TY  - JOUR
A1  - Patel, Suketu
A1  - Murphy, Derek
A1  - Haralmbieva, Eugenia
A1  - Abdulla, Zainalabideen A.
A1  - Wong, Kah Keng
A1  - Chen, Hong
A1  - Gould, Edith
A1  - Roncador, Giovanna
A1  - Hatton, Chris S. R.
A1  - Anderson, Amanda P.
A1  - Banham, Alison H.
A1  - Pulford, Karen
T1  - Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas
JF  - Biomarker Insights
N2  - FAS-associated protein with death domain (FADD) is a major adaptor protein involved in extrinsic apoptosis, embryogenesis, and lymphocyte homeostasis. Although abnormalities of the FADD/death receptor apoptotic pathways have been established in tumorigenesis, fewer studies have analyzed the expression and role of phosphorylated FADD (pFADD). Our identification of FADD as a lymphoma-associated autoantigen in T-cell lymphoma patients raises the possibility that pFADD, with its correlation with cell cycle, may possess role(s) in human T-cell lymphoma development. This immunohistochemical study investigated pFADD protein expression in a range of normal tissues and lymphomas, particularly T-cell lymphomas that require improved therapies. Whereas pFADD was expressed only in scattered normal T cells, it was detected at high levels in T-cell lymphomas (eg, 84% anaplastic large cell lymphoma and 65% peripheral T cell lymphomas, not otherwise specified). The increased expression of pFADD supports further study of its clinical relevance and role in lymphomagenesis, highlighting phosphorylation of FADD as a potential therapeutic target.
KW  - autoantigen
KW  - lymphoma
KW  - pFADD
KW  - PTCL
KW  - FADD
KW  - ALCL
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121403
SN  - 1177-2719
VL  - 9
ER  -