TY  - THES
A1  - Huang, Yi
T1  - Structural and Functional Analysis of Chordin-like 2/BMP-2 Interaction
N2  - We have established the novel interaction between mCHL2, Tsg and BMP-2 for the first time. Tsg binds to VWC1 and VWC3 of mCHL2 in a cooperative waz and plazs a role in strengthening the binding affinity. Furthermore, Tsg/mCHL2/BMP-2 termary complex and Tsg/mCHL2 binary complex have been isolated by gel-filtration chromatography. Therefore mCHL2 can form a ternary complex with Tsg and BMP-2 and this complex makes mCHL2 a better BMP-2 antagnonist.
KW  - BMP-2
Y1  - 2008
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29120
ER  -