TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mephenhydramins T1 - Sila-Analogues of Mephenhydramine N2 - Sila-Analogues A 2, B 2 and C 2 of the drug mephenhydramine from the class of benzhydryl ethers were synthesized for the first time by the steps shown in scheme 1, and they and their precursors I-V characterized by their physical {table 1) and chemical properties, and their structures confirmed by NMR, n1ass and infrared spectroscopy (tables 3-5). Their physiological effects were investigated a.nd compared -with those of the parent carbon compounds (section 5). KW - Anorganische Chemie Y1 - 1975 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63525 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Chlorphenoxamins und des Clofenetamins T1 - Sila-Analogues of Ohlorphenoxamine and Clofenetamine N2 - Sila-ana.logues A 2 and B 2 of two drugs from the benzhydryl ether class, chlorphenoxamine and clofenetamine, were synthesized for the first time by the steps shown in scheme 1. They and their precursors I-VI v;rere characterized by their physical (Table 1) and chemical properties and their structures confirmed by n.m.r., mass and infrared spectroscopy (Tab]es 2-5). Their physiological effects were invest.igated and compared with those of the carbon analogues (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63531 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analoga des Mebrophenhydramins T1 - Sila-Analogues of Mebrophenhydramine N2 - Sila-analogues A 2, B 2 and C 2 of the drug mebrophenhydramine from the class of benzhydryl ethers -were synthesized for the first time by the steps shown in scheme 1, and they and their precurso:rs I-Ill were characterized by their physical (Table 1) and chemical properties, a.nd their structures confirmed by NMR, mass and infrared spectroscopy (Tables 3-5). The histaminolytic and anticholinergic effects of A 2 and C 2 were investigated and compared with some structure-activity relationships of analogue carbon compounds. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63542 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Sila-Analogon des Cicloniumbromids T1 - Sila-Analogue of Ciclonium Bromide N2 - Sila-Analogues B 2 and A 2 of the spasmolytic ciclonium bromide (B 1) respectively the corresponding free base A 1 were synthesized for the first time according to the reaction steps sho·wn in scheme 1, and they and their precursors I and II were characterized by ph;ysical (Table 1} and chemical properties and their structures confirmed by NMR, and mass spectroscopy (Tables 2 and 3}. The pharmacological effects of A 2 and B 2 were investigated and compared with those of the parent carbon compound B 1 (chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63556 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Derivate des Sila-Mephenhydramins und Sila-Chlorphenoxamins T1 - Derivatives of Sila-Mephenhydramine and Sila-Ohlorphenoxamine N2 - Derivatives A and B of the two sila-antihistam.ines silamephenhydramine and sila-chlorphenoxamine were synthesized for the first time by the steps shown in scheme 1. They and their precursors III and IV were characterized by their physical (Table 1) and chemical properties and their structures confirmed by NMR and mass spectroscopy (Tables 2 and 3). Their pharmacological effects were investigated and compared with those of the corresponding sila-antihistamines. KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63562 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Isoelektronische Derivate des Sila-Clofenetamins und des