TY - JOUR A1 - Tacke, Reinhold A1 - Saad, S. M. T1 - Silylation of cellulose N2 - Ethane-l:2-diol and propane-l:3-diol reaet with 1: 1:3:3-tetramethyl-l:3-dichlorodisiloxane forming the corresponding rings. However, no ring compounds could be traced tbrough the reaction between butane-l :4-diol, glycerol and the dichlorodisiloxane respectively, where only polymeric compounds are formed. The silylation products of the di- and trihydroxy alcohols, as model compounds, has confirmed that the ring formation during silylation of cellulose with dichlorodisiloxane is uncertain. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78368 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Bentlage, Anke A1 - Towart, Robertson A1 - Möller, Eike T1 - Sila-pharmaca, XXV. Sila-analogues of nifedipine-like dialkyl 2,6-dimethyl-4-aryl-1,4 dihydropyridine-3,5-dicarboxylates, III N2 - IS neue C/Si-Analogenpaare (C-Verbindungen und sila- bzw. disila-substituierte Derivate), die sich strukturell vom Nifedipin ableiten, wurden synthetisiert. Diese und einige weitere C/Si-Paare wurden hinsichtlich ihrer physikochemischen und pharmakologischen Eigenschaften vergleichend untersucht. Mittels reversed-phase-Dünnschichtchromatographie wurde gezeigt, daß die Sila- bzw. Disila-Analoga lipophiler sind als die entsprechenden C-Verbindungen. Bezüglich der spasmolytischen in vitra-Aktivitäten zeigen die Si-Verbindungen in erster Näherung ähnliche Struktur-Wirkungs-Beziehungen wie ihre Carba-Analoga. Dagegen konnten hinsichtlich der ill vlva-Effekte (cardiovasculäre und antihypertensive Aktivität) in einigen Fällen große Unterschiede nachgewiesen werden. N2 - 15 new C/Si-analogue pairs (C-compounds and sila- or disila-substituted derivatives, respectively), which are structurally related to nifedipine, have been synthesized. These and some further C/Si-pairs have been investigated comparatively with respect to their physicochemical and pharmacological properties. Using reversed-phase thin-layer chromatography it was shown that both the sila- and disila-analogues are more Iipophilic than the corresponding C-compounds. With respect to the in vitra spasmolytic potencies the Si-compounds show approximately similar structure-activity relationships to their carba-analogues. However, in some cases marked differences in in vivo effects (cardiovascular and antihypertensive activity) could be demonstrated. KW - Anorganische Chemie Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78357 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wuttke, F. A1 - Henke, H. T1 - Zur Stereochemie der mikrobiellen Reduktion von rac-Acetyl( t-butyl)methylphenylsilan mit Trigonopsis variabilis (DSM 70714) und Corynebacterium dioxydans (ATCC 21766): Aufklärung der absoluten Konfiguration der Biotransformationsprodukte (SiR,CR)- und ( SiS ,CR)-t-Butyl( 1-hydroxyethyl)methylphenylsilan N2 - No abstract available KW - Anorganische Chemie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64176 ER - TY - JOUR A1 - Braunschweig, Holger A1 - Damme, Alexander T1 - 1,2-Bis(dimethylamino)-1,2-bis(2,4,6-triisopropylphenyl)diborane(4) N2 - In the molecular structure of the title compound, C34H58B2N2, each B atom of the diborane(4) is connected to one dimethylamino group and one Tip ligand (Tip = 2,4,6-triisopropylphenyl). These findings indicate that the increased steric demand of the Tip groups exerts influence solely on the B—B separation but not on the overall geometry of the title compound. KW - Anorganische Chemie Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67639 ER - TY - JOUR A1 - Braunschweig, Holger A1 - Dewhurst, Rian D. A1 - Schwab, Katrin A1 - Wagner, Katharina T1 - {N ',N ''-Bis[2,6-bis(1-methylethyl)phenyl]-N,N-dimethylguanidinato-kappa N-2 ',N ''}dibromidoborane N2 - In the molecular structure of the title compound, C27H40N3BBr2, the B atom is connected to two bromide substituents and a guanidinate scaffold, forming a four– membered ring. An aryl group is connected to each N atom in the ring that contains two isopropyl groups in positions 2 and 6. KW - Anorganische