TY  - JOUR
A1  - Walther, Kay-Arne
A1  - Gonzales, José Roberto
A1  - Gröger, Sabine
A1  - Ehmke, Benjamin
A1  - Kaner, Dogan
A1  - Lorenz, Katrin
A1  - Eickholz, Peter
A1  - Kocher, Thomas
A1  - Kim, Ti-Sun
A1  - Schlagenhauf, Ulrich
A1  - Koch, Raphael
A1  - Meyle, Jörg
T1  - The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy
JF  - International Journal of Molecular Sciences
N2  - Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.
KW  - periodontitis
KW  - polymorphisms
KW  - risk factor
KW  - periodontal therapy
KW  - antibiotics
KW  - GATA-3
KW  - Interleukin-1
KW  - Interleukin-4
KW  - Cyclooxygenase-2
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284386
SN  - 1422-0067
VL  - 23
IS  - 13
ER  -