TY  - JOUR
A1  - Mages, Michelle
A1  - Shojaa, Mahdieh
A1  - Kohl, Matthias
A1  - Stengel, Simon von
A1  - Becker, Clemens
A1  - Gosch, Markus
A1  - Jakob, Franz
A1  - Kerschan-Schindl, Katharina
A1  - Kladny, Bernd
A1  - Klöckner, Nicole
A1  - Lange, Uwe
A1  - Middeldorf, Stefan
A1  - Peters, Stefan
A1  - Schoene, Daniel
A1  - Sieber, Cornel C.
A1  - Tholen, Reina
A1  - Thomasius, Friederike E.
A1  - Uder, Michael
A1  - Kemmler, Wolfgang
T1  - Exercise effects on Bone Mineral Density in men
JF  - Nutrients
N2  - In contrast to postmenopausal women, evidence for a favorable effect of exercise on Bone Mineral Density (BMD) is still limited for men. This might be due to the paucity of studies, but also to the great variety of participants and study characteristics that may dilute study results. The aim of the present systematic review and meta-analysis was to evaluate the effect of exercise on BMD changes with rational eligibility criteria. A comprehensive search of six electronic databases up to 15 March 2021 was conducted. Briefly, controlled trials ≥6 months that determined changes in areal BMD in men >18 years old, with no apparent diseases or pharmacological therapy that relevantly affect bone metabolism, were included. BMD changes (standardized mean differences: SMD) of the lumbar spine (LS) and femoral neck (FN) were considered as outcomes. Twelve studies with 16 exercise and 12 control groups were identified. The pooled estimate of random-effect analysis was SMD = 0.38, 95%-CI: 0.14–0.61 and SMD = 0.25, 95%-CI: 0.00–0.49, for LS and FN, respectively. Heterogeneity between the trials was low–moderate. Funnel plots and rank and regression correlation tests indicate evidence for small study publication bias for LS but not FN-BMD. Subgroup analyses that focus on study length, type of exercise and methodologic quality revealed no significant difference between each of the three categories. In summary, we provided further evidence for a low but significant effect of exercise on BMD in men. However, we are currently unable to give even rough exercise recommendations for male cohorts.
KW  - Bone Mineral Density
KW  - exercise
KW  - men
KW  - overview
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-250247
SN  - 2072-6643
VL  - 13
IS  - 12
ER  - 
TY  - THES
A1  - Riegel, Christian
T1  - Hormonelle Veränderungen bei Männern mit Osteoporose mit speziellem Interesse bezüglich des Hypophysen-Hypothalamus GH/IGF-1-Systems
T1  - Hormonal changes in men with osteoporosis with special interest with regard to hypophysis-hypothalamus GH/IGF-1 system
N2  - Die Osteoporose des Mannes ist eine unterdiagnostizierte Erkrankung. Die Zahl der betroffenen Männer in Deutschland wird auf 0,8 bis 1 Million geschätzt, aber die reale Inzidenz ist wahrscheinlich höher. Die Osteoporose des Mannes ist Schätzungen zufolge in bis zu 60% mit Begleiterkrankungen assoziiert. Hypophysäre Störungen wie Hypogonadismus und Wachstumshormonmangel sind starke Risikofaktoren für die Entwicklung einer Osteoporose. Es gibt in der Literatur nur wenige Daten über Hypophysenerkrankungen und Osteoporose, abgesehen davon, dass bei bestehendem Wachstumshormonmangel die Assoziation der Osteopenie / Osteoporose gesichert ist. Für die nicht diagnostizierten Fälle von GH-Defizienz kann jedoch die Manifestation einer Osteoporose ein erstes und führendes Symptom sein. Es gibt Evidenzen dafür, dass IGF-1 im Serum in gesunden Populationen positiv mit der Knochendichte korreliert. Das Ziel dieser Studie ist, eine große Anzahl an Patienten mit Osteoporose auf die Inzidenz niedriger IGF-1-Spiegel hin zu untersuchen.
N2  - The osteoporosis of the man is an unterdiagnosed disease. The number of the affected men in Germany is estimated at 0.8 to 1 millions, but the real Inzidenz is probably higher. The osteoporosis of the man is associated according to estimates in up to 60% with accompanying illnesses. Hypophysis disturbances like Hypogonadism and growth hormone lack are strong risk factors for the development of an osteoporosis. There are in the literature only few data about hypophysis illnesses and osteoporosis, apart from the fact that with existing growth hormone lack the association of the Osteopenie / osteoporosis is protected. Nevertheless, for the not diagnosed cases of GH-Defizienz the manifestation of an osteoporosis can be the first and leading symptom. There is evidence for the fact that IGF-1 correlates in the Serum in healthy populations positively with the osseous density. The purpose of this study is, a great number to patient with osteoporosis examine for the Inzidenz of low IGF-1-levels.
KW  - Osteoporose
KW  - Männer
KW  - Hormonveränderung
KW  - Geschlechtshormone
KW  - IGF-1
KW  - GH
KW  - Testosteron Östrogene
KW  - SHBG
KW  - Parathormon
KW  - osteoporosis
KW  - men
KW  - hormon
KW  - IGF-1
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39547
ER  -