TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Bentlage, Anke
A1  - Sheldrick, William S.
A1  - Ernst, Ludger
T1  - 2.2.5.5-Tetraorganyl-1.4-dioxa-2.5-disilacyclohexane/2,2,5,5-Tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes
JF  - Zeitschrift für Naturforschung B
N2  - The 2,2,5,5-tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes 2a-2c were prepared by condensation of the corresponding (hydroxymethyl)diorganylsilanes 1 a-1 c. The constitution of the heterocycles was confirmed by elemental analyses, cryoscopic measurements, mass spectrometry, and NMR-spectroscopic \((^1H, ^{13}C)\) investigations. The molecular structure of 2 b was determined by X-ray diffraction analysis.
KW  - 1,4-Dioxa-2
KW  - 5-disila-cyclohexane ring system
KW  - synthesis
KW  - structure
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128423
VL  - 38
IS  - 2
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Sheldrick, William S.
A1  - Lambrecht, Günter
A1  - Moser, Ulrich
A1  - Mutschler, Ernst
T1  - Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
T1  - Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue
JF  - Zeitschrift für Naturforschung B
N2  - In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
KW  - antimuscarinic and papaverine-like activity
KW  - sila-substitution
KW  - crystal and molecular structure
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128410
VL  - 38
IS  - 6
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Linoh, Haryanto
A1  - Attar-Bashi, Moayad T.
A1  - Sheldrick, William S.
A1  - Ernst, Ludger
A1  - Niedner, Roland
A1  - Frohnecke, Joachim
T1  - Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III
T1  - Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III
JF  - Zeitschrift für Naturforschung B
N2  - The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.
KW  - structure-activity relationships
KW  - X-ray
KW  - curare-lik activity
KW  - silicon compounds
KW  - conformational anaylses
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128402
VL  - 37
IS  - 11
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Linoh, Haryanto
A1  - Stumpf, Burghard
A1  - Abraham, Wolf-Rainer
A1  - Kieslich, Klaus
A1  - Ernst, Ludger
T1  - Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigsäure-(trimethylsilylalkyl)estern und deren Carba-Analoga
T1  - Microbiological Transformation of Silicon Compounds: Enantioselective Reduction of Trimethylsilylalkyl Acetoacetates and their Carba-Analogues
JF  - Zeitschrift für Naturforschung B
N2  - The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80% (3a, 3b, 4b) and 65% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.
KW  - enantioselective reduction
KW  - microbiological transformation
KW  - silicon compounds
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128304
VL  - 38
IS  - 5
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Link, Matthias
A1  - Bentlage-Felten, Anke
A1  - Zilch, Harald
T1  - Zum thermischen Verhalten einiger Kohlensäure[(methylphenylsilyl)methyl]ester-Derivate
T1  - On the Thermal Behaviour of Some (Methylphenylsilyl)methyl Carbonate Derivatives
JF  - Zeitschrift für Naturforschung B
N2  - The synthesis and the thermal behaviour of the (methylphenylsilyl)methyl carbonates \(CH_3(C_6H_5)Si(H)CH_2OC(O)X (6: X = OCH_3; 7: X = Cl; 8: X = N(CH_3)_2)\) is described. 8 rearranges in toluene solution at 100 °C quantitatively to give the carbam oyloxysilane \(C_6H_5(CH_3)_2SiOC(O)N(CH_3)_2\) (11), whereas neat 6 and 7 at 135 °C undergo quantitative formation of \(C_6H_5(CH_3)_2SiOCH_3\) (12) and \(C_6H_5(CH_3)_2SiCl\) (13), respectively. The formation of 12 and 13 is explained by a rearrangement reaction (by analogy to the rearrangement of 8), follow ed by a decarboxylation. The thermally induced transformations 6 →12, 7 →13, and 8 →11 were found to be first-order reactions with half-lifes of ~2.6 h (135 °C, neat), ~4.5 h (135 °C, neat), and ~3.7 h (100 °C, in toluene), respectively.
KW  - decarboxylation
KW  - (Methylphenylsilyl)methyl carbonates
KW  - rearrangement
KW  - dimethylphenylsilyl carbonates
Y1  - 1985
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128293
VL  - 40
IS  - 7
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Niederer, Reinhold
T1  - Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I
T1  - Sila-Drugs, 9th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, I
JF  - Zeitschrift für Naturforschung B
N2  - Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.
KW  - curare-like activity
KW  - toxicological properties
KW  - pharmacological properties
KW  - silicon compounds
Y1  - 1978
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128277
VL  - 33
IS  - 4
ER  - 
TY  - JOUR
A1  - Saad, S. M.
A1  - Tacke, Reinhold
T1  - Zur Darstellung von 1,1,3,3-Tetramethyl-1,3-disila-2,4,7-trioxa-cycloheptan (1) und 1,1,3,3-Tetramethyl-1,3-disila-2,4,8-trioxa-cyclooctan (2)
N2  - No abstract available.
