TY - JOUR A1 - Hommers, Wilfried A1 - Steller, Max A1 - Zienert, Hans-Joachim T1 - Über die Verbesserung des Rollenspiels von jugendlichen Inhaftierten in sozialen Interaktionen durch Modellunterstütztes Rollenspiel N2 - 15 jugendliche Inhaftierte einer Entlassungsabteilung nahmen an einem Modellunterstützten Rollentraining in schwierigen Situationen nach der Entlassung teil. Videoaufnahmen von nicht geübten Szenen wurden im Paarvergleich von Ratern auf die Besserung des Rollenspielverhaltens beurteilt. Die Ergebnisse sprechen für eine Verhaltensbesserung, die auf das Modellunterstützte Rollentraining zurückgeführt werden kann. N2 - 15 incarcerated juvenile delinquents of a discharge department took part at a model-assisted role training of suitable behavior in difficult situations after discharge. In a pair comparison videorecords of not trained situations were judged by raters wit~l regard to improvement of subjects in role playing behavior. Results indicate a behavior improvement which can be attributed to the model-assisted role training. KW - Kinderpsychologie KW - Kinderpsychiatrie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43763 ER - TY - JOUR A1 - Wilhelm, Gernot T1 - Zur Rolle des Großgrundbesitzes in der hurritischen Gesellschft N2 - No abstract available KW - hurritische Gesellschft Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82759 ER - TY - JOUR A1 - Hommers, Wilfried A1 - Trempler, Volker T1 - Zum Verhalten von Lernbehinderten in Zwei-Personen-Spielen T1 - The behaviour of slow learners in games involving two people (Le comportement des handicapes a l'apprentissage dans des jeux a deux personnages) N2 - Die Methode der Matrix-Spiele, die in sozialpsychologischen Untersuchungen zur Erfassung von Kooperativität und Kompetitivität verwendet wurde, sollte auf ihre Tragfähigkeit in der Lernbehinderten-Forschung geprüft werden. Es wird über eine Untersuchung berichtet, in der zwei Nicht-Nullsummenspiele und ein Nullsummenspiel mit 56 lernbehinderten und 40 Normalschüler-Vpn durchgeftihrt wurden. Der Vergleich von Wahlhäufigkeiten zwischen Lernbehinderten und Normalschülern zeigte einige Unterschiede, die auf Retardierungen im-Bereich der Kooperativität-Kompetitivität-Entwicklung hinwiesen. Die Diskussion der Ergebnisse unterstützt aber an Hand der Wahlbegründungen nicht eine sozialpsychologische, sondern eine risikobezogene Interpretation des Verhaltens der Vpn. N2 - The matrix game method used in social psychological tests of cooperativity and competitivity was to be examined from the point of view of possible usefulness in research on slow learners. The report concerns a test on 56 slow learners and 40 normal pupils using 2 nonzero sum games and one zero sum game. The comparison of choice frequency between the slow learners and the normal pupils showed some differences which indicated retardation in the development of cooperativity and competitivity. The discussion of the results, however, supports-on the basis of the choice reasons- not a social psychological but a risk related interpretation of the behaviour of the people tested. Resume: La methode des jeux a matrice, employee dans les recherches psycho-sociologiques afin de mesurer le degre d'esprit cooperatif ct competitif, avait a etre contrölee quant a son utilite dans les recherches sur les handicapes a l'apprentissage. On relate des travaux au cours desquels 56 sujets handicapes et 40 ecoliers normaux se sont livres a deux jeux a somme non nulle et a un jeu a somme nulle. La comparaison des frequences de choix entre handicapes et normaux a revele quelques differenees indiquant des retards dans le seeteur du developpement de l'esprit eooperatif et competitif. Cependant, la diseussion des resultats eonfirme, au vu des raisons motivant les ehoix, une interpretation non psyeho-sociologique, mais liee a la notion de risque, du eomportement des sujets. KW - Sonderpädagogik Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43921 ER - TY - CHAP A1 - Langlotz, Maren A1 - Hommers, Wilfried T1 - Ziele, Aufbau und Durchführung des MURT N2 - No abstract available KW - MURT Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-73113 ER - TY - JOUR A1 - Rungger, M. A1 - Crippa, M. A1 - Trendelenburg, M. F. A1 - Scheer, Ulrich A1 - Franke, Werner