TY  - JOUR
A1  - Pfeiffer, A.
A1  - Rochlitz, H.
A1  - Noelke, B.
A1  - Tacke, R.
A1  - Moser, U.
A1  - Mutschler, E.
A1  - Lambrecht, G.
T1  - Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type
JF  - Gastroenterology
N2  - Five subtypes of muscarinic receptors have been identified by pharmacological and molecular biological methods. The muscarinic receptor subtype mediating acid secretion at the level of the parietal cell was unknown. Therefore, this study was performed to characterize muscarinic receptors on rat gastric parietal cells using the 3 subtype-selective antagonists hexahydrosiladifenidol and silahexocyclium, which have high affinity for glandular M3 subtypes, and AF-DX 116, which has high affinity to cardiac M2 receptors. The affinity of these antagonists was determined by radioligand binding experiments. In addition, their inhibitory potency on carbachol-stimulated inositol phosphate production was investigated. Inhibition of carbachol-stimulated aminopyrine uptake was used as an indirect measure of proton production. Both M3 antagonists, hexahydrosiladifenidol and silahexocyclium, had nanomolar affinities for parietal cell muscarinic receptors and potently antagonized inositol phosphate production with nanomolar Ki values. Silahexocyclium similarly antagonized aminopyrine accumulation while hexahydrosiladifenidol behaved as a noncompetitive antagonist. AF-DX 116 was a low-affinity ligand and a weak competitive antagonist at parietal-cell muscarinic receptors. It was concluded that muscarinic M3 receptors mediate acid secretion probably by activation of the phosphoinositide second messenger system in rat gastric parietal cells.
KW  - hexahydrosiladifenidol
KW  - muscarinic receptors
KW  - parasympatholytics
KW  - radioligand assay
KW  - parasympatholytics/pharmacology
KW  - gastric acid/secretion
KW  - animals
KW  - piperidines/pharmacology
KW  - piperazines/pharmacology
KW  - gastric/secretion parietal cells
KW  - muscarinic/physiology receptors
KW  - muscarinic/drug effects receptors
KW  - rats
KW  - piperidines
KW  - piperazines
KW  - silahexocyclium
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128337
VL  - 98
IS  - 1
ER  - 
TY  - JOUR
A1  - Pfeiffer, A.
A1  - Hanack, C.
A1  - Kopp, R.
A1  - Tacke, R.
A1  - Moser, U.
A1  - Mutschler, E.
A1  - Lambrecht, G.
A1  - Herawi, M.
T1  - Human Gastric Mucosa Expresses Glandular M3 Subtype of Muscarinic Receptors
JF  - Digestive Diseases and Sciences
N2  - Five subtypes of muscarinic receptors have been distinguished by pharmacological and molecular biological methods. This report characterizes the muscarinic subtype present in human gastric mucosa by radioligand binding studies. The receptor density was 27 ± 6 fmol/mg protein and the tritiated ligand N-methylscopolamine had an affinity of (Kn) 0.39 ± 0.08 nM (n = 11). The M1 receptor selective antagonist pirenzepine and the M2 receptor selective ligand AF-DX 116 had low affinities of 148 ± 32 nM (n = 13) and 4043 ± 1011 nM (n = 3) K n , respectively. The glandular M3 antagonists hexahydrosiladifenidol and silahexocyclium had high affinities ofKn 78 ± 23 nM (n = 5) and 5.6 ± 1.8 nM (n = 3). The agonist carbachol interacted with a single low-affinity site and binding was insensitive to modulation by guanine nucleotides. Antagonist and agonist binding studies thus showed an affinity profile typical of M3 receptors of the glandular type.
KW  - glandular M3 receptor
KW  - acid secretion
KW  - muscarinic receptor subtype
KW  - human gastric mucosa
KW  - stomach
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128286
VL  - 35
IS  - 12
ER  - 
TY  - CHAP
A1  - Wilhelm, Gernot
T1  - Marginalien zu Herodot, Klio 199
N2  - no Abstract available
KW  - Semitistik
KW  - Aufsatzsammlung
KW  - Moran
KW  - William L.
KW  - Bibliographie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87812
ER  - 
TY  - JOUR
A1  - Wilhelm, Gernot
T1  - "Verhafte ihn!"
N2  - No abstract available.
KW  - Alter Orient
KW  - Semitistik
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72383
ER  - 
TY  - JOUR
A1  - von Gehlen, K.
A1  - Matthes, S.
A1  - Okrusch, Martin
A1  - Richter, P.
A1  - Röhr, C.
A1  - Schüssler, Ulrich
T1  - Metapyroxenite in der KTB-Vorbohrung
N2  - No abstract available.
KW  - Kontinentales Tiefbohrprogramm der Bundesrepublik Deutschland
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87539
ER  - 
TY  - CHAP
A1  - Sodian, Beate
A1  - Schneider, Wolfgang
T1  - Gedächtnisentwicklung im Vorschulalter: "Theoriewandel" im kindlichen Verständnis des Lernens und Erinnerns?
N2  - No abstract available.
KW  - Gedächtnis
KW  - Entwicklung
KW  - Vorschulkind
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87505
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Weinert, Franz E.
T1  - The role of knowledge, strategies, and aptitudes in cognitive Performance: Concluding Comments
N2  - No abstract available.
KW  - Kognitive Entwicklung
KW  - Begabung
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87190
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Sodian, Beate
T1  - Gedächtnisentwicklung im Vorschulalter: "Theoriewandel" im kindlichen Verständnis des Lernens und Erinnerns?
N2  - No abstract available.
KW  - Entwicklungspsychologie
KW  - Pädagogische Psychologie
KW  - Gedächtnis
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87183
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Körkel, Joachim
A1  - Weinert, Franz E.
T1  - Expert knowledge, general abilities, and text processing
N2  - No abstract available.
