TY - JOUR A1 - Wölk, Julian A1 - Sütterlin, Stefan A1 - Koch, Stefan A1 - Vögele, Claus A1 - Schulz, Stefan M. T1 - Enhanced cardiac perception predicts impaired performance in the Iowa Gambling Task in patients with panic disorder JF - Brain and Behavior N2 - OBJECTIVE: Somatic marker theory predicts that somatic cues serve intuitive decision making; however, cardiovascular symptoms are threat cues for patients with panic disorder (PD). Therefore, enhanced cardiac perception may aid intuitive decision making only in healthy individuals, but impair intuitive decision making in PD patients. METHODS: PD patients and age-and sex-matched volunteers without a psychiatric diagnosis (n=17, respectively) completed the Iowa Gambling Task (IGT) as a measure of intuitive decision making. Interindividual differences in cardiac perception were assessed with a common mental-tracking task. RESULTS: In line with our hypothesis, we found a pattern of opposing associations (Fisher's Z=1.78, P=0.04) of high cardiac perception with improved IGT-performance in matched control-participants (r=0.36, n=14) but impaired IGT-performance in PD patients (r=-0.38, n=13). CONCLUSION: Interoceptive skills, typically assumed to aid intuitive decision making, can have the opposite effect in PD patients who experience interoceptive cues as threatening, and tend to avoid them. This may explain why PD patients frequently have problems with decision making in everyday life. Screening of cardiac perception may help identifying patients who benefit from specifically tailored interventions. KW - panic disorder KW - somatic marker hypothesis KW - cardiac perception KW - Iowa Gambling Task KW - decision making KW - interoception Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-119865 SN - 2162-3279 VL - 4 IS - 2 ER - TY - THES A1 - Winkler, Markus Heinrich T1 - Motivational properties of reward associated stimuli - Conditioning studies with smoke and monetary reinforcement T1 - Motivationale Wirkung belohnungsassoziierter Reize – Konditionierungsstudien mit Rauchen und Geldgewinn als Verstärker N2 - Abstract Tobacco addiction is considered as a chronic relapsing disorder, characterized by compul-sive drug seeking and intake. Learning processes are stressed to account for the situational-specific expression of core features of the disorder, e.g., craving for drug, tolerance and ex-cessive consumption. According to incentive theories, smoke conditioned stimuli are hy-pothesized to be appetitive in nature, promoting craving, approach and consummatory be-havior. Commonly, smoking cues are treated as simple excitatory conditioned stimuli formed by a close and reliable overlap with the drug effect. However, the smoking ritual comprises a multitude of stimuli which may give rise to different forms of learning and con-ditioned responses partially opposing each other. Previous research suggests the predictive content and the temporal proximity of smoking stimuli to the drug effect as important de-terminants of cue reactivity. In contrast to stimuli related to the preparatory stage of smok-ing and the start of consumption (BEGIN stimuli), stimuli from the terminal stage of smok-ing (END stimuli) apparently lack high cue reactivity. Several lines of evidence suggest the poor cue properties of terminal stimuli to be related to their signaling of poor smoke availa-bility. Indeed, cue reactivity is commonly decreased when smoking appears to be unavaila-ble. Moreover, the learning literature suggests that stimuli predictive for the non-availability of reward may acquire the capacity to modulate or oppose the responses of ex-citatory conditioned stimuli. Therefore, the aim of the present thesis was to enhance our knowledge of stimulus control in human drug addiction and incentive motivation by running a series of conditioning studies with smoke intake and monetary reward as reinforcer. Sub-jective report and physiological measures of motivational valence and consummatory re-sponse tendencies were used as dependent variables. The first experiment of this thesis used a differential conditioning paradigm to reveal evi-dence for the conditioning of preparatory and consummatory responses to a CS+ for smok-ing. Neutral pictograms served as CSs and single puffs on a cigarette as US. In line with the predictions of incentive theories, the excitatory CS+ for smoking acquired the ability to evoke an appetitive conditioned response, as indicated by enhanced activity of the M. zy-gomaticus major. Moreover, anticipation of puffing on the cigarette increased the activity of the M. orbicularis oris (lip muscle), indicating the activation of consummatory response tendencies. Finally, the CS+ evoked stronger skin conductance responses, indicative of in-creased autonomic arousal and orienting in preparation for action. In contrast, the rating data were apparently unaffected by the experimental contingency. In sum, the physiological data provide support for the notion that excitatory smoke conditioning gives rise to appeti-tive and consummatory conditioned responses, which may at least partially contribute to the maintenance of tobacco addiction. The second experiment of this thesis adapted the conditioning protocol of the first study to probe the functional significance of terminal stimuli in the control of addictive behavior. This study manipulated the predictive relationship of BEGIN and END stimuli to smoke rein-forcement to provide further support for the differential reactivity to both stimuli and the retarded (i.e., delayed) conditioning of END stimuli. Overall, the results of the first study of this thesis were conceptually replicated as the association of a BEGIN stimulus with smoke intake resulted in the acquisition of appetitive and consummatory physiological responses. Importantly, the results revealed evidence for a retarded excitatory conditioning of END stimuli. Thus, pairing of an END stimulus with smoke intake failed to produce a conditioned discrimination in terms of motivational valence and autonomic arousal, as indicated by the activity of the M. corrugator supercilii and the skin conductance data. These results provide further support for the notion that END stimuli may be weak cues for smoking. Moreover, in light of the results of the first study of this thesis, the retarded excitatory conditioning of terminal stimuli may be suggestive of an inhibitory response component, which may be re-lated to their signaling of poor smoke availability. In sum, these results add to a growing body of data, which suggest that the expression of cue reactivity may be modulated by the temporal proximity and the availability of the drug effect. The aim of the third study of this thesis was to provide “proof of concept” for an inhibi-tory conditioning notion of terminal stimuli. In this analog study BEGIN and END stimuli were emulated as discriminative SD and S for monetary reward. During an acquisition phase conditioned inhibition was established to the S predictive of the non-availability of re-ward. Subsequently a retardation test was used to substantiate conditioned inhibition. In this test, excitatory conditioning of the previous S was compared to the excitatory condi-tioning of a novel control stimulus. Importantly, the results revealed evidence for reward conditioned inhibition as indicated by the retarded acquisition of subjective (pleasure and reward expectancy) and physiological (skin conductance and activity of the M. orbicularis oculi) responses. In sum, these results provide support for the notion that stimuli predictive for the non-availability of reward may acquire the capacity to oppose the responses of ex-citatory conditioned stimuli. Thus, future research may benefit from the consideration of inhibitory conditioning processes in drug addiction, which may be of theoretical, methodo-logical and clinical importance. In sum, the present thesis revealed evidence for 1) an appetitive nature of excitatory condi-tioned smoking cues, 2) the dependency of this learning process on the temporal position of the conditioned stimuli in the intake ritual and 3) the acquisition of conditioned