TY  - JOUR
A1  - Higgins, M. J.
A1  - Smilinich, N. J.
A1  - Sait, S.
A1  - Koenig, A.
A1  - Pongratz, J.
A1  - Gessler, Manfred
A1  - Richard III., C. W.
A1  - James, M. R.
A1  - Sanford, J. P.
A1  - Kim, B.-W.
A1  - Cattelane, J.
A1  - Nowak, N. J.
A1  - Winterpacht, A.
A1  - Zabel, B. U.
A1  - Munroe, D. J.
A1  - Bric, E.
A1  - Housman, D. E.
A1  - Jones, C.
A1  - Nakamura, Y.
A1  - Gerhard, D. S.
A1  - Shows, T. B.
T1  - An Ordered NotI Fragment Map of Human Chromosome Band 11p15
N2  - An ordered NotI fragment map containing over 60 loci and encompassing approximately 17 Mb has been constructed for human chromosome band llpl5. Forty-two probes, including 11 NotI-linking cosmids, were subregionaUy mapped to llpl5 using a subset of the Jl-deletion hybrids. These and 23 other probes defining loci previously mapped to 11p15 were hybridized to genomic DNA digested with NotI and 5 other infrequently cleaving restriction enzymes and separated by pulsed-field gel electrophoresis. Thirty-nine distinct NotI fragments were detected encompassing approximately 85% of the estimated length of llp15. The predicted order of the gene loci used is cenMYODI- PTH-CALCA-ST5-RBTNI-HPX-HBB-RRMlTH/ INS!1GF2-H19-CTSD-MUC2-DRD4-HRAS-RNHtel. This map wiu allow higher resolution mapping of new Ilp15 markers, facilitate positional cloning of disease genes, and provide a framework for the physical mapping of llp15 in clone contigs.
KW  - Genom / Genkartierung / Genanalyse
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45766
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Thoenen, Hans
T1  - Oxidative stress and motorneuron disease
N2  - Transgenic mice carrying mutated Cu/Zn superoxide dismutase genes provide insights into the pathogenesis of human motorneuron diseases and may be useful as models in the development and testing of therapies.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42684
ER  - 
TY  - JOUR
A1  - Dittrich, Falk
A1  - Thoenen, Hans
A1  - Sendtner, Michael
T1  - Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42639
ER  - 
TY  - JOUR
A1  - Sendtner, Michael
A1  - Carroll, P.
A1  - Holtmann, B
A1  - Hughes, R. A.
A1  - Thoenen, H.
T1  - Ciliary Neurotrophic Factor
N2  - No abstract available
KW  - ciliary neuron
KW  - ciliary neurotrophic factor
KW  - motoneuron
KW  - nonneuronaI cells
KW  - homologous recombination
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42545
ER  - 
TY  - JOUR
A1  - Klemd, R.
A1  - Matthes, S.
A1  - Schüssler, Ulrich
T1  - Reaction textures and fluid behaviour in very high-pressure calc-silicate rocks of the Münchberg gneiss complex, Bavaria, Germany
N2  - Calc-silicate rocks occur as elliptical bands and boudins intimately interlayered with eclogites and high-pressure gneisses in the Munchberg gneiss complex of NE Bavaria. Core assemblages of the boudins consist of grossular-rich garnet, diopside, quartz, zoisite, clinozoisite, calcite, rutile and titanite. The polygonal granoblastic texture commonly displays mineral relics and reaction textures such as postkinematic grossular-rich garnet coronas. Reactions between these mineral phases have been modelled in the CaO-Al203-Si02-C02-H2 0 system with an internally consistent thermodynamic data base. High-pressure metamorphism in the calc-silicate rocks has been estimated at a minimum pressure of 31 kbar at a temperature of 630°C with X^oSQ.Gi. Small volumes of a C02-N2-rich fluid whose composition was buffered on a local scale were present at peak-metamorphic conditions. The P-T conditions for the onset of the amphibolite facies overprint are about 10 kbar at the same temperature. A'co., of the H20-rich fluid phase is regarded to have been <0.03 during amphibolite facies conditions. These P-T estimates are interpreted as representing different stages of recrystallization during isothermal decompression. The presence of multiple generations of mineral phases and the preservation of very high-pressure relics in single thin sections preclude pervasive post-peak metamorphic fluid flow as a cause of a re-equilibration within the calc-silicates. The preservation of eclogite facies, very high-pressure relics as well as amphibolite facies reactions textures in the presence of a fluid phase is in agreement with fast, tectonically driven unroofing of these rocks.
