TY  - JOUR
A1  - Rasa, Santa
A1  - Nora-Krukle, Zaiga
A1  - Henning, Nina
A1  - Eliassen, Eva
A1  - Shikova, Evelina
A1  - Harrer, Thomas
A1  - Scheibenbogen, Carmen
A1  - Murovska, Modra
A1  - Prusty, Bhupesh K.
T1  - Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
JF  - Journal of Translational Medicine
N2  - Background and main text: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and controversial clinical condition without having established causative factors. Increasing numbers of cases during past decade have created awareness among patients as well as healthcare professionals. Chronic viral infection as a cause of ME/CFS has long been debated. However, lack of large studies involving well-designed patient groups and validated experimental set ups have hindered our knowledge about this disease. Moreover, recent developments regarding molecular mechanism of pathogenesis of various infectious agents cast doubts over validity of several of the past studies. 

Conclusions: This review aims to compile all the studies done so far to investigate various viral agents that could be associated with ME/CFS. Furthermore, we suggest strategies to better design future studies on the role of viral infections in ME/CFS.
KW  - ME/CFS
KW  - Viral infections
KW  - Biomarkers
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-224960
VL  - 16
IS  - 268
ER  -