TY - JOUR A1 - Halder, Sebastian A1 - Takano, Kouji A1 - Ora, Hiroki A1 - Onishi, Akinari A1 - Utsumi, Kota A1 - Kansaku, Kenji T1 - An Evaluation of Training with an Auditory P300 Brain-Computer Interface for the Japanese Hiragana Syllabary JF - Frontiers in Neuroscience N2 - Gaze-independent brain-computer interfaces (BCIs) are a possible communication channel for persons with paralysis. We investigated if it is possible to use auditory stimuli to create a BCI for the Japanese Hiragana syllabary, which has 46 Hiragana characters. Additionally, we investigated if training has an effect on accuracy despite the high amount of different stimuli involved. Able-bodied participants (N = 6) were asked to select 25 syllables (out of fifty possible choices) using a two step procedure: First the consonant (ten choices) and then the vowel (five choices). This was repeated on 3 separate days. Additionally, a person with spinal cord injury (SCI) participated in the experiment. Four out of six healthy participants reached Hiragana syllable accuracies above 70% and the information transfer rate increased from 1.7 bits/min in the first session to 3.2 bits/min in the third session. The accuracy of the participant with SCI increased from 12% (0.2 bits/min) to 56% (2 bits/min) in session three. Reliable selections from a 10 × 5 matrix using auditory stimuli were possible and performance is increased by training. We were able to show that auditory P300 BCIs can be used for communication with up to fifty symbols. This enables the use of the technology of auditory P300 BCIs with a variety of applications. KW - gaze independence KW - assistive technology KW - electroencephalography KW - event-related potentials KW - P300 KW - auditory stimulation KW - brain-computer interface Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165465 VL - 10 IS - 446 ER - TY - JOUR A1 - Issel-Dombert, Sandra A1 - Wieders-Lohéac, Aline T1 - «Nous multiplierons les chansons, les concerts, les spectacles». L’argumentation de François Hollande face aux attaques terroristes du 13 novembre JF - promptus - Würzburger Beiträge zur Romanistik N2 - After the terrorist attacks on November 13th, the French public, the whole of Europe and many parts of the world were waiting for president François Hollande to address his fellow “citoyens”. Being the most important political figure – both by constitution and by influence on public discourse – the president’s words bear great importance for the subsequent debate and interpretation of the events. Therefore, the question arises: How did the president shape the debate in the hours and days after the attacks? To answer this question, we have identified typical structures in Hollande’s rhetorical reaction to the attacks, performing a topos as well as a keyword analysis of the speeches the president held within two weeks after November 13th. In a contrastive analysis we have compared Hollande’s speeches to the Europarl Corpus. Using the software programme sketch engine, we have filtered out the 100 most frequent keywords and classified them into semantic fields (data-driven approach). All in all, terrorism, action and nation/identity are the three predominant semantic fields, whereas references to victimhood barely appear. These findings are congruent with the results of our topos analysis that reveals a predominance of argumentative structures that form a strong main topos of resilience, emphasising the greatness of France and its people and culture, calling to action and avoiding any tendencies of resignation. KW - debate KW - Hollande, François KW - influence KW - terrorist attack, Paris, 13th November 2015 KW - Hollande, François KW - Bataclan (Paris) KW - Attentat KW - Meinungsbildung Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161637 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Brunke, Dirk T1 - Der nationalepische Pionier Esteban Echeverría. Ein Beitrag zur Entstehungsgeschichte des romantischen epischen Gedichts in Hispanoamerika JF - promptus - Würzburger Beiträge zur Romanistik N2 - This article concentrates on the Argentine author Esteban Echeverría who is known as the founding father of Romanticism in the River Plate region. The author of this article intends to show that the importance of Echeverría for the development of Argentine national literature goes beyond the spreading of Romanticist aesthetics. Especially