TY - CHAP A1 - Hommers, Wilfried T1 - Zum Gegenstand der Rechtspsychologie N2 - No abstract available. KW - Rechtspsychologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87014 ER - TY - CHAP A1 - Hoffmann, Joachim T1 - Wird Wissen in Begriffen repräsentiert? T1 - Is knowledge represented in contexts? N2 - Die Arbeit geht von der allgemeinen Feststellung aus, daß die Repräsentation von Wissen der Reduktion des Aufwandes von zu erwartenden Informationsverarbeitungsprozessen dient. Es werden verschiedene Anforderungen an die menschliche Informationsverarbeitung betrachtet, und es wird jeweils gefragt, welche Eigenschaften die Wissensrepräsentation haben muß, um diesen Anforderungen zu genügen. Im einzelnen werden die Objektwahrnehmung, die anschauliche Vorstellungstätigkeit, die Aufmerksamkeitssteuerung, die Erkennung semantischer Relationen, die Handlungskontrolle und der Erwerb von Wortbedeutungen betrachtet. Es wird die Schlußfolgerung gezogen, daß eine Repräsentation in diskreten symbolischen Einheiten der Dynamik der Wissensnutzung unter den verschiedenen Anforderungen wenig gerecht wird. Es scheint naheliegender, Wissen direkt in Handlungseinheiten zu repräsentieren. Solche Einheiten sollten Informationen über einzelne Handlungen mit Informationen über Situationskontexte verbinden, in denen die Handlungen erfolgreich verwendet worden sind. Die Vorteile einer solchen handlungsorientierten Wissensrepräsentation werden diskutiert. N2 - This paper proceeds from the general notion that the representation of knowledge serves to reduce the effort in to be expected information processing. Various demands on human information processing are considered and it is respectively asked, what properlies knowledge representations should have in order to meet these demands. Objectrecognition, imagery activities, the control of attention, the recognition of semantic relations, the control of behavior, and the acquisition of word meaning are especially considered. It is concluded that a representation in discrete symbolic units hardly meets the requirements of a flexible use of knowledge; a representation hy behavioral units seems to be more promising. Such units should integrale information about behavioral steps with information about the contexts where this behavior has been successfully used. The advantages of such a behavioral-oriented representation of knowledge are discussed. KW - Wissensrepräsentation KW - Begriff Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87000 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Memory development N2 - No abstract available. KW - Pädagogik Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69331 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Acquiring expertise: determinants of exceptional performance N2 - No abstract available. KW - Hochbegabung Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86652 ER - TY - CHAP A1 - Körkel, Joachim A1 - Schneider, Wolfgang T1 - Domain-specific versus metacognitive knowledge effects on text recall and comprehension N2 - No abstract available. KW - Unterricht KW - Lerntheorie KW - Unterrichtspsychologie KW - Lernpsychologie KW - Pädagogische Psychologie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86647 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Schneider, Wolfgang A1 - Beckmann, J. T1 - Fähigkeitsunterschiede, Fertigkeitstraining und Leistungsniveau N2 - No abstract available. KW - Leistung KW - Fertigkeit Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86612 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Methodische Probleme und Möglichkeiten schulbezogener Längsschnittforschung N2 - No abstract available. KW - Längsschnittuntersuchung Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86592 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Brügelmann, Hans A1 - Kochan, Barbara T1 - Lesen- und Schreibenlernen in neuer Sicht : vier Perspektiven auf den Stand der Forschung N2 - No abstract available. KW - Lesenlernen KW - Schreibenlernen Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86573 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Körkel, Joachim A1 - Weinert, Franz E. T1 - Expert Knowledge, General Abilities, and Text Processing N2 - No abstract available. KW - Textverarbeitung KW - Wissen Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86548 ER - TY - CHAP A1 - Bjorklund, David F. A1 - Muir-Broaddus, Jacqueline E. A1 - Schneider, Wolfgang T1 - The role of knowledge in the development of strategies N2 - No abstract available. KW - Wissen KW - Strategie KW - Entwicklung Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86538 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Frühe Vorhersage von Lese-/Rechtschreibleistungen: Der Ansatz des Münchner Längsschnittprojekts (LOGIC) N2 - No abstract available. KW - Rechtschreibunterricht KW - Deutsch KW - Rechtschreibung KW - Rechtschreibreform Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86484 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - The longitudinal study of motor development: methodological issues N2 - No abstract available. KW - Motorische Entwicklung KW - Längsschnittuntersuchung KW - Methode Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71393 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - Erwerb von Expertise: Zur Relevanz kognitiver und nichtkognitiver Voraussetzungen N2 - No abstract available. KW - Begabung Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71377 ER - TY - CHAP A1 - Adam, D. A1 - Schartl, A. A1 - Andexinger, S. A1 - Hölter, S. A1 - Wilde, B. A1 - Schartl, Manfred T1 - Genetic factors in tumour formation: The melanoma-inducing gene of Xiphophorus N2 - No abstract available. KW - Humangenetik KW - Tumor KW - Entstehung Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86388 ER - TY - CHAP A1 - Epplen, J. T. A1 - Ammer, H. A1 - Epplen, C. A1 - Kammerbauer, C. A1 - Mitreiter, R. A1 - Roewer, L. A1 - Schwaiger, W. A1 - Steimle, V. A1 - Zischler, H. A1 - Albert, E. A1 - Andreas, A. A1 - Beyermann, B. A1 - Meyer, W. A1 - Buitkamp, J. A1 - Nanda, I. A1 - Nürnberg, P. A1 - Pena, S. D. J. A1 - Pöche, H. A1 - Sprecher, W. A1 - Schartl, Manfred A1 - Weising, K. A1 - Yassouridis, A. T1 - Oligonucleotide fingerprinting using simple repeat motifs: a convenient, ubiquitously applicable method to detect hypervariability for multiple purposes N2 - A panel of simple repetitive oligonucleotide probes has been designed and tested for multilocus DNA fingerprinting in some 200 fungal, plant and animal species as well as man. To date at least one of the probes has been found to be informative in each species. The human genome, however, has been the major target of many fingerprintins studies. Using the probe (CAC)5 or (GTG)5, individualization of all humans is possible except for monozygotic twins. Paternity analyses are now perfonned on a routine basis by the use of multilocus fingerprints, inctuding also cases of deficiency, i.e. where one of the parents is not available for analysis. In forensie science stain analysis is feasible in all tissue remains containing nuc)eated cells. Depending on the degree of DNA degradation a variety of oligonucleotides are informative, and they have been proven useful in actual case work. Advantages in comparison to other methods including enzymatic DNA amplification techniques (PCR) are evident. Fingerprint patterns of tumors may be changed due to the gain or loss of chromosomes and/or intrachromosomal deletion and amplification events. Locus-specific probes were isolated from the human (CAC)5/( GTG)5 fingerprint with a varying degree of informativeness (monomorphic versus truly hypervariable markers). The feasibility of three different approaches. for the isolation of hypervariable mono-locus probes was evaluated. Finally, one particular mixed simple (gt)n(ga)m repeat locus in the second intron of the HLA-DRB genes has been scrutinized to allow comparison of the extent of exon-encoded (protein-) polymorphisms versus intronie bypervariability of simple repeats: adjacent to a single gene sequence (e.g. HLA-DRB1*0401) many different length alleles were found. Group-specific structures of basic repeats were identified within the evolutionarily related DRB alleles. As a further application it is suggested here that due to the ubiquitous interspersion of their targets, short probes for simple repeat sequences are especially useful tools for ordering genomic cosmid, yeast artificial chromosome and phage banks. KW - DNS KW - Fingerprint-Verfahren Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86371 ER - TY - CHAP A1 - Shephard, S. E. A1 - Meier, I. A1 - Lutz, Werner K. T1 - Alkylating potency of nitrosated amino acids and peptides N2 - Tbe alkylating potency of unstable N-nitrosamino acids and N-nitrosopeptides was investigated in vitro using 4-(para-nitrobenzyl)pyridine (NBP) as nucleophile. Of the amino acids, Met and those with an aromatic side chain were the most potent. The relative overall alkylating potency was 23:10:5:4:2:1: for Trp, Met, His, 1)rr, Phe and Gly, respectively. The homo-dipeptides were much more potent than the amino acids, with relative potencies of 400:110:100:8:3:1, for Trp-Trp, l)T-'I)T, Met-Met, Asp-Asp, Phe-Phe and Gly, respectively. In the one-phase reaction system (in which NBP is already present durlog the nitrosation reaction at acidic pH), all amino acids tested showed a second-order reaction for nitrite. In the two-phase system (in which NBP is added only after bringing the nitrosation reaction mixture to neutrality), all amino acids tested except one again showed a second-order reaction for nitrite (Phe, His, Asp and the dipeptide artiticial sweetener aspartame); only Met under these conditions bad a reaction order of one for nitrite. This could mean that nitrosation of the side chain of Metproduces a second N-nitroso product which is relatively stable in acid but reacts with NBP under neutral conditions. In the human stomach, this side-chain nitrosation might become more important than the reactions at the primary amino group, firstly because of the greater stability of the product(s) in acid and secondly because of the tirst-order reaction rate for nitrite. A decrease in nitrite concentration from the millimolar concentrations ofthe in-vitro assay to the micromolar concentrations in the stomach reduces the reaction rate