TY - JOUR A1 - Alrefai, Hani A1 - Muhammad, Khalid A1 - Rudolf, Ronald A1 - Pham, Duong Anh Thuy A1 - Klein-Hessling, Stefan A1 - Patra, Amiya K. A1 - Avots, Andris A1 - Bukur, Valesca A1 - Sahin,, Ugur A1 - Tenzer, Stefan A1 - Goebeler, Matthias A1 - Kerstan, Andreas A1 - Serfling, Edgar T1 - NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells JF - Nature Communications N2 - Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulminant inflammation upon IMQ exposure, whereas ablation of NFATc1 in B cells results in a suppression of Aldara-induced inflammation. In vitro, IMQ induces the proliferation and IL-10 expression by B cells that is blocked by BCR signals inducing NFATc1. By binding to HDAC1, a transcriptional repressor, and to an intronic site of the Il10 gene, NFATc1 suppresses IL-10 expression that dampens the production of tumour necrosis factor-α and IL-17 by T cells. These data indicate a close link between NFATc1 and IL-10 expression in B cells and suggest NFATc1 and, in particular, its inducible short isoform, NFATc1/αA, as a potential target to treat human psoriasis. KW - B cells KW - psoriasis KW - interleukins KW - inflammation Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-173053 VL - 7 ER - TY - JOUR A1 - Alnawaiseh, Maged A1 - Schubert, Friederike A1 - Nelis, Pieter A1 - Wirths, Gabriele A1 - Rosentreter, André A1 - Eter, Nicole T1 - Optical coherence tomography (OCT) angiography findings in retinal arterial macroaneurysms JF - BMC Ophthalmology N2 - Background Optical coherence tomography angiography is a novel imaging technique that allows dyeless in vivo visualization of the retinal and choroidal vasculature. The purpose of this study was to describe optical coherence tomography (OCT) angiography findings in patients with retinal arterial macroaneurysms (RAMs). Methods Three eyes of three patients with RAMs were retrospectively included. Fundus photography, OCT, fluorescein angiography (FA), and OCT angiography were performed. The entire imaging data was analyzed in detail. Results OCT angiography could detect the RAMs noninvasively without dye injection. By simultaneously observing the OCT scans, it was possible to determine the depth of the RAMs in the retina, to detect the exact localization in relation to the main vessel, and to determine the level of blood flow in the RAMs. Conclusions OCT angiography can clearly visualize RAMs without use of a dye. It also allows layer-specific observation of blood flow in each layer of the RAM. OCT angiography provides additional dynamic information on RAMs, which is not obtained with FA and facilitates a better understanding of its morphology and activity. This information in combination with ICG and fluorescein angiography can help to optimize direct laser treatment. KW - OCT angiography KW - Retinal arterial macroaneurysms KW - Fluorescein angiography Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-164702 VL - 16 IS - 120 ER - TY - JOUR A1 - Almanzar, Giovanni A1 - Klein, Matthias A1 - Schmalzing, Marc A1 - Hilligardt, Deborah A1 - El Hajj, Nady A1 - Kneitz, Hermann A1 - Wild, Vanessa A1 - Rosenwald, Andreas A1 - Benoit, Sandrine A1 - Hamm, Henning A1 - Tony, Hans-Peter A1 - Haaf, Thomas A1 - Goebeler, Matthias A1 - Prelog, Martina T1 - Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis JF - International Archives of Allergy and Immunology N2 - Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype. KW - methylation KW - systemic sclerosis KW - suppression KW - Tregs KW - Th17 Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196577 SN - 1018-2438 SN - 1423-0097 N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 171 IS - 2 ER - TY - JOUR A1 - Alma, Harma A1 - de Jong, Corina A1 - Jelusic, Danijel A1 - Wittmann, Michael A1 - Schuler, Michael A1 - Flokstra-de Blok, Bertine A1 - Kocks, Janwillem A1 - Schultz, Konrad A1 - van der Molen, Thys T1 - Health status instruments for patients with COPD in pulmonary rehabilitation: defining a minimal clinically important difference JF - npj Primary Care Respiration Medicine N2 - The minimal clinically important difference (MCID) defines to what extent change on a health status instrument is clinically relevant, which aids scientists and physicians in measuring therapy effects. This is the first study that aimed to establish the MCID of the Clinical chronic obstructive pulmonary disease (COPD) Questionnaire (CCQ), the COPD Assessment Test (CAT) and the St George’s Respiratory Questionnaire (SGRQ) in the same pulmonary rehabilitation population using multiple approaches. In total, 451 COPD patients participated in a 3-week Pulmonary Rehabilitation (PR) programme (58 years, 65% male, 43 pack-years, GOLD stage II/III/IV 50/39/11%). Techniques used to assess the MCID were anchor-based approaches, including patient-referencing, criterion-referencing and questionnaire-referencing, and the distribution-based methods standard error of measurement (SEM), 1.96SEM and half standard deviation (0.5s.d.). Patient- and criterion-referencing led to MCID estimates of 0.56 and 0.62 (CCQ); 3.12 and 2.96 (CAT); and 8.40 and 9.28 (SGRQ). Questionnaire-referencing suggested MCID ranges of 0.28–0.61 (CCQ), 1.46–3.08 (CAT) and 6.86–9.47 (SGRQ). The SEM, 1.96SEM and 0.5s.d. were 0.29, 0.56 and 0.46 (CCQ); 3.28, 6.43 and 2.80 (CAT); 5.20, 10.19 and 6.06 (SGRQ). Pooled estimates were 0.52 (CCQ), 3.29 (CAT) and 7.91 (SGRQ) for improvement. MCID estimates differed depending on the method used. Pooled estimates suggest clinically relevant improvements needing to exceed 0.40 on the CCQ, 3.00 on the CAT and 7.00 on the SGRQ for moderate to very severe COPD patients. The MCIDs of the CAT and SGRQ in the literature might be too low, leading to overestimation of treatment effects for patients with COPD. KW - COPD KW - rehabilitation KW - health status instruments Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-166327 VL - 26 IS - 16041 ER - TY - JOUR A1 - Ali, Qasim A1 - Montenegro, Sergio T1 - Decentralized control for scalable quadcopter formations JF - International Journal of Aerospace Engineering N2 - An innovative framework has been developed for teamwork of two quadcopter formations, each having its specified formation geometry, assigned task, and matching control scheme. Position control for quadcopters in one of the formations has been implemented through a Linear Quadratic Regulator Proportional Integral (LQR PI) control scheme based on explicit model following scheme. Quadcopters in the other formation are controlled through LQR PI servomechanism control scheme. These two control schemes are compared in terms of their performance and control effort. Both formations are commanded by respective ground stations through virtual leaders. Quadcopters in formations are able to track desired trajectories as well as hovering at desired points for selected time duration. In case of communication loss between ground station and any of the quadcopters, the neighboring quadcopter provides the command data, received from the ground station, to the affected unit. Proposed control schemes have been validated through extensive simulations using MATLAB®/Simulink® that provided favorable results. KW - scalable quadcopter Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-146704 VL - 2016 ER - TY - JOUR A1 - Ali, Qasim A1 - Montenegro, Sergio T1 - Explicit Model Following Distributed Control Scheme for Formation Flying of Mini UAVs JF - IEEE Access N2 - A centralized heterogeneous formation flight position control scheme has been formulated using an explicit model following design, based on a Linear Quadratic Regulator Proportional Integral (LQR PI) controller. The leader quadcopter is a stable reference model with desired dynamics whose output is perfectly tracked by the two wingmen quadcopters. The leader itself is controlled through the pole placement control method with desired stability characteristics, while the two followers are controlled through a robust and adaptive LQR PI control method. Selected 3-D formation geometry and