W. T1 - Visualization of rDNA spacer transcription in Xenopus oocytes treated with fluorouridine N2 - Under the intluence of 5-tluoro-uridine, the ultrastructure of the rDNA transcription units in Xenopus oocytes is altered. Whereas part of the matrix units maintains anormal aspect or shows various degrees of inhibition, in a strong proportion of the transcription units the alternating pattern of matrix units and fibril-free spacer regions is no longer recognized. Transcriptional complexes are found along the entire DNP axis, including the regions of the spacers. These observations support biochemical data on transcription in rDNA spacer region. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33082 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Clarke, A. H. T1 - Verlaufsbeobachtungen anhand standardisierter Videoaufzeichnungen bei depressiven Patienten N2 - No abstract available Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33744 ER - TY - CHAP A1 - Clarke, A. H. A1 - Ellgring, Johann Heinrich T1 - Verfahren zur halbautomatischen Bearbeitung von Videoaufzeichnungen N2 - No abstract available Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33750 ER - TY - JOUR A1 - Christl, Manfred A1 - Freitag, G. A1 - Brüntrup, G. T1 - Tricyclo[4.1.0.0\(^{2,7}\)]hept-3-ene durch Umlagerung von 7-endo-Brom- und 7-endo-Chlortetracyclo[4.1.0.0\(^{2,4}\).0\(^{3,5}\)]heptanen N2 - No abstract available KW - Organische Chemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58029 ER - TY - JOUR A1 - Viviani, A. A1 - Lutz, Werner K. A1 - Schlatter, C. T1 - Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers N2 - Aryl hydrocarbon hydroxylase (AHH) has been measured in male rat Jiver nucJei and microsomes after treatment of adult animals with various inducers for up to 14 days. After daily i.p. injections of 3-methylcholanthrene (MC, 20 mg/kg) the nuclear activity increased to a maximum of 600 per cent of the control activity after 4 days whereas the microsomal activity was 400 per cent of control at the same date. After 12 days, both activities equilibrated at 400 per cent. A similar time course was found after a single i.p. injection of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD, 0.01 mg/kg) with an induction to .500 and 300 per cent for nuclei and microsomes, respectiveJy. after 2 days, and to 400 per cent for both after 12 days. PhenobarbitaJ (PB) was given continuously in the drinking water (I g/1) and induced the microsomal activity to 200 per cent after 8 days and 170 per cent after 14 days. The nuclear activity was only slightly induced to a constant Ievei of 130 per cent between day 8 and 14. Dieldrin did not significantly increase the microsomal activity after daiJy i.p. injections (20 mg/kg), but the nuclear activity raised to 200 per cent after 3 days and levelled down tocontrol valuesafter 12 days. Other inducers tested were benz[a)anthracene (BA), hexachlorobenzene (HCB} and 1,1.1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). The induction pattern with BA was similar tothat of MC, a modeJ compound for the group of cytochrome P448 inducers. The induction by HCB and DDT resembled that by PB. a typical cytochrome P450 inducer. KW - Toxikologie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61182 ER - TY - JOUR A1 - Krohne, Georg A1 - Franke, Werner W. A1 - Scheer, Ulrich T1 - The major polypeptides of the nuclear pore complex N2 - Nuclear envelopes of maturing oocytes of various amphibia contain an unusually high number of pore complexes in very close packing. Consequently, nuclear envelopes , which can be manually isolated in great purity, provide a remarkable enrichment of nuclear pore complex material, relative to membranous and other interporous structures. When the polypeptides of nuclear envelopes isolated from oocytes of Xenopl/s la evis and Triturus alpestris are examined by gel electrophoresis, visualized either by staining with Coomassie blue or by radiotluorography after in vitro reaction with [3H]dansyl chloride , a characteristic pattern is obtained (10 major and 15 minor bands). This polypeptide pattern is radically different from that of the nuclear contents isolated from the same cell. Extraction of the nuclear envelope with high salt concentrations