acrolein. From the overview presented, it becomes clear that the field of assessing human exposure to process-related contaminants in food by biomarker monitoring is promising and strongly developing. The current state of the art as well as the existing data gaps and challenges for the future were defined. They include (1) using PBK modelling and duplicate diet studies to establish, preferably in humans, correlations between external exposure and biomarkers; (2) elucidation of the possible endogenous formation of the process-related contaminants and the resulting biomarker levels; (3) the influence of inter-individual variations and how to include that in the biomarker-based exposure predictions; (4) the correction for confounding factors; (5) the value of the different biomarkers in relation to exposure scenario's and risk assessment, and (6) the possibilities of novel methodologies. In spite of these challenges it can be concluded that biomarker-based exposure assessment provides a unique opportunity to more accurately assess consumer exposure to process-related contaminants in food and thus to better inform risk assessment. KW - Dietary process-related contaminants KW - Biomarkers KW - External exposure assessment KW - Physiologically based kinetic models KW - Risk assessment Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226268 VL - 92 IS - 1 ER - TY - JOUR A1 - Batzke, Katharina A1 - Büchel, Gabriele A1 - Hansen, Wiebke A1 - Schramm, Alexander T1 - TrkB-target Galectin-1 impairs immune activation and radiation responses in neuroblastoma: implications for tumour therapy JF - International Journal of Molecular Sciences N2 - Galectin-1 (Gal-1) has been described to promote tumour growth by inducing angiogenesis and to contribute to the tumour immune escape. We had previously identified up-regulation of Gal-1 in preclinical models of aggressive neuroblastoma (NB), the most common extracranial tumour of childhood. While Gal-1 did not confer a survival advantage in the absence of exogenous stressors, Gal-1 contributed to enhanced cell migratory and invasive properties. Here, we review these findings and extend them by analyzing Gal-1 mediated effects on immune cell regulation and radiation resistance. In line with previous results, cell autonomous effects as well as paracrine functions contribute to Gal-1 mediated pro-tumourigenic functions. Interfering with Gal-1 functions in vivo will add to a better understanding of the role of the Gal-1 axis in the complex tumour-host interaction during immune-, chemo- and radiotherapy of neuroblastoma. KW - Galectin-1 KW - radiation response KW - neuroblastoma Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285097 SN - 1422-0067 VL - 19 IS - 3 ER - TY - JOUR A1 - Kaiser, Mathias A1 - Burek, Malgorzata A1 - Britz, Stefan A1 - Lankamp, Frauke A1 - Ketelhut, Steffi A1 - Kemper, Björn A1 - Förster, Carola A1 - Gorzelanny, Christian A1 - Goycoolea, Francisco M. T1 - The influence of capsaicin on the integrity of microvascular endothelial cell monolayers JF - International Journal of Molecular Sciences N2 - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions. KW - tight junctions KW - capsaicin KW - endothelial cells Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284865 SN - 1422-0067 VL - 20 IS - 1 ER - TY - JOUR A1 - Adam, Alexander A1 - Deimel, Stephan A1 - Pardo-Medina, Javier A1 - García-Martínez, Jorge A1 - Konte, Tilen A1 - Limón, M. Carmen A1 - Avalos, Javier A1 - Terpitz, Ulrich T1 - Protein activity of the \(Fusarium\) \(fujikuroi\) rhodopsins CarO and OpsA and their relation to fungus−plant interaction JF - International Journal of Molecular Sciences N2 - Fungi possess diverse photosensory proteins that allow them to perceive different light wavelengths and to adapt to changing light conditions in their environment. The biological and physiological roles of the green light-sensing rhodopsins in fungi are not yet resolved. The rice plant pathogen Fusarium fujikuroi exhibits two different rhodopsins, CarO and OpsA. CarO was previously characterized as a light-driven proton pump. We further analyzed the pumping behavior of CarO by patch-clamp experiments. Our data show that CarO pumping activity is strongly augmented in the presence of the plant hormone indole-3-acetic acid and in sodium acetate, in a dose-dependent manner under slightly acidic conditions. By contrast, under these and other tested conditions, the Neurospora rhodopsin (NR)-like rhodopsin OpsA did not exhibit any pump activity. Basic local alignment search tool (BLAST) searches in the genomes of ascomycetes revealed the occurrence of rhodopsin-encoding genes mainly in phyto-associated or phytopathogenic fungi, suggesting a possible correlation of the presence of rhodopsins with fungal ecology. In accordance, rice plants infected with a CarO-deficient F. fujikuroi strain showed more severe bakanae symptoms than the reference strain, indicating