static stability are maintained under a number of possible perturbations. With this control scheme, formation geometry may also be switched to any arbitrary shape during flight, provided a suitable collision avoidance mechanism is incorporated. In case of communication loss between the leader and any of the followers, the other follower provides the data, received from the leader, to the affected follower. The stability of the closed-loop system has been analyzed using singular values. The proposed approach for the tightly coupled formation flight of mini unmanned aerial vehicles has been validated with the help of extensive simulations using MATLAB/Simulink, which provided promising results. KW - quadcopter KW - robustness KW - intelligent vehicles KW - rotors KW - mathematical model KW - aerodynamics KW - adaptation models KW - vehicle dynamics KW - unmanned aerial vehicle KW - distributed control KW - formation flight KW - model following Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-146061 N1 - (c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works VL - 4 IS - 397-406 ER - TY - JOUR A1 - Albers, Gregory W. A1 - Bernstein, Richard A. A1 - Brachmann, Johannes A1 - Camm, John A1 - Easton, J. Donald A1 - Fromm, Peter A1 - Goto, Shinya A1 - Granger, Christopher B. A1 - Hohnloser, Stefan H. A1 - Hylek, Elaine A1 - Jaffer, Amir K. A1 - Krieger, Derk W. A1 - Passman, Rod A1 - Pines, Jesse M. A1 - Reed, Shelby D. A1 - Rothwell, Peter M. A1 - Kowey, Peter R. T1 - Heart Rhythm Monitoring Strategies for Cryptogenic Stroke: 2015 Diagnostics and Monitoring Stroke Focus Group Report JF - Journal of the American Heart Association N2 - No abstract available. KW - anticoagulants KW - atrial fibrillation KW - diagnosis KW - electrocardiography KW - insertable cardiac monitor KW - stroke prevention Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165709 VL - 5 IS - e00294 ER - TY - JOUR A1 - Ahmed, Zeeshan A1 - Zeeshan, Saman A1 - Dandekar, Thomas T1 - Mining biomedical images towards valuable information retrieval in biomedical and life sciences JF - Database - The Journal of Biological Databases and Curation N2 - Biomedical images are helpful sources for the scientists and practitioners in drawing significant hypotheses, exemplifying approaches and describing experimental results in published biomedical literature. In last decades, there has been an enormous increase in the amount of heterogeneous biomedical image production and publication, which results in a need for bioimaging platforms for feature extraction and analysis of text and content in biomedical images to take advantage in implementing effective information retrieval systems. In this review, we summarize technologies related to data mining of figures. We describe and compare the potential of different approaches in terms of their developmental aspects, used methodologies, produced results, achieved accuracies and limitations. Our comparative conclusions include current challenges for bioimaging software with selective image mining, embedded text extraction and processing of complex natural language queries. KW - humans KW - software KW - image processing KW - animals KW - computer-assisted KW - data mining/methods KW - natural language processing Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-162697 VL - 2016 ER - TY - JOUR A1 - Adrián-Martínez, S. A1 - Albert, A. A1 - André, M. A1 - Anton, G. A1 - Ardid, M. A1 - Aubert, J.