KW  - Anorganische Analyse
Y1  - 1977
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86958
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Bentlage-Felten, Anke
A1  - Linoh, Haryanto
A1  - Magda, Stephen
T1  - Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften
T1  - Sila-analogues of Triparanol and Ethamoxytriphetol: synthesis as well as pharmacological and toxicological properties
N2  - No abstract available.
KW  - sila-subsitution
KW  - triparanol
KW  - ethamoxytriphetol
KW  - hypolipidemic activity
KW  - toxicological properties
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86940
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Link, Matthias
A1  - Joppien, Hartmut
A1  - Ernst, Ludger
T1  - Sila-Substitution des Akarizids Fenbutatinoxid und einiger seiner Derivate: Synthese und Eigenschaften von Hexakis[(dimethylphenylsilyl)methyl]distannoxan und Tris[(dimethylphenylsilyl)methyl](1,2,4-triazol-1-yl)stannan
T1  - Sila-substitution of the Acaricide Fenbutatinoxide and some of its derivatives: synthesis and properties of Hexakis[(dimethylphenylsilyl)methyl](1,2,4-triazol-1-yl)stannane
N2  - No abstract available.
KW  - Chemische Synthese
KW  - Akarizid
KW  - sila-substitution
KW  - fenbutatinoxide
KW  - hexasila-fenbutatinoxide
KW  - acaricides
KW  - syntheses
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86937
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Wiesenberger, Frank
T1  - (Acetoxymethyl)methylphenylgerman: Synthese, thermisches Verhalten und olfaktorische Eigenschaften
T1  - (Acetoxymethyl)methylphenylgermane: Synthesis, Thermal Behaviour and Olfactoric Properties
N2  - No abstract available.
KW  - Chemische Synthese
KW  - Temperaturabhängigkeit
KW  - Olfaktorische Analyse
KW  - (Acetoxymethyl)methylphenylgermane
KW  - (Acetoxymethyl)methylphenylsilane
KW  - hydratropyl acetate
KW  - thermal stability
KW  - perfumes
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86927
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Wiesenberger, Frank
A1  - Lopez-Mras, Angel
A1  - Sperlich, Jörg
A1  - Mattern, Günter
T1  - Neuartige zwitterionische λ5-Spirosilicate: Synthese und Kristallstruktur von Bis[1,2-benzoldiolato(2-)][2-(dimethylammonio)phenyl]silicat sowie Synthese von Bis[2,3-naphthalindiolato(2-)][2-(dimethylammonio)phenyl]silicat-Hemiacetonitril-Solvat
N2  - No abstract available.
KW  - Silicate
KW  - Bis[1,2-benzenediolato(2-)][2-(dimethylammonio)phenyl]silicate
KW  - Bis[2,3-naphthalenediolato(2-)][2-(dimethylammonio)phenyl]silicate
KW  - zwitterionic λ5-Spirosilicates
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86916
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Kropfgans, Martin
A1  - Tafel, Andrea
A1  - Wiesenberger, Frank
A1  - Sheldrick, William S.
A1  - Mutschler, Ernst
A1  - Egerer, Hansjörg
A1  - Rettenmayr, Nikola
A1  - Gross, Jan
A1  - Waelbroeck, Magali
A1  - Lambrecht, Günter
T1  - (Hydroxymethyl)diphenyl(piperidinoalkyl)silane des Typs (HOCH2)(C6H5)2Si(CH2)nNC5H10 (n = 2,3) und deren Methoiodide: Synthese, Struktur und antimuscarinische Eigenschaften
N2  - No abstract available.
KW  - (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes
KW  - Sila-pridinol
KW  - Sila-difenidol
KW  - muscarinic antagonists
KW  - muscarinic receptors
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86904
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Haller, Ingo
A1  - Zeiler, Hans-Joachim
T1  - Sila-Analoga der Antiseptica Octafoniumchlorid und p-tert-Butylphenol
N2  - No abstract available.
KW  - Silaanaloga
KW  - Antiseptikum
Y1  - 1979
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86893
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Sperlich, Jörg
A1  - Strohmann, Carsten
A1  - Frank, Brigitta
A1  - Mattern, Günter
T1  - Bis[3,4,5,6-tetrabrom-1,2-benzoldiolato(2-)]-(pyrrolidiniomethyl)silicat-Acetonitril-Solvat [(C6Br4O2)2SiCH2(H)NC4H8 · CH3CN]: Synthese sowie Kristall- und Molekülstruktur eines zwitterionischen [lambda]5-Spirosilicats
N2  - Single crystal X-ray studies on bis[3,4,5,6-tetrabromo-1 ,2-benzenediolato(2- )](pyrrolidiniomethyl)silicate acetonitrile solvate [(C6Br40 2hSiCH2(H)NC4H8 · CH3CN; monoclinic, P2t/c, a = 808.5(4), b = 1533.0(8), c = 2212.6(1) pm, ß = 97.67(2)0 , Z = 4] revealed a  zwitterionic structure with a pentacoordinate, formally negatively charged silicon atom and a positively charged ammonium moiety. The silicon atom is surrounded by four oxygen atoms and one carbon atom in a trigonalbipyramidal fashion, with the carbon atom in an equatorial position. The structure is displaced by 7.0% from the trigonal bipyramid towards the square pyramid. The zwitterion and the CH3CN molecule form intermolecular N-H · · · N hydrogen bonds.
