TY  - JOUR
A1  - Wegener, Christian
A1  - Chen, Jiangtian
T1  - Allatostatin A signalling: progress and new challenges from a paradigmatic pleiotropic invertebrate neuropeptide family
JF  - Frontiers in Physiology
N2  - Neuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. In insects and other panarthropods, AstA peptides qualify as brain-gut peptides and have regained attention with the discovery of their role in regulating feeding, growth, activity/sleep and learning. AstA receptor homologs are found throughout the protostomia and group with vertebrate somatostatin/galanin/kisspeptin receptors. In this review, we summarise the current knowledge on the evolution and the pleiotropic and cell-specific non-allatostatic functions of AstA. We speculate about the core functions of AstA signalling, and derive open questions and challengesfor future research on AstA and invertebrate neuropeptides in general.
KW  - neuropeptide signalling
KW  - feeding
KW  - intestinal control
KW  - sleep/activity
KW  - kisspeptin/galanin/spexin signalling
KW  - metabolism and growth
KW  - learning
KW  - cardioactive factor
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-278749
SN  - 1664-042X
VL  - 13
ER  -