KW  - Kognitive Entwicklung
KW  - Begabung
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87175
ER  - 
TY  - BOOK
A1  - Krüger, Hans-Peter
A1  - Kohnen, Ralf
A1  - Diehl, Monika
A1  - Hüppe, Angelika
T1  - Auswirkungen geringer Alkoholmengen auf Fahrverhalten und Verkehrssicherheit (Problemstudie)
N2  - Die Literaturstudie zum Thema "Auswirkungen geringer Alkoholmengen auf Fahrverhalten und Verkehrssicherheit• (FP 8707) wählte aus rund 100 000 geprüften Literaturangaben, nach strengen methodischen Kriterien , 1 126 empirische Befunde im Bereich unter 0,84 Promille BAK aus. Es zeigt sich , daß ab 0,3 Promille BAK nachweisbare Wirkungen des Alkohols vorhanden sind. Bis zu 0,5 Promille sind diese noch stark von den untersuchten Personen und Situationen abhängig, so daß dieser Bereich nicht maßnahmenrelevant erscheint. Bei Konzentrationen über 0 ,5 Promille hat Alkohol deutliche Wirkungen in Verkehrssituationen, die ein hohes Maß an Kontrollprozessen verlangen. Solche sind gefordert, wenn das Fahren an rasch wechselnde, unvorhersehbare Situationen angepaßt werden muß oder wenn sich mehrere Anforderungen gleichzeitig stellen . Ebenfalls deutliche Wirkungen sind in Verkehrssituationen zu erwarten. die einen sozialen Aufforderungsgehalt haben, insbesondere solche mit aggressionsauslösenden Reizen (etwa Bedrängen , Überholtwerden, Vorfahrtsfragen usw). Geringere Wirkungen zeigen sich in Standardsituationen wie Abbiegen, Überholen usw. Fast keine Wirkungen zeigen sich in nicht beanspruchenden Situationen , wo eine leichte Beeinträchtigung nicht leistungsmindernd ins Gewicht fällt oder durch eine Erhöhung der Anstrengung kompensiert werden kann. Die gleiche BAK ist umso gefährlicher, je weniger der Fahrer über automatisierte Handlungen verfügen kann, je mehr er auf Kontrollprozesse angewiesen ist. Dies ist der Fall vor allem bei wenig geübten Fahrern, regelhaft bei Fahranfängern. Aber auch älteren Verkehrsteilnehmer mit ihren größeren Schwierigkeiten bei Kontrollprozessen sind in besonderem Maße betroffen. Legt man die in§ 24a StVG für den Grenzwert von 0 ,8 ausgesprochene Wirkungsvermutung zugrunde, zeigt das Review eindeutig , daß eine BAK über 0,5 Promille in vielen Verkehrssituationen (nicht in allen ) und/oder bei zahlenmäßig großen Risikopopulationen (nicht bei allen) die Leistungen so deutlich mindert, daß von einer abstrakten Gefährdung des Straßenverkehrs auszugehen ist. Damit ist eine Absenkung des Gefahrengrenzwerts auf 0,5 Promille zu befürworten .
KW  - Alkohol
KW  - Fahrverhalten
KW  - Verkehrssicherheit
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87068
ER  - 
TY  - JOUR
A1  - Sponholz, Barbara
T1  - Silicate karst in eastern Niger - a geomorphological study
N2  - No abstract available.
KW  - Niger <Ost>
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86846
ER  - 
TY  - JOUR
A1  - Schulz, Erhard
A1  - Joseph, Alain
A1  - Baumhauer, Roland
A1  - Schultze, Ekkerhard
A1  - Sponholz, Barbara
T1  - Upper Pleistocene and Holocene history of the Bilma region (Kawar, NE-Niger)
T1  - Evolution de la region de Bilma (Kawar, NE-Niger) au Pleistocene superier et a l'Holocene
N2  - A 42 m drilling was pertormed in the depresalon of Bilma, Xawar, NE-Niger. The sediment and pollen records show that after an initial deposition of dune sands there were repeated lake phases which terminated by desiccation and consolidation of spring mounds. The pollen record indicates a continuous presence of savanna vegetation. The record probably covers the period between the Upper Pleistocene and the Late Holocene. The climate was characterised by a monssonal summer rain regime giving effective rain fall of about 450-500 mm per year. Groundwater recharge was possible but estimates of the amount of water resources are difficult because of the karstic system of the escarpment and the nearly unknown hydrogeological situation.
N2  - Dans la dépression de Bilma, Kawar, NE-Niger, un forage de 42 m a été réalisé. La séquence couvre la période entre le Pléistocene supérieur et l'Holocéne tardif. Apres une phase initiale de dépôts des sables dunaires, trois phases lacustres sont visibles, chaque fois terminées par une période de dessiccation et formation de dépôts de sources en buttes. Les invertigations polliniques montrent que, pendant toute la période, une végétation de savane était dominante. Le paléoclimat était caractérisé par un régime de mousson et des précipitations effectives d'environ 450-500 mm par an ainsi que des invasions de dépressions atlantiques. Une recharge de la nappe phréatique était possible, mais la connaissance insuffisante de l'hydrologéologie et du systeme karstique rend une estimation des ressources en eau tres difficile.
KW  - Pleistozän
KW  - Holozän
KW  - Bilma <Region>
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86828
ER  - 
TY  - JOUR
A1  - Wilhelm, Gernot
T1  - Zur babylonisch-assyrischen Schultradition in Ḫattuša
N2  - no Abstract available
KW  - Boğazkale
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86457
ER  - 
TY  - JOUR
A1  - Barnekow, Angelika
A1  - Jahn, Reinhard
A1  - Schartl, Manfred
T1  - Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles
N2  - Expression of pp60 c-src, the first well defined proto-oncogene product, is developmentally regulated and tissue-specific, with neuronal tissues displaying high amounts of the c-src encoded pp60 c-src kinase activity. In the central nervous system pp60 s-src is preferentially expressed in regions characterized by a high content of grey matter and elevated density of nerve terminals. In this study we show for the first time a direct interaction between pp60 c-src and synaptophysin as a physiological target protein in neurons by demonstrating that endogenous pp60 c-src is able to phosphorylate synaptophysin (p38). p38 is a major constituent of the synaptic vesicle membrane protein and is thought to play a key role in the exocytosis of small synaptic vesicles and possibly small clear vesicles in neuroendocrine cells.
