TY  - JOUR
A1  - Lisowski, Dominik
A1  - Hartrampf, Philipp E.
A1  - Hasenauer, Natalie
A1  - Nickl, Vera
A1  - Monoranu, Camelia-Maria
A1  - Tamihardja, Jörg
T1  - Complete loss of E-cadherin expression in a rare case of metastatic malignant meningioma: a case report
JF  - BMC Neurology
N2  - Background
Hematogenous tumor spread of malignant meningiomas occurs very rarely but is associated with very poor prognosis.

Case presentation
We report an unusual case of a patient with a malignant meningioma who developed multiple metastases in bones, lungs and liver after initial complete resection of the primary tumor. After partial hepatic resection, specimens were histologically analyzed, and a complete loss of E-cadherin adhesion molecules was found. No oncogenic target mutations were found. The patient received a combination of conventional radiotherapy and peptide receptor radionuclide therapy (PRRT). Due to aggressive tumor behavior and rapid spread of metastases, the patient deceased after initiation of treatment.

Conclusions
E-cadherin downregulation is associated with a higher probability of tumor invasion and distant metastasis formation in malignant meningioma. Up to now, the efficacy of systemic therapy, including PRRT, is very limited in malignant meningioma patients.
KW  - beta-catenin
KW  - E-cadherin
KW  - meningioma
KW  - peptide receptor radionuclide therapy (PRRT)
KW  - radiotherapy
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-357996
VL  - 23
ER  - 
TY  - JOUR
A1  - Breun, Maria
A1  - Flock, Katharina
A1  - Feldheim, Jonas
A1  - Nattmann, Anja
A1  - Monoranu, Camelia M.
A1  - Herrmann, Pia
A1  - Ernestus, Ralf-Ingo
A1  - Löhr, Mario
A1  - Hagemann, Carsten
A1  - Stein, Ulrike
T1  - Metastasis associated in colorectal cancer 1 (MACC1) mRNA expression is enhanced in sporadic vestibular schwannoma and correlates to deafness
JF  - Cancers
N2  - Vestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated with NF2-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1) is known to contribute to angiogenesis, cell growth, invasiveness, cell motility and metastasis of solid malignant cancers. In addition, MACC1 may be associated with nonsyndromic hearing impairment. Therefore, we evaluated whether MACC1 may be involved in the pathogenesis of VS. Sporadic VS, recurrent sporadic VS, NF2-associated VS, recurrent NF2-associated VS and healthy vestibular nerves were analyzed for MACC1 mRNA and protein expression by quantitative polymerase chain reaction and immunohistochemistry. MACC1 expression levels were correlated with the patients’ clinical course and symptoms. MACC1 mRNA expression was significantly higher in sporadic VS compared to NF2-associated VS (p < 0.001). The latter expressed similar MACC1 concentrations as healthy vestibular nerves. Recurrent tumors resembled the MACC1 expression of the primary tumors. MACC1 mRNA expression was significantly correlated with deafness in sporadic VS patients (p = 0.034). Therefore, MACC1 might be a new molecular marker involved in VS pathogenesis.
KW  - vestibular schwannoma
KW  - metastasis associated in colorectal cancer 1 (MACC1)
KW  - pathogenesis
KW  - deafness
KW  - NF2-related schwannomatosis (NF2)
KW  - mRNA expression
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-362543
SN  - 2072-6694
VL  - 15
IS  - 16
ER  - 
TY  - THES
A1  - Stollburges, Elisa
T1  - Therapeutisches Potential der IL-1ß-Neutralisierung nach Schädel-Hirn-Trauma - eine präklinische randomisierte Kontrollstudie
T1  - The therapeutic potential of interleukin 1 beta neutralisation treating Traumatic Brain injury - A preclinical randomised control study
N2  - Durch die Interleukin 1ß Neutralisierung mittels eines Antikörpers soll versucht werden, das Outcome nach einem Schädelhirntrauma zu verbessern und den erlittenen Schaden zu minimieren
N2  - With the support of antibodies, interleukin 1 beta neutralisation attempts to improve the outcome after suffering from a traumatic brain injury and to limit the damage suffered
KW  - Interleukin 1-beta
KW  - Interleukin 1 beta Neutralisierung
KW  - Schädel-Hirn-Trauma
Y1  - 2024
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-349346
ER  -