his poem La cautiva (1837) has been regarded as the national epic poem of Argentina because it represents national landscape and the early days of national history. However, as the classification of this narrative poem as the national epic poem already indicates, Echeverría also contributed to the presence of this prestigious genre at the River Plate region. By investigating Echeverría‘s less known verse texts – namely the texts which were read by all Romantics but which have been neglected by literary studies so far – this article illustrates that Echeverría gave decisive impulses for the presence of the epic poem at the River Plate. KW - episches Gedicht KW - romantisches Gedicht KW - Hispanoamerika KW - Entstehungsgeschichte KW - Echeverría, Esteban KW - Hispanoamerika KW - Literatur KW - Gedicht Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161592 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Buch, Marina-Rafaela T1 - Madame Chrysanthème (1887) et Japoneries d’automne (1889) de Pierre Loti entre japonisme et exotisme désenchanté JF - promptus - Würzburger Beiträge zur Romanistik N2 - The novel Madame Chrysanthème (1887) and the essays collected in Japoneries d’automne (1889) written by French travel author Pierre Loti offer a paradoxical view of Japan during the Meiji period. In both travel writings, the author is torn between aesthetic japonism – which spread all over Europe at the end of the 19th century – and exotic expectations, i.e. the picturesque fascination of the Other. The latter, however, remains unsatisfied throughout his stay. In both writings, Pierre Loti provides an insight into Japan that entirely reflects the spirit of his time. Thereby, he contributes to an image of Japan, which will long remain vivid in the Occident. Contemporaries perceive Loti’s representation of Japan as a realistic testimony, tinged with both sensory impressions and his highly ambiguous feelings towards the distant country, which in the end remained incomprehensible to him. KW - Madame Chrysanthème KW - Japoneries d’automne KW - Pierre Loti KW - Loti, Pierre KW - Japan KW - Meiji-Periode Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161603 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Fliege, Daniel T1 - Le dégoût du cadavre. Une comparaison entre la représentation du corps mort dans le De Miseria Condicionis Humane d’Innocent III et dans son adaptation française Double lay de fragilité humaine d’Eustache Deschamps JF - promptus - Würzburger Beiträge zur Romanistik N2 - The study uses the category of disgust in order to analyse the representation of the human body and the corpse in one of the most influential medieval treatises, the De Miseria Condicionis Humanae (1195) written by Pope Innocent III, and its little known old French adaptation Double lay de fragilité humaine (1383) by Eustache Deschamps. Analysing how both use disgust as an aesthetic means, which appeals to emotions and turns off reason, helps to point out the pedagogical and moral function of the texts. The comparison between them shows that Deschamps stays faithful to his Latin model, but that he nevertheless has to make certain modifications in order to adapt the prose text into a lyrical form. Furthermore, this approach clearly elucidates what differences there are between the conceptions of the human body and death in the two texts, revealing at the same time divergent theological points of view. KW - De Miseria Condicionis Humanae KW - Double lay de fragilité humaine KW - Deschamps, Eustache KW - Innocent III KW - Ekel KW - Leiche KW - Körper KW - Mittelalter KW - Literatur Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161616 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Kloster, Kerstin T1 - Der Körper als Einschreibungsfläche des weiblichen Gedächtnisses. Eine Analyse der mündlichen Überlieferung in Le livre d’Emma von Marie-Célie Agnant JF - promptus - Würzburger Beiträge zur Romanistik N2 - Women in Caribbean culture traditionally occupy the role of guardians of collective memory, as tellers of stories, legends and myths. Through oral tradition, they transfer the cultural and family knowledge from one generation of women to the next. We will offer an analysis of oral transmission as a way of preserving a memory of women in Le livre d’Emma (2001) by the Québec author of Haitian origin, Marie-Célie Agnant. We will