Sila-Mebrophenhydramins T1 - Isoelectronic Derivatives of Sila-Clofenetamine and Sila-Mebrophenhydramine N2 - Isoelectronic derivatives (A and B) and a homolog (C) of the two sila-antihistamines sila-clofenetamine and silamebrophenhydramine were synthesized for the first time by the steps shown in scheme 1. They and their unknown precursors II-IV were characterized by their physical (Table 1) and chemical properties and their structures confinned by lH-NMR and rnass spectroscopy (Tables 2 and 3). The pharrnacological effects of A and B were investigated and compared with those of the corresponding 0-isosteric sila-antihistarnines (Chapter 5). KW - Anorganische Chemie Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63574 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - N-Quaternäre Derivate basischer Sila-benzhydryläther T1 - N-Quaternary Derivatives of Basic Silabenzhydryl Ethers N2 - Die quartären Ammoniumsalze 1-10 einiger bioaktiver Sila-benzhydryläther wurden erstmalig durch Reaktion der entsprechenden freien Basen A-E mit CH\(_3\)J, CH\(_3\)Br bzw. CH\(_3\)Cl in CH\(_3\)CN dargestellt. Die Strukturen von 1-10 wurden durch Elementaranalysen und 1 H-NMR-Spektren bestätigt. Die pharmakologischen Effekte einiger Verbindungen wurden sowohl mit den Eigenschaft der entsprechenden freien Basen als auch mit einigen Struktur-Wirkungsbeziehungen analoger Kohlenstoffverbindungen verglichen. N2 - Quaternary ammonium salts 1-10 of some biologically active silabenzhydryl ethers were synthesized for the frrst time by the reaction of the corresponding free bases A-E with CH\(_3\)I, CH\(_3\)Br or CH\(_3\)Cl in CH\(_3\)CN. The structures of 1-10 were confirmed by elementary analysis and 1 HNMR spectroscopy. The pharmacological effects of some compounds were compared with those of the corresponding free bases and of analogaus carbon cornpounds. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63583 ER - TY - JOUR A1 - Tacke, Reinhold T1 - Sila-Analoga des Meflophenhydramins T1 - Sila-analogues of Meflophenhydramine N2 - Die Sila-Analoga A, 8, C des Antihistaminikums Meflophenhydramin, sowie die Derivate D und E, das Hydrolyseprodukt 8 und die Vorstufen 3-7 wurden dargestellt. Die chemischen und physikalischen Eigenschaften aller Verbindungen und das pharmakologische Verhalten von A-D und 8 wurden untersucht. N2 - Sila-analogues A, 8, C of the antihistamine meflophenhydramine as weil as the derivatives D and E, the product of hydrolysis 8 and the precursors 3-7 were synthesized. The chemical and physical properties and the pharmacological behaviour of A-D and 8 are described. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63594 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Saad, S. M. T1 - Silylation of cellulose N2 - Ethane-l:2-diol and propane-l:3-diol reaet with 1: 1:3:3-tetramethyl-l:3-dichlorodisiloxane forming the corresponding rings. However, no ring compounds could be traced tbrough the reaction between butane-l :4-diol, glycerol and the dichlorodisiloxane respectively, where only polymeric compounds are formed. The silylation products of the di- and trihydroxy alcohols, as model compounds, has confirmed that the ring formation during silylation of cellulose with dichlorodisiloxane is uncertain. KW - Anorganische Chemie Y1 - 1977 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78368 ER - TY - JOUR A1 - Werner, H. A1 - Leonhard, K. A1 - Burschka, Christian T1 - Basische Metalle: IX. Synthese und Kristallstruktur von C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) : Reaktionen zu zweikernkomplexen mit