KW  - Synaptophysin
KW  - Synaptische Vesikel
KW  - Protein-Tyrosin-Kinasen
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86168
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Brügelmann, Hans
A1  - Kochan, Barbara
T1  - Lesen- und Schreibenlernen in neuer Sicht : vier Perspektiven auf den Stand der Forschung
N2  - No abstract available.
KW  - Lesenlernen
KW  - Schreibenlernen
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86573
ER  - 
TY  - JOUR
A1  - Opwis, Klaus
A1  - Gold, Andreas
A1  - Gruber, Hans
A1  - Schneider, Wolfgang
T1  - Zum Einfluß von Expertise auf Gedächtnisleistungen sowie deren Selbsteinschätzung bei Kindern und Erwachsenen
N2  - Junge und erwachsene Schachexperten und -novizen wurden bezüglich ihrer Behaltensleistungen für kurzzeitig dargebotene Schachstellungen und für Anordnungen geometrischer Körper miteinander verglichen. Die Ergebnisse zeigen eine differenzierte Wirksamkeit von Expertise in Abhängigkeit von der Vertrautheit mit dem zu Lernenden Material und von der Art der Aufgabenstellung. Je vorwissensbezogener das zu Lernende Material ist, desto deutlicher ist der Einfluß von Expertise auf Gedächtnisleistungen nachweisbar. Dies gilt in gleicher Weise für unmittelbare wie für längerfristige Behaltensleistungen und für den Lernfortschritt. Im Unterschied dazu zeigt sich weder bei der Vorhersage eigener künftiger noch bei der Bewertung erbrachter Gedächtnisleistungen ein systematischer Einfluß von Expertise.
KW  - Gedächtnisleistung
KW  - Selbsteinschätzung
KW  - Kind
KW  - Erwachsener
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86565
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Weinert, Franz E.
T1  - The role of knowledge, strategies, and aptitudes in cognitive performance : concluding comments
N2  - No abstract available.
KW  - Intelligenzleistung
KW  - Wissen
KW  - Begabung
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86554
ER  - 
TY  - CHAP
A1  - Schneider, Wolfgang
A1  - Körkel, Joachim
A1  - Weinert, Franz E.
T1  - Expert Knowledge, General Abilities, and Text Processing
N2  - No abstract available.
KW  - Textverarbeitung <Psycholinguistik>
KW  - Wissen
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86548
ER  - 
TY  - CHAP
A1  - Bjorklund, David F.
A1  - Muir-Broaddus, Jacqueline E.
A1  - Schneider, Wolfgang
T1  - The role of knowledge in the development of strategies
N2  - No abstract available.
KW  - Wissen
KW  - Strategie
KW  - Entwicklung
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86538
ER  - 
TY  - JOUR
A1  - Schneider, Wolfgang
A1  - Uhl, Christhild
T1  - Metagedächtnis, Strategienutzung und Gedächtnisleistung: Vergleichende Analysen bei Kindern, jüngeren Erwachsenen und alten Menschen
N2  - Am Beispiel einer semantischen Kategorisierungsaufgabe (sort-recall task) wurde der Frage nachgegangen, in welchen Bestimmungsgrößen sich die Gedächtnisleistungen von Schulkindern, jüngeren sowie älteren Erwachsenen voneinander unterscheiden. Es wurde angenommen, daß für diese drei Altersgruppen Gedächtnisleistungen bei dieser Aufgabe in unterschiedlicher Weise durch Strategie- und Wissensaspekte bestimmt sind. Die im Vergleich zu Schulkindern und älteren Erwachsenen üblicherweise besseren Leistungen jüngerer Erwachsener sollten demnach im wesentlichen auf die konsequentere Nutzung von Gedächtnisstrategien rückführbar sein. Erwartet wurde weiterhin, daß die bei Schulkindern und älteren Erwachsenen oft vorfindbaren "Produktionsdefizite" in der Strategienutzung unterschiedliche Ursachen haben : fehlt es bei den Schülern am notwendigen Gedächtniswissen (Metagedächtnis), so sind die Defizite der älteren Menschen vorwiegend auf die mangelnde Erfahrung mit der Aufgabe zurückzuführen. Diese Annahmen wurden in einer Studie mit je 24 Probanden aus den drei genannten Altersgruppen überprüft. Während sich das erwartete Produktionsdefizit bei den Kindern auf unzureichendes Metagedächtnis zurückführen ließ, gab es wenig Anhaltspunkte dafür, daß das Strategiedefizit älterer Menschen in wesentlichen auf mangelnde Aufgabenerfahrung rückführbar ist. Leistungsunterschiede zwischen jüngeren und älteren Erwachsenen beruhen nicht auf unterschiedlichem Gedächtniswissen, sondern dürften auf dem kombinierten Einfluß von Strategie- und Kapazitätsdefiziten basieren.
KW  - Metagedächtnis
KW  - Strategie
KW  - Gedächtnisleistung
KW  - Kind
KW  - Erwachsener
KW  - Alter
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69418
ER  - 
TY  - CHAP
A1  - Rethwilm, Axel
A1  - Baunach, Gerald
A1  - Mori, Kazuyasu
A1  - ter Meulen, Volker
T1  - Transactivation of HIV by human spumaretrovirus
N2  - To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected.