a potential role of the CarO rhodopsin in the regulation of plant infection by this fungus. KW - fungal rhodopsins KW - CarO KW - OpsA KW - Fusarium fujikuroi KW - Oryza sativa KW - rice–plant infection KW - green light perception KW - indole-3-acetic acid (IAA) KW - bakanae KW - patch-clamp Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285125 SN - 1422-0067 VL - 19 IS - 1 ER - TY - JOUR A1 - Ungern-Sternberg, Saskia N. I. von A1 - Zernecke, Alma A1 - Seizer, Peter T1 - Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease JF - International Journal of Molecular Sciences N2 - The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells. There is also evidence that EMMPRIN controls energy metabolism of cells and that EMMPRIN binding partners modulate intracellular glycosylation and trafficking of EMMPRIN towards the cell membrane. In this review, we systematically discuss these multifaceted roles of EMMPRIN and its interaction partners, such as Cyclophilins, in cardiovascular disease. KW - cardiovascular disease KW - immunoglobulin superfamily KW - inflammation KW - platelets KW - monocyte-platelet aggregates Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285014 SN - 1422-0067 VL - 19 IS - 2 ER - TY - JOUR A1 - Salinger, Tim A1 - Hu, Kai A1 - Liu, Dan A1 - Taleh, Scharoch A1 - Herrmann, Sebastian A1 - Oder, Daniel A1 - Gensler, Daniel A1 - Müntze, Jonas A1 - Ertl, Georg A1 - Lorenz, Kristina A1 - Frantz, Stefan A1 - Weidemann, Frank A1 - Nordbeck, Peter T1 - Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis JF - Cardiology Research and Practice N2 - Background. Fast progression of the transaortic mean gradient (P-mean) is relevant for clinical decision making of valve replacement in patients with moderate and severe aortic stenosis (AS) patients. However, there is currently little knowledge regarding the determinants affecting progression of transvalvular gradient in AS patients. Methods. This monocentric retrospective study included consecutive patients presenting with at least two transthoracic echocardiography examinations covering a time interval of one year or more between April 2006 and February 2016 and diagnosed as moderate or severe aortic stenosis at the final echocardiographic examination. Laboratory parameters, medication, and prevalence of eight known cardiac comorbidities and risk factors (hypertension, diabetes, coronary heart disease, peripheral artery occlusive disease, cerebrovascular disease, renal dysfunction, body mass index >= 30 Kg/m(2), and history of smoking) were analyzed. Patients were divided into slow (P-mean < 5 mmHg/year) or fast (P-mean >= 5 mmHg/year) progression groups. Results. A total of 402 patients (mean age 78 +/- 9.4 years, 58% males) were included in the study. Mean follow-up duration was 3.4 +/- 1.9 years. The average number of cardiac comorbidities and risk factors was 3.1 +/- 1.6. Average number of cardiac comorbidities and risk factors was higher in patients in slow progression group than in fast progression group (3.3 +/- 1.5 vs 2.9 +/- 1.7; P = 0.036). Patients in slow progression group had more often coronary heart disease (49.2% vs 33.6%; P = 0.003) compared to patients in fast progression group. LDL-cholesterol values were lower in the slow progression group (100 +/- 32.6 mg/dl vs 110.8 +/- 36.6 mg/dl; P = 0.005). Conclusion. These findings suggest that disease progression of aortic valve stenosis is faster in patients with fewer cardiac comorbidities and risk factors, especially if they do not have coronary heart disease. Further prospective studies are warranted to investigate the outcome of patients with slow versus fast progression of transvalvular gradient with regards to comorbidities and risk factors. KW - Valvular heart-desease KW - Prognostic impact KW - Risk-factors KW - Chronic heart-failure KW - Prevalence KW - mild KW - statins KW - therapy KW - mortality Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227291 ER - TY - JOUR A1 - Scherpf, Thorsten A1 - Schwarz, Christopher A1 - Scharf, Lennart T. A1 - Zur, Jana-Alina A1 - Helbig, Andeas A1 - Gessner, Viktoria H. T1 - Ylide-Functionalized Phosphines: Strong Donor Ligands for Homogeneous Catalysis JF - Angewandte Chemie - International Edition N2 - Phosphines are important ligands in homogenous catalysis and have been crucial for many advances, such as in cross-coupling, hydrofunctionalization, or hydrogenation reactions. Herein we report the synthesis and application of a novel class of phosphines bearing ylide substituents. These phosphines are easily accessible via different synthetic routes from commercially available starting materials. Owing to the extra donation from the ylide group to the phosphorus center the ligands are unusually electron-rich and can thus function as strong electron donors. The donor capacity surpasses that of commonly used phosphines and carbenes and can easily be tuned by changing the substitution