by a factor of 1000 for the side-chain nitrosation, whereas a million-fold reduction will be observed for nitrosation of the amino group. KW - Aminosäuren Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86320 ER - TY - CHAP A1 - Cantoreggi, S. A1 - Gupta, R. C. A1 - Lutz, Werner K. T1 - An improved 32P-postlabelling assay for detection and quantitation of styrene 7,8-oxide-DNA adducts N2 - Using DNA modified with [7-3H]styrene 7,8-oxide (SO) in vitro we have standardized the 32P-postlabelling assay for detecting SO-DNA adducts. Nuclease P 1-enriched adducts were 32P-labelled and purified by high-salt ( 4.0 M ammonium formate, pH 6.1} C1s reverse-phase TLC. After elution from the layer with 2-butoxyethanol:H20 (4:6), adducts were separated by two-dimensional PEI cellulose TLC in non-urea solvents (2.0 M ammonium formate, pH 3.5, and 2.7 M sodium phosphate, pH 5.6). One major, three minor and several trace adducts were detected. The efficiency of the kinase reaction depended on the ATP concentration. Use of standard labelling conditions (['Y· 32P]ATP, <3000 Ci/mmol; <2 Mikromol) resulted in poor ( 4-7%) adduct recovery. An ATP concentration of 40 Mikromol, however, increased the labeJling efficiency by a factor of 5-8 (35-55% based on 3H-SO labelied DNA). The results indicate that the new separation technique is suitable for the relatively polar SO-DNA adducts and that high labelling efficiency can be achieved. KW - Medizin Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86305 ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - The driver under the influence of passenger and alcohol T1 - Le conducteur sous l'influence des passagers et de l'alcool N2 - No abstract available. KW - Kraftfahrer KW - Trunkenheit im Verkehr KW - Beifahrer KW - Einfluss Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86275 ER - TY - CHAP A1 - Lohse, M. J. A1 - Klotz, K.-N. A1 - Schwabe, U. A1 - Christalli, G. A1 - Vittori, S. A1 - Grifantini, M. T1 - Pharmacology and Biochemistry of Adenosine Receptors N2 - Adenosine modulates a variety of physiological functions via membrane-bound receptors. These receptors couple via G proteins to adenylate cyclase and K+channels. The A1 subtype mediates an inhibition of adenylate cyclase and an opening of K+-channels, and the A2 subtype a Stimulation of adenylate cyclase. Both subtypes have been characterized by radioligand binding. This has facilitated the development of agonists and antagonists with more than 1000-fold A1 selectivity. A1-selective photoaffinity labels have been used for the biochemical characterization of A1 receptors and the study of their coupling to adenylate cyclase. Such selective ligands allow the analysis of the involvement of adenosine receptors in physiological functions. Selective interference with adenosine receptors provides new pharmacological tools and eventually new therapeutic approaches to a number of pathophysiological states. KW - Adenosinrezeptor KW - Pharmakologie KW - Toxikologie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86251 ER - TY - CHAP A1 - Shephard, S. E. A1 - Hegi, M. E. A1 - Lutz, Werner K. T1 - In-vitro assays to detect alkylating and mutagenic activities of dietary components nitrosated in situ N2 - Nitrosation of dietary components has been combined with the 4-(para-nitrobenzyl)pyridine (NBP) colorimetric test for screening alkylating agents and with the Ames test for the detection of mutagenic activity. This allowed the investigation of short-hved nitrosation products of dietary components which generate electrophilic degradation products requiring no metabolic activation (natural amino acids and some derivatives, ureas, guanidines, primary alkyl and aryl amines). In a first system, precursor, nitrous acid and NBP were present simultaneously. All amino acids tested, except glutamic acid and glutamine, gave positive results. The reactivities spanned more than three orders of magnitude, with the aromatic amino acids and methionine the most active; two primary amines, tryptamine and histamine, were also strongly reactive. All guanidines tested, except the amino acid arginine, gave negative results. A second system consisted of two phases: NBP was added only after destruction of residual nitrite and adjustment of the pH to neutrality. This system was useful for the study of ureas, which are stable in acid but not in neutral media. The range of responses covered more than two orders of magnitude. Most amino acids and primary amines also gave positive results, but could be assessed only after analysing the kinetics of the competing reactions and choosing appropriate reaction times. In a third system, Salmonella typhimurium strain TA1OO replaced NBP. Representatives of the class of amino acids, ureas, the primary amine tryptamine, and aniline became higbly mutagenic upon nitrosation. Methylguanidine was only weakly mutagenic under the present assay conditions. The results indicate that further studies with unstable nitrosation products of dietary components are required to understand more thoroughly the role of endogenous nitrosation in gastric cancer. KW - Medizin Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86194 ER -