-J. A1 - Avgitas, T. A1 - Baret, B. A1 - Barrios-Martí, J. A1 - Basa, S. A1 - Bertin, V. A1 - Biagi, S. A1 - Bormuth, R. A1 - Bouwhuis, M.C. A1 - Bruijn, R. A1 - Brunner, J. A1 - Busto, J. A1 - Capone, A. A1 - Caramete, L. A1 - Carr, J. A1 - Celli, S. A1 - Chiarusi, T. A1 - Circella, M. A1 - Coleiro, A. A1 - Coniglione, R. A1 - Costantini, H. A1 - Coyle, P. A1 - Creusot, A. A1 - Deschamps, A. A1 - De Bonis, G. A1 - Distefano, C. A1 - Donzaud, C. A1 - Dornic, D. A1 - Drouhin, D. A1 - Eberl, T. A1 - El Bojaddaini, I. A1 - Elsässer, D. A1 - Enzenhöfer, A. A1 - Fehn, K. A1 - Felis, I. A1 - Fusco, L.A. A1 - Galatà, S. A1 - Gay, P. A1 - Geißelsöder, S. A1 - Geyer, K. A1 - Giordano, V. A1 - Gleixner, A. A1 - Glotin, H. A1 - Gracia-Ruiz, R. A1 - Graf, K. A1 - Hallmann, S. A1 - van Haren, H. A1 - Heijboer, A.J. A1 - Hello, Y. A1 - Hernández-Rey, J.J. A1 - Hößl, J. A1 - Hofestädt, J. A1 - Hugon, C. A1 - Illuminati, G. A1 - James, C.W. A1 - de Jong, M. A1 - Jongen, M. A1 - Kadler, M. A1 - Kalekin, O. A1 - Katz, U. A1 - Kießling, D. A1 - Kouchner, A. A1 - Kreter, M. A1 - Kreykenbohm, I. A1 - Kulikovskiy, V. A1 - Lachaud, C. A1 - Lahmann, R. A1 - Lefèvre, D. A1 - Leonora, E. A1 - Loucatos, S. A1 - Marcelin, M. A1 - Margiotta, A. A1 - Marinelli, A. A1 - Martínez-Mora, J.A. A1 - Mathieu, A. A1 - Melis, K. A1 - Michael, T. A1 - Migliozzi, P. A1 - Moussa, A. A1 - Mueller, C. A1 - Nezri, E. A1 - Pavalas, G.E. A1 - Pellegrino, C. A1 - Perrina, C. A1 - Piattelli, P. A1 - Popa, V. A1 - Pradier, T. A1 - Racca, C. A1 - Riccobene, G. A1 - Roensch, K. A1 - Saldaña, M. A1 - Samtleben, D.F.E. A1 - Sánchez-Losa, A. A1 - Sanguineti, M. A1 - Sapienza, P. A1 - Schnabel, J. A1 - Schüssler, F. A1 - Seitz, T. A1 - Sieger, C. A1 - Spurio, M. A1 - Stolarczyk, Th. A1 - Taiuti, M. A1 - Tönnis, C. A1 - Trovato, A. A1 - Tselengidou, M. A1 - Turpin, D. A1 - Vallage, B. A1 - Vallée, C. A1 - Van Elewyck, V. A1 - Vivolo, D. A1 - Wagner, S. A1 - Wilms, J. A1 - Zornoza, J.D. A1 - Zúñiga, J. T1 - Limits on dark matter annihilation in the sun using the ANTARES neutrino telescope JF - Physics Letters B N2 - A search for muon neutrinos originating from dark matter annihilations in the Sun is performed using the data recorded by the ANTARES neutrino telescope from 2007 to 2012. In order to obtain the best possible sensitivities to dark matter signals, an optimisation of the event selection criteria is performed taking into account the background of atmospheric muons, atmospheric neutrinos and the energy spectra of the expected neutrino signals. No significant excess over the background is observed and 90% C.L. upper limits on the neutrino flux, the spin-dependent and spin-independent WIMP-nucleon cross-sections are derived for WIMP masses ranging from 50 GeV to 5 TeV for the annihilation channels WIMP + WIMP→ b\(\overline{b}\), W\(^{+}\)W\(^{−}\) and τ\(^{+}\)τ\(^{−}\). KW - dark matter KW - WIMP KW - neutralino KW - indirect detection KW - neutrino telescope KW - sun Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-166642 VL - 759 ER - TY - JOUR A1 - Adrián-Martínez, S. A1 - Albert, A. A1 - André, M. A1 - Anton, G. A1 - Ardid, M. A1 - Aubert, J.-J. A1 - Avgitas, T. A1 - Baret, B. A1 - Barrios-Martí, J. A1 - Basa, S. A1 - Bertin, V. A1 - Biagi, S. A1 - Bormuth, R. A1 - Bou-Cabo, M. A1 - Bouwhuis, M.C. A1 - Bruijn, R. A1 - Brunner, J. A1 - Busto, J. A1 - Capone, A. A1 - Caramete, L. A1 - Carr, J. A1 - Celli, S. A1 - Chiarusi, T. A1 - Circella, M. A1 - Coleiro, A. A1 - Coniglione, R. A1 - Costantini, H. A1 - Coyle, P. A1 - Creusot, A. A1 - Deschamps, A. A1 - De Bonis, G. A1 - Distefano, C. A1 - Donzaud, C. A1 - Dornic, D. A1 - Drouhin, D. A1 - Eberl, T. A1 - El Bojaddaini, I. A1 - Elsässer, D. A1 - Enzenhöfer, A. A1 - Fehn, K. A1 - Felis, I. A1 - Fusco, L.A. A1 - Galatà, S. A1 - Gay, P. A1 - Geißelsöder, S. A1 - Geyer, K. A1 - Giordano, V. A1 - Gleixner, A. A1 - Glotin, H. A1 - Gracia-Ruiz, R. A1 - Graf, K. A1 - Hallmann, S. A1 - van Haren, H. A1 - Heijboer, A.J. A1 - Hello, Y. A1 - Hernández-Rey, J.-J. A1 - Hößl, J. A1 - Hofestädt, J. A1 - Hugon, C. A1 - Illuminati, G. A1 - James, C.W. A1 - de Jong, M. A1 - Kadler, M. A1 - Kalekin, O. A1 - Katz, U. A1 - Kießling, D. A1 - Kouchner, A. A1 - Kreter, M. A1 - Kreykenbohm, I. A1 - Kulikovskiy, V. A1 - Lachaud, C. A1 - Lahmann, R. A1 - Lefèvre, D. A1 - Leonora, E. A1 - Loucatos, S. A1 - Marcelin, M. A1 - Margiotta, A. A1 - Marinelli, A. A1 - Martínez-Mora, J.A. A1 - Mathieu, A. A1 - Michael, T. A1 - Migliozzi, P. A1 - Moussa, A. A1 - Mueller, C. A1 - Nezri, E. A1 - Păvălaș, G.E. A1 - Pellegrino, C. A1 - Perrina, C. A1 - Piattelli, P. A1 - Popa, V. A1 - Pradier, T. A1 - Racca, C. A1 - Riccobene, G. A1 - Roensch, K. A1 - Saldaña, M. A1 - Samtleben, D.F.E. A1 - Sanguineti, M. A1 - Sapienza, P. A1 - Schnabel, J. A1 - Schüssler, F. A1 - Seitz, T. A1 - Sieger, C. A1 - Spurio, M. A1 - Stolarczyk, Th. A1 - Sánchez-Losa, A. A1 - Taiuti, M. A1 - Trovato, A. A1 - Tselengidou, M. A1 - Turpin, D. A1 - Tönnis, C. A1 - Vallage, B. A1 - Vallée, C. A1 - Van Elewyck, V. A1 - Vivolo, D. A1 - Wagner, S. A1 - Wilms, J. A1 - Zornoza, J.D. A1 - Zúñiga, J. T1 - A search for Secluded Dark Matter in the Sun with the ANTARES neutrino telescope JF - Journal of Cosmology and Astroparticle Physics N2 - A search for Secluded Dark Matter annihilation in the Sun using 2007-2012 data of the ANTARES neutrino telescope is presented. Three different cases are considered: a) detection of dimuons that result from the decay of the mediator, or neutrino detection from: b) mediator that decays into a dimuon and, in turn, into neutrinos, and c) mediator that decays directly into neutrinos. As no significant excess over background is observed, constraints are derived on the dark matter mass and the lifetime of the mediator. KW - dark matter experiments KW - neutrino detectors KW - dark matter detectors KW - neutrino astronomy Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189035 VL - 2016 IS - 5 ER - TY - JOUR A1 - Adrián-Martínez, S. A1 - Albert, A. A1 - André, M. A1 - Anghinolfi, M. A1 - Anton, G. A1 - Ardid, M. A1 - Aubert, J.-J. A1 - Avgitas, T. A1 - Baret, B. A1 - Barrios-Martí, J. A1 - Basa, S. A1 - Bertin, V. A1 - Biagi, S. A1 - Bormuth, R. A1 - Bouwhuis, M.C. A1 - Bruijn, R. A1 - Brunner, J. A1 - Busto, J. A1 - Capone, A. A1 - Caramete, L. A1 - Carr, J. A1 - Celli, S. A1 - Chiarusi, T. A1 - Circella, M. A1 - Coleiro, A. A1 - Coniglione, R. A1 - Constantini, H. A1 - Coyle, P. A1 - Creusot, A. A1 - Deschamps, A. A1 - De Bonis, G. A1 - Distefano, C. A1 - Donzaud, C. A1 - Dornic, D. A1 - Drouhin, D. A1 - Eberl, T. A1 - El Bojaddaini, I. A1 - Elsässer, D. A1 - Enzenhöfer, A. A1 - Fehn, K. A1 - Felis, I. A1 - Fusco, L.A. A1 - Galatà, S. A1 - Gay, P. A1 - Geißelsöder, S. A1 - Geyer, K. A1 - Giordano, V. A1 - Gleixner, A. A1 - Glotin, H. A1 - Gracia-Ruiz, R. A1 - Graf, K. A1 - Hallmann, S. A1 - van Haren, H. A1 - Heijboer, A.J. A1 - Hello, Y. A1 - Hernández-Rey, J.J. A1 - Hößl, J. A1 - Hofestädt, J. A1 - Hugon, C. A1 - Illuminati, G. A1 - James, C.W. A1 - de Jong, M. A1 - Kadler, M. A1 - Kalekin, O. A1 - Katz, U. A1 - Kießling, D. A1 - Kouchner, A. A1 - Kreter, M. A1 - Kreykenbohm, I. A1 - Kulikovskiy, V. A1 - Lachaud, C. A1 - Lahmann, R. A1 - Lefèvre, D. A1 - Leonora, E. A1 - Loucatos, S. A1 - Marcelin, M. A1 - Margiotta, A. A1 - Marinelli, A. A1 - Martínez-Mora, J.A. A1 - Mathieu, A. A1 - Michael, T. A1 - Migliozzi, P. A1 - Moussa, A. A1 - Mueller, C. A1 - Nezri, E. A1 - Pavalas, G.E. A1 - Pellegrino, C. A1 - Perrina, C. A1 - Piattelli, P. A1 - Popa, V. A1 - Pradier, T. A1 - Racca, C. A1 - Riccobene, G. A1 - Roensch, K. A1 - Saldaña, M. A1 - Samtleben, D.F.E. A1 - Sánchez-Losa, A. A1 - Sanguineti, M. A1 - Sapienza, P. A1 - Schnabel, J. A1 - Schüssler, F. A1 - Seitz, T. A1 - Sieger, C. A1 - Spurio, M. A1 - Stolarczyk, Th. A1 - Taiuti, M. A1 - Trovato, A. A1 - Tselengidou, M. A1 - Turpin, D. A1 - Tönnis, C. A1 - Vallage, B. A1 - Vallée, C. A1 - Van Elewyck, V. A1 - Visser, E. A1 - Vivolo, D. A1 - Wagner, S. A1 - Wilms, J. A1 - Zornoza, J.D. A1 - Zúñiga, J. T1 - Constraints on the neutrino emission from the Galactic Ridge with the ANTARES telescope JF - Physics Letters B N2 - A highly significant excess of high-energy astrophysical neutrinos has been reported by the IceCube Collaboration. Some features of the energy and declination distributions of IceCube events hint at a North/South asymmetry of the neutrino flux. This could be due to the presence of the bulk of our Galaxy in the Southern hemisphere. The ANTARES neutrino telescope, located in the Mediterranean Sea, has been taking data since 2007. It offers the best sensitivity to muon neutrinos produced