TY  - JOUR
A1  - Stauss, Dennis
A1  - Brunner, Cornelia
A1  - Berberich-Siebelt, Friederike
A1  - Höpken, Uta E.
A1  - Lipp, Martin
A1  - Müller, Gerd
T1  - The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6
JF  - Embo Journal
N2  - Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4\(^+\) T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by the Pou2af1 gene, promotes Bcl6 expression and Tfh cell development. We found that Bob1 together with the octamer transcription factors Oct1/Oct2 can directly bind to and transactivate the Bcl6 and Btla promoters. Mixed bone marrow chimeras revealed that Bob1 is required for the expression of normal levels of Bcl6 and BTLA, thereby controlling the pool size and composition of the Tfh compartment in a T cell-intrinsic manner. Our data indicate that T cell-expressed Bob1 is directly involved in Tfh cell differentiation and required for mounting normal T cell-dependent B-cell responses.
KW  - follicular T helper cells
KW  - germinal center
KW  - humoral immunity
KW  - Pou2af1
KW  - T cell differentiation
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189506
VL  - 35
IS  - 8
ER  -