TY - JOUR A1 - Becker, T. A1 - Franzek, E. A1 - Jost, C. A1 - Hofmann, E. A1 - Schneider, M. A1 - Stöber, Gerald T1 - Hirnläsionen bei affektiven Erkrankungen: eine retrospektive CT-Studie T1 - Cerebral Lesions in Affective Disorders: a Retrospective CT Study N2 - 46 Patienten mit affektiven Erkrankungen und pathologischem CT wurden untersucht (Infarkt: 22, Kontusion: 6, Leukoaraiose: 11, frühkindlicher Hirnschaden: 7). Monopolar Depressive (DSMIII- R; MD) zeigten oft Leukoaraiose, Infarkte waren mit MD, Kontusionen und frühkindliche Schäden mit bipolarer Erkrankung assoziiert (BP; ANCOV A, p< .1). Kortikale Läsionen waren bei BP häufiger, jedoch fehlten signifikante Effekte von Läsionsort oder -zeitpunkt auf die Polarität der Erkrankung (ANOV A). Bei einigen Infarktpatienten kam es zur Verlaufsänderung (Chronifizierung, Bipolarität) nach Infarkt, alle Post-Infarkt-Ersterkrankungen waren bipolar. N2 - 46 patients with affective disorder and a pathologic CT scan were studied (infarct: 22, brain trauma: 6, leukoaraiosis: 11 , perinatal brain damage: 7). Unipolar depressives (DSM-I1I-R; MD) frequently had le ukoaraiosis, brain infarct was associated with unipolar depression , brain trauma and perinatal damage with bipolar illness (BP; ANCOV A , p < .1). Corticallesions were more frequ ent in BP, but ANOV A revealed no significant effect of lesion location and time of insu lt on illness polarity. In some patients with stroke course of illness changed (Ionger phases, bipolarity), first onset post-stroke went along with bipolar illness. KW - Psychiatrie KW - Klinische Psychiatrie KW - Gemeindepsychiatrie KW - organische affektive Störungen KW - Hirninfarkt KW - Kontusion KW - Frühkindlicher Hirnschaden KW - Leukoaraiose KW - Secondary affective disorder KW - Poststroke depression KW - Brain trauma KW - Perinatal brain damage KW - Leukoaraiosis Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82237 ER - TY - JOUR A1 - Stöber, Gerald A1 - Franzek, E. A1 - Beckmann, H. T1 - Obstetric complications in distinct Schizophrenie subgroups N2 - In 55 chronic DSM I11 -R schi zophre nics the occurrence of obstetr ic complica ti ons (OCs) was investigated us ing the famili al/sporael ic strategy and Leonhard's unsystemati c/systematic distin ction. The overa ll frequency and severity of OCs elid not differ be tween patie nts anel controls. A sub-sample of patients, whose genetic ri sk was supposed to be high in both class ification systems (d iagnos is 01' unsystematic anel fa mili al sc hizophre ni a), had s igni ficantly fewer OCs than controls on the Lewis anel Murray scale (P < 0.05). With reference to previous reports of inc reased morta lity rates in the offspring of schizop hre nics, high genetic risk and addition al perinatal stressors may in crease perin atal mortality. In contrast, pat ie nts whose genetic ri sk was sllpposed to be low in both systems (di agnos is of systematic and sporadic sc hizophrenia) showed a trend to an increased freqllency of OCs in the Fuchs scale. In the context of the recently reported highl y signi ficantly increased rate of matern al infections dllring midgestation in these pati e nts, it was supposed th at perin atal complications may be of so me ae tio logical importance in sc hizophrenics with low genetic ri sk. KW - Psychiatrie KW - obstetric complications KW - schizophrenia KW - famiIiaI ·sporadic concept KW - Leonhard cIassification Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82223 ER - TY - JOUR A1 - Stöber, Gerald A1 - Franzek, E. A1 - Beckmann, H. T1 - The role of maternal infectious diseases during pregnancy in the etiology of schizophrenia in offspring N2 - In 55 chronic schizophrenics, the occurrence of infectious diseases during their mothers' pregnancies was investigated. Different psychiatrie diagnostic systems were compared. Infections were reported by the mothers of familial and sporadic DSM I1I-R schizophrenics in equal proportion. However, applying Leonhard's classification, the frequency of infections was found to be significantly increased in 'systematic' schizophrenia (mainly exogenously induced in the view of Leonhard) compared to 'unsystematic' schizophrenia (mainly genetically determined according to Leonhard's findings). Most of the infections occurred during the second trimester (nine out of 13). Thus, in the 'systematic' forms of schizophrenia (low genetic loading), maternal infections in this crucial period of neurodevelopment would appear to be important causative factors in the cytoarchitectural deviance detected in the central nervous system of schizophrenics. KW - Psychiatrie KW - maternal infection KW - pregnancy KW - schizophrenia KW - familial-sporadic concept KW - Leonhard classification Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82216 ER - TY - JOUR A1 - Franzek, E. A1 - Sperling, W. A1 - Stöber, Gerald A1 - Beckmann, H. T1 - Die frühkindliche Form einer negativistischen Katatonie N2 - Es wird ein Krankheitsbild negativistischer Katatonie nach Leonhard mit nachweislichem Beginn in der frühen Kindheit beschrieben. Dieses zeichnet sich durch Negativismus, negativistische Erregungen mit (Auto)aggressivität und triebhaften Durchbrüchen aus. Die expressive Sprachentwicklung fehlt oder sie bleibt auf dem erreichten Entwicklungsstand stehen. Die körperliche Gesamtreifung ist retardiert. Zumeist nicht als frühkindliche Katatonien erkannt, werden diese Krankheiten fälschlich als "Schwachsinn bei frühkindlichem Hirnschaden" oder unspezifisch als "tiefgreifende Entwicklungsstörung" (DSM III-R, ICD 10) diagnostiziert. N2 - In a case report the clinical manifestation of negativistic catatonia with its modified symptomatology by first onset in early childhood is presented. The symptomatology consists of negativism, negativistic excitations with (auto)aggressivity and impulsive behaviour. Development of expressive language is lacking or is arrested. Physical development is retarded. These conditions are seldom recognized but diagnosed as organic brain syndrome or more unspecifically as "pervasive developmental disorder" (DSM III-R, ICD 10). KW - Schizophrenie KW - Neurologie KW - Psychiatrie KW - Frühkindliche Katatonie KW - Leonhard-Klassifikation KW - Schizophrenia KW - Early infant catatonia KW - Leonhard classification Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78448 ER -