inhibition by a stimulus predictive for the non-availability of reward, as evident in retarded excitatory conditioning. Overall, these studies made a novel contribution to the field of human drug addiction and incentive motivation and provided valuable suggestions for further research. N2 - Zusammenfassung Tabakabhängigkeit wird als eine chronische Störung betrachtet, die durch exzessives dro-gensuchendes und -konsumierendes Verhalten gekennzeichnet ist. Lernprozesse werden zur Erklärung der Situationsspezifität zentraler Merkmale einer Abhängigkeit (z.B. Craving, Tole-ranz und übermäßiger Konsum) herangezogen. Anreiztheorien postulieren, dass konditio-nierte Rauchreize appetitiv sind, ein Verlangen zu konsumieren hervorrufen sowie Annähe-rungs- und konsummatorische Reaktionen induzieren. Gewöhnlich werden Rauch-Cues als einfache, exzitatorisch konditionierte Reize aufgefasst, die durch eine enge und reliable Überlappung mit der Drogenwirkung entstehen. Das Rauchritual beinhaltet allerdings eine Vielzahl von Reizen, die vermutlich unterschiedliche Lernformen begünstigen und dadurch teils einander entgegengesetzte konditionierte Reaktionen hervorrufen können. Die bisheri-ge Forschung legt nahe, dass die zeitliche Nähe und der prädiktive Wert von Reizen hinsicht-lich der Drogenwirkung die Cue-Reaktivität entscheidend beeinflussen. Im Gegensatz zu Reizen aus der präparatorischen Phase des Rauchrituals und solchen vom Konsumbeginn (Anfangsreize) lösen Reize aus der Endphase des Konsums (Endreize) nur geringe Cue-Reaktivität aus. Verschiedene Befunde legen nahe, dass die schwache Cue-Wirkung von End-reizen mit der wahrgenommenen Verfügbarkeit der Droge(nwirkung) zusammenhängt. So ist die Cue-Reaktivität gewöhnlich reduziert, wenn keine Möglichkeit zum Konsum besteht. Zudem legt die Lernliteratur nahe, dass Reize, die die Nicht-Verfügbarkeit einer Belohnung vorhersagen die Fähigkeit erwerben, exzitatorisch konditionierten Reaktionen entgegenzu-wirken. Das Ziel der vorliegenden Arbeit war es somit, unser Verständnis der Reizabhängig-keit süchtigen Verhaltens und der zugrundeliegenden motivationalen Prozesse zu erweitern. Dazu wurde eine Reihe von Konditionierungsstudien mit Rauchaufnahme und Geldgewinn als Verstärker durchgeführt. Als abhängige Variablen wurde der Selbstbericht der Proban-den sowie physiologische Maße motivationaler Valenz und konsummatorischer Reaktions-tendenzen erfasst. Im ersten Experiment dieser Arbeit wurde ein differentielles Konditionierungsparadigma ver-wendet, um den Nachweis zu erbringen, dass ein CS+ für Rauchen präparatorische und kon-summatorische Reaktionen hervorruft. Dabei wurden neutrale Symbole als konditionierte Reize verwendet und einzelne Züge an einer Zigarette als US. In Übereinstimmung mit den Vorhersagen von Anreiztheorien löste der exzitatorische CS+ eine appetitive konditionierte Reaktion aus, die sich in einer erhöhten Aktivität des M. zygomaticus major zeigte. Zudem war die Aktivität des M. orbicularis oris (Lippenmuskel) erhöht, was für die Aktivierung kon-summatorischer Reaktionstendenzen spricht. Schließlich rief der CS+ eine erhöhte Haut-leitfähigkeitsreaktion hervor, die eine Orientierungsreaktion und erhöhte autonome Reak-tivität im Rahmen der Handlungsvorbereitung anzeigt. Die experimentelle Kontingenz spie-gelte sich jedoch nicht in den Reizbewertungen wieder. Insgesamt stützen die physiologi-schen Befunde die Auffassung, dass exzitatorisch konditionierte Rauchreize appetitive und konsummatorische Reaktionen auslösen, die zur Aufrechterhaltung einer Tabakabhängig-keit beitragen können. Im zweiten Experiment wurde das Konditionierungsparadigma der ersten Studie adaptiert. Ziel des Experiments war es, die funktionellen Auswirkungen von Endreizen auf verschiedene Parameter abhängigen Verhaltens zu untersuchen. In der Studie wurde der prädiktive Gehalt von Anfangs- und Endreizen experimentell manipuliert, indem die Reize entweder als CS+ oder als CS- (und umgekehrt) mit Rauchen gepaart wurden. Zum einen sollten dadurch bis-herige Befunde erweitert werden, die zeigen, dass beide Reize unterschiedliche Reaktionen auslösen. Zum anderen sollte der Nachweis einer verlangsamten exzitatorischen Konditio-nierung von Endreizen erbracht werden. Insgesamt konnten die Ergebnisse der ersten Studie der vorliegenden Arbeit konzeptuell repliziert werden. So lösten Anfangsreize appetitive und konsummatorische physiologische Reaktionen aus, wenn sie mit Rauchen gepaart wurden. Wichtiger jedoch war der Befund einer verlangsamten exzitatorischen Konditionierung von Endreizen, wie er sich in Maßen motivationaler Valenz (M. corrugator supercilii) und auto-nomer Erregung (Hautleitfähigkeitsreaktionen) zeigte. Diese Befunde stützen die Auffas-sung, dass Endreize nur eine schwache Cue-Wirkung besitzen. In der Zusammenschau mit den Befunden der ersten Studie sprechen die Ergebnisse andeutungsweise dafür, dass End-reize eine inhibitorische Reaktionskomponente besitzen. Diese könnte damit in Zusam-menhang stehen, dass die wahrgenommene Verfügbarkeit der Droge(nwirkung) im Falle von Endreizen reduziert ist. Insgesamt gliedern sich die Befunde gut in eine Reihe von Studien ein, die nahelegen, dass Cue-Reaktivität durch die zeitliche Nähe und die Verfügbarkeit der Drogenwirkung moduliert wird. Das Ziel der dritten Studie war es einen inhibitorischen Konditionierungsansatz zur Entste-hung von Endreizen konzeptuell zu überprüfen. In einer Analogstudie wurden Anfangs- und Endreize als diskriminative Hinweisreize SD bzw. S für einen Geldgewinn modelliert. In einer Akquisitionsphase wurde der S, der die Nicht-Verfügbarkeit eines Gewinns signalisierte, als konditionierter Hemmreiz etabliert. Anschließend wurde ein Retardationstest zum Nach-weis konditionierter Hemmung durchgeführt. In diesem Test wurde die exzitatorische Kon-ditionierung des ehemaligen S mit der exzitatorischen Konditionierung eines neuen Kon-trollreizes verglichen. Dabei konnte konditionierte Hemmung in Form einer verlangsamten exzitatorischen Konditionierung subjektiver (positiver Affekt und Belohnungserwartung) und physiologischer (Hautleitfähigkeitsreaktionen und Aktivität des M. orbicularis oculi) Reaktionen nachgewiesen werden. Insgesamt stützen diese Befunde die Auffassung, dass Reize, die die Nicht-Verfügbarkeit einer Belohnung vorhersagen die Fähigkeit erwerben, exzitatorisch konditionierten Reaktionen entgegenzuwirken. Die weitere Suchtforschung könnte somit von einer stärkeren Berücksichtigung konditionierte Hemmprozesse sowohl hinsichtlich der Theorienbildung als auch in methodischer und klinischer Hinsicht profitie-ren. Insgesamt hat die vorliegende Arbeit gezeigt, dass 1) exzitatorisch konditionierte Rauchrei-ze eine appetitive Wirkung entfalten, 2) dieser Lernprozess von der zeitlichen Stellung der konditionierten Reize im Konsumritual abhängig ist und 3) Reize, die prädiktiv für die Nicht-Verfügbarkeit einer Belohnung sind als konditionierte Hemmreize fungieren können, was sich in einer verlangsamten exzitatorischen Konditionierung wiederspiegelt. Die vorliegende Arbeit erbrachte einen neuen Beitrag im Bereich der Sucht- und Motivationsforschung sowie mehrere Anknüpfungspunkte für zukünftige Forschungsvorhaben. KW - BEGIN stimuli KW - END stimuli KW - Incentive motivation KW - Conditioned inhibition KW - Facial EMG KW - Smoking KW - Addiction KW - Conditioning KW - Nicotine KW - Reward KW - Cue KW - Rauchen KW - Konditionierung Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121794 ER - TY - JOUR A1 - Wieser, Matthias J. A1 - Gerdes, Antje B. M. A1 - Reicherts, Philipp A1 - Pauli, Paul T1 - Mutual influences of pain and emotional face processing JF - Frontiers in Psychology N2 - The perception of unpleasant stimuli enhances whereas the perception of pleasant stimuli decreases pain perception. In contrast, the effects of pain on the processing of emotional stimuli are much less known. Especially given the recent interest in facial expressions of pain as a special category of emotional stimuli, a main topic in this research line is the mutual influence of pain and facial expression processing. Therefore, in this mini-review we selectively