primarily analyze the transformation of communicative memory into cultural memory, following the distinction by Jan Assmann. We will interpret the oral transfer as a possibility to stabilize, to legitimize female memory and to inscribe it into the female body. KW - Agnant, Marie-Célie : Le livre d'Emma KW - Agnant, Marie-Célie : Le livre d'Emma KW - Mündliche Überlieferung Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161645 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - White, P. Lewis A1 - Wiederhold, Nathan P. A1 - Loeffler, Juergen A1 - Najvar, Laura K. A1 - Melchers, Willem A1 - Herrera, Monica A1 - Bretagne, Stephane A1 - Wickes, Brian A1 - Kirkpatrick, William R. A1 - Barnes, Rosemary A. A1 - Donnelly, J. Peter A1 - Patterson, Thomas F. T1 - Comparison of nonculture blood-based tests for diagnosing invasive aspergillosis in an animal model JF - Journal of Clinical Microbiology N2 - The European Aspergillus PCR Initiative (EAPCRI) has provided recommendations for the PCR testing of whole blood (WB) and serum/plasma. It is important to test these recommended protocols on nonsimulated "in vivo" specimens before full clinical evaluation. The testing of an animal model of invasive aspergillosis (IA) overcomes the low incidence of disease and provides experimental design and control that is not possible in the clinical setting. Inadequate performance of the recommended protocols at this stage would require reassessment of methods before clinical trials are performed and utility assessed. The manuscript describes the performance of EAPCRI protocols in an animal model of invasive aspergillosis. Blood samples taken from a guinea pig model of IA were used for WB and serum PCR. Galactomannan and beta-D-glucan detection were evaluated, with particular focus on the timing of positivity and on the interpretation of combination testing. The overall sensitivities for WB PCR, serum PCR, galactomannan, and beta-D-glucan were 73%, 65%, 68%, and 46%, respectively. The corresponding specificities were 92%, 79%, 80%, and 100%, respectively. PCR provided the earliest indicator of IA, and increasing galactomannan and beta-D-glucan values were indicators of disease progression. The combination of WB PCR with galactomannan and beta-D-glucan proved optimal (area under the curve AUC], 0.95), and IA was confidently diagnosed or excluded. The EAPRCI-recommended PCR protocols provide performance comparable to commercial antigen tests, and clinical trials are warranted. By combining multiple tests, IA can be excluded or confirmed, highlighting the need for a combined diagnostic strategy. However, this approach must be balanced against the practicality and cost of using multiple tests. KW - high-risk hematology KW - Guinea pig model KW - real-time PCR KW - fungal disease KW - galactomannan KW - pulmonary aspergillosis KW - amphotericin B KW - Aspergillus fumigatus KW - beta-D-glucan Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189674 VL - 54 IS - 4 ER - TY - JOUR A1 - Barquist, Lars A1 - Mayho, Matthew A1 - Cummins, Carla A1 - Cain, Amy K. A1 - Boinett, Christine J. A1 - Page, Andrew J. A1 - Langridge, Gemma C. A1 - Quail, Michael A. A1 - Keane, Jacqueline A. A1 - Parkhill, Julian T1 - The TraDIS toolkit: sequencing and analysis for dense transposon mutant libraries JF - Bioinformatics N2 - Transposon insertion sequencing is a high-throughput technique for assaying large libraries of otherwise isogenic transposon mutants providing insight into gene essentiality, gene function and genetic interactions. We previously developed the Transposon Directed Insertion Sequencing (TraDIS) protocol for this purpose, which utilizes shearing of genomic DNA followed by specific PCR amplification of transposon-containing fragments and Illumina sequencing. Here we describe an optimized high-yield library preparation and sequencing protocol for TraDIS experiments and a novel software pipeline for analysis of the resulting data. The Bio-Tradis analysis pipeline is implemented as an extensible Perl library which can either be used as is, or as a basis for the development of more advanced analysis tools. This article can serve as a general reference for the application of the TraDIS methodology. KW - mechanisms KW - Transposon insertion sequencing KW - sequencing protocol KW - TraDIS Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189667 VL - 32 IS - 7 ER - TY - JOUR A1 - Schiele, Miriam A. A1 - Reinhard, Julia A1 - Reif, Andreas A1 - Domschke, Katharina A1 - Romanos, Marcel A1 - Deckert, Jürgen A1 - Pauli, Paul T1 - Developmental aspects of fear: Comparing the acquisition and generalization of conditioned fear in children and adults JF - Developmental Psychobiology N2 - Most research on human fear conditioning and its generalization has focused on adults whereas only little is known about these processes in children. Direct comparisons between child and adult populations are needed to determine developmental risk markers of fear and anxiety. We compared 267 children and 285 adults in a differential fear conditioning paradigm and generalization test. Skin conductance responses (SCR) and ratings of valence and arousal were obtained to indicate fear learning. Both groups displayed robust and similar differential conditioning on subjective and physiological levels. However, children showed heightened fear generalization compared to adults as indexed by higher arousal ratings and SCR to the generalization stimuli. Results indicate overgeneralization of conditioned fear as a developmental correlate of fear learning. The developmental change from a shallow to a steeper generalization gradient is likely related to the maturation of brain structures that modulate efficient discrimination between danger and (ambiguous) safety cues. KW - fear conditioning KW - fear generalization KW - development KW - skin conductance KW - maturation Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189488 VL - 58 IS - 4 ER - TY - JOUR A1 - Manukjan, Georgi A1 - Ripperger, Tim A1 - Venturini, Letizia A1 - Stadler, Michael A1 - Göhring, Gudrun A1 - Schambach, Axel A1 - Schlegelberger, Brigitte A1 - Steinemann, Doris T1 - GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia JF - Stem Cell Research N2 - Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-binding protein (GABP) plays a crucial role in self-renewal of murine hematopoietic and leukemic stem cells. Here, we report the consequences of functional impairment of GABP in human hematopoietic and in leukemic stem/progenitor cells. Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34\(^{+}\) hematopoietic stem/progenitor cells obtained from healthy donors. Moreover, drastically reduced clonogenic capacity of leukemic stem/progenitor cells isolated from bone marrow aspirates of chronic myeloid leukemia (CML) patients underlines the importance of GABP on stem/progenitor cell maintenance and confirms the relevance of GABP for human myelopoiesis in healthy and diseased states. KW - GABP KW - stem cells KW - human hematopoiesis KW - leukemia Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-168165 VL - 16 IS - 3 ER - TY - JOUR A1 - Gambaryan, Stepan A1 - Subramanian, Hariharan A1 - Kehrer, Linda A1 - Mindukshev, Igor A1 - Sudnitsyna, Julia A1 - Reiss, Cora A1 - Rukoyatkina, Natalia A1 - Friebe, Andreas A1 - Sharina, Iraida A1 - Martin, Emil A1 - Walter, Ulrich T1 - Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis JF - Cell Communication and Signaling N2 - Background Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfusion of RBCs, which indicates that RBCs play an important role in hemostasis and platelet activation. However, in the last few years, opposing mechanisms of platelet inhibition by RBCs derived nitric oxide (NO) were proposed. The aim of our study was to identify whether RBCs could produce NO and activate soluble guanylate cyclase (sGC) in platelets. Methods To test whether RBCs could activate sGC under different conditions (whole blood, under hypoxia, or even loaded with NO), we used our well-established and highly sensitive models of NO-dependent sGC activation in platelets and activation of purified sGC. The activation of sGC was monitored by detecting the phosphorylation of Vasodilator Stimulated Phosphoprotein (VASPS239) by flow cytometry and Western blot. ANOVA followed by Bonferroni’s test and Student’s t-test were used as appropriate. Results We show that in the whole blood, RBCs prevent NO-mediated inhibition of ADP and TRAP6-induced platelet activation. Likewise, coincubation of RBCs with platelets results in strong inhibition of NO-induced sGC activation. Under hypoxic conditions, incubation of RBCs with NO donor leads to Hb-NO formation which inhibits sGC activation in platelets. Similarly, RBCs inhibit activation