TY  - JOUR
A1  - Bertram, Ralph
A1  - Bartsch, Vanessa
A1  - Sodmann, Johanna
A1  - Hennig, Luca
A1  - Müjde, Engin
A1  - Stock, Jonathan
A1  - Ruedig, Vivienne
A1  - Sodmann, Philipp
A1  - Todt, Daniel
A1  - Steinmann, Eike
A1  - Hitzl, Wolfgang
A1  - Steinmann, Joerg
T1  - Risk stratification of SARS-CoV-2 breakthrough infections based on an outbreak at a student festive event
JF  - Vaccines
N2  - In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants' vaccination status.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - outbreak
KW  - breakthrough infection
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267270
SN  - 2076-393X
VL  - 10
IS  - 3
ER  -