TY  - JOUR
A1  - Schartl, Manfred
A1  - Barnekow, Angelika
T1  - The expression in eukaryotes of a tyrosine kinase which is reactive with pp60v-src antibodies
N2  - All specimens of Eumetazoa and Parazoa, ranging from mammals, birds, teleosts, sharks, lampreys, amphioxus, insects, down to sponges showed the pp60c-src associated kinase activity, indicating that c-src, which is the cellular homologue of the oncogene v-src of Rous sarcoma virus (RSV) is probably present in all multicellular animals. Protozoa and plants did not show pp60c-src: kinase activity.
The degree of c-src expression depends on the taxonomic rank of the Eumetazoa tested, and is organ-specific with nervaus tissues displaying the highest kinase activities. In the central nervous system of mammals and birds we found a high c-src expression, and in that of the lampreys, amphioxus, and insects the lowest. Unexpectedly, total extracts of sponges showed an amount of pp60c-src kinase activity similar to that of brain cell extracts of mammals and birds. These findings suggest that pp60c-src is a phylogenetic old protein that might have evolved together with the multicellular organisation of Metazoa, and that might be of importance in proliferation and differentiation of nontransformed cells.
KW  - Protein-Tyrosin-Kinasen
KW  - Eukaryoten
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86208
ER  - 
TY  - JOUR
A1  - Schartl, Manfred
A1  - Barnekow, A.
A1  - Bauer, H.
A1  - Anders, F.
T1  - Correlations of inheritance and expression between a tumor gene and the cellular homolog of the Rous sarcoma virus-transforming gene in Xiphophorus
N2  - No abstract available
KW  - Physiologische Chemie
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61937
ER  - 
TY  - JOUR
A1  - Schartl, A.
A1  - Schartl, Manfred
A1  - Anders, F.
T1  - Promotion and regression of neoplasia by testosterone-promoted cell differentiation in Xiphophorus and Girardinus
N2  - No abstract available.
KW  - Schwertkärpfling
KW  - Lebendgebärende Zahnkarpfen
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86684
ER  - 
TY  - JOUR
A1  - Barnekow, A.
A1  - Schartl, Manfred
A1  - Anders, F.
A1  - Bauer, H.
T1  - Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein
N2  - No abstract available
KW  - Physiologische Chemie
Y1  - 1982
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61946
ER  -