KW  - HIV
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86436
ER  - 
TY  - CHAP
A1  - Mori, Kazuyasu
A1  - Rethwilm, Axel
A1  - Schwinn, Andreas
A1  - Horak, Ivan
T1  - Replication of human immunodeficiency virus type 1 in human t-cells expressing antisense RNA
N2  - No abstract available.
KW  - HIV
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86426
ER  - 
TY  - CHAP
A1  - Schwinn, Andreas
A1  - Rethwilm, Axel
A1  - Esers, Stefan
A1  - Borisch, Bettina
A1  - ter Meulen, Volker
T1  - Interaction of HIV-1 and HHV-6
N2  - No abstract available.
KW  - HIV
KW  - Herpesviren
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86415
ER  - 
TY  - JOUR
A1  - Schartl, Manfred
A1  - Nanda, Indrajit
A1  - Schlupp, Ingo
A1  - Parzefall, Jakob
A1  - Schmid, Michael
A1  - Epplen, Jörg T.
T1  - Genetic variation in the clonal vertebrate Poecilia formosa is limited to few truly hypervariable loci
N2  - No abstract available.
KW  - Amazon Molly
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86359
ER  - 
TY  - CHAP
A1  - Krüger, Hans-Peter
T1  - The driver under the influence of passenger and alcohol
T1  - Le conducteur sous l'influence des passagers et de l'alcool
N2  - No abstract available.
KW  - Kraftfahrer
KW  - Trunkenheit im Verkehr
KW  - Beifahrer
KW  - Einfluss
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86275
ER  - 
TY  - JOUR
A1  - Krüger, Hans-Peter
T1  - 0.5 statt 0.8 Promille - Warum eigentlich? Neue Argumente für eine alte Forderung
N2  - No abstract available
KW  - Promillegrenze
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86218
ER  - 
TY  - CHAP
A1  - Spielmann, W.-S.
A1  - Arend, L. J.
A1  - Klotz, Karl-Norbert
A1  - Schwabe, U.
T1  - Adenosine receptors and singnaling in the kidney
N2  - No abstract available.
KW  - Adenosinrezeptor
KW  - Niere
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86114
ER  - 
TY  - CHAP
A1  - Lohse, Martin J.
A1  - Klotz, Karl-Norbert
A1  - Maurer, K.
A1  - Ott, I.
A1  - Schwabe, Ulrich
T1  - Effects of adenosine on mast cells
N2  - No abstract available
KW  - Adenosin
KW  - Mastzelle
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86101
ER  - 
TY  - CHAP
A1  - Weinert, Franz E.
A1  - Helmke, Andreas
A1  - Schneider, Wolfgang
T1  - Individual differences in learning Performance and in school achievement: Plausible parallels and some unexplained discrepancies
N2  - No abstract available.
KW  - Lernerfolg
KW  - Schulleistung
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-71210
ER  - 
TY  - JOUR
A1  - Wilken, Anke
A1  - Klotz, Karl-Norbert
A1  - Tawfik-Schlieper, Hoda
A1  - Schwabe, Ulrich
T1  - Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes
N2  - No abstract available.
KW  - Pharmakologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86061
ER  - 
TY  - JOUR
A1  - Schartl, Angelika
A1  - Schartl, Manfred
T1  - Genes and cancer: Molecular biology of the melanoma oncogene of Xiphophorus
N2  - No abstract available.
KW  - Schwertkärpfling
KW  - Krebs <Medizin>
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-72670
ER  - 
TY  - JOUR
A1  - Schüssler, Ulrich
A1  - Okrusch, M.
A1  - Patzak, M.
A1  - Müller, P.
A1  - Kreuzer, H.
T1  - The polyphase thermal history of the Erbendorf-Vohenstrauß (ZEV) and the Erbendorf Greenschist (EGZ) zones of NE Bavaria in the light of Ar-Ar spectra
N2  - no abstract available
KW  - Erbendorf
KW  - Vohenstrauß
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-81862
ER  - 
TY  - JOUR
A1  - Schüssler, Ulrich
A1  - Skinner, D. N. B.
A1  - Roland, N.
T1  - Basischer bis intermediärer Plutonismus im NW-Teil des Wilson Terrane, Nordvictorialand, Antarktis
N2  - no abstract available
KW  - Wilson Terrane
KW  - Nordvictorialand
KW  - Antarktis
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-81850
ER  - 
TY  - JOUR
A1  - Lutz, Werner K.
T1  - Dosis-Wirkungs-Beziehungen in der chemischen Kanzerogenese
T1  - Dose-response relations in chemical carcinogenesis
N2  - Ich habe versucht darzulegen, daß mechanistische Überlegungen zur Extrapolation der Dosis-WirkungsBeziehung herangezogen werden können. Ein nichtlinearer Verlauf ist nicht nur bei den epigenetischen Kanzerogenen wahrscheinlich, sondern auch bei den DNA-bindenden. Echte Schwellen sind aber nur in solchen Fällen zu erwarten, wo kein endogenes Korrelat besteht. Immerhin können auch steile Nichtlinearitäten zu einer drastischen Risikoreduktion führen, so daß die Anstrengungen dahin gehen sollten, die Steigung und den Bereich des überproportionalen Abfalls experimentell zu zeigen. In einer heterogenen Population kann die 0 0- sis-Wirkungs-Kurve zusätzliche "Wellen" bekommen und wird dadurch grundsätzlich flacher. Im Extremfall ergibt sich eine lineare Dosis-Wirkungs-Beziehung unabhängig vom Wirkmechanismus des Kanzerogens. Diese Proportionalität zwischen tiefster Dosis und Effekt wird bei genotoxischen Kanzerogenen aus mechanistischen Gründen schon für eine homogene Population postuliert, doch kann dies in einer heterogenen Population auch bei epigenetischen Kanzerogenen in Frage kommen.