pattern at the ylidic carbon atom. The huge potential of ylide-functionalized phosphines in catalysis is demonstrated by their use in gold catalysis. Excellent performance at low catalyst loadings under mild reaction conditions is thus seen in different types of transformations. KW - carbanion KW - homogeneous catalysis KW - phosphine ligands KW - structure elucidation KW - ylides Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-228551 VL - 57 IS - 39 ER - TY - JOUR A1 - Weber-Lassalle, Nana A1 - Hauke, Jan A1 - Ramser, Juliane A1 - Richters, Lisa A1 - Groß, Eva A1 - Blümcke, Britta A1 - Gehrig, Andrea A1 - Kahlert, Anne-Karin A1 - Müller, Clemens R. A1 - Hackmann, Karl A1 - Honisch, Ellen A1 - Weber-Lassalle, Konstantin A1 - Niederacher, Dieter A1 - Borde, Julika A1 - Thiele, Holger A1 - Ernst, Corinna A1 - Altmüller, Janine A1 - Neidhardt, Guido A1 - Nürnberg, Peter A1 - Klaschik, Kristina A1 - Schroeder, Christopher A1 - Platzer, Konrad A1 - Volk, Alexander E. A1 - Wang-Gohrke, Shan A1 - Just, Walter A1 - Auber, Bernd A1 - Kubisch, Christian A1 - Schmidt, Gunnar A1 - Horvath, Judit A1 - Wappenschmidt, Barbara A1 - Engel, Christoph A1 - Arnold, Norbert A1 - Dworniczak, Bernd A1 - Rhiem, Kerstin A1 - Meindl, Alfons A1 - Schmutzler, Rita K. A1 - Hahnen, Eric T1 - BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer JF - Breast Cancer Research N2 - Background Germline mutations in the BRIP1 gene have been described as conferring a moderate risk for ovarian cancer (OC), while the role of BRIP1 in breast cancer (BC) pathogenesis remains controversial. Methods To assess the role of deleterious BRIP1 germline mutations in BC/OC predisposition, 6341 well-characterized index patients with BC, 706 index patients with OC, and 2189 geographically matched female controls were screened for loss-of-function (LoF) mutations and potentially damaging missense variants. All index patients met the inclusion criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for germline testing and tested negative for pathogenic BRCA1/2 variants. Results BRIP1 LoF mutations confer a high OC risk in familial index patients (odds ratio (OR) = 20.97, 95% confidence interval (CI) = 12.02–36.57, P < 0.0001) and in the subgroup of index patients with late-onset OC (OR = 29.91, 95% CI = 14.99–59.66, P < 0.0001). No significant association of BRIP1 LoF mutations with familial BC was observed (OR = 1.81 95% CI = 1.00–3.30, P = 0.0623). In the subgroup of familial BC index patients without a family history of OC there was also no apparent association (OR = 1.42, 95% CI = 0.70–2.90, P = 0.3030). In 1027 familial BC index patients with a family history of OC, the BRIP1 mutation prevalence was significantly higher than that observed in controls (OR = 3.59, 95% CI = 1.43–9.01; P = 0.0168). Based on the negative association between BRIP1 LoF mutations and familial BC in the absence of an OC family history, we conclude that the elevated mutation prevalence in the latter cohort was driven by the occurrence of OC in these families. Compared with controls, predicted damaging rare missense variants were significantly more prevalent in OC (P = 0.0014) but not in BC (P = 0.0693) patients. Conclusions To avoid ambiguous results, studies aimed at assessing the impact of candidate predisposition gene mutations on BC risk might differentiate between BC index patients with an OC family history and those without. In familial cases, we suggest that BRIP1 is a high-risk gene for late-onset OC but not a BC predisposition gene, though minor effects cannot be excluded. KW - breast cancer KW - ovarian cancer KW - BRIP1 gene KW - germline mutations Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-233433 VL - 20 ER - TY - JOUR A1 - Köping, Maria A1 - Shehata-Dieler, Wafaa A1 - Schneider, Dieter A1 - Cebulla, Mario A1 - Oder, Daniel A1 - Müntze, Jonas A1 - Nordbeck, Peter A1 - Wanner, Christoph A1 - Hagen, Rudolf A1 - Schraven, Sebastian P. T1 - Characterization of vertigo and hearing loss in patients with Fabry disease JF - Orphanet Journal of Rare Diseases N2 - Background Fabry Disease (FD) is an X-linked hereditary lysosomal storage disorder which leads to a multisystemic intralysosomal accumulation of globotriaosylceramid (Gb3). Besides prominent renal and cardiac organ involvement, patients commonly complain about vestibulocochlear symptoms like high-frequency hearing loss, tinnitus and vertigo. However, comprehensive data especially on vertigo remain scarce. The aim of this study was to examine the prevalence and characteristics of vertigo and hearing loss in patients with FD, depending on renal and cardiac parameters and get hints about the site and the pattern of the lesions. Methods Single-center study with 57 FD patients. Every patient underwent an oto-rhino-laryngological examination as well as videonystagmography and vestibular evoked myogenic potentials (VEMPs) and audiological measurements using pure