TY  - JOUR
A1  - Hankir, Mohammed K.
A1  - Rotzinger, Laura
A1  - Nordbeck, Arno
A1  - Corteville, Caroline
A1  - Dischinger, Ulrich
A1  - Knop, Juna-Lisa
A1  - Hoffmann, Annett
A1  - Otto, Christoph
A1  - Seyfried, Florian
T1  - Leptin receptors are not required for Roux-en-Y gastric bypass surgery to normalize energy and glucose homeostasis in rats
JF  - Nutrients
N2  - Sensitization to the adipokine leptin is a promising therapeutic strategy against obesity and its comorbidities and has been proposed to contribute to the lasting metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We formally tested this idea using Zucker fatty fa/fa rats as an established genetic model of obesity, glucose intolerance, and fatty liver due to leptin receptor deficiency. We show that the changes in body weight in these rats following RYGB largely overlaps with that of diet-induced obese Wistar rats with intact leptin receptors. Further, food intake and oral glucose tolerance were normalized in RYGB-treated Zucker fatty fa/fa rats to the levels of lean Zucker fatty fa/+ controls, in association with increased glucagon-like peptide 1 (GLP-1) and insulin release. In contrast, while fatty liver was also normalized in RYGB-treated Zucker fatty fa/fa rats, their circulating levels of the liver enzyme alanine aminotransferase (ALT) remained elevated at the level of obese Zucker fatty fa/fa controls. These findings suggest that the leptin system is not required for the normalization of energy and glucose homeostasis associated with RYGB, but that its potential contribution to the improvements in liver health postoperatively merits further investigation.
KW  - Roux-en-Y gastric bypass surgery
KW  - energy homeostasis
KW  - glucose homeostasis
KW  - fatty liver
KW  - leptin system
KW  - Zucker fatty fa/fa rats
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239550
SN  - 2072-6643
VL  - 13
IS  - 5
ER  -