KW  - Toxikologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80046
ER  - 
TY  - JOUR
A1  - Linsenmair, Karl Eduard
T1  - Tropische Biodiversitat: Befunde und offene Probleme
T1  - Tropical hiodiversity: facts and unsolved problems
N2  - During the past 50 to over 100 million years communities evolved in the tropics which attained unprecedented levels of biodiversity, strikingly represented by evergreen lowland rain forests offering home to more than 50% of all the world's extant species. Within only some 30 years human action reduced the area covered with tropical rain forests to about half of its former size, thereby negatively affecting local and global functions of the biosphere and exterminating an unknown number of species. With an exponentially increasing rate we are throwing away our and all future generations' biological heritage. We destroy the most complicated, scientifically most interesting living systems before we have gained any knowledge of their structures ,and dynamics. To understand the particular structures and dynamics of tropical communities means in the first place to understand the causes and consequences of their ten- to more than hundredfold higher alphadiversity (as compared to temperate systems). This problem has a historical dimension and a functional side requiring answers as to the nature of the proximate mechanisms of its maintenance. My review is only concerned with the latter aspect, and its maIn emphasis is on the gaps in our knowledge. Two sets of hypotheses have been developed for explaining the high within-commUnIty diversity. (1) According to the classical concept interspecific niche competition and subsequent niche separation are the main forces determining the structure of the community. These so-called equilibrium models have been contrasted in recent times with (2) non-equilibrium models. These models do not attribute the decisive role to interspecific competition. Strong niche overlaps are presumed to be very common within species-rich communities. Continuous stochastic local disturbances are assumed to prevent the achievement of any long-term equilibrium (climax) state. Being on the right spot at the right time is regarded as most important. Whether oneor a combination of both models provide the best key for understanding the structure of a special section within a community will certainly depend on many properties of the species at debate (mobility, disr.ersal, fertility etc.). For the vast majority of tropical organisms all such information is at present unavailable. The principles governing the structure of communities is just one of the very ,basic open problems. Another very prominent question is how the qualitatively very rich, however quantitatively poor resources are distributed among the members of highly diverse guilds of consumers and decomposers. Does the scarcity rather favour generalists or specialists, are small species overrepresented, are resources more extensively used than in temperate communities? One important property is fairly well established: Populations of most tropical species seem to be very small. Since a) in very many' cases distribution range is obviously very limited, since b) predator pressure is generally assumed to be higher in the tropics and c) recent - perhaps unduely generalized - results claim abundance fluctuations in the tropics fully comparable in their dimensions to those in the temperate zone, the question arises as to how these small populations can persist for seemingly long periods of time and avoid rapid extinction. Additionally treated PoInts concern detritivore communities, plant animal Interactions, key stone groups. Saving biodiversity in general and the tropical species and community richness in particular is one of the most urgent tasks of our generation, and biologists have to play a still more prominent role in this extremely important endeavor than they have in the past decades.
KW  - Zoologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78302
ER  - 
TY  - BOOK
A1  - Krueger, Hans-Peter
T1  - Niedrige Alkoholkonzentrationen und Fahrverhalten
T1  - Low blood alcohol concentrations and driver behaviour
T1  - Des taux d'alcoolemie peu eleves et le comportement au volant
N2  - Auf der Grundlage von 1.126 empirischen Befunden stellt die vorliegende Literaturstudie dar, inwieweit die Fahrtüchtigkeit von Verkehrsteilnehmern bei Blutalkoholkonzentrationen (BAK) bis 0,8 Promille beeinträchtigt wird. Es zeigt sich, daß ab 0,3 Promille BAK bereits nachweisbare Wirkungen feststellbar sind. Ab 0,5 Promille treten deutliche Beeinträchtigungen auf: Rasch wechselnde Verkehrssituationen, unvorhersehbare Ereignisse, Mehrfachanforderungen an den Fahrer oder Situationen mit agressionsauslösenden Reizen werden schlecht bewältigt. Fahranfänger, die über weniger automatisierte Handlungen verfügen und ältere Verkehrsteilnehmer mit ihren größeren Schwierigkeiten bei Kontrollprozessen sind besonders gefährdet. Die Studie kommt zu dem Schluß, daß eine Absenkung des Gefahrengrenzwertes auf 0,5 Promille BAK zu befürworten ist. Das detaillierte Gesamtergebnis sowie ein umfangreiches Verzeichnis der bearbeiteten Literatur ist als Heft 213 der Reihe Forschungsberichte der Bundesanstalt für Straßenwesen veröffentlicht.
N2  - Based on 1,126 empirical findings, this Iiterature study describes the effects on the driving ability of road users of EACs up to 80 mg/100 ml. The review revealed that clear effects of alcohol can be ascertained from 30 mg/100 ml BAC. At BACs greater than 50 mg/100 ml, alcohol affects driving noticeably: rapidly changing traffic situations, unforeseen events, multiple demands on drivers at the same time or situations triggering emotional responses, such as aggression, are coped with badly. ln experienced drivers whose actions habe not yet become automatic to the extent desired and elderly road users with their growing difficulties with control processes are at special risk. The study concludes with the recommendation that the risks should be reduced by reducing the legal BAC Iimit to 50 mg/100 ml. A detailed description of the summary result an an extensive Iist of the references checked have been published in No. 213 of the Research Reports of the Federal Highway Research Institute (BASt). französisch: Sur Ia base de 1.126 resultats empiriques, la presente etude de litterature demontre dans quelle mesure Ia faculte de conduire des usagers de la raute est reduite sous l'influence d'un taux d'alcoolemie jusqu'a 0,8 g d'alcool par litre de sang. Deja a partir de 0,3 g d'alcool par litre de sang, des effets prouvables se presentent. A partir de 0,5 g, des prejudices evidentes sont a constater: JeS reactions dU COnducteur ViS-aViS des Situations de trafic changeant rapidement, des evenements imprevus, des sollicitations simultanees mutiples ou des Situations produisant des aggressions sont mal adaprees. Des conducteurs debutants qui ne disposent pas encore des automatismes d'action suffisants ainsi que des usagers de Ia raute plus äges qui ont des plus grandes difficultes avec les processus de contröle sont les groupes les plus eyposes au risque. L'etude conclut avec Ia recommendation de reduire Je risque en baissant Iimite du taux d'alcoolemie a 0,5 g par litre de sang. Une presentation detaillee des resultats ainsi qu'une Iiste extensive des references prises en campte sont publiees en tant que No. 213 des Rapports de Recherehes de !'Institut Federal des Recherehes Rautieres (BASt).
