TY  - JOUR
A1  - Schmalzl, Jonas
A1  - Plumhoff, Piet
A1  - Gilbert, Fabian
A1  - Gohlke, Frank
A1  - Konrads, Christian
A1  - Brunner, Ulrich
A1  - Jakob, Franz
A1  - Ebert, Regina
A1  - Steinert, Andre F.
T1  - Tendon-derived stem cells from the long head of the biceps tendon
JF  - Bone & Joint Research
N2  - Objectives
The long head of the biceps (LHB) is often resected in shoulder surgery and could therefore serve as a cell source for tissue engineering approaches in the shoulder. However, whether it represents a suitable cell source for regenerative approaches, both in the inflamed and non-inflamed states, remains unclear. In the present study, inflamed and native human LHBs were comparatively characterized for features of regeneration.

Methods
In total, 22 resected LHB tendons were classified into inflamed samples (n = 11) and non-inflamed samples (n = 11). Proliferation potential and specific marker gene expression of primary LHB-derived cell cultures were analyzed. Multipotentiality, including osteogenic, adipogenic, chondrogenic, and tenogenic differentiation potential of both groups were compared under respective lineage-specific culture conditions.

Results
Inflammation does not seem to affect the proliferation rate of the isolated tendon-derived stem cells (TDSCs) and the tenogenic marker gene expression. Cells from both groups showed an equivalent osteogenic, adipogenic, chondrogenic and tenogenic differentiation potential in histology and real-time polymerase chain reaction (RT-PCR) analysis.

Conclusion
These results suggest that the LHB tendon might be a suitable cell source for regenerative approaches, both in inflamed and non-inflamed states. The LHB with and without tendinitis has been characterized as a novel source of TDSCs, which might facilitate treatment of degeneration and induction of regeneration in shoulder surgery.
KW  - biceps tendon
KW  - tendon-derived stem cell
KW  - mesenchymal stem cell
KW  - tissue engineering
KW  - shoulder
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-200370
VL  - 8
IS  - 9
ER  - 
TY  - JOUR
A1  - Reichel, Thomas
A1  - Rueckl, Kilian
A1  - Fenwick, Annabel
A1  - Vogt, Niklas
A1  - Rudert, Maximilian
A1  - Plumhoff, Piet
T1  - Hibernoma of the upper extremity: complete case of a rare but benign soft tissue tumor
JF  - Case Reports in Orthopedics
N2  - Hibernoma is a rare benign lipomatous tumor showing differentiation of brown fatty tissue. To the author’s best knowledge, there is no known case of malignant transformation or metastasis. Due to their slow, noninfiltrating growth hibernomas are often an incidental finding in the third or fourth decade of life. The vast majority are located in the thigh, neck, and periscapular region. A diagnostic workup includes ultrasound and contrast-enhanced MRI. Differential diagnosis is benign lipoma, well-differentiated liposarcoma, and rhabdomyoma. An incisional biopsy followed by marginal resection of the tumor is the standard of care, and recurrence after complete resection is not reported. The current paper presents diagnostic and intraoperative findings of a hibernoma of the upper arm and reviews similar reports in the current literature.
KW  - benige tumor
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-201669
VL  - 2019
ER  -