TY  - JOUR
A1  - Stoevesandt, Johanna
A1  - Keita, Dyamilatou Ulrike
A1  - Goebeler, Matthias
T1  - Disease-related burden and long-term outcome in orofacial granulomatosis: observations from a large single-centre cohort
JF  - Clinical and Experimental Dermatology
N2  - There is a lack of standardized treatment recommendations for orofacial granulomatosis, a chronic inflammatory condition aetiologically related to Crohn disease. To assess clinical baseline parameters and treatment strategies, we retrospectively analysed 61 consecutive cases from our institutional database. Disease-related functional/psychological impairment and long-term outcomes were descriptively evaluated using a standardized self-reporting questionnaire. The median age of patients was 45 (7–77) years. Oral steroids were given in 41.0% of cases, but only produced short-term disease control, while response to steroid-sparing agents was inconsistent. Only a minority of patients reported relevant disease-related functional impairment in eating (21.7%) or speaking (4.3%), but the majority perceived psychological distress due to the cosmetic aspects of the disease (69.6%), comments from others (65.2%) and/or general anxiety/insecurity (73.9%). Regardless of the initial treatment, long-term outcomes after 71 months (range 7–304 months) were beneficial, with most patients being in complete remission (52.2%) or reporting only mild residual swelling (43.5%).
KW  - orofacial granulomatosis
KW  - Crohn disease
KW  - long-term outcome
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-318412
VL  - 47
IS  - 6
SP  - 1169
EP  - 1173
ER  -