KW  - Kristallstruktur
KW  - Spirosilicate
KW  - crystal structure
KW  - zwitterionic spirosilicate
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86884
ER  - 
TY  - JOUR
A1  - Sperlich, Jörg
A1  - Becht, Joachim
A1  - Mühleisen, Mathias
A1  - Wagner, Stephan A.
A1  - Mattern, Günter
A1  - Tacke, Reinhold
T1  - Zwitterionische Bis[vic-arendiolato(2-)][(morpholinio)alkyl]silicate: Synthese sowie strukturelle Charakterisierung in Lösung und im Kristall
N2  - No abstract available.
KW  - Silicate
KW  - Bis[1,2-benzendiolato(2-)][(morpholinio)alkyl]silicates
KW  - Bis[2,3-naphthalenediolato(2-)][(morpholinio)alkyl]silicates
KW  - Zwitterionic [lambda]5-Spirosilicates
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-73153
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Bentlagem, A.
A1  - Towart, R.
A1  - Meyer, H.
A1  - Bossert, F.
A1  - Vater, W.
A1  - Stoepe, K.
T1  - Sila-Analoga von Nifedipin-ähnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin-3.5-dicarbonsäure-dialkylestern, I
N2  - no abstract available
KW  - Chemie
Y1  - 1980
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82430
ER  - 
TY  - JOUR
A1  - Mühleisen, M.
A1  - Tacke, Reinhold
T1  - Twofold deprotonated citric acid as a bidentate ligand of pentacoordinate silicon: synthesis and structural characterization of the zwitterionic \(\lambda_5\)Si-spirosilicate bis[citrato(2-)-O\(^3\),O\(^4\)][(dimethylammonio)methyl]silicate hydrate
N2  - The zwitterionic \(\lambda_5\) Si-spirosilicate bis[ citrato(2-)-0\(^3\) ,0\(^4\) )[ ( dimethylammonio) methyl]silicate (4) was synthesized by reaction of (MeO)\(_3\)SiCH\(_2\)NMe\(_2\) (3) with citric acid (molar ratio 1 :2) in acetonitrile at room temperature and isolated, after crystallization from water, as the hydrate 4 · H\(_2\)O (yield 81 %). The crystal structure of 4 · H\(_2\)O was studied by single-crystal X-ray diffraction. The alcoxide oxygen atoms and central carboxylate oxygen atoms of two citrato(2-) ligands and one carbon atom coordinate to the silicon atom of 4 · H\(_2\)O. The coordination polyhedron around the pentacoordinate silicon atom (SiO\(_4\)C framework) can be described as a distorted trigonal bipyramid, the two carboxylate oxygen atoms occupying the axial sites. The \(\lambda_5\) Si~silicon(IV) complex 4 also exists in solution (DMSO, H\(_2\)O).
KW  - Anorganische Chemie
KW  - Silicon
KW  - pentacoordinate
KW  - Lambda5Si-Spirosilicate
KW  - zwitterionic
KW  - Citrato(2-)-03
KW  - 04ligand
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64388
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Mühleisen, M.
T1  - Hexakoordiniertes Silicium in einer molekularen Verbindung mit einer F\(_5\)SiC-Einheit
N2  - No abstract available
KW  - Anorganische Chemie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64365
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Mühleisen, M.
A1  - Jones, P. G.
T1  - Das erste zwitterionische, optisch aktive Disilicat mit pentakoordiniertem Silicium
N2  - No abstract available
KW  - Anorganische Chemie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64343
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Wagner, S. A.
A1  - Sperlich, J.
T1  - Synthese von (-)-(Acetoxymethyl)(hydroxy-methyl)methyl(phenyl)german [(-)-MePhGe(CH\(_2\)OAc)(CH\(_2\)OH)] durch eine Esterase-katalysierte Umesterung: Die erste enzymatische Synthese eines optisch aktiven Germans
N2  - No abstract available.
KW  - Anorganische Chemie
KW  - Germane
KW  - optically active
KW  - Biotransformation
KW  - stereoselective Transesterification
KW  - enzymatic
KW  - Porcine liver esterase
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64310
ER  -