TY  - JOUR
A1  - Penagos-Calvete, Diana
A1  - Duque, Valeria
A1  - Marimon, Claudia
A1  - Parra, Diana M.
A1  - Restrepo-Arango, Sandra K.
A1  - Scherf-Clavel, Oliver
A1  - Holzgrabe, Ulrike
A1  - Montoya, Guillermo
A1  - Salamanca, Constain H.
T1  - Glycerolipid composition and advanced physicochemical considerations of sacha inchi oil toward cosmetic products formulation
JF  - Cosmetics
N2  - Sacha inchi oil is a premier raw material with highly nutritional and functional features for the foodstuff, pharmaceutical, beauty, and personal care industries. One of the most important facts about this oil is the huge chemical content of unsaturated and polyunsaturated fatty acids. However, the current available information on the characterization of the triglyceride composition and the advance physicochemical parameters relevant to emulsion development is limited. Therefore, this research focused on providing a detailed description of the lipid composition using high-resolution tandem mass spectrometry and thorough physicochemical characterization to find the value of the required hydrophilic–lipophilic balance (HLB). For this, a study in the interfacial tension was evaluated, followed by the assessment of different parameters such as creaming index, droplet size, viscosity, zeta potential, pH, and electrical conductivity for a series emulsified at thermal stress condition. The results show that fatty acids are arranged into glycerolipids and the required HLB to achieve the maximum physical stability is around 8.
KW  - sacha inchi oil
KW  - unsaturated fatty acids
KW  - triacylglycerides
KW  - high-resolution tandem mass spectrometry
KW  - emulsions oil-in-water
KW  - required hydrophilic–lipophilic balance
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193857
SN  - 2079-9284
VL  - 6
IS  - 4
ER  - 
TY  - JOUR
A1  - Gutiérrez, Gustavo
A1  - Giraldo-Dávila, Deisy
A1  - Combariza, Marianny Y.
A1  - Holzgrabe, Ulrike
A1  - Tabares-Guevara, Jorge Humberto
A1  - Ramírez-Pineda, José Robinson
A1  - Acín, Sergio
A1  - Muñoz, Diana Lorena
A1  - Montoya, Guillermo
A1  - Balcazar, Norman
T1  - Serjanic acid improves immunometabolic markers in a diet-induced obesity mouse model
JF  - Molecules
N2  - Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.
KW  - Cecropia telenitida
KW  - serjanic acid
KW  - type 2 diabetes
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203253
SN  - 1420-3049
VL  - 25
IS  - 7
ER  -