summarize research on the effects of emotional stimuli on pain, but more extensively turn to the opposite direction namely how pain influences concurrent processing of affective stimuli such as facial expressions. Based on the motivational priming theory one may hypothesize that the perception of pain enhances the processing of unpleasant stimuli and decreases the processing of pleasant stimuli. This review reveals that the literature is only partly consistent with this assumption: pain reduces the processing of pleasant pictures and happy facial expressions, but does not – or only partly – affect processing of unpleasant pictures. However, it was demonstrated that pain selectively enhances the processing of facial expressions if these are pain-related (i.e., facial expressions of pain). Extending a mere affective modulation theory, the latter results suggest pain-specific effects which may be explained by the perception-action model of empathy. Together, these results underscore the important mutual influence of pain and emotional face processing. KW - emotion KW - facial expression KW - ERPs KW - perception-action KW - pain Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-118446 SN - 1664-1078 VL - 5 ER - TY - JOUR A1 - Wieser, Matthias J. A1 - Flaisch, Tobias A1 - Pauli, Paul T1 - Raised Middle-Finger: Electrocortical Correlates of Social Conditioning with Nonverbal Affective Gestures N2 - Humans form impressions of others by associating persons (faces) with negative or positive social outcomes. This learning process has been referred to as social conditioning. In everyday life, affective nonverbal gestures may constitute important social signals cueing threat or safety, which therefore may support aforementioned learning processes. In conventional aversive conditioning, studies using electroencephalography to investigate visuocortical processing of visual stimuli paired with danger cues such as aversive noise have demonstrated facilitated processing and enhanced sensory gain in visual cortex. The present study aimed at extending this line of research to the field of social conditioning by pairing neutral face stimuli with affective nonverbal gestures. To this end, electro-cortical processing of faces serving as different conditioned stimuli was investigated in a differential social conditioning paradigm. Behavioral ratings and visually evoked steady-state potentials (ssVEP) were recorded in twenty healthy human participants, who underwent a differential conditioning procedure in which three neutral faces were paired with pictures of negative (raised middle finger), neutral (pointing), or positive (thumbs-up) gestures. As expected, faces associated with the aversive hand gesture (raised middle finger) elicited larger ssVEP amplitudes during conditioning. Moreover, theses faces were rated as to be more arousing and unpleasant. These results suggest that cortical engagement in response to faces aversively conditioned with nonverbal gestures is facilitated in order to establish persistent vigilance for social threat-related cues. This form of social conditioning allows to establish a predictive relationship between social stimuli and motivationally relevant outcomes. KW - analysis of variance KW - face KW - behavioral conditioning KW - conditioned response KW - semiotics KW - non-verbal communication KW - amygdala KW - human learning Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-113061 ER - TY - THES A1 - Schmidt, Barbara T1 - Taking your chances: risk behavior and its relation to arousal, framing and motivation T1 - Die eigenen Chancen ergreifen: Risikoverhalten und dessen Beziehung zu Arousal, Framing und Motivation N2 - Human risk behavior is the subject of growing research in the field of psychology as well as economics. One central topic is the influence of psychological variables on risk behavior. Studies contained in this work investigated the impact of arousal, framing and motivation on risk behavior. Arousal can on the one hand be a temporarily stable trait and on the other hand a situation-dependent variable. We showed that low trait arousal, measured via resting heart rate, predicted risky behavior. After physical exercise, state arousal was heightened in the experiment. Participants tended to act less risky after physical exercise. Taken together, the results suggest an inverse relation of arousal and risk behavior. Most studies investigating risk behavior employ a payment method that we call pay-one method: although the gambles that are used consist of many trials, only one trial is paid out. We investigated the effect of the payment method on risk behavior by employing both the pay-one and a pay-all method, which pays out all trials, in a within-subjects design. We found that participants acted about 10% less risky in the pay-one condition compared to the pay-all condition. This result suggests that risk-aversion is over-estimated in common risk paradigms that use the pay-one method. When we worked on a hard task before, we like to engage in a more likable task afterwards. That observation led to the general classification of tasks in want-to and have-to tasks. Our body system strives towards a balance between those two task types in the sense of a homeostasis. We assessed event-related potentials (ERPs) in a risk game that we treated as a want-to task. When participants worked on a difficult have-to task before, amplitudes of the ERP-components in the risk game were raised compared to a condition where participants worked on an easy task before. We conclude that the motivation shift towards a want-to task after a have-to task can be assessed via ERP amplitudes. In conclusion, it was shown that arousal, framing and motivation are important psychological variables that influence risk behavior. The specific mechanisms of these influences have been investigated and discussed. N2 - Menschliches Risikoverhalten ist zunehmend Gegenstand psychologischer und ökonomischer Forschung. Eine zentrale Rolle spielt dabei der Einfluss psychologischer Variablen auf Risikoverhalten. Die in dieser Arbeit vorgestellten Studien untersuchen den Einfluss von physiologischer Erregung, Framing und Motivation auf Risikoverhalten. Physiologische Erregung kann einerseits als zeitlich stabile Eigenschaft, andererseits als situationsabhängige Variable gesehen werden. Wir konnten zeigen, dass niedrige zeitlich stabile physiologische Erregung, die über die Ruhe-Herzrate gemessen wurde, riskantes Verhalten vorhersagte. Nach körperlichem Training war die physiologische Erregung der Versuchspersonen im Experiment kurzzeitig erhöht. Die Versuchspersonen tendierten dazu, nach diesem Training weniger riskant zu handeln. Zusammengenommen legen die Ergebnisse nahe, dass eine inverse Relation zwischen physiologischer Erregung und Risikoverhalten vorliegt. Die meisten Studien, die sich mit Risikoverhalten befassen, verwenden die sogenannte pay-one Auszahlungsmethode: In Risikospielen, die aus vielen Durchgängen bestehen, wird nur ein Durchgang des gesamten Risikospiels ausbezahlt. Wir untersuchten den Effekt der Auszahlungsmethode auf das Risikoverhalten, indem wir sowohl die pay-one Methode als auch die pay-all Methode, bei der die Gewinne aller Durchgänge ausbezahlt werden, in einem Zwischensubjekt-Design verwendeten. Wir fanden heraus, dass die Versuchspersonen in der pay-one Bedingung etwa 10% weniger riskant handelten, verglichen mit der pay-all Bedingung. Dieses Ergebnis legt nahe, dass die Risiko-Aversion in Paradigmen, die die pay-one Methode verwenden, überschätzt wird. Nachdem wir an einer schwierigen Aufgabe gearbeitet haben, sehnen wir uns nach einer angenehmeren Aufgabe. Diese Beobachtung führte zu einer generellen Unterscheidung von want-to und have-to Aufgaben. Unser Körper strebt nach einem Gleichgewicht zwischen diesen beiden Aufgabentypen im Sinne einer Homöostase. Wir erfassten ereigniskorrelierte Potentiale (ERPs) durch das Elektroencephalogramm in einem Risikospiel, das wir als want-to Aufgabe verwendeten. Wenn Versuchspersonen vorher eine schwere Aufgabe bearbeitet hatten, waren die Amplituden der ERP- Komponenten im Risikospiel