KW  - Alkoholkonsum
KW  - Fahrerverhalten
KW  - Älterer Verkehrsteilnehmer
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-74242
ER  - 
TY  - JOUR
A1  - Krämer-Neubert, Sabine
T1  - Mundart und Geschichte des Miltenberger Raumes
N2  - No abstract available
KW  - Mundart
KW  - Miltenberg
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-73135
ER  - 
TY  - JOUR
A1  - Pressley, Michael
A1  - Borkowski, John G.
A1  - Schneider, Wolfgang
T1  - Good information processing: What it is and how education can promote it
N2  - The nature of good information processing is outlined as determined by intact neurology, information stored in long-term memory, and general cognitive tendencies, attitudes, and styles. Educators can promote the development of good information processing by promoting what is in long-term memory. This can be accomplished by teaching important literary, scientific, and cultural knowledge; teaching strategies; motivating the acquisition and use of important conceptual knowledge and strategies; and encouraging the general tendencies supporting good information processing. Good information processing can be produced by years of appropriate educational input. Good information processors cannot be produced by short-term interventions.
KW  - Psychologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62127
ER  - 
TY  - JOUR
A1  - Paakkari, P.
A1  - Paakkari, I.
A1  - Sirén, Anna-Leena
A1  - Feuerstein, G.
T1  - Respiratory and locomotor stimulation by low doses of dermorphin - a Mu\(_1\)-receptor mediated effect
N2  - The selective opioid mu receptor agonist dermorphin increased the locomotor activity of rats dose dependently at 1 0 to 1 00 pmol/kg i.c.v. Respiratory rate, relative tidal volume and respiratory minute volume also increased unrelated to changes in locomotor activity. Higher doses, on the other hand, produced catalepsy and respiratory depression. Pretreatment of the rats with the mu,-selective antagonist naloxonazine (10 mg/kg i.v.) blocked the stimulant locomotor and respiratory effects of low doses of dermorphin (1 0--1 00 pmol/kg), but potentiated the respiratory depressant effect of a high dose (1 0 nmol/kg) of dermorphin. The selective benzodiazepine antagonist flumazenil (5 mg/kg), which has been shown previously to antagonize catalepsy and respiratory depression produced by relatively high doses of dermorphin, did not antagonize the respiratory or locomotor stimulant effect of dermorphin. The data suggest that mu\(_1\)-opioid receptors are responsible for the low dose stimulant effects of dermorphin on locomotor activity and respiration whereas mu\(_2\) receptors mediate the respiratory depressant effect of dermorphin.
KW  - Neurobiologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63110
ER  - 
TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - Feuerstein, G.
T1  - Cardiovascular effects of anatoxin-a in the conscious rat
N2  - Cardiovascular Effects of Anatoxin-A in the Conscious Rat. SJREN, A.-L., AND FEUERSTEIN, G. (1990). Toxicol. Appl. Pharmacol. 102,91-100. The effects ofanatoxin-A on mean arterial pressure (MAP), heart rate, cardiac index (CI), and blood flow (BF) in hindquarter (HQ), renal (R). and mesenteric (M) vascular beds were studied after intravenous (iv) and intracerebroventricular (icv) administration in the conscious rat. The pharmacological profile of anatoxin-A was further compared to nicotine administered iv and icv. MAP and heart rate were measured from femoral artery, CI by thermodilution method, and blood flow by Doppler velocimetry. Anatoxin-A and nicotine (30, 100 and 300 1-!g/kg iv) produced an increase in MAP with concomitant bradycardia. The highest doses increased Cl. MBF and RBF decreased due to a vasoconstriction in M and R vasculature. These effects were attenuated by the ganglion blocker chlorisondamine (5 mg/kg, iv). Anatoxin-A ( 100 1-!g/k~ iv) increased plasma epinephrine Ievels by 2- fold with virtually no effect on norepinephrine whereas nicotine ( 100 ~oLg/kg, iv) increased plasma epinephrine and norepinephrine by 20- to 30-fold. Central administration of anatoxin-A and nicotine (30-100 ,ug/kg icv) increased MAP with no effect on heart rate and produced M and R vasoconstriction. In summary, the present study demonstrates that anatoxin-A acts as a nicotinic cholinergic agonist in the c.onscious rat after both systemic and centrat administration. Anatoxin-A and nicotine produced pressor and reno-splanchnic vasoconstrictor responses and at high doses increased cardiac output. These effects were mediated by activation ofthe nicotinic receptors in the adrenal medulla and sympathetic ganglia. However, marked differences were found in the potency ofanatoxin-A versus nicotine to stimulate the sympathoadrenomedullary axis.
KW  - Neurobiologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63103
ER  - 
TY  - JOUR
A1  - Epe, B.
A1  - Harttig, U.
A1  - Stopper, Helga
A1  - Metzler, M.