tone audiometry and auditory brainstem response audiometry (ABR). Renal function was measured by eGFR, cardiac impairment was graduated by NYHA class. Results More than one out of three patients (35.1%) complained about hearing loss, 54.4% about vertigo and 28.1% about both symptom. In 74% a sensorineural hearing loss of at least 25 dB was found, ABR could exclude any retrocochlear lesion. Caloric testing showed abnormal values in 71.9%, VEMPs were pathological in 68%. A correlation between the side or the shape of hearing loss and pathological vestibular testing could not be revealed. Conclusions Hearing loss and vertigo show a high prevalence in FD. While hearing loss seems due to a cochlear lesion, peripheral vestibular as well as central nervous pathologies cause vertigo. Thus, both the site of lesion and the pathophysiological patterns seem to differ. KW - Fabry disease KW - vertigo KW - VEMP KW - cardiomyopathy KW - chronic kidney disease KW - lysosomal storage disorder Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-222818 VL - 13 ER - TY - JOUR A1 - Qamar, Muhammad Uzair A1 - Azmat, Muhammad A1 - Abbas, Azhar A1 - Usman, Muhammad A1 - Shahid, Muhammad Adnan A1 - Khan, Zahid Mahmood T1 - Water Pricing and Implementation Strategies for the Sustainability of an Irrigation System: A Case Study within the Command Area of the Rakh Branch Canal JF - Water N2 - The command area of the Rakh branch canal grows wheat, sugarcane, and rice crops in abundance. The canal water, which is trivial for irrigating these crops, is conveyed to the farms through the network of canals and distributaries. For the maintenance of this vast infrastructure; the end users are charged on a seasonal basis. The present water charges are severely criticized for not being adequate to properly manage the entire infrastructure. We use the residual value to determine the value of the irrigation water and then based on the quantity of irrigation water supplied to farm land coupled with the infrastructure maintenance cost, full cost recovery figures are executed for the study area, and policy recommendations are made for the implementation of the full cost recovery system. The approach is unique in the sense that the pricings are based on the actual quantity of water conveyed to the field for irrigating crops. The results of our analysis showed that the canal water is severely under charged in the culturable command area of selected distributaries, thus negating the plan of having a self-sustainable irrigation system. KW - irrigation pricing KW - value of water KW - distributary KW - culturable command area KW - sustainable irrigation system Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-224711 VL - 10 IS - 4, 509 ER - TY - JOUR A1 - Santoro, Nicole A1 - Labopin, Myriam A1 - Giannotti, Federica A1 - Ehninger, Gerard A1 - Niederwieser, Dietger A1 - Brecht, Arne A1 - Stelljes, Matthias A1 - Kröger, Nicolaus A1 - Einsele, Herman A1 - Eder, Matthias A1 - Hallek, Michael A1 - Glass, Bertram A1 - Finke, Jürgen A1 - Ciceri, Fabio A1 - Mohty, Mohamad A1 - Ruggeri, Annalisa A1 - Nagler, Arnon T1 - Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT JF - Journal of Hematology & Oncology N2 - Background: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. Methods: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients >= 60 years. Results: Median follow-up was 23 months. Disease status at transplant differs significantly between the two groups (p < 10(-4)). Reduced intensity conditioning (RIC) was administrated to 73 and 77% of Haplo and MUD, respectively (p = 0.23). Stem cell source was the bone marrow (BM) in 52% of the Haplo and 6% of MUD (p < 10(-4)). Anti-thymocyte globulin (ATG) was most frequently used in MUD (p < 10(-4)) while post-Tx cyclophosphamide (PT-Cy) was given in 62% of Haplo. Engraftment was achieved in 90% of the Haplo vs 97% of MUD (p < 10(-4)). In multivariate analysis, no significant difference was found between Haplo and MUD for acute (a) graft versus host disease (GVHD) grade II-IV, relapse incidence (RI), non-relapse mortality (NRM), leukemia free survival (LFS), graft-versus-host-free-relapse free survival (GRFS), and overall survival (OS). Extensive chronic (c) GVHD was significantly higher for MUD as compared to Haplo (HR 2, p = 0.01, 95% CI 1.17-3.47). A propensity score analysis confirmed the higher risk of extensive cGVHD for MUD without differences for other outcomes. Conclusions: Allo-SCT from both Haplo and MUD are valid option for AML patients >= 60 years of age with similar results. Transplantation from MUD was associated with higher extensive cGVHD. Our findings suggest that Haplo is a suitable and attractive graft source for patients >= 60 with AML in need of allo-SCT. KW - MUD KW - Haploidentical KW - Allogeneic stem cell transplantation KW - Acute myeloid leukemia KW - Elderly Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227315 VL - 11 ER -