erhöht im Vergleich zu einer Bedingung, in der die Versuchspersonen vorher eine einfache Aufgabe bearbeitet hatten. Wir schlussfolgern, dass die Motivationsänderung nach einer have-to Aufgabe in Richtung einer want-to Aufgabe mit Hilfe von ERP Amplituden erfasst werden kann. Zusammenfassend wurde gezeigt, dass physiologische Erregung, Framing und Motivation wichtige psychologische Variablen sind, die Risikoverhalten beeinflussen. Die spezifischen Wirkungsweisen dieser Einflüsse wurden untersucht und diskutiert. KW - Risikoverhalten KW - Motivation KW - arousal KW - framing KW - risk behavior Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-107149 ER - TY - THES A1 - Reichert, Andreas T1 - Eltern stark machen! Eine randomisiert-kontrollierte Studie zur Evaluation des modularen Elterntrainings „Plan E“ im kinder- und jugendpsychiatrischen Setting T1 - Strengthening parents! A randomized-controlled trial to evaluate the modular parental training “Plan E” in the setting of child and adolescent psychiatric treatment. N2 - Die Arbeit legt bei den Ausführungen zum theoretischen Hintergrund dar, dass sich hinsichtlich der Rahmenbedingungen für erzieherisches Handeln in den letzten Jahrzehnten viele gesellschaftliche und familiäre Veränderungen ergaben. Befragungen von Eltern zeigten teilweise eine Verunsicherung in Bezug auf die Erziehung ihrer Kinder. Gleichzeitig stellen psychische Störungen und Verhaltensauffälligkeiten im Kindes- und Jugendalter ein gesellschaftlich relevantes Problem dar. Nahezu jedes fünfte Kind weist nach epidemiologischen Studien psychische Probleme auf. Aus Studien zu Risiko- und Schutzfaktoren hinsichtlich der Entstehung solcher Störungen lassen sich verschiedene präventive oder therapeutische Interventionen ableiten. Häufig werden dabei biologische, psychosoziale und familiäre Risikofaktoren unterschieden. Aspekte der Erziehung oder des familiären Umfelds können sowohl förderlich als auch dysfunktional bezüglich der Entwicklung eines Kindes sein. Familiäre Risikofaktoren sind im Vergleich zu vielen biologischen oder psychosozialen Einflüssen potentiell veränderbare Faktoren und sollten unbedingt bei der Behandlung von psychisch kranken Kindern und Jugendlichen mit berücksichtigt werden. Generell erweist sich die Psychotherapie im Kindes- und Jugendalter als ähnlich effektiv wie bei Erwachsenen. Verschiedene Original-, Übersichtsarbeiten und Metaanalysen belegen die Wirksamkeit von Elterntrainings hinsichtlich der Verbesserung von Erziehungsverhalten und Verhaltensauffälligkeiten der Kinder. Wirksamkeitsnachweise finden sich mehrheitlich zu kognitiv-behavioralen Elterntrainings. Sie legen meistens den Schwerpunkt auf konkretes Erziehungsverhalten und versuchen im Sinne des Selbstmanagementansatzes eine Hilfe zu Selbsthilfe bzw. eine Stärkung der elterlichen Ressourcen zu erreichen. Während vor allem randomisiert-kontrollierte Studien aus dem angloamerikanischen und australischen Raum vorliegen, bestanden in Deutschland - im Vergleich zu der Vielzahl der Elterntrainings und der Häufigkeit der Angebote - bis vor einigen Jahren nur relativ wenige Evaluationsstudien. Mit „Plan E“ stellte sich ein neues Elterntraining in der vorliegenden Studie der Frage nach seinem Wirksamkeitsnachweis. Nach Kenntnis des Autors handelt es sich dabei um das bisher einzige Elterntraining, welches störungsunspezifisch, altersunabhängig, als offene Gruppe und für den Einsatz sowohl im ambulanten als auch im (teil-)stationären Bereich konzipiert wurde. Nachdem in dieser Studie zunächst das Ausmaß der psychischen Belastung der teilnehmenden Kinder, Jugendlichen und deren Eltern ausführlich dargestellt und entsprechende Zusammenhangsmaße berechnet und präsentiert werden, besteht der Hauptfokus der Arbeit auf der Evaluation des Trainings „Plan E“. Die Untersuchung erfolgte anhand einer klinischen Inanspruchnahmepopulation in einem randomisiert-kontrollierten Design. Diesbezüglich kamen verschiedene Fragebogen- sowie ein standardisiertes Beobachtungsverfahren zum Einsatz. Durch „Plan E“ ließ sich eine Reduktion dysfunktionaler Erziehungspraktiken sowie eine Verbesserung der emotionalen Befindlichkeit der Eltern erreichen. Auf das elterliche Kompetenzerleben zeigte das Programm keinen Einfluss. Hinsichtlich der Verhaltensauffälligkeiten der Kinder fanden sich bei varianzanalytischen Auswertungen keine Hinweise für einen zusätzlichen Effekt durch die Teilnahme an „Plan E“; dagegen wurde bei Analysen durch non-parametrische Verfahren deutliche Hinweise dafür gefunden, dass durch die Teilnahme am Elterntraining der Anteil von auffällig klassifizierten Kindern deutlicher abnahm. Überprüfungen der Wirksamkeit des Elterntrainings auf die Eltern-Kind-Interaktion anhand einer Beobachtungsskala lieferten keine eindeutigen Befunde. Die Ergebnisse sowie die Untersuchungsmethodik werden abschließend kritisch diskutiert. Schlussfolgerungen für mögliche weitere Forschungsvorhaben werden dargestellt. N2 - First, the theoretical background of the dissertation is presented. Facts of societal changes and parental uncertainties concerning education are shown. Studies indicate that psychological disorders and behavior problems among children and adolescents are socially relevant. In the context of the development of mental disorders, studies about risk and protective factors allow us to suggest different preventative or therapeutic interventions. Family environment and education can have supportive effects on childhood development; but in some cases they may have also detrimental effects. Familial risk factors are often more malleable than biological or social risk factors and must be considered in the context of psychiatric or psychotherapeutic treatment. Therefore, parental training programs are appropriate and effective interventions. Second, the new parental training “Plan E” is introduced. It is a program for parents of mentally ill children. It is appropriate for different disorders and ages of the children and may be offered as an “open group”. Third, methodological issues are presented. The evaluation of “Plan E” was conducted as a randomized-controlled trial in a naturalistic clinical setting. Outcome variables are the child behavioral problems, the stress level of the parents, and parenting style, for example. Fourth, the results of the dissertation are presented. The main results can be summarized as follows: the participation in “Plan E” leads to a reduction of parental stress level and a decline of dysfunctional parental education strategies. Therefore, “Plan E” seems to be an effective parental training. Fifth, the research strategies, methodological issues, and results are critically discussed and analyzed against the theoretical background. KW - Elternbildung KW - Elternarbeit KW - Kinder- und Jugendpsychiatrie KW - Psychische Störung KW - Deutschland KW - Kind KW - Erziehung KW - Erziehungsstil KW - Elterntraining Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-98337 ER - TY - JOUR A1 - Real, Ruben G. L. A1 - Kotchoubey, Boris A1 - Kübler, Andrea T1 - Studentized continuous wavelet transform (t-CWT) in the analysis of individual ERPs: real and simulated EEG data N2 - This study aimed at evaluating the performance of the Studentized Continuous Wavelet Transform (t-CWT) as a method for the extraction and assessment of event-related brain potentials (ERP) in data from a single subject. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of the t-CWT were assessed and compared to a variety of competing procedures using simulated EEG data at six low signal-to-noise ratios. Results show that the t-CWT combines high sensitivity and specificity with favorable PPV and NPV. Applying the t-CWT to authentic EEG data obtained from 14 healthy participants confirmed its high sensitivity. The t-CWT may thus be well suited for the assessment of weak ERPs in single-subject settings. KW - electroencephalogram KW - wavelet KW - EEG KW - t-CWT KW - significance KW - detection KW - ERP Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-113581 ER - TY - JOUR A1 - Pohl, Carsten A1 - Kunde, Wilfried A1 - Ganz, Thomas A1 - Conzelmann, Annette A1 - Pauli, Paul A1 - Kiesel, Andrea T1 - Gaming to see: action video gaming is associated with enhanced processing of masked stimuli N2 - Recent research revealed that action video game players outperform non-players in a wide range of attentional, perceptual and cognitive tasks. Here we tested if expertise in action video games is related to differences regarding the potential of shortly presented stimuli to bias behavior. In a response priming paradigm, participants classified four animal pictures functioning as targets as being smaller or larger than a reference frame. Before each target, one of the same four animal pictures was presented as a masked prime to influence participants' responses in a congruent or incongruent way. Masked primes induced congruence effects, that is, faster responses for congruent compared to incongruent conditions, indicating processing of hardly visible primes. Results also suggested that action video game players showed a larger congruence effect than non-players for 20 ms primes, whereas there was no group difference for 60 ms primes. In addition, there was a tendency for action video game players to detect masked primes for some prime durations better than non-players. Thus, action video game expertise may be accompanied by faster and more efficient processing of shortly presented visual stimuli. KW - video gaming masked stimuli KW - masked priming KW - action videogaming KW - unconscious processing KW - prime visibility KW - expertise Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-112681 ER - TY - JOUR A1 - Pieczykolan, Aleksandra A1 - Huestegge, Lynn T1 - Oculomotor dominance in multitasking: Mechanisms of conflict resolution in cross-modal action N2 - In daily life, eye movement control usually occurs in the context of concurrent action demands in other effector domains. However, little research has focused on understanding how such cross-modal action demands are coordinated, especially when conflicting information needs to be processed conjunctly in different action modalities. In two experiments, we address this issue by studying vocal responses in the context of spatially conflicting eye movements (Experiment 1) and in the context of spatially conflicting manual actions (Experiment 2, under controlled eye fixation conditions). Crucially, a comparison across experiments allows us to assess resource scheduling priorities among the three effector systems by comparing the same (vocal) response demands in the context of eye movements in contrast to manual responses. The results indicate that in situations involving response conflict, eye movements are prioritized over concurrent action demands in another effector system. This oculomotor dominance effect corroborates previous observations in the context of multiple action demands without spatial response conflict. Furthermore, and in line with recent theoretical accounts of parallel multiple action control, resource scheduling patterns appear to be flexibly adjustable based on the temporal proximity of the two actions that need to be performed. KW - saccades KW - oculomotor dominance KW - dual-task control KW - divided attention KW - resource scheduling KW - crosstalk Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-111024 ER - TY - JOUR A1 - Pfister, Roland A1 - Obhi, Sukhvinder S. A1 - Rieger, Martina A1 - Wenke, Dorit T1 - Action and perception in social contexts: intentional binding for social action effects N2 - The subjective experience of controlling events in the environment alters the perception of these events. For instance, the interval between one's own actions and their consequences is subjectively compressed—a phenomenon known as intentional binding. In two experiments, we studied intentional binding in a social setting in which actions of one agent prompted a second agent to perform another action. Participants worked in pairs and were assigned to a “leader” and a “follower” role, respectively. The leader's key presses triggered (after a variable interval) a tone and this tone served as go signal for the follower to perform a keypress as well. Leaders and followers estimated the interval between the leader's keypress and the following tone, or the interval between the tone and the follower's keypress. The leader showed reliable intentional binding for both intervals relative to the follower's estimates. These results indicate that human agents experience a pre-reflective sense of agency for genuinely social consequences of their actions. KW - intentional binding KW - action effects KW - social actions KW - action and perception KW - sense of agency Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-112828 ER - TY - JOUR A1 - Petrasek, Tomas A1 - Prokopova, Iva A1 - Sladek, Martin A1 - Weissova, Kamila A1 - Vojtechova, Iveta A1 - Bahnik, Stepan A1 - Zemanova, Anna A1 - Schönig, Kai A1 - Berger, Stefan A1 - Tews, Bjoern A1 - Bartsch, Dusan A1 - Schwab, Martin E. A1 - Sumova, Alena A1 - Stuchlik, Ales T1 - Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns JF - Frontiers in Behavioral Neuroscience N2 - Decreased levels of Nogo-A-dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity, and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A-deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality, and activity patterns. KW - AAPA KW - circadian rhythmicity KW - passive avoidance KW - Nogo-A KW - anhedonia KW - neophobia KW - morris water maze KW - place avoidance task KW - neurite outgrowth inhibitor KW - axon regeneration KW - synaptic plasticity KW - down regulation KW - traumatic brain injury KW - carousel maze KW - messenger RNA KW - genetic deletion Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117073 VL - 8 IS - 90 ER - TY - JOUR A1 - Meule, Adrian A1 - Lutz, Annika P. C. A1 - Krawietz, Vera A1 - Stützer, Judith A1 - Vögele, Claus A1 - Kübler, Andrea T1 - Food-cue affected motor response inhibition and self-reported dieting success: a pictorial affective shifting task JF - Frontiers in Psychology N2 - Behavioral inhibition is one of the basic facets of executive functioning and is closely related to self-regulation. Impulsive reactions, that is, low inhibitory control, have been associated with higher body mass index (BMI), binge eating, and other problem behaviors (e.g., substance abuse, pathological gambling, etc.). Nevertheless, studies which investigated the direct influence of food-cues on behavioral inhibition have been fairly inconsistent. In the current studies, we investigated food-cue affected behavioral inhibition in young women. For this purpose, we used a go/no-go task with pictorial food and neutral stimuli in which stimulus-response mapping is reversed after every other block (affective shifting task). In study 1, hungry participants showed faster reaction times to and omitted fewer food than neutral targets. Low dieting success and higher BMI were associated with behavioral disinhibition in food relative to neutral blocks. In study 2, both hungry and satiated individuals were investigated. Satiation did not influence overall task performance, but modulated associations of task performance with dieting success and self-reported impulsivity. When satiated, increased food craving during the task was associated with low dieting success, possibly indicating a preload-disinhibition effect following food intake. Food-cues elicited automatic action and approach tendencies regardless of dieting success, self-reported impulsivity, or current hunger levels. Yet, associations between dieting success, impulsivity, and behavioral food-cue responses were modulated by hunger and satiation. Future research investigating clinical samples and including other salient non-food stimuli as control category is warranted. KW - impulsivity KW - inhibitory control KW - response inhibition KW - go/no-go task KW - food-cues KW - dieting success KW - body mass index Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-119840 SN - 1664-1078 VL - 5 ER - TY - JOUR A1 - Meule, Adrian A1 - Hermann, Tina A1 - Kübler, Andrea T1 - A short version of the Food Cravings Questionnaire—Trait: the FCQ-T-reduced N2 - One of the most