of purified sGC, even under conditions optimal for RBC-mediated generation of NO from nitrite. Conclusions All our experiments demonstrate that RBCs act as strong NO scavengers and prevent NO-mediated inhibition of activated platelets. In all tested conditions, RBCs were not able to activate platelet or purified sGC. KW - hemoglobin KW - erythrocytes KW - nitric oxide KW - soluble guanylate cyclase KW - platelets Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161223 VL - 14 IS - 16 ER - TY - JOUR A1 - Schöpe, Kai T1 - Unaufhörliches Suchen – Gaddas Roman Quer pasticciaccio brutto de via Merulana als carmen perpetuum JF - promptus - Würzburger Beiträge zur Romanistik N2 - Gadda’s novel Quer Pasticciaccio brutto de Via Merulana tells the tale of two crimes committed in Rome in the 1920s. The search for the perpetrators turns into a pasticciaccio brutto (an awful mess), challenging the reader with its linguistic complexity and a myriad of references to history and culture; the large number of allusions to antiquity is particularly striking. References to Virgil’s Aeneid and to Rome’s mythical past do not constitute a mere transfer, but document a creative approach of transformational nature. Deformation and inversion are part of this process, changing the μορφή not only in formal terms, but also within the plot itself. These transformations of both form and content are read as Metamorphoses and analysed in comparison to Ovid’s homonymous work. The perpetual, never-ending quest for truth in Gadda’s novel necessitates a perpetual, never-ending narrative, which is conceptually related to Ovid’s carmen perpetuum. KW - Gadda, Carlo Emilio : Quer pasticciaccio brutto de Via Merulana KW - perpetual, never-ending narrative KW - Gadda, Carlo Emilio : Quer pasticciaccio brutto de Via Merulana Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161673 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Suslenkova, Anastasiya T1 - Diskursanalytische Untersuchungen der politischen Rede in Italien am Beispiel der ausgewählten Reden von Silvio Berlusconi und Matteo Renzi JF - promptus - Würzburger Beiträge zur Romanistik N2 - The present study is concerned with a critical discourse analysis of the speeches of the Italian politicians Silvio Berlusconi and Matteo Renzi in different situations. The aim of the study was to find out how historical and speech contexts influence discourse structures and argumentations, and if any similar speech patterns or speech strategies were used. The results show that both politicians in many cases tend to utilize similar speech patterns to achieve different aims; each of them shows a preference for particular words, structures and strategies. It is noteworthy that one of the important differences between speeches of Berlusconi and Renzi is the use of various speech strategies. While Renzi uses these strategies to create an image of himself as a young and honest politician, Berlusconi makes use of them to defend himself or attack his opponents. KW - Renzi, Matteo KW - Berlusconi, Silvio KW - critical discourse analysis KW - speeches KW - Diskursanalyse KW - Politische Rede KW - Berlusconi, Silvio KW - Renzi, Matteo Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161681 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Winter, Ursula T1 - Literarisierung von Musik als Intermedialitätsphänomen. Exemplarische Betrachtung der oratorischen Rezeption Dantes und Goethes bei Wolf-Ferrari und Berlioz JF - promptus - Würzburger Beiträge zur Romanistik N2 - This article deals with the reception of Dante and Goethe in Ermanno Wolf-Ferrari’s and Hector Berlioz’s compositions La Vita Nuova and La Damnation de Faust. Although Dante Alighieri’s Vita Nova and Johann Wolfgang von Goethe’s Faust belong to completely different genres and epochs, the texts provide the basis for the oratorio-style works from the Romantic era, which justifies a comparative analysis of the latter. The examined reductions, extensions, modifications and rearrangements of the texts in the libretti – which were compiled almost entirely by the composers themselves – as well as the instrumental parts and the use and functions of the orchestra, the choir and the soloists, portray the intermedia relations between literature and music in the selected compositions. The chosen examples will show that the common idea of setting literature to music and the