and moderateIy ac tive detergents such as Triton X- 100 results in the removal of membrane material but leaves most of the non-membranous structure of the pore complexes. The dry weight of the pore complex (about 0.2 femtograms) remains essentially unchanged during such extractions as measured by quantitative electron microscopy . The extracted preparations which are highly enriched in nuclear pore complex material contain only two major polypeptide components with apparent molecular weights of 150000 and 73000. Components of such an electrophoretic mobility are not present as major bands , if at all , in nuclear contents extracted in the same way. lt is concluded that these two polypeptides are the major constituent protein(s) of the oocyte nuclear pore complex and are specific for this structure. When nuclear envelopes are isolated from rat liver and extracted with high salt buffers and Triton X- 100 similar bands are predominant, but two additional major components of molecular weights of 78000 and 66000 are also recognized. When the rat liver nuclear membranes are further subfractionated material enriched in the 66000 molecular weight component can be separated from the membrane material, indicating that this is relatively loosely associated material , probably a part of the nuclear matrix . The results suggest that the nuclear pore complex is not only a characteristic ubiquitous structure but also contains similar, if not identical , skeletal proteins that are remarkably re sistant to drastic changes of ionic strength as weil as to treatments with detergents and thiol reagents. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33078 ER - TY - JOUR A1 - Graf, T. A1 - Sebald, Walter T1 - The dicyclohexylcarbodiimide-binding protein of the mitochondrial ATPase complex from beef heart. Isolation and amino acid composition N2 - No abstract available KW - Biochemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62806 ER - TY - CHAP A1 - Franke, Werner W. A1 - Zentgraf, Hanswalter A1 - Scheer, Ulrich T1 - Supranucleosomal and non-nucleosomal chromatin configurations N2 - A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin? Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39447 ER - TY - JOUR A1 - Volz, H. A1 - Shin, J.-H. A1 - Prinzbach, H. A1 - Babsch, H. A1 - Christl, Manfred T1 - Stability of Tricyclo[4.1.0.0\(^{2,7}\)]heptenyl-Cations N2 - No abstract available KW - Organische Chemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58001 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Niederer, Reinhold T1 - Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I T1 - Sila-Drugs, 9th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, I JF - Zeitschrift für Naturforschung B N2 - Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported. KW - curare-like activity KW - toxicological properties KW - pharmacological properties KW - silicon compounds Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128277 VL - 33 IS - 4 ER - TY - JOUR A1 - Kreft, Jürgen A1 - Bernhard, K. A1 - Goebel, Werner T1 - Recombinant plasmids capable to replication in B. subtilis and E. coli N2 - The plasmid pBC16 (4.25 kbases), ongtnally isolated from Bacillus cereus, determines tetracycline resistance and can be transformed into competent cells of B. subtilis. A miniplasmid of pBCl6 (pBCI6-1), 2,7 kb) which has lost an EcoRI fragment of pBCI6 retains the replication functions and the tetracycline resistance. This plasmid which carries only one EcoRI site has been joined in vitro to pBS], a cryptic plasmid previously isolated from B. subtilis and shown to carry also a single EcoRI site (Bernhard et aI., 1978). The recombinant plasmid is unstable and dissociates into the plasmid pBSl61 (8.2 kb) and the smaller plasmid pBS162 (2. I kb). Plasmid pBS161 retains the tetracycline resistance. It possesses a single EcoRI site and 6 HindlII sites. The largest HindIII fragment of pBS161 carries the tetracycline resistance gene and the replication function. After circularization in vitro of this fragment a new plasmid, pBS161-l is generated, which can be used as a HindlII and EcoRI cloning vector in Bacillus suhtilis. Hybrid plasmids consisting of the E. coli plasmids pBR322, p WL 7 or pACl84 and different HindlII fragments of pBSI61 were constructed in vitro. Hybrids containing together with the E. coli plasmid the largest HindlII fragment of pBS161 can replicate in E. coli and B. sublilis. In E. coli only the replicon of the E. coli plasmid part is functioning whereas in B. suhtilis replication of the hybrid plasmid is under the control of the Bacillus replicon. The tetracycline resistance of the B. subtilis plasmid is expressed in E. coli, but several antibiotic resistances of the E. coli plasmids (ampicillin, kanamycin and chloramphenicol) are not expressed in B. suhtilis. The hybrid plasmids seem to be more unstable in B. subtilis than in E. coli. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47000 ER - TY - JOUR A1 - Weiss, H. A1 - Sebald, Walter T1 - Purification of cytochrome oxidase from Neurospora crassa and other sources N2 - A chromatographic procedure 1 is described by means of which cytochrome oxidase has been purified from a variety of organisms including the fungus N eurospora crassa,2,3 the unicellular alga Po/ytoma mirum, 4 the insect Locusta migratoria ,5 the frog Xenopus muel/eri,4 and the mammal Rattus norwegicus. 4 This procedure can be used to equal effect for large-scale preparations, starting from grams of mitochondrial protein, or for small-scale preparations starting from milligrams. The cytochrome oxidase preparations from the different organisms are enzymically active. They show similar subunit compositions. KW - Biochemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82082 ER - TY - JOUR A1 - Scheer, Ulrich A1 - Zentgraf, Hanswalter T1 - Nucleosomal and supranucleosomal organization of transcriptionally inactive rDNA circles in Dytiscus oocytes N2 - Oocytes of the water beetle, Dytiscus marginalis, contain large amounts of rDNA most of which is present in the form of rings containing one or several pre-rRNA genes. Electron microscopy of spread preparations of vitellogenic oocytes has shown that the rDNA is extended in chromatin rings with transcribed pre- rRNA genes and is not packed into nucleosomes (Trendelenburg eta!. , 1976). When similar preparations are made from previtellogenic ooytes in which a large proportion of the nuc1eolar chromatin is transcriptionally inactive, a different morphological form of this chromatin is recognized. In contrast to the transcribed chromatin rings the inactive nucleolar chromatin circles show the characteristic beaded configuration, indicative of nucleosomal packing. Nuc1eosomal packing is also indicated by the comparison of the lengths of these chromatin rings with both iso lated rDNA circ1es and transcribed chromatin rings. In addition, these inactive nuc1eofilaments often appear to be compacted into globular higher order structures of diameters from 21 to 34nm, each composed of an aggregate of 6-9 nuc1eosomes. While the estimated reduction of the overall length of rDNA, as seen in our preparations, is, on the average, only 2.2 - 2.4 fold in the nuc1eosomal state it is 10- 13 fold when supranuc1eosomal globules are present. These data show that the extrachromosomal rDNA of these oocytes goes through a cycle of condensation and extensio n, as a function of the specific transcriptional activity, and that the beaded state described here is exc1usively found in the non-transcribed state. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33188 ER - TY - JOUR A1 - Lutz, Werner K. A1 - Viviant, A. A1 - Schlatter, C. T1 - Nonlinear dose-response relationship for the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo N2 - Wlth radioactive compound of high specific activity, the binding of carcinogene to DNA can be measured wlth doses that are ineffective ln long-term studies. The binding of tritiated benzo(a )pyrene to liver DNA of adult male rats has been determined 50 hr after a singie l.p. injection of doses between 40 1'9/kg and 4 mg/kg. The doseresponse relationship is linear up to 1 mg/kg, shows a step towards 2 mg/kg, and gives a shallow linear slope above that value. The observed binding ranges from 1.7 to 180 nmoles benzo(a)pyrene per mole DNA phosphate. The nonlinearity could be due to an induction of metabolizing enzymes. The microsomal aryl hydrocarbon hydroxylase activity increases significantly 24 hr after a single dose of 4 mg/kg and 48 