TY  - JOUR
A1  - Beyhoff, Niklas
A1  - Lohr, David
A1  - Thiele, Arne
A1  - Foryst-Ludwig, Anna
A1  - Klopfleisch, Robert
A1  - Schreiber, Laura M.
A1  - Kintscher, Ulrich
T1  - Myocardial Infarction After High-Dose Catecholamine Application—A Case Report From an Experimental Imaging Study
JF  - Frontiers in Cardiovascular Medicine
N2  - Although heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultrahigh-frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatial resolution of 100 × 100 × 100 μm\(^{3}\) using diffusion tensor magnetic resonance imaging (DT-MRI) and histopathologic analyses. Two weeks after ISO treatment, the animal showed an apical aneurysm accompanied by reduced radial strain in corresponding segments and impaired global systolic function. DT-MRI revealed a loss of contractile fiber tracts together with a disarray of remaining fibers as corresponding microstructural correlates. This preclinical case report provides valuable insights into pathophysiology and morphologic–functional relations of heart failure following MI using emerging imaging technologies.
KW  - myocardial infarction
KW  - catecholamines
KW  - speckle tracking
KW  - diffusion tensor imaging
KW  - magnetic resonance imaging
KW  - case report
KW  - heart failure
KW  - echocardiography
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-217959
VL  - 7
ER  -