TY  - JOUR
A1  - Homann, Arne
A1  - Qamar, Riaz-ul
A1  - Serim, Sevnur
A1  - Dersch, Petra
A1  - Seibel, Juergen
T1  - Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid
N2  - Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
KW  - Organische Chemie
KW  - bioorthogonal metabolic glycoengineering; click chemistry; sialic acid
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67806
ER  -