TY  - JOUR
A1  - Petrasek, Tomas
A1  - Prokopova, Iva
A1  - Sladek, Martin
A1  - Weissova, Kamila
A1  - Vojtechova, Iveta
A1  - Bahnik, Stepan
A1  - Zemanova, Anna
A1  - Schönig, Kai
A1  - Berger, Stefan
A1  - Tews, Bjoern
A1  - Bartsch, Dusan
A1  - Schwab, Martin E.
A1  - Sumova, Alena
A1  - Stuchlik, Ales
T1  - Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns
JF  - Frontiers in Behavioral Neuroscience
N2  - Decreased levels of Nogo-A-dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity, and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A-deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality, and activity patterns.
KW  - AAPA
KW  - circadian rhythmicity
KW  - passive avoidance
KW  - Nogo-A
KW  - anhedonia
KW  - neophobia
KW  - morris water maze
KW  - place avoidance task
KW  - neurite outgrowth inhibitor
KW  - axon regeneration
KW  - synaptic plasticity
KW  - down regulation
KW  - traumatic brain injury
KW  - carousel maze
KW  - messenger RNA
KW  - genetic deletion
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117073
VL  - 8
IS  - 90
ER  -