Chemie Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67622 ER - TY - JOUR A1 - Werner, H. A1 - Leonhard, K. A1 - Burschka, Christian T1 - Basische Metalle: IX. Synthese und Kristallstruktur von C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) : Reaktionen zu zweikernkomplexen mit Co(SCS)Cr- und Co(SCS)Mn-Brückenbindungen T1 - Basic metals. IX. Synthesis and crystal structure of C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\). Reactions to binuclear complexes with Co(SCS)Cr and Co(SCS)Mn bridging compounds. N2 - Durch Reaktion von C\(_5\)H\(_5\)Co(PMe\(_3\))\(_2\) (I) oder des Hetero-Zweikernkomplexes C\(_5\)H\(_5\)(PMe\(_3\))Co(CO)\(_2\)Mn(CO)C\(_3\)H .. Me (III) mit CS\(_2\) entsteht in praktisch quantitativer Ausbeute C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) (IV). Die Kristallstruktur zeigt, dass der Carbondisulfid-Ligal'ld iiber Kohlenstoff und ein Schwefelatom (S(2)) dihaptogebunden vorliegt (Co-C = 1.89, Co-S(2) = 2.24 A, S(2)-C-S(1) = 141.2°). Die beiden C-S-AbsUinde in IV (C-S(2) = 1.68, C-S(l) = 1.60 A) sind gegenliber dem C-S-Abstand in freiem CS\(_2\) (1.554 A) aufgeweitet, was in Einklang mit dem aus spektroskopischen Daten zu folgernden starken 1T-Akzeptorcharakter von h\(^2\)-CS\(_2\) steht. IV reagiert mit Cr(CO)\(_5\)THF und C\(_5\)H\(_5\)Mn(CO)\(_2\)THF zu den Komplexen C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Cr(CO)\(_5\) (V) bzw. C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Mn(CO)\(_2\)C\(_5\)H\(_5\) (VI), in den en das in IV nicht am Cobalt gebundene Schwefelatom S(l) als Koordinationspartner gegenüber den 16-Elektronen-Fragmenten Cr(CO)\(_5\) und Mn(CO)\(_2\)C\(_5\)H\(_5\) fungierl. Die spektroskopischen Daten von IV, V und VI werden diskutiert. N2 - C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) (IV) is formed in practically quantitative yield in the reaction of C\(_5\)H\(_5\)Co(PMe\(_3\))\(_2\) (I) or the heterobinuclear complex C\(_5\)H\(_5\)(PMe\(_3\))Co(CO)\(_2\)Mn(CO)C\(_3\)H .. Me (III) with CS\(_2\). The crystal structure shows that the carbon disulfide bonds as a dihapto ligand through the carbon and one sulfur atom (S(2)) (Co-C = 1.89, Co-S(2) = 2.24 ft., S(2)-C-S(1) = 141.2°). The two C-S bond lengths in IV (C-S(2) = 1.68, C-S(l) = 1.60 A) are greater than in free CS\(_2\) (1.554 A) which is in agreement with the strong 7T-acceptor character of h\(^2\)-CS\(_2\) as shown in the spectroscopic data. IV reacts with Cr(CO)\(_5\)THF and C\(_5\)H\(_5\)Mn(CO)\(_2\)THF to give the complexes C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Cr(CO)\(_5\) (V) and C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Mn(CO)\(_2\)C\(_5\)H\(_5\) (VI) respectively, in which the sulfur atom S(l) that is not bound to cobalt coordinates to the 16-electron fragments Cr(CO)\(_5\) and Mn(CO)\(_2\)C\(_5\)H\(_5\). The spectroscopic data of IV, V and VI are discussed. KW - Anorganische Chemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-70444 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Mühleisen, M. T1 - Bis[benzilato(2-)-O\(^1\),O\(^2\)][2-(dimethylammonio)ethoxy]silicate: synthesis and structural characterization of a zwitterionic \(\lambda^5\)Si-silicate with a SiO\(_5\) framework N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64400 ER - TY - JOUR A1 - Mühleisen, M. A1 - Tacke, Reinhold T1 - meso-[1,4-Piperaziniumdiylbis(methylene)]bis{bis[2-methyllactato(2-)-O1,O2]silicate} octahydrate: synthesis and crystal structure analysis of a zwitterionic dispirocyclic \(\lambda^5\)Si,\(\lambda^5\)Si'-disilicate N2 - The zwitterionic dispirocyclic \(\lambda^5\)Si,\(\lambda^5\)Si'-disilicate meso-[1 ,4-piperaziniumdiylbis( methylene)]bis{ bis[ 2-methyllactato(2-)-O\(^1\),O\(^2\)]silicate} octahydrate (6-8H\(_2\)O) was synthesized by reaction of 1,4-bis[(trimethoxysilyl}methyl] piperazine (8) with 2-methyllactic acid (molar ratio 1:4) in water/acetone (yield 82%). The molecular dinuclear silicon(IV) complex 6 contains two pentacoordinate (formally negatively charged) silicon atoms and two tetracoordinate (formally positively charged) nitrogen