often used instruments for the assessment of food cravings is the Food Cravings Questionnaire (FCQ), which consists of a trait (FCQ-T; 39 items) and state (FCQ-S; 15 items) version. Scores on the FCQ-T have been found to be positively associated with eating pathology, body mass index (BMI), low dieting success and increases in state food craving during cognitive tasks involving appealing food stimuli. The current studies evaluated reliability and validity of a reduced version of the FCQ-T consisting of 15 items only (FCQ-T-r). Study 1 was a questionnaire study conducted online among students (N = 323). In study 2, female students (N = 70) performed a working memory task involving food and neutral pictures. Study 1 indicated a one-factorial structure and high internal consistency (α = 0.94) of the FCQ-T-r. Scores of the FCQ-T-r were positively correlated with BMI and negatively correlated with dieting success. In study 2, participants reported higher state food craving after the task compared to before. This increase was positively correlated with the FCQ-T-r. Hours since the last meal positively predicted food craving before the task when controlling for FCQ-T-r scores and the interaction of both variables. Contrarily, FCQ-T-r scores positively predicted food craving after the task when controlling for food deprivation and the interaction term. Thus, trait food craving was specifically associated with state food craving triggered by palatable food-cues, but not with state food craving related to plain hunger. Results indicate high reliability of the FCQ-T-r. Replicating studies that used the long version, small-to-medium correlations with BMI and dieting success could be found. Finally, scores on the FCQ-T-r predicted cue-elicited food craving, providing further support of its validity. The FCQ-T-r constitutes a succinct, valid and reliable self-report measure to efficiently assess experiences of food craving as a trait. KW - food carving KW - Food Carvings Questionnaire KW - psychometric properties KW - validity KW - reliability KW - body mass index KW - dieting success KW - food-cues Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-112748 ER - TY - JOUR A1 - Meule, Adrian A1 - Gearhard, Ashley N. T1 - Food Addiction in the Light of DSM-5 JF - Nutrients N2 - The idea that specific kind of foods may have an addiction potential and that some forms of overeating may represent an addicted behavior has been discussed for decades. In recent years, the interest in food addiction is growing and research on this topic lead to more precise definitions and assessment methods. For example, the Yale Food Addiction Scale has been developed for the measurement of addiction-like eating behavior based on the diagnostic criteria for substance dependence of the fourth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). In 2013, diagnostic criteria for substance abuse and-dependence were merged, thereby increasing the number of symptoms for substance use disorders (SUDs) in the DSM-5. Moreover, gambling disorder is now included along SUDs as a behavioral addiction. Although a plethora of review articles exist that discuss the applicability of the DSM-IV substance dependence criteria to eating behavior, the transferability of the newly added criteria to eating is unknown. Thus, the current article discusses if and how these new criteria may be translated to overeating. Furthermore, it is examined if the new SUD criteria will impact future research on food addiction, for example, if "diagnosing" food addiction should also be adapted by considering all of the new symptoms. Given the critical response to the revisions in DSM-5, we also discuss if the recent approach of Research Domain Criteria can be helpful in evaluating the concept of food addiction. KW - food addiction KW - obesity KW - binge eating KW - RDoC KW - DSM-IV KW - DSM-5 KW - substance dependence KW - substance use disorder KW - gambling KW - craving Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-119279 SN - 2072-6643 VL - 6 IS - 9 ER - TY - JOUR A1 - Meule, Adrian A1 - Beck Teran, Carina A1 - Berker, Jasmin A1 - Gründel, Tilman A1 - Mayerhofer, Martina A1 - Platte, Petra T1 - "On the differentiation between trait and state food craving: Half-year retest-reliability of the Food Cravings Questionnaire-Trait-reduced (FCQ-T-r) and the Food Cravings Questionnaire-State (FCQ-S)" N2 - Background: Food craving refers to an intense desire to consume a specific food. The Food Cravings Questionnaires (FCQs) assess food cravings on a trait and a state level. Method: The current study examined half-year retest-reliability of the Food Cravings Questionnaire-Trait-reduced (FCQ-T-r) and the Food Cravings Questionnaire-State (FCQ-S) and reports associations with current food deprivation in female students. Results: The FCQ-T-r had higher retest-reliability (rtt = .74) than the FCQ-S (rtt = .39). Although trait food craving was correlated with state food craving, it was unaffected by current food deprivation. Conclusions: Although state and trait food craving are interdependent, the FCQs are able to differentiate between the two. As scores of the FCQ-T-r represent a stable trait, but are also sensitive to changes in eating behavior, they may be useful for the investigation of the course of eating disorders and obesity. KW - Food craving KW - Food Cravings Questionnaires KW - Retest-reliability KW - University students Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-110585 ER - TY - JOUR A1 - Meule, Adrian T1 - Are certain foods addictive? JF - Frontiers in Psychiatry N2 - A commentary on Lifestyle medicine: the importance of firmgrounding on evidence by Rippe JM. Am J Lifestyle Med (2014) doi:10.1177/ 1559827613520527 Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-120257 SN - 1664-0640 VL - 5 IS - 38 ER - TY - THES A1 - Meule, Adrian T1 - Food craving as a central construct in the self-regulation of eating behavior T1 - Craving nach Nahrungsmitteln als zentrales Konstrukt bei der Selbst-Regulation des Essverhaltens N2 - Background: Food craving refers to an intense desire to consume a specific kind of food of which chocolate is the most often craved one. It is this intensity and specificity that differentiates food craving from feelings of hunger. Although food craving and hunger often co-occur, an energy deficit is not a prerequisite for experiencing food craving, that is, it can also occur without being hungry. Food craving often precedes and predicts over- or binge eating which makes it a reasonable target in the treatment of eating disorders or obesity. One of the arguably most extensively validated measures for the assessment of food craving are the Food Cravings Questionnaires (FCQs), which measure food craving on a state (FCQ-S) and trait (FCQ-T) level. Specifically, the FCQ-S measures the intensity of current food craving whereas the FCQ-T measures the frequency of food craving experiences in general. The aims of the present thesis were to provide a German measure for the assessment of food craving and to investigate cognitive, behavioral, and physiological correlates of food craving. For this purpose, a German version of the FCQs was presented and its reliability and validity was evaluated. Using self-reports, relationships between trait food craving and dieting were examined. Cognitive-behavioral correlates of food craving were investigated using food-related tasks assessing executive functions. Psychophysiological correlates of food craving were investigated using event-related potentials (ERPs) in the electroencephalogram and heart rate variability (HRV). Possible intervention approaches to reduce food craving were derived from results of those studies. Methods: The FCQs were translated into German and their psychometric properties and correlates were investigated in a questionnaire-based study (articles #1 & #2). The relationship between state and trait food craving with executive functioning was examined with behavioral tasks measuring working memory performance and behavioral inhibition which involved highly palatable food-cues (articles #3 & #4). Electrophysiological