TY  - JOUR
A1  - Falk, W.
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - 15-Deoxyspergualin (a new guanidine-like drug) blocks T lymphocyte proliferation
N2  - No abstract available
KW  - Chirurgie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45215
ER  - 
TY  - CHAP
A1  - Ulrichs, Karin
A1  - Euler, HH
A1  - Müller-Ruchholtz, W.
T1  - A Clinically Successful Protocol to Suppress Autoantibody Production in SLE Patients Is Analyzed For Its Efficacy To Inhibit Natural Xenophile Antibodies (NXA)
N2  - No abstract available
Y1  - 1991
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45693
ER  - 
TY  - JOUR
A1  - Müller-Buchholtz, W.
A1  - Leyhausen, G.
A1  - Peterson, P.
A1  - Schubert, G.
A1  - Ulrichs, Karin
T1  - A simple methodological principle for large scale extraction and purification of collagenase-digested islets
N2  - No abstract available
KW  - Chirurgie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44770
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Winoto-Morbach, S.
A1  - Hering, B.
A1  - Müller-Ruchholtz, W.
T1  - A Useful Biotechnological Approach to Solve the Problem of Graft Purity in Human Pancreatic Islet Transplantation
N2  - No abstract available
KW  - Chirurgie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45619
ER  - 
TY  - JOUR
A1  - Kekow, J.
A1  - Ulrichs, Karin
T1  - Determination of total immunoreactive rat insulin (IRI) in culture supernatants of rat islets by an enzyme linked immunosorbent assay (ELISA) as a routine method to assess the viability of rat islets prior to their use in islet transplantation
N2  - No abstract available
KW  - Immunobiologie
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72989
ER  - 
TY  - JOUR
A1  - Deltz, E.
A1  - Müller-Hermelink, HK
A1  - Ulrichs, Karin
A1  - Thiede, A.
A1  - Müller-Ruchholtz, W.
T1  - Development of graft-versus-host reaction in various target organs after small intestine transplantation
N2  - The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself.
KW  - Chirurgie
Y1  - 1981
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45459
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Wang, H.
A1  - Müller-Buchholtz, W.
T1  - Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model
N2  - No abstract available
KW  - Chirurgie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44733
ER  - 
TY  - CHAP
A1  - Wang, HY
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation
N2  - No abstract available
KW  - Immunbiologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45669
ER  - 
TY  - CHAP
A1  - Heiser, A.
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Enzyme Activities in Commercial Collagenase Preparations and Their Kinetics During Islet Isolation Procedure
N2  - No abstract available
KW  - Transplantation
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45633
ER  - 
TY  - CHAP
A1  - Heiser, A.
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Enzyme Kinetics of Commercial Collagenases and their Influence on Porcine Islet Isolation
N2  - No abstract available
KW  - Heterotransplantation
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45488
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues
N2  - No abstract available
KW  - Chirurgie
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45557
ER  - 
TY  - CHAP
A1  - Ulrichs, Karin
A1  - Eckstein, V.
A1  - Korsgren, O.
A1  - Müller-Ruchholtz, W.
T1  - Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA)
N2  - No abstract available
KW  - Immunbiologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45655
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Further Analyses of Pancreas Islet Immunogenicity, a Major Barrier to Successful Islet Transplantation
N2  - No abstract available
KW  - Chirurgie
Y1  - 1985
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45563
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Nöthling, R.
A1  - Keller, R.
A1  - Heusermann, U.
A1  - Müller-Buchholtz, W.
T1  - Genetically determined variation of constitutive major histocompatibility complex class II antigen expression in various rat strains and cell types
N2  - No abstract available
KW  - Chirurgie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44769
ER  - 
TY  - JOUR
A1  - Strauss, Armin
A1  - Moskalenko, Vasily
A1  - Tiurbe, Christian
A1  - Chodnevskaja, Irina
A1  - Timm, Stephan
A1  - Wiegering, Verena A.
A1  - Germer, Chrioph Thomas
A1  - Ulrichs, Karin
T1  - Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes
N2  - Purpose: Preclinical experiments on large animals are indispensable for evaluating the effectiveness of diabetes therapies. Miniature swine are well suited for such studies due to their physiological and pathophysiological responses. Methods: We compare two methods for inducing diabetes in Goettingen minipigs (GMP), in five with the beta cell toxin streptozotocin (STZ) and in five other GMP by total pancreatectomy (PE). Glucose homeostasis was assessed with the intravenous glucose-tolerance test (IVGTT) and continual monitoring of interstitial glucose levels. At conclusion of the observation period, the pancreata were examined histologically. Three non-diabetic GMP served as control group. Results: The IVGTT revealed markedly diabetic profiles in both GMP groups. STZ-GMP were found to harbor residual C-peptides and scattered insulin-positive cells in the pancreas. PE-GMP survived the total pancreatectomy only with intensive postoperative care. Conclusions: Although both methods reliably induced diabetes in GMP, the PE-GMP clearly had more health problems and required a greater expenditure of time and resources. The PE-GMP model, however, was better at eliminating endogenous insulin and C-peptide than the STZ-GMP model.
