TY  - JOUR
A1  - Luber, Verena
A1  - Lutz, Mathias
A1  - Abele-Horn, Marianne
A1  - Einsele, Hermann
A1  - Grigoleit, Götz Ulrich
A1  - Mielke, Stephan
T1  - Excretion of Ascaris lumbricoides following reduced‐intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole
JF  - Transplant Infectious Disease
N2  - Here, we present the unique case of a 51‐year‐old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after allogeneic hematopoietic stem cell transplantation. Stool analysis remained negative for the presence of eggs, and there was no eosinophilia in the peripheral blood at any time around stem cell transplantation. The patient was commenced on a three‐day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post‐transplant medication or negative effects on the hematopoiesis were observed, and the myeloma still is in complete remission. To our knowledge, this is the first report on excretion of A lumbricoides in the context of allogeneic stem cell transplantation. The case is remarkable with view to the fact that the parasite has supposedly survived all courses of myeloma treatment including autologous and allogeneic conditioning. Parasitosis with A lumbricoides has a worldwide prevalence of about a billion and is extremely rare in northern Europe. Possibly the patient got infected during a trip to Egypt years before multiple myeloma was diagnosed.
KW  - sirolimus
KW  - mycophenolic acid
KW  - multiple myeloma
KW  - mebendazole
KW  - hematopoietic stem cell transplantation
KW  - Ascaris lumbricoides
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-219608
SN  - 1399-3062
VL  - 22
IS  - 1
ER  - 
TY  - JOUR
A1  - Kapp, Markus
A1  - Kosmala, Aleksander
A1  - Kircher, Stefan
A1  - Luber, Verena
A1  - Kunzmann, Volker
T1  - Exceptional Response to Nanoparticle Albumin-Bound Paclitaxel and Gemcitabine in a Patient with a Refractory Adenocarcinoma of the Ampulla of Vater
JF  - Case Reports in Oncology
N2  - Ampullary carcinoma is a rare tumor and evidence on the treatment of recurrent metastatic disease is scarce. We report the case of a 60-year-old patient with an R0-resected node-positive adenocarcinoma of the papilla of Vater of an initially diagnosed intestinal subtype who developed pulmonary metastases 2 months after adjuvant gemcitabine chemotherapy and, subsequently, liver metastases. Palliative combination chemotherapy with standard regimens for intestinal-type adenocarcinoma (FOLFOX and FOLFIRI) failed. However, subsequent combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine, a regimen with proven efficacy in metastatic adenocarcinoma of the pancreas, resulted in a durable, very good partial remission. Treatment was manageable and well tolerated. Primary tumor and metastatic tissue were reassessed by immunohistochemistry and had to be reclassified to a mixed phenotype containing predominant elements of the pancreatobiliary subtype. Our case suggests that combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine could represent a promising option for the treatment of this rare disease and warrants further investigation within controlled clinical trials. Moreover, thorough characterization of ampullary carcinomas by histomorphology and additional immunohistochemistry should become mandatory in order to start a chemotherapeutic regimen tailored for the definitive subtype.
KW  - adenocarcinoma of the ampulla of Vater
KW  - intestinal-type adenocarcinoma
KW  - pancreatobiliary type
KW  - FOLFOX
KW  - FOLFIRI
KW  - gemcitabine
KW  - nanoparticle albumin-bound paclitaxel
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-168358
VL  - 9
IS  - 1
ER  - 
TY  - JOUR
A1  - Luber, Verena
A1  - Lutz, Mathias
A1  - Thiede, Christian
A1  - Haferlach, Claudia
A1  - Dürk, Heinz Albert
A1  - Einsele, Hermann
A1  - Grigoleit, Götz Ulrich
A1  - Mielke, Stephan
T1  - Donor-cell leukemia with novel genetic features 2 years after sex-mismatched T cell-depleted haploidentical stem cell transplantation
JF  - Annals of Hematology
N2  - No abstract available.
KW  - donor-cell leukemia
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-232596
SN  - 0939-5555
VL  - 99
ER  -