atoms. The crystal structure of 6•8H20 was studied by X-ray diffraction. KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64396 ER - TY - JOUR A1 - Mühleisen, M. A1 - Tacke, Reinhold T1 - Twofold deprotonated citric acid as a bidentate ligand of pentacoordinate silicon: synthesis and structural characterization of the zwitterionic \(\lambda_5\)Si-spirosilicate bis[citrato(2-)-O\(^3\),O\(^4\)][(dimethylammonio)methyl]silicate hydrate N2 - The zwitterionic \(\lambda_5\) Si-spirosilicate bis[ citrato(2-)-0\(^3\) ,0\(^4\) )[ ( dimethylammonio) methyl]silicate (4) was synthesized by reaction of (MeO)\(_3\)SiCH\(_2\)NMe\(_2\) (3) with citric acid (molar ratio 1 :2) in acetonitrile at room temperature and isolated, after crystallization from water, as the hydrate 4 · H\(_2\)O (yield 81 %). The crystal structure of 4 · H\(_2\)O was studied by single-crystal X-ray diffraction. The alcoxide oxygen atoms and central carboxylate oxygen atoms of two citrato(2-) ligands and one carbon atom coordinate to the silicon atom of 4 · H\(_2\)O. The coordination polyhedron around the pentacoordinate silicon atom (SiO\(_4\)C framework) can be described as a distorted trigonal bipyramid, the two carboxylate oxygen atoms occupying the axial sites. The \(\lambda_5\) Si~silicon(IV) complex 4 also exists in solution (DMSO, H\(_2\)O). KW - Anorganische Chemie KW - Silicon KW - pentacoordinate KW - Lambda5Si-Spirosilicate KW - zwitterionic KW - Citrato(2-)-03 KW - 04ligand Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64388 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Mühleisen, M. T1 - Hexacoordinate silicon in a compound with an F\(_5\)SiC unit N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64378 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Mühleisen, M. T1 - Hexakoordiniertes Silicium in einer molekularen Verbindung mit einer F\(_5\)SiC-Einheit N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64365 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Mühleisen, M. A1 - Jones, P. G. T1 - The first zwitterionic, optically active disilicate with pentacoordinate silicon N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64358 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Mühleisen, M. A1 - Jones, P. G. T1 - Das erste zwitterionische, optisch aktive Disilicat mit pentakoordiniertem Silicium N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64343 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Lopez-Mras, A. A1 - Jones, P. G. T1 - Syntheses, crystal structure analyses, and NMR studies of [2-(dimethylammonio)phenyl]bis[glycolato(2-)-O1,O2]silicate and related zwitterionic spirocyclic \(\lambda_5\)Si-silicates N2 - No abstract available KW - Anorganische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64339 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Sperlich, J. A1 - Becker, B. T1 - Bis[2,3-naphthalenediolato(2-)](pyrrolidinio-methyl)germanate-tetartoacetonitrile, the first zwitterionic \(\lambda_5\)-germanate: synthesis and crystal structure analysis N2 - The zwitterionic spirocyclic \(\lambda_5\)-germanate bis(2,3-naphthalenediolato( 2-)](pyrrolidiniomethyl)germanate (8) was synthesized and the crystal structure of its tetartoacetonitrile solvate 8 · 1/4 CH\(_3\)CN studied by single-crystal X-ray diffraction. Compound 8 was prepared by reaction of (MeO)\(_3\)GeCH\(_2\)NC\(_4\)H\(_8\) (11; NC\(_4\)H\(_8\) = pyrrolidino) with two equivalents of 2,3-naphthalenediol (isolated as 8 · 1/4 CH\(_3\)CN; yield 92%). The coordination polyhedron around the pentacoordi- naphthalenediolatonate germanium atom of 8 · 1/4 CH\(_3\)CN can be described as a strongly distorted trigonal bipyramid (the structure is displaced by 38.9% from the ideal trigonal bipyrarnid towards the ideal square pyramid), the carbon atom occupying an equatorial position. In the crystal lattice of 8 · 1/4 CH\(_3\)CN, the zwitterions form intermolecular N-H ... o hydrogen bonds leading to the formation of dimers. 