KW  - calc-silicate rocks; fluid behaviour; P-T path; reaction textures; Variscan basement; very high-pressure metamorphism
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31035
ER  - 
TY  - JOUR
A1  - Gessler, Manfred
A1  - König, A.
A1  - Arden, K.
A1  - Grundy, P.
A1  - Orkin, S. H.
A1  - Sallan, S.
A1  - Peters, C.
A1  - Ruyle, S.
A1  - Mandell, J.
A1  - Li, F.
A1  - Cavenee, W.
A1  - Bruns, G. A.
T1  - Infrequent mutation of the WT1 gene in 77 Wilms' Tumors
N2  - Homozygous deletions in Wilms' tumor DNA have been a key step in the identification and isolation of the WTI gene. Several additional loci are also postulated to contribute to Wilms' tumor formation. To assess the frequency of WTI alterations we have analyzed the WTI locus in a panel of 77 Wilms' tumors. Eight tumors showed evidence for large deletions of several hundred or thousand kilobasepairs of DNA, some of which were also cytogenetically detected. Additional intragenic mutations were detected using more sensitive SSCP analyses to scan all 10 WTI exons. Most of these result in premature stop codons or missense mutations that inactivate the remaining WTI allele. The overall frequency of WTI alterations detected with these methods is less than 15%. While some mutations may not be detectable with the methods employed, our results suggest that direct alterations of the WTI gene are present in only a small fraction of Wilms' tumors. Thus, mutations at other Wilms' tumor loci or disturbance of interactions between these genes likely play an important role in Wilms' tumor development.
KW  - Wilms' tumor
KW  - WTI
KW  - Zinc finger gene
KW  - Tumor suppressor gene
KW  - Nephroblastoma
KW  - Deletion analysis
KW  - SSCP analysis
KW  - Mutation screening
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34308
ER  - 
TY  - JOUR
A1  - Quast, Helmut
A1  - Schmitt, Edeltraud
A1  - Schäfer, Peter
A1  - Heller, Eberhard
A1  - Aldenkortt, Sven
T1  - Synthesis and Thermolysis of a Chiral, Non-Racemic Iminoaziridine
N2  - The 2-halo imidoyl chlorides 7 are obtained from the amide 5 and the 2-halo amides 6 by the action of phosphorus pentachloride and thionyl chloride, respectively. Non-racemic (S)-6a is converted into 7a which is racemic, however. The reaction of Lawesson's reagent with 6a furnishes the diastereomeric 1,3.2-thiazaphospholidine derivatives 15. Treatment of (S)-6a (98% eel with methyl triflate affords 2-chloro imidate 8 (95% eel which reacts with methanamine in the presence of methanammonium chloride to yield the 2-chloro amidine (S)-9a (90% eel. The 2-halo imidoyl halides 7a and b react with methanamine to produce the 2-halo amidines 9a and b. - Strong bases, e.g. potassium tert-butoxide or sodium hydride in the presence of catalytic amounts of tertbutyl alcohol, eliminate hydrogen chloride or bromide from the 2-halo amidines 9a and band (S)-9a to yield mixtures of Recently, we demonstrated that the formation of the chiral non-racemic aziridinone (R)-2 from the a-chloro amide (5)-1 by base-promoted dehydrochlorination[2) as well as the nucleophilic cleavage of the N-C(3) bond of (R)_2[3,4) occur with inversion of configuration, thus excluding the intervention of achiral (acyclic) intermediates. In the temperature range of lOO-170°C, however, slow racemization accompanies the thermolysis of (R)-2 and indicates the existence of an achiral or a racemic transient, e. g. (M)-3 + (P)-3. Indeed, high-level quantum-chemical calculations reveal that an activation energy of (170 ± 25) kJmol- 1 is required for the unimolecular ring opening of the parent aziridinone which affords a species of high diradical character[41. Subsequently, the unstable N-phenylaziridinone invoked in the decomposition