translation studies concept of intersemiotic translation are not appropriate for all literature-based pieces of music, as the analysis of both works demonstrates that with regard to vocal music a distinction should be made between the musicalization of literature and the literarization of music. KW - Dante, Alighieri KW - Goethe, Johann Wolfgang von KW - Wolf-Ferrari, Ermanno KW - Berlioz, Hector KW - Musik KW - Literarisierung KW - Intermedialität Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161690 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Scholz, Janek T1 - Eine Künstlerkooperation ‘além das fronteiras’ – Banda desenhada de língua portuguesa JF - promptus - Würzburger Beiträge zur Romanistik N2 - Economic, academic or artistic cooperation among actors of different countries or disciplines offers numerous new perspectives, but it also confronts the ones profiting from it with several challenges. First, identity has to be firmly established, which requires intercultural skills, such as role-distance, empathy and tolerance for ambiguities. Secondly, a third space is required in which meaning can be newly negotiated to make the partnership succeed. This paper proposes that even within one and the same language-group, one can speak of intercultural communication. A particular collaboration between Portuguese-speaking comic artists will be introduced, raising questions of the conditions necessary to make such a cooperation work. Answers will be provided according to the decisions the artists made in their publications. KW - Banda desenhada de língua portuguesa KW - BDLP KW - Künstlerkooperation KW - Kooperation KW - Künstler Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161662 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Stolze, Ina A1 - Trautmann, Axel A1 - Goebeler, Matthias A1 - Stoevesandt, Johanna T1 - Dangerous Leg Cramps: Severe Pustular Exanthema Caused by an Over-the-Counter Drug JF - Acta Dermato-Venereologica N2 - Abstract is missing KW - leg cramps KW - over-the-counter drugs KW - pustular exanthema KW - quinine KW - allergy Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-171285 VL - 96 ER - TY - JOUR A1 - Sonnenberg, Christoph A1 - Bannert, Maria T1 - Evaluating the Impact of Instructional Support Using Data Mining and Process Mining: A Micro-Level Analysis of the Effectiveness of Metacognitive Prompts JF - Journal of Educational Data Mining N2 - In computer-supported learning environments, the deployment of self-regulatory skills represents an essential prerequisite for successful learning. Metacognitive prompts are a promising type of instructional support to activate students’ strategic learning activities. However, despite positive effects in previous studies, there are still a large number of students who do not benefit from provided support. Therefore, it may be necessary to consider explicitly the conditions under which a prompt is beneficial for a student, i.e., so-called adaptive scaffolding. The current study aims to (i) classify the effectiveness of prompts on regulatory behavior, (ii) investigate the correspondence of the classification with learning outcome, and (iii) discover the conditions under which prompts induce regulatory activities (i.e., the proper temporal positioning of prompts). The think-aloud data of an experiment in which metacognitive prompts supported the experimental group (n = 35) was used to distinguish between effective and non-effective prompts. Students’ activities preceding the prompt presentation were analyzed using data mining and process mining techniques. The results indicate that approximately half of the presented prompts induced metacognitive learning activities as expected. Moreover, the number of induced monitoring activities correlates positively with transfer performance. Finally, the occurrence of orientation and monitoring activities, which are not well-embedded in the course of learning, increases the effectiveness of a presented prompt. In general, our findings demonstrate the benefits of investigating metacognitive support using process data, which can provide implications for the design of effective instructional support. KW - process mining KW - think-aloud data KW - metacognitive prompting KW - micro-level analysis KW - instructional support KW - self-regulated learning Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-152375 