by galactic cosmic ray interactions in this region of the sky. In this letter a search for an extended neutrino flux from the Galactic Ridge region is presented. Different models of neutrino production by cosmic ray propagation are tested. No excess of events is observed and upper limits for different neutrino flux spectral indices Γ are set. For Γ=2.4 the 90% confidence level flux upper limit at 100 TeV for one neutrino flavour corresponds to Φ\(^{1f}_{0}\) (100 TeV) = 2.0 · 10\(^{−17}\) GeV\(^{−1}\) cm\(^{−2}\)s\(^{−1}\)sr\(^{−1}\). Under this assumption, at most two events of the IceCube cosmic candidates can originate from the Galactic Ridge. A simple power-law extrapolation of the Fermi-LAT flux to account for IceCube High Energy Starting Events is excluded at 90% confidence level. KW - neutrino emission KW - Galactic Ridge KW - ANTARES telescope Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-166608 VL - 760 ER - TY - JOUR A1 - Adrián-Martínez, S. A1 - Ageron, M. A1 - Aharonian, F. A1 - Aiello, S. A1 - Albert, A. A1 - Ameli, F. A1 - Annasontzis, E. A1 - Andre, M. A1 - Androulakis, G. A1 - Anghinolfi, M. A1 - Anton, G. A1 - Ardid, M. A1 - Avgitas, T. A1 - Barbarino, G. A1 - Baret, B. A1 - Barrios-Martí, J. A1 - Belhorma, B. A1 - Belias, A. A1 - Berbee, A. A1 - van den Berg, A. A1 - Bertin, V. A1 - Beurthey, S. A1 - van Beeveren, V. A1 - Beverini, N. A1 - Biagi, S. A1 - Biagioni, A. A1 - Billault, M. A1 - Bondì, M. A1 - Bormuth, R. A1 - Bouhadef, B. A1 - Bourlis, G. A1 - Bourret, S. A1 - Boutonnet, C. A1 - Bouwhuis, M. A1 - Bozza, C. A1 - Bruijn, R. A1 - Brunner, J. A1 - Buis, E. A1 - Busto, J. A1 - Cacopardo, G. A1 - Caillat, L. A1 - Calmai, M. A1 - Calvo, D. A1 - Capone, A. A1 - Caramete, L. A1 - Cecchini, S. A1 - Celli, S. A1 - Champion, C. A1 - Cherkaoui El Moursli, R. A1 - Cherubini, S. A1 - Chiarusi, T. A1 - Circella, M. A1 - Classen, L. A1 - Cocimano, R. A1 - Coelho, J. A. B. A1 - Coleiro, A. A1 - Colonges, S. A1 - Coniglione, R. A1 - Cordelli, M. A1 - Cosquer, A. A1 - Coyle, P. A1 - Creusot, A. A1 - Cuttone, G. A1 - D'Amico, A. A1 - De Bonis, G. A1 - De Rosa, G. A1 - De Sio, C. A1 - Di Capua, F. A1 - Di Palma, I. A1 - Díaz García, A. F. A1 - Distefano, C. A1 - Donzaud, C. A1 - Dornic, D. A1 - Dorosti-Hasankiadeh, Q. A1 - Drakopoulou, E. A1 - Drouhin, D. A1 - Drury, L. A1 - Durocher, M. A1 - Eberl, T. A1 - Eichie, S. A1 - van Eijk, D. A1 - El Bojaddaini, I. A1 - El Khayati, N. A1 - Elsaesser, D. A1 - Enzenhöfer, A. A1 - Fassi, F. A1 - Favali, P. A1 - Fermani, P. A1 - Ferrara, G. A1 - Filippidis, C. A1 - Frascadore, G. A1 - Fusco, L. A. A1 - Gal, T. A1 - Galatà, S. A1 - Garufi, F. A1 - Gay, P. A1 - Gebyehu, M. A1 - Giordano, V. A1 - Gizani, N. A1 - Gracia, R. A1 - Graf, K. A1 - Grégoire, T. A1 - Grella, G. A1 - Habel, R. A1 - Hallmann, S. A1 - van Haren, H. A1 - Harissopulos, S. A1 - Heid, T. A1 - Heijboer, A. A1 - Heine, E. A1 - Henry, S. A1 - Hernández-Rey, J. J. A1 - Hevinga, M. A1 - Hofestädt, J. A1 - Hugon, C. M. F. A1 - Illuminati, G. A1 - James, C. W. A1 - Jansweijer, P. A1 - Jongen, M. A1 - de Jong, M. A1 - Kadler, M. A1 - Kalekin, O. A1 - Kappes, A. A1 - Katz, U. F. A1 - Keller, P. A1 - Kieft, G. A1 - Kießling, D. A1 - Koffeman, E. N. A1 - Kooijman, P. A1 - Kouchner, A. A1 - Kulikovskiy, V. A1 - Lahmann, R. A1 - Lamare, P. A1 - Leisos, A. A1 - Leonora, E. A1 - Lindsey Clark, M. A1 - Liolios, A. A1 - Llorenz Alvarez, C. D. A1 - Lo Presti, D. A1 - Löhner, H. A1 - Lonardo, A. A1 - Lotze, M. A1 - Loucatos, S. A1 - Maccioni, E. A1 - Mannheim, K. A1 - Margiotta, A. A1 - Marinelli, A. A1 - Mariş, O. A1 - Markou, C. A1 - Martínez-Mora, J. A. A1 - Martini, A. A1 - Mele, R. A1 - Melis, K. W. A1 - Michael, T. A1 - Migliozzi, P. A1 - Migneco, E. A1 - Mijakowski, P. A1 - Miraglia, A. A1 - Mollo, C. M. A1 - Mongelli, M. A1 - Morganti, M. A1 - Moussa, A. A1 - Musico, P. A1 - Musumeci, M. A1 - Navas, S. A1 - Nicoleau, C. A. A1 - Olcina, I. A1 - Olivetto, C. A1 - Orlando, A. A1 - Papaikonomou, A. A1 - Papaleo, R. A1 - Păvălaş, G. E. A1 - Peek, H. A1 - Pellegrino, C. A1 - Perrina, C. A1 - Pfutzner, M. A1 - Piattelli, P. A1 - Pikounis, K. A1 - Poma, G. E. A1 - Popa, V. A1 - Pradier, T. A1 - Pratolongo, F. A1 - Pühlhofer, G. A1 - Pulvirenti, S. A1 - Quinn, L. A1 - Racca, C. A1 - Raffaelli, F. A1 - Randazzo, N. A1 - Rapidis, P. A1 - Razis, P. A1 - Real, D. A1 - Resvanis, L. A1 - Reubelt, J. A1 - Riccobene, G. A1 - Rossi, C. A1 - Rovelli, A. A1 - Saldaña, M. A1 - Salvadori, I. A1 - Samtleben, D. F. E. A1 - Sánchez García, A. A1 - Sánchez Losa, A. A1 - Sanguineti, M. A1 - Santangelo, A. A1 - Santonocito, D. A1 - Sapienza, P. A1 - Schimmel, F. A1 - Schmelling, J. A1 - Sciacca, V. A1 - Sedita, M. A1 - Seitz, T. A1 - Sgura, I. A1 - Simeone, F. A1 - Siotis, I. A1 - Sipala, V. A1 - Spisso, B. A1 - Spurio, M. A1 - Stavropoulos, G. A1 - Steijger, J. A1 - Stellacci, S. M. A1 - Stransky, D. A1 - Taiuti, M. A1 - Tayalati, Y. A1 - Tézier, D. A1 - Theraube, S. A1 - Thompson, L. A1 - Timmer, P. A1 - Tönnis, C. A1 - Trasatti, L. A1 - Trovato, A. A1 - Tsirigotis, A. A1 - Tzamarias, S. A1 - Tzamariudaki, E. A1 - Vallage, B. A1 - Van Elewyk, V. A1 - Vermeulen, J. A1 - Vicini, P. A1 - Viola, S. A1 - Vivolo, D. A1 - Volkert, M. A1 - Voulgaris, G. A1 - Wiggers, L. A1 - Wilms, J. A1 - de Wolf, E. A1 - Zachariadou, K. A1 - Zornoza, J. D. A1 - Zúñiga, J. T1 - Letter of intent for KM3NeT 2.0 JF - Journal of Physics G-Nuclear and Particle Physics N2 - The main objectives of the KM3NeT Collaboration are (i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and (ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: (1) the high-energy astrophysical neutrino signal reported by IceCube and (2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergistic opportunities for the Earth and sea sciences community. Three suitable deep-sea sites are selected, namely off-shore Toulon (France), Capo Passero (Sicily, Italy) and Pylos (Peloponnese, Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a three-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be sparsely configured to fully explore the IceCube signal with similar instrumented volume, different methodology, improved resolution and KW - neutrino astronomy KW - eutrino physics KW - deep sea neutrino telescope KW - neutrino mass hierarchy Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-188050 VL - 43 IS - 8 ER - TY - JOUR A1 - Adolfi, Mateus C. A1 - Herpin, Amaury A1 - Regensburger, Martina A1 - Sacquegno, Jacopo A1 - Waxman, Joshua S. A1 - Schartl, Manfred T1 - Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka JF - Scientific Reports N2 - In vertebrates, one of the first recognizable sex differences in embryos is the onset of meiosis, known to be regulated by retinoic acid (RA) in mammals. We investigated in medaka a possible meiotic function of RA during the embryonic sex determination (SD) period and in mature gonads. We found RA mediated transcriptional activation in germ cells of both sexes much earlier than the SD stage, however, no such activity during the critical stages of SD. In adults, expression of the RA metabolizing enzymes indicates sexually dimorphic RA levels. In testis, RA acts directly in Sertoli, Leydig and pre-meiotic germ cells. In ovaries, RA transcriptional activity is highest in meiotic oocytes. Our results show that RA plays an important role in meiosis induction and gametogenesis in adult medaka but contrary to common expectations, not for initiating the first meiosis in female germ cells at the SD stage. KW - developmental biology KW - molecular biology Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-147843 VL - 6 ER - TY - JOUR A1 - Acqualagna, Laura A1 - Botrel, Loic A1 - Vidaurre, Carmen A1 - Kübler, Andrea A1 - Blankertz, Benjamin T1 - Large-Scale Assessment of a Fully Automatic Co-Adaptive Motor Imagery-Based Brain Computer Interface JF - PLoS ONE N2 - In the last years Brain Computer Interface (BCI) technology has benefited from the development of sophisticated machine leaning methods that let the user operate the BCI after a few trials of calibration. One