of the (5)-2-bromopropananilide anion was shown to react with tert-butylamine or dimethylformamide with inversion of configuration at C(3)[51. Thus, the stereochemical evidence in the series of 3-alkylaziridinones excludes achiral (acyclic) aziridinone isomers as intermediates at low tempera tures [6J. Similar stereochemical studies are still missing in the related series of iminoaziridines. Therefore, we report on the synthesis and thermolysis of the diastereomeric chiral racemic (E)- and (Z)-(4)[71 and non-racemic iminoaziridines (E,R)- and (Z,R)-4. Racemic Iminoaziridines (E)- and (Z)-4 Though a photochemical route to the iminoaziridines (E)- and (Z)-4 has been devised more recently, i. e. the phothe 2-iminoaziridines (E)- and (Z)-4, and (E,R)- and (Z.R)-4 (83% eel, respectively. The 1.3-elimination of hydrogen bromide from 9b is diastereoselective at -30 to -40°C [(E)-4:(Z)-4 = <10:>90). The diastereomers equilibrate at 36°C with (kEZ + k ZE) = (5.92 ± 0.08) . 10-5 S-I (K = kEZlkzE = 0.428 ± 0.013). - The thermolysis of (E)- and (Z)-4 in [D61benzene solution yields the imine 16 and methyl isocyanide (17). The decomposition follows the first-order rate law. The following Arrhenius and Eyring parameters are calculated from five rate constants obtained in the temperature range of 70-110°C: Ea = (115.2 ± 0.4) kJmol-t, IgA = (12.06 ± 0.28), AH* = (112.1 ± 0.4) kJmol- l , AS'" = (-23.9 ± 0.7) JK-I mol-I, AGj73K = 121 kJmol-1 . The enantiomeric excess of the surviving fraction of (E,R)- and (Z.R)-4 is unchanged after two half-lives at 80°C.
KW  - Aziridines
KW  - 2-imino-
KW  - chiral
KW  - non-racemic
KW  - Imidoyl halides
KW  - 2-halo
KW  - Imidates
KW  - 2-chloro
KW  - 1
KW  - 3
KW  - 2-Thiazaphospholidines
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38298
ER  - 
TY  - JOUR
A1  - Rösch, M.
A1  - Atzmüller, R.
A1  - Schaack, G.
A1  - Becker, Charles R.
T1  - Resonant Raman scattering in a zero-gap semiconductor: Interference effects and deformation potentials at the E\(_1\) and E\(_1\) + \(\Delta_1\) gaps of HgTe
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38062
ER  - 
TY  - JOUR
A1  - Tönnies, D.
A1  - Bacher, G.
A1  - Forchel, Alfred
A1  - Waag, A.
A1  - Litz, Th.
A1  - Hommel, D.
A1  - Becker, Charles R.
A1  - Landwehr, G.
A1  - Heuken, M.
A1  - Scholl, M.
T1  - Optical study of interdiffusion in CdTe and ZnSe based quantum wells
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37750
ER  - 
TY  - JOUR
A1  - Schikora, D.
A1  - Hausleitner, H.
A1  - Einfeldt, S.
A1  - Becker, Charles R.
A1  - Widmer, T.
A1  - Giftige, C.
A1  - Lischka, K.
A1  - von Ortenburg, M.
A1  - Landwehr, G.
T1  - Epitaxial overgrowth of II-VI compounds on patterned substrates
N2  - The selected area epitaxial overgrowth of narrow gap HgTe as well as wide gap CdTe and ZnTe on CdTe/GaAs substrates, which had been structured by dry etching techniques, has been investigated. A plasma etching process using a barrel reactor with CH\(_4\)-CH\(_2\) gases has been employed to prepare stripes with a width of about 1 μm with anisotropic as well as isotropic etching profiles. It has been found, that the selected area HgTe overgrowth takes place with a high local selectivity to the low index planes of the patterned surface. In contrast, the selected area overgrowth of the wide gap CdTe and ZnTe is controlled by anisotropic growth kinetics provided that the substrate temperature is not lower than 220°C and the starting surface consists of well developed low index crystallographic planes.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-37985
ER  - 
TY  - JOUR
A1  - Einfeldt, S.
A1  - Heinke, H.
A1  - Behringer, M.
A1  - Becker, Charles R.
A1  - Kurtz, E.
A1  - Hommel, D.
