TY - THES A1 - Krause, Rorbert T1 - Optokinetischer Afternystagmus bei Tinnituspatienten T1 - optokinetic afternystagmus in patients with tinnitus N2 - In dieser Dissertation wurden aus dem Patientenstamm der neurootologischen Abteilung der Universitäts-Hals-Nasen-Ohren-Klinik Würzburg Daten aus den Jahrgängen November 1994 bis Februar 2002 entnommen. Insgesamt waren es 479 Patienten. Alle Patienten hatten einen beidseitigen optokinetischen Afternystagmus (OKAN) ≥ 10 Schläge pro 30s. Die allgemeinen Symptome der Patienten fielen entsprechend früheren Untersuchungen aus. Es zeigte sich, daß ca. 80% der Patienten die einen OKAN hatten auch einen Tinnitus hatten, wobei nur etwa 60% aller Patienten einen subjektiven Tinnitus angaben. Die Patientendaten wurden in verschiedene Kollektive aufgeteilt, um eine deskriptive Statistik zu erhalten. Die Tinnituskollektive wurden mit statistischen Methoden (Mann-Whitney U-Test) geprüft. Es ließen sich aber keine Signifikanzen feststellen, die Zusammenhänge zwischen Tinnitus und Optokinetik sowie Kalorimetrie sinnvoll beschreiben würden. N2 - This dissertation is a retrospective study that includes 479 patients which were examinated between 1994-2002 in the Neurootologic Departement of the University of Wuerzburg. All patients had an optokinetic afternystagmus (OKAN) with more than 10 strokes per 30 seconds. General symptoms of the patients in the group were the same as in older studies. We could prove that 80% of the patients with OKAN had tinnitus, but only 60% of all patients had tinnitus. To compare our datas, groups were formed, analysed and controlled with the Mann-Whitney u-test. But it couldn’t be found correlations between the statistic groups that make sense to explain that more patients with OKAN have tinnitus. KW - optokinetischer Afternystagmus KW - Tinnitus KW - Optokinetik KW - Kalorimetrie KW - Nystagmus KW - optokinetic afternystagmus KW - tinnitus KW - optokinetic KW - calorimetry KW - nystagmus Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-14638 ER - TY - JOUR A1 - Vona, Barbara A1 - Nanda, Indrajit A1 - Shehata-Dieler, Wafaa A1 - Haaf, Thomas T1 - Genetics of Tinnitus: Still in its Infancy JF - Frontiers in Neuroscience N2 - Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade. Nine studies have examined genes in a case-control association approach. Recently, a genome-wide association study has highlighted several potentially significant pathways that are implicated in tinnitus. Two twin studies have calculated a moderate heritability for tinnitus and disclosed a greater concordance rate in monozygotic twins compared to dizygotic twins. Despite the more recent data alluding to genetic factors in tinnitus, a strong association with any specific genetic locus is lacking and a genetic study with sufficient statistical power has yet to be designed. Future research endeavors must overcome the many inherent limitations in previous study designs. This review summarizes the previously embarked upon tinnitus genetic investigations and summarizes the hurdles that have been encountered. The identification of candidate genes responsible for tinnitus may afford gene based diagnostic approaches, effective therapy development, and personalized therapeutic intervention. KW - twin study KW - complex disorders KW - genetics KW - genetic heterogeneity KW - genome-wide association study (GWAS) KW - hearing loss KW - tinnitus Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-170926 VL - 11 IS - 236 ER - TY - THES A1 - Ruether, Barbara T1 - Der Hörsturz - nur ein Phänomen des akustischen Systems? T1 - Sudden hearing loss - only a phenomenon of the acoustical system? N2 - Das Ziel der vorliegenden Arbeit war, die Mitbeteiligung des vestibulären Teils des Labyrinthes beim akuten Hörsturz an 200 Patienten der Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen der Universität Würzburg näher zu untersuchen. Den größten Anteil Hörsturzerkrankter findet man im sechsten Lebensjahrzehnt, wobei Männer und Frauen etwa gleich häufig betroffen sind. Die Mehrzahl unserer Patienten ist von einem monauralen Hörsturz betroffen. Das Verhältnis von einseitigem zu beidseitigem Hörsturz beträgt etwa 4:1. Die Auswertung der kalorischen Vestibularisprüfung ergibt bei 73,5% unserer Hörsturzpatienten einen pathologischen Befund, wobei periphere Vestibularisstörungen überwiegen, gefolgt von zentralen und kombinierten Störungen. N2 - The aim of the thesis is to investigate the participation of the vestibular part of the inner ear within the sudden hearing loss. 200 patients of the ear, nose and throat department of the Wuerzburg University hospital were studied. The largest amount of patients with sudden deafness can be found in the sixth decade of their lifes, whereby both genders are more or less equally affected. Most of our patients suffer from a monaural sudden hearing loss. The relation between monaural and bilateral sudden deafness is 4 to 1, respectively. The analysis of the calorical test of vestibular function reveals a pathological finding in 73,5% of our patients. Peripheral vestibulopathy is most often found, followed by central and combined vestibulopathy. KW - Hörsturz KW - Periphere Vestibularisstörungen KW - zentrale Vestibularisstörungen KW - Tinnitus KW - Schwindel KW - Peripheral vestibulopathy KW - central vestibulopathy KW - combined vestibulopathy KW - tinnitus KW - vertigo Y1 - 2008 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37399 ER - TY - THES A1 - Bruckner, Thomas T1 - Brain Electrical Activity Mapping vestibulär evozierter Potentiale bei Tinnituspatienten - kompetitiv-kinästhetische Interaktionstherapie - T1 - Brain Electrical Activity Mapping of vestibular evoked potentials among patients with tinnitus - competitive kinesthetic therapy - N2 - Diese Dissertation stellt das Verfahren des Brain Electrical Activity Mappings der späten Vestibulär Evozierten Potentiale (BEAM-VestEP) bei Tinnituspatienten vor im Hinblick auf die therapeutische Wirksamkeit der kompetitiv-kinästhetischen-Interaktionstherapie auf der Basis der Brügger Therapie im „Murnauer Konzept“ und überprüft ihre Evidenz. N2 - This dissertation introduces the procedure of Brain Electrical Activity Mapping of the Late Vestibular Evoked Potentials (BEAM-VestEP) among patients with Tinnitus in view of the therapeutic efficacy of the competitive kinesthetic therapy as explained by Brügger based on the "Murnauer concept" and examines its evidence. KW - BEAM KW - Brain Electrical Activity Mapping KW - vestibulär evozierte Potentiale KW - Tinnitus KW - kompetitiv-kinästhetische Interaktionstherapie KW - BEAM KW - Brain Electrical Activity Mapping KW - vestibular evoked potentials KW - tinnitus KW - competitive kinesthetic therapy Y1 - 2005 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-17797 ER -