T1  - Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation
N2  - Neoplastic cell transfonnation induced by estrogens and some other carcinogen& such as benzene appears to involve the induction of mitotic aneuploidy rather than DNA damage and point mutations. As metabolic activation may also play an important roJe in the mechanism of carcinogenesis of these nongenotoxic compounds, we have studied the Interaction of reactive quinone metabolites of various estrogens and of benzene with the major microtubular protein, tubulin, in a cell-free system. Covalent binding of the radioactively labeled metabolites to the a- and 13-subunit of tubulin was found to depend on the structure of the metabolite. When the adducted tubulins were tested in vitro for their ability to polymerize to microtubules, Inhibition of microtubule assembly was obsened in every case, although to varying extents. It is proposed that the fonnation of covalent tubulin adducts may impair the formation of mitotic spindies and thus contribute to chromosomal nondisjunction and aneuploidy induction.
KW  - Toxikologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63478
ER  - 
TY  - JOUR
A1  - Kurtz, Beth E.
A1  - Schneider, Wolfgang
A1  - Carr, Martha
A1  - Borkowski, John G.
A1  - Rellinger, Elizabeth
T1  - Strategy instruction and attributional beliefs in West Germany and the United States: Do teachers foster metacognitive development?
N2  - Previous research has shown German children to be more strategic on sort-recall memory tasks than their American age-mates, and to show fewer effort-related attributions. We conducted this study to determine if those differences are due to systematic differences in the strategy instruction and attributional beliefs of German and U.S. teachers, and to explore metacognitive instructional practices in the two countries. Teachers responded to a questionnaire that inquired about their use of strategy instructions, fostering of reflective thinking in pupils, sources of children’s learning problems, and modeling of metacognitive skills such as monitoring. The second part of the questionnaire asked about the reasons underlying children’s academic successes and failures. German teachers reported more instruction of task-specific strategies, while American teachers showed more effort-related attributions. The types of strategies instructed and types of learning problems most frequently described varied across the two countries, and also according to how many years the teachers had taught. Results were discussed regarding their implications for metacognitive developmental theory, particularly regarding culture and other environmental influences on the development of controlled processing.
KW  - Psychologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62145
ER  - 
TY  - JOUR
A1  - Sodian, Beate
A1  - Schneider, Wolfgang
T1  - Children's understanding of cognitive cueing: How to manipulate cues to fool a competitor
N2  - 4-6-year-old children's understanding of cognitive cuing was studied in 2 experiments using a strategic interaction paradigm. Ghildren could fool a competitor by hiding targets in locations that were labeled with semantically weakly associated cues and help a cooperative partner by hiding them in semantically highly associated locations. Very few 4-year-olds, half the 5-year-olds, and almost all 6-year-olds appropriately chose semantically highly vs. weakly associated hiding places to make the targets easy vs. difficult to find. The second experiment showed that 4-year-olds did not strategically manipulate cues as sources of information, although they themselves proficiently used them as such in a search task. These findings are discussed with regard to research on children's developing understanding of origins of knowledge and belief and with regard to recent claims that young preschoolers possess a metacognitive understanding of cognitive cuing.
KW  - Psychologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62132
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Sibylle
A1  - Liebert, U. G.
A1  - Baczko, K.
A1  - ter Meulen, V.
T1  - Restricted expression of measles virus in primary rat astroglial cells
N2  - No abstract available
KW  - Virologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62283
ER  - 
TY  - JOUR
A1  - Liebert, U. G.
A1  - Schneider-Schaulies, Sibylle
A1  - Baczko, K.
A1  - ter Meulen, V.
T1  - Antibody-induced restriction of viral gene expression in measles encephalitis in rats
N2  - No abstract available
KW  - Virologie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62271
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - von Brunn, A.
A1  - Schachner, M.
T1  - Recombinant peripheral myelin protein P\(_o\) confers both adhesion and neurite outgrowth promoting properties
N2  - To probe into the functional properties of the major peripheral myelin cell surface glycoprotein P 0 , its ability to confer adhesion and neurite outgrowth-promoting properfies was studied in cell culture. Tothis aim, Po was expressed as integral membrane glycoprotein at the surface of CV -1 cells with the help of a recombinant vaccinia virus expression system. Furthermore, the immunoglobulin-like extracellular domain of P0 (P0 -ED) was expressed as soluble profein in a bacterial expression system and used as substrafe coated to plastic dishes or as competitor in cell adhesion and neurite outgrowth-promoting assays. The adhesion of P0 -expressing CV-1 cells to P0 -ED substrafe was specifically inhibitable by polyclonal Po antibodies (54% :t 6% ). In addition, the specific interaction between Po molecules could be reduced ( 49% ± 8%) by adding soluble P0 -ED to the culture medium, demonstrating that the homophilic inter~ction between recombinant Po molecules can be mediated, at least on one partner of interacting molecules, by the unglycosylated Ig-like domain. Substrate-coated p -ED also conferred adhesion and neurite outgrowth ability to dorsal root ganglion neurons with neurites of a mean length of about 150 ,_..m. This neurite outgrowth was specifically inhibitable by soluble P" (74% ± 14%) and P 0 antibodies (65% ± 9% ). These observations indicate that Po is capable of displaying two different types of functional roles in the myelination process of . peripheral nerves: The heterophilic interaction with neurons may be responsible for the recognition between axon and myelinating Schwann cell at the onset of myelination, whereas the homophilic interacton may indicate its roJe in the selfrecognition of the apposing loops of Schwann cell surface membranes during the myelination process and in the mature compact myelin sheath.
KW  - Immunologie
KW  - immunoglobulin superfamily
KW  - peripheral nervous system
KW  - vaccinia virus
KW  - Po
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54841
ER  - 
TY  - JOUR
A1  - Merz, H.
A1  - Fliedner, A.
A1  - Lehrnbecher, T.
A1  - Sebald, Walter
A1  - Müller-Hermelink, H. K.
A1  - Feller, A. C.