hr after doses of 2 and 4 mg/kg, but no induction Ia found with 1 mg/kg. The binding from an equimolar dose is 35 times lower than the one found on mouse skin DNA and 300 times lower than that of N,Ndlmethylnitrosamine in rat liver. A good correlatlon exiats to the respective tumor formation in long-term studles. KW - Toxikologie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61179 ER - TY - JOUR A1 - Hommers, Wilfried T1 - Multinomiale und Bayes-statistische konfigurale Klassifikation T1 - Multi-nomial and Bayes-statistical configural classification N2 - Ein Verfahren zur Klassifikation von Pbn aufgrund individueller Abweichung von der Annahme wiederholter multinornialer Zufallsereignisse und aufgrund individueller maximaler Likelihood der Zugehörigkeit zu einer bestimmten Gruppe wird nebst Modelltest dargelegt. Als Anwendungsbeispiel wird über die Ergebnisse bei zwei denkbaren Klassifikationen in verschiedenen Therapiemotivationsgruppen berichtet N2 - The author suggests a method and a "model test" for the classification of subjects on grounds on individual deviation from the assumption of repeated multi-nomial chance encounters and on grounds of individual maximallikelihood of membership in a certain group. The author reports on the results reached with two conceivable classifications into different therapy-motivation groups. (L. Canders) französisch: L'auteur presente - avec test-modele - un procede permettant de c1asser les sujets selon leur tendance individuelle a s'ecarter de la croyance aux evenements fortuits multinomiques repetes et selon la likelihood maximale individuelle d'appartenance a un groupe precis. En guise d'application, on relate les resultats dans le cas de deux classifications possibles dans deux groupes differents de motivation therapeutique. (J. Chanel) KW - Psychologie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43798 ER - TY - CHAP A1 - Franke, Werner W. A1 - Scheer, Ulrich A1 - Trendelenburg, Michael F. A1 - Zentgraf, H. A1 - Spring, H. T1 - Morphology of transcriptionally active chromatin N2 - Some decades ago it was noted by cytologists that within the interphase nucleus large portions of the transcriptionally ("genetically," in their terms) inactive chromosomal material are contained in aggregates of condensed chromatin, the "chromocenters," whereas transcriptionally active regions of chromosomes appear in a more dispersed form and are less intensely stained with DNA-directed staining procedures (Heitz 1929, 1932, 1956; Bauer 1933). The hypothesis that condensed chromatin is usually characterized by very low or no transcriptional activity, and that transcription occurs in loosely packed forms of chromatin (including, in most cells, the nucleolar chromatin) has received support from studies of ultrathin sections in the electron microscope and from the numerous attempts to separate transcriptionally active from inactive chromatin biochemically (for references, see Anderson et al. 1975; Berkowitz and Doty 1975; Krieg and Wells 1976; Rickwood and Birnie 1976; Gottesfeld 1977). Electron microscopic autoradiography has revealed that sites of RNA synthesis are enriched in dispersed chromatin regions located at the margins of condensed chromatin (Fakan and Bernhard 1971, 1973; Bouteille et al. 1974; Bachellerie et al. 1975) and are characterized by the occurrence of distinct granular and fibrillar ribonucleoprotein (RNP) structures, such as perichromatin granules and fibrils. The discovery that, in most eukaryotic nuclei, major parts of the chromatin are organized in the form of nucleosomes (Olins and Olins 1974; Kornberg 1974; Baldwin et al. 1975) has raised the question whether the same nucleosomal packing of DNA is also present in transcriptionally active chromatin strands. Recent detailed examination of the morphology of active and inactive chromatin involving a diversity of electron microscopic methods, particularly the spreading technique by Miller and coworkers (Miller and Beatty 1969; Miller and Bakken 1972), has indicated that the DNA of some actively transcribed regions is not packed into nucleosomal particles but is present in a rather extended form within a relatively thin (4-7 nm) chromatin fiber. Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41097 ER -