correlates of food craving were tested with ERPs during a craving regulation task (article #5). Finally, a pilot study on the effects of HRV-biofeedback for reducing food craving was conducted (article #6). Results: The FCQs demonstrated high internal consistency while their factorial structure could only partially be replicated. The FCQ-T also had high retest-reliability which, expectedly, was lower for the FCQ-S. Validity of the FCQ-S was shown by positive relationships with current food deprivation and negative affect. Validity of the FCQ-T was shown by positive correlations with related constructs. Importantly, scores on the subscales of the FCQ-T were able to discriminate between non-dieters and successful and unsuccessful dieters (article #1). Furthermore, scores on the FCQ-T mediated the relationship between rigid dietary control strategies and low dieting success (article #2). With regard to executive functioning, high-calorie food-cues impaired working memory performance, yet this was independent of trait food craving and rarely related to state food craving (article #3). Behavioral disinhibition in response to high-calorie food-cues was predicted by trait food craving, particularly when participants were also impulsive (article #4). Downregulation of food craving by cognitive strategies in response to high-calorie food-cues increased early, but not later, segments of the Late Positive Potential (LPP) (article #5). Few sessions of HRV-biofeedback reduced self-reported food cravings and eating and weight concerns in high trait food cravers (article #6). Conclusions: The German FCQs represent sound measures with good psychometric properties for the assessment of state and trait food craving. Although state food craving increases during cognitive tasks involving highly palatable food-cues, impairment of task performance does not appear to be mediated by current food craving experiences. Instead, trait food craving is associated with low behavioral inhibition in response to high-calorie food-cues, but not with impaired working memory performance. Future studies need to examine if trait food craving and, subsequently, food-cue affected behavioral inhibition can be reduced by using food-related inhibition tasks as a training. Current food craving and ERPs in response to food-cues can easily be modulated by cognitive strategies, yet the LPP probably does not represent a direct index of food craving. Finally, HRV-biofeedback may be a useful add-on element in the treatment of disorders in which food cravings are elevated. To conclude, the current thesis provided measures for the assessment of food craving in German and showed differential relationships between state and trait food craving with self-reported dieting behavior, food-cue affected executive functioning, ERPs and HRV-biofeedback. These results provide promising starting points for interventions to reduce food craving based on (1) food-cue-related behavioral trainings of executive functions, (2) cognitive craving regulation strategies, and (3) physiological parameters such as HRV-biofeedback. N2 - Hintergrund: Craving nach Essen bezeichnet ein starkes Verlangen ein bestimmtes Nahrungsmittel zu konsumieren, welches sich meist auf Schokolade bezieht. Diese Intensität und Spezifität unterscheidet Craving nach Nahrungsmitteln von generellen Hungergefühlen. Obwohl Craving und Hunger häufig Hand in Hand gehen, ist ein Energiedefizit keine Voraussetzung dafür, Craving zu erleben; das bedeutet, es kann ebenfalls auftreten, obwohl man nicht hungrig ist. Craving geht häufig Überessen oder Essanfällen voraus, was es zu einem plausiblen Ansatzpunkt in der Therapie von Essstörungen und Adipositas macht. Eines der wohl am umfangreichsten validierten Maße zur Erfassung von Craving nach Nahrungsmitteln sind die Food Cravings Questionnaires (FCQs), die Craving als momentanen Zustand (engl. state, FCQ-S) und überdauerndes Merkmal (engl. trait, FCQ-T) erfassen. Genauer gesagt misst der FCQ-S die Intensität von aktuellem Craving nach Nahrungsmitteln, während der FCQ-T die Häufigkeit des Erlebens von Craving im Allgemeinen erfasst. Die Ziele der vorliegenden Arbeit waren die Bereitstellung eines deutschen Fragebogens zur Erfassung von Craving nach Nahrungsmitteln und die Untersuchung von kognitiven, behavioralen, und physiologischen Korrelaten von Craving. Hierfür wurde eine deutsche Version der FCQs präsentiert und deren Reliabilität und Validität überprüft. Zusammenhänge zwischen der Häufigkeit des Erlebens von Craving und Diätverhalten wurden mit Selbstberichtsfragebögen getestet. Kognitiv-behaviorale Korrelate von Craving wurden anhand von essensbezogenen Aufgaben zur Erfassung von exekutiven Funktionen untersucht. Psychophysiologische Korrelate von Craving wurden anhand von ereigniskorrelierten Potentialen (EKPs) im Elektroenzephalogramm und der Herzratenvariabilität (HRV) erforscht. Mögliche Interventionsansätze zur Reduktion von Craving wurden aus den Ergebnissen dieser Studien abgeleitet. Methoden: Die FCQs wurden auf Deutsch übersetzt und deren psychometrische Eigenschaften und Korrelate wurden in einer Fragebogenstudie untersucht (Artikel #1 & #2). Der Zusammenhang zwischen momentanem und habituellem Craving mit exekutiven Funktionen wurde anhand von behavioralen Aufgaben zur Erfassung der Arbeitsgedächtnisleistung und Verhaltenshemmung, die sehr schmackhafte Essensreize enthielten, überprüft (Artikel #3 & #4). Elektrophysiologische Korrelate von Craving wurden mit Hilfe von EKPs während einer Aufgabe zur Regulation von Craving getestet (Artikel #5). Schließlich wurde eine Pilotstudie zu den Effekten von HRV-Biofeedback zur Reduktion von Craving durchgeführt (Artikel #6). Ergebnisse: Die FCQs zeigten eine sehr hohe interne Konsistenz, wohingegen deren Faktorenstruktur nur teilweise repliziert werden konnte. Der FCQ-T hatte außerdem eine hohe Retest-Reliabilität, welche erwartungsgemäß geringer für den FCQ-S ausfiel. Validität des FCQ-S zeigte sich durch positive Zusammenhänge mit aktueller Essensdeprivation und momentaner negativer Stimmung. Validität des FCQ-T zeigte sich durch positive Korrelationen mit verwandten Konstrukten. Zudem konnte anhand der Subskalen des FCQ-T zwischen nicht-diäthaltenden und erfolgreichen und erfolglosen diäthaltenden Personen diskriminiert werden (Artikel #1). Weiterhin zeigte sich, dass der Zusammenhang zwischen rigiden Diätstrategien und geringem Diäterfolg durch Werte des FCQ-T vermittelt wurde (Artikel #2). Bezüglich der exekutiven Funktionen ergab sich, dass die Arbeitsgedächtnisleistung durch das darbieten von hochkalorischen Essensreizen vermindert wurde, allerdings war dies unabhängig von habituellem Craving und stand kaum mit momentanem Craving in Verbindung (Artikel #3). Häufiges Erleben von Craving konnte dahingegen eine behaviorale Enthemmung als Reaktion auf hochkalorische Essensreize vorhersagen, insbesondere wenn die Teilnehmer ebenfalls eine hohe Impulsivität berichteten (Artikel #4). Die Herunterregulierung von Craving während der Präsentation hochkalorischer Essensreize mit Hilfe kognitiver Strategien führte zu einer Erhöhung von früheren, nicht jedoch von späteren, Abschnitten des Late Positive Potential (LPP) (Artikel #5). Bereits wenige Übungssitzungen von HRV-Biofeedback resultierten in einer Reduktion selbstberichteter Cravings sowie essens- und gewichtsbezogener Sorgen bei Menschen mit häufigem Erleben von Cravings (Artikel #6). Schlussfolgerungen: Die deutschen FCQs stellen brauchbare Maße mit guten psychometrischen Eigenschaften zur Erfassung von Craving auf aktueller und habitueller Ebene dar. Obwohl momentanes Craving während kognitiven Aufgaben, die sehr schmackhafte Essensreize beinhalten, ansteigt, scheint eine Verminderung der Aufgabenleistung nicht durch das momentane Erleben solcher Cravings vermittelt zu sein. Habituelles Erleben von Craving ist dahingegen mit einer geringen Inhibitionsleistung auf hochkalorische Essensreize assoziiert, allerdings nicht mit einer eingeschränkten Arbeitsgedächtnisleistung. Zukünftige Studien sollten sich der Frage widmen, ob häufiges Erleben von Craving, und entsprechend auch der