UR - http://www.educationaldatamining.org/JEDM/index.php/JEDM/article/view/JEDM2016-8-2-3 N1 - Dieser Artikel ist auch Bestandteil der Dissertation: Sonnenberg, Christoph: Analyzing Technology-Enhanced Learning Processes: What Can Process Mining Techniques Contribute to the Evaluation of Instructional Support?. - Würzburg, Univ., Diss., 2017. - [online]. URN: urn:nbn:de:bvb:20-opus-152354 VL - 8 IS - 2 ER - TY - JOUR A1 - Goldmann, Julius A1 - Hornung, Christoph T1 - Interview mit Prof. (em.) Dr. Frank-Rutger Hausmann JF - promptus - Würzburger Beiträge zur Romanistik N2 - Frank-Rutger Hausmann war Professor für Romanische Philologie (Schwerpunkt französische und italienische Literatur) in Freiburg, Aachen und wiederum Freiburg. Hausmann hat sich zudem intensiv mit der Fachgeschichte der deutschen Romanistik und der Geisteswissenschaften allgemein beschäftigt. Für die zweite Ausgabe der promptus-Interviewreihe durften wir ihn nach seiner Perspektive auf die historische und aktuelle Situation der Romanistik befragen. Er arbeitet momentan u.a. an einem Romanistenlexikon, das online veröffentlicht wird, und hat das Romanistenarchiv in Augsburg gegründet. KW - Romanistik KW - Interview KW - aktuelle Situation KW - historische Situation KW - Romansitik KW - Biographisches Interview KW - Perspektive Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161586 SN - 2510-2613 VL - 2 ER - TY - JOUR A1 - Widmann, Annekathrin A1 - Artinger, Marc A1 - Biesinger, Lukas A1 - Boepple, Kathrin A1 - Peters, Christina A1 - Schlechter, Jana A1 - Selcho, Mareike A1 - Thum, Andreas S. T1 - Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae JF - PLoS Genetics N2 - Memory formation is a highly complex and dynamic process. It consists of different phases, which depend on various neuronal and molecular mechanisms. In adult Drosophila it was shown that memory formation after aversive Pavlovian conditioning includes—besides other forms—a labile short-term component that consolidates within hours to a longer-lasting memory. Accordingly, memory formation requires the timely controlled action of different neuronal circuits, neurotransmitters, neuromodulators and molecules that were initially identified by classical forward genetic approaches. Compared to adult Drosophila, memory formation was only sporadically analyzed at its larval stage. Here we deconstruct the larval mnemonic organization after aversive olfactory conditioning. We show that after odor-high salt conditioning larvae form two parallel memory phases; a short lasting component that depends on cyclic adenosine 3’5’-monophosphate (cAMP) signaling and synapsin gene function. In addition, we show for the first time for Drosophila larvae an anesthesia resistant component, which relies on radish and bruchpilot gene function, protein kinase C activity, requires presynaptic output of mushroom body Kenyon cells and dopamine function. Given the numerical simplicity of the larval nervous system this work offers a unique prospect for studying memory formation of defined specifications, at full-brain scope with single-cell, and single-synapse resolution. KW - genetic dissection KW - Drosophila KW - memory formation Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-166672 VL - 12 IS - 10 ER - TY - JOUR A1 - Stauss, Dennis A1 - Brunner, Cornelia A1 - Berberich-Siebelt, Friederike A1 - Höpken, Uta E. A1 - Lipp, Martin A1 - Müller, Gerd T1 - The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 JF - Embo Journal N2 - Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4\(^+\) T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by the Pou2af1 gene, promotes Bcl6 expression and Tfh cell development. We found that Bob1 together with the octamer transcription factors Oct1/Oct2 can directly bind to and transactivate the Bcl6 and Btla promoters. Mixed bone marrow chimeras revealed that Bob1 is required for the expression of normal levels of Bcl6 and BTLA, thereby controlling the pool size and composition of the Tfh compartment in a T cell-intrinsic manner. Our data indicate that T cell-expressed Bob1 is directly involved in Tfh cell differentiation and required for mounting normal T cell-dependent B-cell responses. KW - follicular T helper cells KW - germinal center KW - humoral immunity KW - Pou2af1 KW - T cell differentiation Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189506 VL - 35 IS - 8 ER -