Co(SCS)Cr- und Co(SCS)Mn-Brückenbindungen T1 - Basic metals. IX. Synthesis and crystal structure of C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\). Reactions to binuclear complexes with Co(SCS)Cr and Co(SCS)Mn bridging compounds. N2 - Durch Reaktion von C\(_5\)H\(_5\)Co(PMe\(_3\))\(_2\) (I) oder des Hetero-Zweikernkomplexes C\(_5\)H\(_5\)(PMe\(_3\))Co(CO)\(_2\)Mn(CO)C\(_3\)H .. Me (III) mit CS\(_2\) entsteht in praktisch quantitativer Ausbeute C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) (IV). Die Kristallstruktur zeigt, dass der Carbondisulfid-Ligal'ld iiber Kohlenstoff und ein Schwefelatom (S(2)) dihaptogebunden vorliegt (Co-C = 1.89, Co-S(2) = 2.24 A, S(2)-C-S(1) = 141.2°). Die beiden C-S-AbsUinde in IV (C-S(2) = 1.68, C-S(l) = 1.60 A) sind gegenliber dem C-S-Abstand in freiem CS\(_2\) (1.554 A) aufgeweitet, was in Einklang mit dem aus spektroskopischen Daten zu folgernden starken 1T-Akzeptorcharakter von h\(^2\)-CS\(_2\) steht. IV reagiert mit Cr(CO)\(_5\)THF und C\(_5\)H\(_5\)Mn(CO)\(_2\)THF zu den Komplexen C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Cr(CO)\(_5\) (V) bzw. C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Mn(CO)\(_2\)C\(_5\)H\(_5\) (VI), in den en das in IV nicht am Cobalt gebundene Schwefelatom S(l) als Koordinationspartner gegenüber den 16-Elektronen-Fragmenten Cr(CO)\(_5\) und Mn(CO)\(_2\)C\(_5\)H\(_5\) fungierl. Die spektroskopischen Daten von IV, V und VI werden diskutiert. N2 - C\(_5\)H\(_5\)Co(PMe\(_3\))CS\(_2\) (IV) is formed in practically quantitative yield in the reaction of C\(_5\)H\(_5\)Co(PMe\(_3\))\(_2\) (I) or the heterobinuclear complex C\(_5\)H\(_5\)(PMe\(_3\))Co(CO)\(_2\)Mn(CO)C\(_3\)H .. Me (III) with CS\(_2\). The crystal structure shows that the carbon disulfide bonds as a dihapto ligand through the carbon and one sulfur atom (S(2)) (Co-C = 1.89, Co-S(2) = 2.24 ft., S(2)-C-S(1) = 141.2°). The two C-S bond lengths in IV (C-S(2) = 1.68, C-S(l) = 1.60 A) are greater than in free CS\(_2\) (1.554 A) which is in agreement with the strong 7T-acceptor character of h\(^2\)-CS\(_2\) as shown in the spectroscopic data. IV reacts with Cr(CO)\(_5\)THF and C\(_5\)H\(_5\)Mn(CO)\(_2\)THF to give the complexes C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Cr(CO)\(_5\) (V) and C\(_5\)H\(_5\)(PMe\(_3\))Co(SCS)Mn(CO)\(_2\)C\(_5\)H\(_5\) (VI) respectively, in which the sulfur atom S(l) that is not bound to cobalt coordinates to the 16-electron fragments Cr(CO)\(_5\) and Mn(CO)\(_2\)C\(_5\)H\(_5\). The spectroscopic data of IV, V and VI are discussed. KW - Anorganische Chemie Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-70444 ER - TY - JOUR A1 - Steiling, L. A1 - Tacke, Reinhold A1 - Wannagat, U. T1 - Diphenyl(3-piperidinopropyl)silanol, ein Sila-Analogon des Difenidols T1 - Dipbenyl(3-piperidinopropyl)silanol, a Sila-Analogue of Difenidol N2 - Diphenyl(3-piperidinopropyl)silanol (6b), ein Sila-Analogon des Arzneimittels Difenidol (6a), und dessen Methoiodid 7 wurden erstmals gemäß Schema 1 synthetisiert. - Die pharmakologischen und toxikologischen Eigenschaften der Analoga 6a und 6b wurden vergleichend untersucht. N2 - Diphenyl(3-piperidinopropyl)silanol (6b), a sila-analogue of the drug difenidol (6a), and its methoiodide 7 were synthesized for the firsttime according to scheme 1. - The pharmacological and toxicological properties of the analogues 6a and 6b were investigated comparatively. KW - Anorganische Chemie Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63618 ER - TY - JOUR A1 - Ackermann, J. A1 - Tacke, Reinhold A1 - Wannagat, U. A1 - Koke, U. A1 - Meyer, F. T1 - Derivate des 1-(4-Chlorphenyl)silacyclohexans mit 3-(Diethylamino)propyl- und 2-(Diethylamino)ethyl-Gruppierungen T1 - Derivatives of 1-(4-Chlorophenyl)silacyclobexane with 3-(Diethylamino)propyl- and 2-(Diethylamino)etbyl Groups N2 - Die Darstellung der Verbindungen 3a (sowie 3b) und 10, die sich vom 1-(4-Chlorphenyl)-1-(2~ diethylaminoethoxy)silacyclohexan (Sila-Chlorphencyclan, II a) ableiten, wird beschrieben. Die Verbindung 3 b wurde pharmakologisch und toxikologisch untersucht. Die biologischen Eigen· schaften von 3b wurden mit denen von Ila (sowie Chlorphencyclan) und seinem Hydrochiarid Ilb verglichen. N2 - The preparation of the compounds 3a (and 3b) and 10, which derive from 1-(4-chlorophenyl)-1· (2-diethylaminoethoxy)silacyclohexane (sila-chlorophencyclane, II a). is described. Compound 3 b has been investigated pharmacologically and toxicologically. The biological properties of 3 b and those of ßa (and chlorophencyclane) and its hydrochloride Ilb are compared. KW - Anorganische Chemie Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63621 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Zimonyi-Hegedüs, E. A1 - Wannagat, U. T1 - Si-C-Spaltung in 2-Thienylsilanen durch sekundäre Amine N2 - Die Umsetzung von Diphenyl-vinylsilan mit zyklischen sekundären Aminen (z.B. Morpholin) in Gegenwart der entsprechenden Lithium-amide führt zu einer Substitution des an Silicium gebundenen H-Atoms durch eine Aminogruppe und zu einer Addition des Amins an die Vinylgruppe. 2-Thienylphenyl- vinylsilan reagiert jedoch zusätzlich unter Spaltung der Si-e-Bindung und Aminosubstitution der 2-Thienylgruppe. N2 - Treatment of diphenylvinylsilane with cyclic secondary amines (e.g. morpholine) in the presence of the corresponding Iithium amides leads to substitution of the SiH hydrogen atom by an amino group and to. addition of the amine to the vinyl group. A similar reaction observed in the case of 2-thienylphenylvinylsilane is accompanied by cleavage of the Si-e band and substitution of the 2-thienyl group by an amino group. KW - Anorganische Chemie Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63608 ER - TY - JOUR A1 - Werner, Helmut A1 - Kuehn, Alfred A1 - Burschka, Christian T1 - Strukturdynamische Organometall-Komplexe II: Synthese, Struktur und Dynamik der Komplexe C\(_5\)H\(_5\)M(2-R'C\(_3\)H\(_4\))PR\(_3\) (M = Pd, Pt) T1 - Structurally dynamic organometallic complexes II: Synthesis, structure, and dynamics of the complexes C\(_5\)H\(_5\)M(2-R'C\(_3\)H\(_4\))PR\(_3\) (M = Pd, Pt) N2 - No abstract available KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-57853 ER - TY - JOUR A1 - Ackermann, J. A1 - Tacke, Reinhold A1 - Wannagat, U. A1 - Koke, U. A1 - Meyer, F. T1 - Sila-Analoga des Chlorphencyclans T1 - Sila Analogues of Chlorphencyclane N2 - Sila-Chlorphencyclan (8b), ein Sila-Analogon des Chlorphencyclans (8a), die Derivate 7 und 9, deren Ammoniumsalze 11, 12, 13 und 14b, das Hydrolyseprodukt 10 sowie die Vorstufen 3-6 wurden erstmalig dargestellt. Die neuen Verbindungen wurden in ihren chemischen und physikalischen Eigenschaften charakterisiert, ihre Struktur wurde sichergestellt. Chlorphencyclan, Sila-Chlorphencyclan und einige seiner Derivate wurden vergleichend pharmakologisch und toxikologisch untersucht. N2 - Silachlorphencyclane (8b), a sila analogue of chlorphencyclane (8a), the derivatives 7 and 9, their amrnonium salts 11, 12, 13 and 14b, the product of hydro Iysis 10, as weil as the precursors ~ were synthesized. The new compounds were characterized by their chemical and physical properties. The pharmacological and toxicological properties of chlorphencyclane, silachlorphencyclane and some derivatives were investigated. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63633 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Heeg, E. A1 - Berndt, B T1 - Sila-Analogon des Rythmols T1 - Sila Analogue of Rythmol N2 - Sila-Rythmol (llb), ein Sila-Analogon des Antiarrhythmieums Rythmol (lla), wurde erstmalig dargestellt. llb sowie die Vorstufen und Nebenprodukte 4, 5, 6, 7, 9b und lOb wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur sichergestellt. Die pharmakologischen und toxikologischen Eigenschaften der Analoga lla und llb wurden vergleichend untersucht. N2 - Silarythmol (llb), a sila analogue of the antiarrhythmic rythmol (lla), was synthesized for the first time. llb as weil as the precursors and byproducts 4, 5, 6, 7, 9b, and lOb were characterized by their physical and chemical properties. The pharmacological and toxicological properties of the analogues lla and llb were also investigated. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63642 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Strecker, M. A1 - Sheldrick, W. S. A1 - Ernst, L. A1 - Heeg, E. A1 - Berndt, B. A1 - Knapstein, C.-M. A1 - Niedner, R. T1 - Sila-Pridinol und Pridinol: Darstellung und Eigenschaften sowie Strukturen im kristallinen und gelösten Zustand T1 - Sila-Pridinol and Pridinol: Preparation and Properties as weil as Structures ln the Solid Stateand in Solution N2 - Sila-Pridinol (2 b), ein Sila-Analogon des Anticholinergicums Pridinol (2a), wurde auf zwei verschiedenen Wegen dargestellt. Die Kristall- und Molekülstrukturen von 2 a und 2 b wurden röntgenstrukturanalytisch bestimmt. 2a bildet im festen Zustand intramolekulare Wasserstoffbrückenbindungen aus, während sich in kristallinem 2 b zentrosymmetrische, durch intermolekulare H-Brückenbindungen verknüpfte cyclische Dimere finden. IR- und \8^1\)H-NMR-spektroskopische sowie kryoskopische Untersuchungen ergaben Informationen über die Strukturen von 2a und 2 b in verschiedenen Lösungsmitteln. - Die pharmakologischen und toxikologischen Eigen" schaften von 2a und 2b wurden unter dem Gesichtspunkt bekannter Struktur-Wirkungs-Beziehungen vergleichend untersucht. 2 b erwies sich als ein etwa fünfmal so starkes Anticholincrgicum wie 2a. N2 - Sila"pridinol (2 b), a sila"analogue of the anticholinergic pridinol (2a). was prepared by two different routes. The crystal and molecular structures of 2 a and 2 b were determined by X-ray structural analyses. 2a forms intramolecular hydrogen bonds in the solid state, whereas centrosymrnetric cyclic dimers linked through intermolecular hydrogen bonds are observed for crystalline 2 b. IR- and \(^1\)H NMR spectroscopic as weil as cryoscopic studies yielded information ab out the structures of 2a and 2 bin different solvents. - The pharmacological and toxicological properties of2a and 2b were compared with one another on the basis ofknown structure-activity relationships. The anticholinergic properties of 2b were found tobe about five times as strong as those of 2a. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63654 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Zimonyi-Hegedüs, E. A1 - Strecker, M. A1 - Heeg, E. A1 - Berndt, B. A1 - Langner, R. T1 - Sila-Analogon des Tiemoniumiodids T1 - Sila-Analogue of Tiemonium Iodide N2 - Sila-Tiemoniumiodid (16b), ein Sila-Analogon des Anticholinergicums Tiemoniumiodid (16a), und das Sila-Analogon 14b der entsprechenden Tiemonium-Base 14a wurden erstmalig synthetisiert.14b und 16b sowie die Vorstufen 10-13 und 15 wurden in ihren physikalischen und chemischen Eigenschaften charakterisiert und in ihrer Struktur durch Elementaranalysen sowie \(^1\)H-NMR- und Massenspektren sichergestellt. Die spasmolytischen Eigenschaften der Paare 14a/14b und 16a/16b wurden am isolierten Meerschweinchendarm vergleichend untersucht. N2 - Silatiemonium iodide (16b), a sila-analogue of the anticholinergic tiemonium iodide (16a), and the siJa-analogue 14b of the corresponding free base 14a were synthesized for the first time. Compounds 14b and 16b as weil as their precursors 10-13 and 15 were characterized by their physical and chemical properties. Their structures were confirmed by elementary analyses, (^1\)H NMRand massspectroscopy. The spasmolytic properties of the pairs 14a/14b and 16a/16b were compared on the isolated guinea pig ileum. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63669 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Niedner, R. A1 - Frohnecke, J. A1 - Ernst, L. A1 - Sheldrick, W. S. T1 - Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, II T1 - Preparation and Properties of Silicon Compounds withPotential Curare-Like Activity, II N2 - Die potentiell curarewirksamen Silicium-Verbindungen Sa, Sc, Sd, Sg, Sh und 9a-9d wurden dargestellt. \(^1\)H-NMR-spektroskopische Untersuchungen ergaben Informationen über die Konformationen von 5 a- Sc in Lösung. Die Kristall- und Molekülstruktur von 5 c wurde röntgenstrukturanalytisch bestimmt. Die muskelrelaxierenden Eigenschaften von S a- 5 h und 9 a-9 d wurden vergleichend an der Maus (i.v., LD50-Werte) untersucht. Die ermittelten Struktur-WirkungsBeziehungen werden in Hinblick auf die unterschiedlichen kovalenten Radien des Kohlenstoffund Siliciumatoms und die hieraus resultierenden N ... N-Abstände diskutiert. N2 - 'The potential curare-like silicon compounds Sa, Sc, Sd, Sg, Sb, and 9a-9d were synthesized. \(^1\)H-NMR spectroscopic investigations provided information about the conformations of Sa-Sc in solution. The crystal and molecular structures 5 c were determined by X-ray structural analysis. The muscle relaxing properties of Sa-Sb and 9a-9d were investigated comparatively on mice (i. v., LD50 values). The observed structure-activity relationships are discussed with respect to the different covalent radii of the carbon and silicon atoms and the N ... N distances resulting therefrom. KW - Anorganische Chemie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63670 ER - TY - JOUR A1 - Tacke, Reinhold A1 - Strecker, M. A1 - Niedner, R. T1 - Cholinesterase-hemmende Organophosphorsäureester und ihre Sila-Analoga T1 - Organophosphates with Anticholinesterase Activity and their Sila-Analogues N2 - Die Organophosphorsäureester la-4a und ihre Sila-Analoga lb-4b des Typs R\(^1\)R\(^2\)P(O)( p-OC\(_6\)H\(_4\)ElMe\(_3\)) (EI = C, Si) wurden synthetisiert. Die Kohlenstoff-Verbindungen 1 a- 4a zeigen hinsichtlich ihrer Anticholinesterase-Aktivität die gleichen Struktur-Wirkungs-Beziehungen wie die Silicium-Verbindungen 1 b- 4 b. Letztere sind jeweils wirksamer als die entsprechenden C-Analoga. N2 - The organophosphates la-4a and their sila-analogues lb-4b of the type R\(^1\)R\(^2\)P(O)( p-OC\(_6\)H\(_4\)ElMe\(_3\) (El = C, Si) were synthesized. With regard to their anticholinesterase activity, the carbon compounds ta- 4a exhibit the same structure-activity relationships as the silicon compounds 1 b- 4b. The latter are more activ than the corresponding C-analogues. KW - Anorganische Chemie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63689 ER -