KW  - Göttingen
KW  - Minischwein
KW  - diabetes
KW  - pig or swine
KW  - real-time glucose monitoring
KW  - intravenous glucose tolerance test
KW  - total pancreatectomy
KW  - streptozotocin
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-75119
ER  - 
TY  - JOUR
A1  - Deltz, Eberhard
A1  - Ulrichs, Karin
A1  - Schack, Thorsten
A1  - Friedrichs, Birgit
A1  - Müller-Ruchholtz, Wolfgang
A1  - Müller-Hermelink, Hans K.
A1  - Thiede, Arnulf
T1  - Graft-versus-host reaction in small bowel transplantation and possibilities for its circumvention
N2  - No abstract available
KW  - Dünndarm
KW  - Transplantation
KW  - transplantation
KW  - small bowel
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64425
ER  - 
TY  - JOUR
A1  - Waaga, AM
A1  - Krzymanski, M.
A1  - Ulrichs, Karin
A1  - Wierusz-Wysocka, Bogna
A1  - Müller-Buchholtz, Wolfgang
T1  - Hematological effects of the new immunosuppressive drug 15-deoxyspergualin
N2  - Since systematic hematological studies on blood and bone marrow changes after treatment with 15-Deoxyspergualin (DOS) are lacking, a quantitative assessment was performed fourteen or twenty eight days after intraperitoneal application of DOS to rats. Further observations done 7 and 14 days after discontinuation of DOS administration allowed analysis of banc marrow regeneration. DOS induced lymphocytopenia, granUlocytopenia and anemia with a decrease of bone marrow cellularity due to suppression of cell maturation. The effect was dose-dependent and bone marrow as well as blood changes were observed in animals treated with doses from 0.5 to 10.0 mg/kg DOS. Within 14 days after termination of the treatment, rapid recovery with normalization of all hematological parameters was observed. In the light of our data, these hematological side effects may not be a major disadvantage, if DOS is used in doses below 2.5 mg/kg, and for a course of therapy which is limited to 7 to 14 days.
KW  - Chirurgie
KW  - 15-Deoxyspergualin
KW  - hematology
KW  - immunosuppression
KW  - bone marrow
KW  - regeneration
KW  - experimental therapy
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44701
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Bosse, M.
A1  - Wacker, HH
A1  - Heiser, A.
A1  - Müller-Ruchholtz, W.
T1  - Histologic analysis of the porcine pancreas to improve islet yield and integrity after collagenase digestion
N2  - No abstract available
KW  - Chirurgie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45166
ER  - 
TY  - GEN
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, W.
T1  - Identification and Manipulation of Human Islet Alloimmunogenicity: Morphologic and Functional in Vitro Studies with Various Islet Preparations
N2  - No abstract available
KW  - Immunbiologie
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45584
ER  - 
TY  - JOUR
A1  - Von Gaudecker, Brita
A1  - Ulrichs, Karin
A1  - Müller-Ruchholtz, Wolfgang
T1  - Immunoelectron microscopic localization of MHC structures in isolated pancreatic rat islets
N2  - An immunogold-silver enhancement technique, which combines effective labeling of viable isolated islets with the ultrastructural resolution of cytological details, was applied in electron microscopy to identify major histocompatibility complex (MHC) structures on islet cells. Incubation of freshly isolated islets from CAP (RT1C) and LEW (RT1') rats with OX18, an MHC class I antibody, showed strong positive reactivity in macrophages and/or dendritic-like cells (M0-DCs) and vascular endothelial cells (VEs) and a comparatively weaker reactivity in endocrine a-, p-, and 8-ce"s. With MHC class" antibody OX6 (anti-I-A), M0-DCs were strongly labeled in both rat strains on the surface and on internal structures. Three of five particularly high titered batches of OX6 revealed MHC class" expression on VE and p-ce"s. Four days of in vitro culture in combination with a high concentration of glucose and interferon-'Y induced strong enhancement of MHC class I structures and, to a lesser extent, class " structures on p-ce"s.
KW  - Immunbiologie
Y1  - 1989
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45596
ER  -