1H- and \(^{13}\C-NMR studies revealed that 8 also exists in solution ([D\(_6\)]DMSO). KW - Anorganische Chemie KW - Lambda5-Germanate KW - zwitterionic KW - Germanium KW - pentacoordinate Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64329 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wagner, S. A. A1 - Sperlich, J. T1 - Synthese von (-)-(Acetoxymethyl)(hydroxy-methyl)methyl(phenyl)german [(-)-MePhGe(CH\(_2\)OAc)(CH\(_2\)OH)] durch eine Esterase-katalysierte Umesterung: Die erste enzymatische Synthese eines optisch aktiven Germans N2 - No abstract available. KW - Anorganische Chemie KW - Germane KW - optically active KW - Biotransformation KW - stereoselective Transesterification KW - enzymatic KW - Porcine liver esterase Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64310 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Pikies, J. A1 - Wiesenberger, F. A1 - Ernst, L. A1 - Schomburg, D. A1 - Waelbroeck, M. A1 - Christophe, J. A1 - Lambrecht, G. A1 - Gross, J. A1 - Mutschler, E. T1 - Sila-biperiden und endo-Sila-biperiden: Synthesen, Kristallstrukturen und antimuscarinische Eigenschaften N2 - Starting from trichloro(vinyl)silane (Cl\(_3\)SiCH=CH\(_2\)), the musearinic antagonists sila-biperiden [rac-(SiRS,C2SR>-ao-2] and endosila- biperiden [rac-(SiRS,C2SR)-endo-2] were prepared by a seven-step synthesis. Both silanols are configurationally stableininert organic solvents but undergo slow epimerization in aqueous solution (pH 7.4, 32°C) by inversion of the configuration at the silicon atom. The relative configurations of sila-biperiden and endo-sila-biperiden were detennined by single-crystal X-ray diffraction. Both compounds form intennolecular 0-H · · · N hydrogen bonds in the crystal leading to the fonnation of centrosymmetric dimers (sila-biperiden) and infinite chains (endo-sila-biperiden), respectively. Sila-biperiden is a silicon analogue (C/Si exchange) of the antiparkinsonian drug biperiden [rac-(CRS/C2SR}-exo-1]. In functional phannacological experiments, as well as in radioligand competition studies, biperiden, sila-biperiden and endo-sila-biperiden behaved as simple competitive antagonists at muscarinic Ml-, M2-, M3- and M4-receptors. The three compounds displayed the highest affinity for Ml-receptors (pA\(_2\) values: 8.72-8.80; pK\(_i\) values: 8.8-9.1), intermediate affinity for M4- and M3-receptors, and lowest affinity for M2-receptors (pA\(_2\) values: 7.57-7.79; pK\(_i\) values: 7.7-7.8). The affinity profile (Ml >. M4 > M3 > M2) of biperiden, sila-biperiden and endo-sila-biperiden is qualitatively similar to that of the M1-selective muscarinic antagonist pirenzepine. The antimuscarinic properlies of the C/Si analogues biperiden and sila-biperiden are almost identical. N2 - Die Antimuscarinica Sila-biperiden [rac-(SiRS,C2SR)-exo-2] und endo-Sila-biperiden [rac-(SiRS,C2SR)-endo-2] wurden ausgehend von Trichlor(vinyl)silan (Cl\(_3\)SiCH=CH\(_2\)) durch eine siebenstufige Synthese dargestellt. Die beiden Silanoie sind in inerten organischen Solvenzien konfigurationsstabil, unterliegen aber in wässeriger Lösung (pH 7.4, 3ZOC) einer Epimerisierung durch Inversion der Konfiguration am Silicium-Atom. Die relativen Konfigurationen von Sila-biperiden und endo-Sila-biperiden wurden durch Einkristall-Röntgenstrukturanalysen bestimmt. Beide Verbindungen bilden im Kristall intermolekulare 0-H · · · N-Wasserstoff- Brückenbindungen aus, die zum Aufbau von zentrosymmetrischen Dimeren (Sila-biperiden) bzw. unendlichen Ketten (endo-Sila-biperiden) führen. Sila-biperiden ist ein Silicium-Analogon (C/Si-Austausch) des Antiparkinsonmittels Biperiden [rac-(CRS,C2SR>-ao-1). Sowohl in funktionellen pharmakologischen Untersuchungen als auch in Radioligand-Kompetitionsexperimenten erwiesen sich Biperiden, Sila-biperiden und endo-Sila-biperiden als rein kompetitive Antagonisten an muscarinischen M1-, M2-, M3- und M4-Rezeptoren. Alle drei Verbindungen zeigten die höchste Affinität zu den Mt-Rezeptoren (pA\(_2\)-Werte: 8.72-8.80; pKrWerte: 8.8-9.1), eine deutlich geringere Affinität zu den M4- und M3-Rezeptoren und die niedrigste Affinität zu den kardialen M2-Rezeptoren (pA\(_2\)-Werte: 7.57-7.79; pKi-Werte: 7.7-7.8). Das Affinitätsprofil (Ml > M4 > M3 > M2) von Biperiden, Sila-biperiden und endo-Sila-biperiden ist dem des Mt-selektiven Antimuscarinicums Pirenzepin qualitativ sehr ähnlich. Die antimuscarinischen Eigenschaften der C/Si-Analoga Biperiden und Sila-biperiden sind nahezu identisch. KW - Anorganische Chemie KW - Silicon KW - Silanol KW - Sila-biperiden KW - Bioorganosilicon chemistry KW - Muscarinic antagonist KW - Muscarinic receptor subtype Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64303 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wagner, S. A. A1 - Brakmann, S. A1 - Wuttke, F. A1 - Eilert, U. A1 - Fischer, L. A1 - Syldatk, C. T1 - Synthesis of acetyldimethyl(phenyl)silane and its enantioselective conversion into (R)-(1-hydroxyethyl)dimethyl(phenyl)silane by plant cell suspension culytures of Symphytum officinale L. and Ruta graveolens L. N2 - Starting from chlorodimethyl(phenyl)silane (3), acetyldimethyl(phenyl)silane (l) was prepared by a two-step synthesis in a total yield of 90% [PhMe\(_2\)SiCl (3)-> PhMe\(_2\)SiCCOMe)=CH\(_2\) (4)-> PhMe\(_2\)SiC(O)Me (1)]. The prochiral acetylsilane 1 was transfonned enantioselectively into (R)-(1-hydroxyethyl)dimethyl(phenyl)silane [(R)-2] using plant cell Suspension cultures of Symphytum officinale L. or Ruta graveolens L. Under preparative conditions (300-mg scale, not optimized), (R)-2 was isolated in 15% (Symphytum) and 9% yield (Ruta), respectively. The enantiomeric purities of the products were 81% ee (Syrnphytum) and 60% ee (Ruta), respectively. KW - Anorganische Chemie Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64299 ER - TY - JOUR A1 - Eltze, M. A1 - Ullrich, B. A1 - Mutschler, E. A1 - Moser, U. A1 - Bungardt, E. A1 - Friebe, T. A1 - Gubitz, C. A1 - Tacke, Reinhold A1 - Lambrecht, G. T1 - Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney N2 - The muscarinic receptor mediating vasodilation of resistance vessels in the rat isolated, constant-pressure perfused kidney (preconstriction by w- 7 M cirazoline) was characterized by subtype-preferring agonists and se]ective antagonists. The agonists produced vasodi1ation with the fol1owing rank order of potency: arecaidine propargy] ester (APE) > 5-methylfurtrethonium = methacholine = oxotremorine > (S)-aceclidine > arecaidine 2-butyne-1,4-diyl bisester > 4-Cl-McN-A-343 = (R)-nipecotic acid ethyl ester = N-ethyl-guvacine propargyl ester- (R)-aceclidine = (S)-nipecotic acid ethyl ester > McN-A-343. Agonist-induced vasodilation disappeared after destruction of the endothelium with detergent. Highly significant correlations of agonist potencies for vasodilation were found between rat kidney and guinea-pig ileum submucosal arterioles as weH as agonist potencies at smooth muscle muscarinic M\(_3\) receptors of the guinea-pig ileum. The rank order of antagonist potencies (4-diphenylacetoxy-Nmethylpiperidine methiodide (4-DAMP) > (R)-hexahydro-difenidol - hexahydro-sila-difenidol > pirenzepine - p-fluorohexahydro- sila-difenidol- himbacine- AF-DX 384- AQ-RA 741 > (S)-hexahydro-difenidol) to attenuate vasodilation to APE in rat kidney, correlated significantly with affinities at M\(_3\) receptors in submucosal arterioles and in smooth muscle of the guinea-pig ileum, but differed from those at M\(_1\) and M\(_2\) receptors in rabbit vas deferens. The agonist and antagonist potencies suggest that vasodilation elicited by muscarinic stimuli in endothelium-intact rat renal vasculature is mediated by functional muscarinic M\(_3\) receptors. KW - Anorganische Chemie KW - Kidney (perfused KW - rat) KW - Muscarinic receptor agonists KW - Muscarinic receptor antagonists KW - Arterioles (submucosal) KW - Ileum; Atrium KW - Vas deferens Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64283 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Becht, J. A1 - Lopez-Mras, A. A1 - Sheldrick, W. S. A1 - Sebald, A. T1 - Syntheses, X-ray crystal structure analyses, and solid-state NMR studies of some zwitterionic organofluorosilicates N2 - No abstract available KW - Anorganische Chemie Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64272 ER -