TY  - JOUR
A1  - Isaias, Ioannis U.
A1  - Marzegan, Alberto
A1  - Pezzoli, Gianni
A1  - Marotta, Giorgio
A1  - Canesi, Margherita
A1  - Biella, Gabriele E. M.
A1  - Volkmann, Jens
A1  - Cavallari, Paolo
T1  - A role for locus coeruleus in Parkinson tremor
JF  - Frontiers in Human Neuroscience
N2  - We analyzed rest tremor, one of the etiologically most elusive hallmarks of Parkinson disease(PD), in 12 consecutive PD patients during a specific task activating the locus coeruleus (LC) to investigate a putative role of noradrenaline (NA) in tremor generation and suppression. Clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (DAT) binding values investigated by single photon computed tomography imaging (SPECT) with [\(^{123}\)I] N-\(\omega\)-fluoropropyl-2 \(\beta\)-carbomethoxy-3 \(\beta\)-(4-iodophenyl) tropane (FP-CIT). The intensity of tremor (i.e., the power of Electromyography [EMG] signals), but not its frequency, significantly increased during the task. In six subjects, tremor appeared selectively during the task. In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). This study suggests a role of the LC in Parkinson tremor.
KW  - locus coeruleus
KW  - disease
KW  - basal ganglia
KW  - resting tremor
KW  - functional neuroanatomy
KW  - dopamine
KW  - norepinephrine
KW  - progression
KW  - binding
KW  - rat
KW  - noradrenalin
KW  - parkinson disease
KW  - tremor
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133955
VL  - 5
IS  - 179
ER  -