remarkable example is the recent development of co-adaptive techniques that proved to extend the use of BCIs also to people not able to achieve successful control with the standard BCI procedure. Especially for BCIs based on the modulation of the Sensorimotor Rhythm (SMR) these improvements are essential, since a not negligible percentage of users is unable to operate SMR-BCIs efficiently. In this study we evaluated for the first time a fully automatic co-adaptive BCI system on a large scale. A pool of 168 participants naive to BCIs operated the co-adaptive SMR-BCI in one single session. Different psychological interventions were performed prior the BCI session in order to investigate how motor coordination training and relaxation could influence BCI performance. A neurophysiological indicator based on the Power Spectral Density (PSD) was extracted by the recording of few minutes of resting state brain activity and tested as predictor of BCI performances. Results show that high accuracies in operating the BCI could be reached by the majority of the participants before the end of the session. BCI performances could be significantly predicted by the neurophysiological indicator, consolidating the validity of the model previously developed. Anyway, we still found about 22% of users with performance significantly lower than the threshold of efficient BCI control at the end of the session. Being the inter-subject variability still the major problem of BCI technology, we pointed out crucial issues for those who did not achieve sufficient control. Finally, we propose valid developments to move a step forward to the applicability of the promising co-adaptive methods. KW - large-scale assessment KW - Brain Computer Interface KW - machine leaning KW - fully automatic KW - co-adaptive Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-167230 VL - 11 IS - 2 ER - TY - JOUR T1 - The prototype detection unit of the KM3NeT detector JF - The European Physical Journal C N2 - A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80 km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the 40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 h of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3∘. KW - Zenith Angle KW - Remotely Operate Vehicle KW - Combinatorial Background KW - Time Calibration KW - Neutrino Telescope Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-165159 VL - 76 IS - 54 ER - TY - JOUR T1 - Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment JF - Leukemia N2 - Tyrosine kinase inhibitors represent today's treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective randomized CML-study IIIA recruited 669 patients with newly diagnosed CML between July 1997 and January 2004 from 143 centers. Of these, 427 patients were considered eligible for HSCT and were randomized by availability of a matched family donor between primary HSCT (group A; N = 166 patients) and best available drug treatment (group B; N = 261). Primary end point was long-term survival. Survival probabilities were not different between groups A and B (10-year survival: 0.76 (95% confidence interval (CI): 0.69-0.82) vs 0.69 (95% CI: 0.61-0.76)), but influenced by disease and transplant risk. Patients with a low transplant risk showed superior survival compared with patients with high( P < 0.001) and non-high-risk disease (P = 0.047) in group B; after entering blast crisis, survival was not different with or without HSCT. Significantly more patients in group A were in molecular remission (56% vs 39%; P = 0.005) and free of drug treatment (56% vs 6%; P < 0.001). Differences in symptoms and Karnofsky score were not significant. In the era of tyrosine kinase inhibitors, HSCT remains a valid option when both disease and transplant risk are considered. KW - chronic myelogenous leukemia KW - hematopoietic SCT KW - interferon-alpha KW - molecular response in cml KW - Imatinib KW - european leukemia net Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-190738 VL - 30 IS - 3 SP - 562 EP - 569 ER -