Einfluss von Essensreizen auf die Verhaltenshemmung, durch essensbezogene Inhibitionstrainings reduziert werden kann. Momentanes Craving und EKPs während der Präsentation von Essensreizen können leicht durch kognitive Strategien moduliert werden. Die LPP stellt hier wohl allerdings kein direktes Maß des Erlebens von Craving dar. Zu guter Letzt könnte HRV-Biofeedback ein nützliches, zusätzliches Therapieelement bei Störungen, die mit häufigem und intensivem Craving nach Nahrungsmitteln einhergehen, darstellen. Zusammenfassend lässt sich sagen, dass die vorliegende Arbeit Instrumente zur Erfassung von Craving nach Nahrungsmitteln im deutschen Sprachraum bereitgestellt hat und differenzielle Zusammenhänge zwischen momentanem und habituellem Craving mit selbstberichtetem Diätverhalten, durch Essensreize beeinträchtige exekutive Funktionen, EKPs und HRV-Biofeedback, aufgezeigt wurden. Diese Ergebnisse stellen vielversprechende Ansatzpunkte für Interventionen zur Reduktion von Craving nach Nahrungsmitteln dar, die auf (1) essensbezogenen Verhaltenstrainings der exekutiven Funktionen, (2) kognitiven Craving-Regulationsstrategien, und (3) physiologischen Parametern wie beispielsweise HRV-Biofeedback, basieren. KW - Craving KW - Essgewohnheit KW - Nahrung KW - food craving KW - Heißhunger KW - eating behavior KW - self-regulation KW - Essverhalten KW - Selbstregulation Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-104597 ER - TY - JOUR A1 - Martens, Suzanne A1 - Bensch, Michael A1 - Halder, Sebastian A1 - Hill, Jeremy A1 - Nijboer, Femke A1 - Ramos-Murguialday, Ander A1 - Schoelkopf, Bernhard A1 - Birbaumer, Niels A1 - Gharabaghi, Alireza T1 - Epidural electrocorticography for monitoring of arousal in locked-in state JF - Frontiers in Human Neuroscience N2 - Electroencephalography (EEG) often fails to assess both the level (i.e., arousal) and the content (i.e., awareness) of pathologically altered consciousness in patients without motor responsiveness. This might be related to a decline of awareness, to episodes of low arousal and disturbed sleep patterns, and/or to distorting and attenuating effects of the skull and intermediate tissue on the recorded brain signals. Novel approaches are required to overcome these limitations. We introduced epidural electrocorticography (ECoG) for monitoring of cortical physiology in a late-stage amytrophic lateral sclerosis patient in completely locked-in state (CLIS) Despite long-term application for a period of six months, no implant related complications occurred. Recordings from the left frontal cortex were sufficient to identify three arousal states. Spectral analysis of the intrinsic oscillatory activity enabled us to extract state-dependent dominant frequencies at <4, similar to 7 and similar to 20 Hz, representing sleep-like periods, and phases of low and elevated arousal, respectively. In the absence of other biomarkers, ECoG proved to be a reliable tool for monitoring circadian rhythmicity, i.e., avoiding interference with the patient when he was sleeping and exploiting time windows of responsiveness. Moreover, the effects of interventions addressing the patient's arousal, e.g., amantadine medication, could be evaluated objectively on the basis of physiological markers, even in the absence of behavioral parameters. Epidural ECoG constitutes a feasible trade-off between surgical risk and quality of recorded brain signals to gain information on the patient's present level of arousal. This approach enables us to optimize the timing of interactions and medical interventions, all of which should take place when the patient is in a phase of high arousal. Furthermore, avoiding low responsiveness periods will facilitate measures to implement alternative communication pathways involving brain-computer interfaces (BCI). KW - temporal-lobe epilepsy KW - neuroprosthetic devices KW - brain computer interface KW - event-related potentials KW - intraoperative electrocoicography KW - electrocorticography KW - epidural recording KW - locked-in state KW - coma KW - consciousness KW - paralyzed patients KW - EEG KW - sleep KW - communication KW - frequencies KW - amyotrophic-lateral-sclerosis Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-114863 VL - 8 ER - TY - JOUR A1 - Kübler, Andrea A1 - Holz, Elisa M. A1 - Riccio, Angela A1 - Zickler, Claudia A1 - Kaufmann, Tobias A1 - Kleih, Sonja C. A1 - Staiger-Sälzer, Pit A1 - Desideri, Lorenzo A1 - Hoogerwerf, Evert-Jan A1 - Mattia, Donatella T1 - The User-Centered Design as Novel Perspective for Evaluating the Usability of BCI-Controlled Applications N2 - Albeit research on brain-computer interfaces (BCI) for controlling applications has expanded tremendously, we still face a translational gap when bringing BCI to end-users. To bridge this gap, we adapted the user-centered design (UCD) to BCI research and development which implies a shift from focusing on single aspects, such as accuracy and information transfer rate (ITR), to a more holistic user experience. The UCD implements an iterative process between end-users and developers based on a valid evaluation procedure. Within the UCD framework usability of a device can be defined with regard to its effectiveness, efficiency, and satisfaction. We operationalized these aspects to evaluate BCI-controlled applications. Effectiveness was regarded equivalent to accuracy of selections and efficiency to the amount of information transferred per time unit and the effort invested (workload). Satisfaction was assessed with questionnaires and visual-analogue scales. These metrics have been successfully applied to several BCI-controlled applications for communication and entertainment, which were evaluated by end-users with severe motor impairment. Results of four studies, involving a total of N = 19 end-users revealed: effectiveness was moderate to high; efficiency in terms of ITR was low to high and workload low to medium; depending on the match between user and technology, and type of application satisfaction was moderate to high. The here suggested evaluation metrics within the framework of the UCD proved to be an applicable and informative approach to evaluate BCI controlled applications, and end-users with severe impairment and in the locked-in state were able to participate in this process. KW - computer software KW - event related potentials KW - games KW - head KW - head injury KW - man-computer interface KW - prototypes KW - speech Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-111051 ER - TY - JOUR A1 - Kübler, Andrea A1 - Hautzinger, Martin A1 - Ludolph, Albert A1 - Dickhaus, Thorsten A1 - Real, Ruben G. L. T1 - Well-being in amyotrophic lateral sclerosis: a pilot experience sampling study N2 - Objective: The aim of this longitudinal study was to identify predictors of instantaneous well-being in patients with amyotrophic lateral sclerosis (ALS). Based on flow theory well-being was expected to be highest when perceived demands and perceived control were in balance, and that thinking about the past would be a risk factor for rumination which would in turn reduce well-being. Methods: Using the experience sampling method, data on current activities, associated aspects of perceived demands, control, and well-being were collected from 10 patients with ALS three times a day for two weeks. Results: Results show that perceived control was uniformly and positively associated with well-being, but that demands were only positively associated with well-being when they were perceived as controllable. Mediation analysis confirmed thinking about the past, but not thinking about the future, to be a risk factor for rumination and reduced well-being. Discussion: Findings extend our knowledge of factors contributing to well-being in ALS as not only perceived control but also perceived demands can contribute to well-being. They further show that a focus on present experiences might contribute to increased well-being. KW - amyotrophic lateral sclerosis KW - ALS KW - coping KW - well-being KW - experience sampling KW - ESM KW - reminiscence KW - rumination Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-113057 ER -