TY  - JOUR
A1  - Altieri, Barbara
A1  - Di Dato, Carla
A1  - Modica, Roberta
A1  - Bottiglieri, Filomena
A1  - Di Sarno, Antonella
A1  - Pittaway, James F.H.
A1  - Martini, Chiara
A1  - Faggiano, Antongiulio
A1  - Colao, Annamaria
T1  - Bone metabolism and vitamin D implication in gastroenteropancreatic neuroendocrine tumors
JF  - Nutrients
N2  - Patients affected by gastroenteropancreatic–neuroendocrine tumors (GEP–NETs) have an increased risk of developing osteopenia and osteoporosis, as several factors impact on bone metabolism in these patients. In fact, besides the direct effect of bone metastasis, bone health can be affected by hormone hypersecretion (including serotonin, cortisol, and parathyroid hormone-related protein), specific microRNAs, nutritional status (which in turn could be affected by medical and surgical treatments), and vitamin D deficiency. In patients with multiple endocrine neoplasia type 1 (MEN1), a hereditary syndrome associated with NET occurrence, bone damage may carry other consequences. Osteoporosis may negatively impact on the quality of life of these patients and can increment the cost of medical care since these patients usually live with their disease for a long time. However, recommendations suggesting screening to assess bone health in GEP–NET patients are missing. The aim of this review is to critically analyze evidence on the mechanisms that could have a potential impact on bone health in patients affected by GEP–NET, focusing on vitamin D and its role in GEP–NET, as well as on factors associated with MEN1 that could have an impact on bone homeostasis.
KW  - bone
KW  - vitamin D
KW  - neuroendocrine tumor
KW  - osteoporosis
KW  - mineral bone density
KW  - cortisol
KW  - serotonin
KW  - miRNA
KW  - MEN1
KW  - therapy
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203823
SN  - 2072-6643
VL  - 12
IS  - 4
ER  - 
TY  - JOUR
A1  - Modica, Roberta
A1  - Altieri, Barbara
A1  - D’Aniello, Francesco
A1  - Benevento, Elio
A1  - Cannavale, Giuseppe
A1  - Minotta, Roberto
A1  - Liccardi, Alessia
A1  - Colao, Annamaria
A1  - Faggiano, Antongiulio
T1  - Vitamin D and bone metabolism in adult patients with neurofibromatosis type 1
JF  - Metabolites
N2  - Neurofibromatosis type 1 (NF1) is a genetic multisystemic autosomal dominant disorder determining reduced life expectancy due to higher risk of developing benign and malignant tumors. Low levels of vitamin D and reduced bone mineral density (BMD) have been reported in young patients with NF1. However, correlation between vitamin D and NF1 phenotype needs to be elucidated. Aim of this study was to assess vitamin D levels and bone metabolism in NF1 patients, analyzing potential correlations with clinical phenotype. A cross-sectional study was carried out in a monocentric series of NF1 patients, evaluating genotype, clinical phenotype, BMD, biochemical evaluation with focus on serum 25OH-vitamin D, parathyroid hormone (PTH), calcium and phosphate levels. Correlations between clinical manifestations, neurofibromas, and vitamin D status have been studied in comparison with healthy controls. 31 NF1 adult patients were matched for sex, age and body mass index with 31 healthy controls. A significantly difference in vitamin D level emerged in NF1 patients compared to controls. Interestingly low vitamin D levels correlated with a more aggressive phenotype and with a bigger size of neurofibromas. These data underline that vitamin D deficiency/insufficiency may play a role in clinical severity of neurofibromas in patients with NF1, suggesting the need to check bone status and replace vitamin D in these patients.
KW  - neurofibromatosis type 1
KW  - vitamin D
KW  - bone metabolism
KW  - osteoporosis
KW  - tumor
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-303957
SN  - 2218-1989
VL  - 13
IS  - 2
ER  -