T1  - Cytokine expression in B-cell non-Hodgkin lymphomas
N2  - No abstract available
KW  - Biochemie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62539
ER  - 
TY  - JOUR
A1  - Dörje, F.
A1  - Friebe, T.
A1  - Tacke, Reinhold
A1  - Mutschler, E.
A1  - Lambrecht, G.
T1  - Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus
N2  - The present study was designed to further characterize the muscarinic receptors mediating contraction of the guinea-pig uterus. The affinities of various selective muscarinic antagonists were determined and compared with those obtained at M\(_1\) (rabbit vas deferens), M\(_2\) (guinea-pig atria) and M\(_3\) receptors (guinea-pig ileum). The contractile responses of uterine smooth muscle from immature guinea-pigs to carbachol (pD\(_2\) = 5.73) were competitively antagonized by pirenzepine (pA\(_2\) = 7.04), AF-DX 116 (11-[[2-[(diethylamino)methyl]-1-piperidinyl] acetyl]- 5,11-dihydro-6H -pyrido[2,3-b][1 ,4]benzo. diazepin-6-one) (pA\(_2\) = 6.96), himbacine (pA\(_2\) = 7.92), methoctramine (pA\(_2\) = 7.52), 4-DAMP (4-diphenylacetoxy- N-methylpiperidine methiodide) (pA\(_2\) = 8.87) and sila-hexocyclium (pA\(_2\) = 8.81). A comparison of affinity values indicates that the muscarinic receptors present in guinea-pig uterus display a novel pharmacological profile which is not consistent with the presence of either an M\(_1\), M\(_2\) or M\(_3\) receptor. The affinities determined for the different antagonists rather showed a close similarity to those obtained at muscarinic receptors present in rat striatum and NG108-15 cells which are considered pharmacological equivalents (M\(_4\) receptors) of the m4 gene product. We thus hypothesize that the guinea-pig isolated uterus preparation may serve as a simple functional assay system to study the pharmacology of M\(_4\) receptors.
KW  - Anorganische Chemie
KW  - Muscarinic receptors
KW  - M4 receptors
KW  - Guinea-pig uterus
KW  - Pirenzepine
KW  - Methoctramine
KW  - Sila-hexocyclium
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64071
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Becker, B.
A1  - Lange, H.
T1  - (Thioacetoxy-S-methyl)diorganylsilane und (Mercaptomethyl)diorganylsilane: Synthese und Eigenschaften
N2  - Die erstmalige Synthese der (Thioacetoxy-S-methyl)diorganylsilane (CH\(_3\))\(_2\)Si(H)CH\(_2\)SC(O)CH\(_3\) (9) und (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)SC(O)CH\(_3\) (10) und der (Mercaptomethyl) diorganylsilane (CH\(_3\))\(_2\)Si(H)CH\(_2\)SH (11) und (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)SH (12) wird beschrieben. Während sich die Silane 9 und 10 leicht handhaben lassen, neigen die strukturanalogen (Hydroxymethyl)diorganylsilane (CH\(_3\))\(_2\)Si(H)CH\(_2\)OH (1) und (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)OH (2) zu einer basenkatalysierten Zersetzung (Bildung oligomerer (polymerer) Alkoxysilane und Wasserstoff). Im Gegensatz zu den thermisch labilen (Acetoxymethyl)diorganylsilanen (CH\(_3\))\(_2\)Si(H)CH\(_2\)OC(O)CH\(_3\) (3) und (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)OC(O)CH\(_3\) (4) (--+ Umlagerung zu den entsprechenden Acetoxy(methyl) diorganylsilanen (CH\(_3\)) \(_3\)SiOC(O)CH\(_3\) (5) und CH\(_3\)(C\(_6\)H\(_5\))\(_2\)SiOC(O)CH\(_3\) {6)) sind die Thio-Analoga 9 und 10 thermisch stabil (I-molare Lösungen in C\(_6\)D\(_6\), 30 h bei 180 o C).
N2  - The novel synthesis of the (thioacetoxy-S-methyl)diorganylsilanes (CH\(_3\))\(_2\)Si(H)CH\(_2\)SC(O)CH\(_3\) (9) and (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)SC(O)CH\(_3\) (10) and the (mercaptomethyl) diorganylsilanes (CH\(_3\))\(_2\)Si(H)CH\(_2\)SH (11) and (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)SH (12) is described. The silanes 11 and 12 areeasy to handle, whereas the structurally analogous (hydroxymethyl)diorganylsilanes (CH\(_3\))\(_2\)Si(H)CH\(_2\)OH (1) and (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)OH (2) tend to undergo a base-catalyzed decomposition (formation of oligomeric (polymeric) alkoxysilanes and hydrogen). In cantrast to the thermally unstable (acetoxymethyl)diorganylsilanes (CH\(_3\))\(_2\)Si(H)CH\(_2\)OC(O)CH\(_3\) (3) and (C\(_6\)H\(_5\))\(_2\)Si(H)CH\(_2\)OC(O)CH\(_3\) (4) (--+ rearrangement to the corresponding acetoxy(methyl)diorganylsilanes (CH\(_3\)) \(_3\)SiOC(O)CH\(_3\) (5) and CH\(_3\)(C\(_6\)H\(_5\))\(_2\)SiOC(O)CH\(_3\) (6)), the thio-analogues 9 and 10 are thermally stable (1 molar solutions in C\(_6\)D\(_6\) , 30 h at 180°C).
KW  - Anorganische Chemie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64065
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Fritsche, K.
A1  - Tafel, A.
A1  - Wuttke, F.
T1  - Synthese von racemischem Acetyl(t-butyl)methylphenylsilan und Acetylmethylphenyl[(trimethylsilyl)methyl]silan: Substrate für stereoselektive mikrobielle Reduktionen
KW  - Anorganische Chemie
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64055
ER  -