A1  - Landwehr, G.
T1  - The growth of HgSe by molecular beam epitaxy for ohmic contacts to p-ZnSe
N2  - The structural properties of HgSe grown by molecular beam epitaxy (MBE) are investigated for different lattice mismatches to the substrate and various growth conditions. The growth rate is shown to depend strongly on the growth temperature above lOO°C as well as on the Hg/Se flux ratio. It has been found that the crystalline perfection and the electrical properties are mainly determined by the layer thickness, especially for the growth on highly lattice mismatched substrates. Changes in the surface morphology are related to growth parameters. Differences between the electrical behavior of MBE-grown and bulk HgSe are discussed. The electrical properties of HgSe contacts on p-ZnSe are investigated as a function of different annealing procedures.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38001
ER  - 
TY  - JOUR
A1  - Zhang, X. F.
A1  - Becker, Charles R.
A1  - Zhang, H.
A1  - He, L.
A1  - Landwehr, G.
T1  - Investigation of a short period (001) HgTe-Hg\(_{0.6}\)Cd\(_{0.4}\)Te  superlattice by transmission electron microscopy
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38029
ER  - 
TY  - JOUR
A1  - Schmuck, R.
A1  - Geise, W.
A1  - Linsenmair, Karl Eduard
T1  - Life cycle strategies and physiological adjustments of Reedfrog Tadpoles (Amphibia, Anura, Hyperoliidae) in relation to environmental conditions.
N2  - The relationship between different degrees of intraspecific crowding of reedfrog tadpoles and their physiological responses to a deterioration of the natal pond water quality was examined under laboratory conditions. Tadpoles that were reared at a lower density metamorphosed significantly earlier than those raised at a higher density. As density increases, the average body length at metamorphosis decreases. However, at low tadpole density, a significantly higher diversity of body size classes among freshly metamorphosed froglets was observed than under more crowded conditions. Mortality increased during metamorphic climax and was inversely correlated with the tadpole density. In ephemeral ponds, an accumulation of nitrogenous wastes from metabolic processes and/or a concentration by evaporation in prolonged rainless periods can pose a considerable chemical stress to reedfrog tadpoles. Hyperolius viridiflavus ommatostictus responded to an increasing ammonia concentration with an activity increase of the ornithine cycle (intensified urea synthesis). hi contrast, Hyperolius marmoratus taeniatus exhibited a strong tolerance against high ammonia levels. A deterioration of the natal pond water quality caused H. v. ommatostictus and H. v. nitidulus tadpoles to adjust to harsher climatic conditions at the time of metamorphosis. This physiological preadjustment enabled the froglets to start feeding and growing immediately after metamorphosis even at low air humidity and rare precipitation events. In contrast, froglets that were raised in daily refreshed water exhibited high mortality rates if subjected to identical conditions. As one possible indicator of the actual climatic conditions prevailing in the surrounding terrestrial habitat, fluctuations in the water ammonia level are discussed.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31009
ER  - 
TY  - JOUR
A1  - Frischholz., S.
A1  - Röllinghoff, M.
A1  - Moll, Heidrun
T1  - Cutaneous leishmaniasis: Co-ordinate expression of granzyme A and lymphokines by CD4\(^+\) T cells from susceptible mice.
JF  - Immunology
N2  - We have recently demonstrated that the frequency ofT cells expressing granzyme A is significantly higher in skin lesions and spleens of susceptible BALB/c mice compared with resistant C57BL/6 mice infected with Leishmania major, a cause of human cutaneous leishmaniasis. In the present study, we have performed in vitro studies to characterize the subpopulation, the antigen responsiveness and the lymphokine production pattern of granzyme A-expressing T cells in L. major-infected mice. Using a limiting dilution system for functional analysis of selected T cells at the clonallevel, we could show that granzyme A activity in infected BALB/c mice can be assigned to L. major-reactive CD4\(^+\) T cells secreting interleukin-2 (IL-2) and IL-4. Granzyme A production was most pronounced in the early phase of infection. On the other hand, granzyme A expression could not be detected in C57BL/6-derived T cells responding to L. major. The da ta support the suggestion that granzyme A is produced by L. major-responsive CD4\(^+\) T cells facilitating lesion formation and the dissemination of infection.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30954
VL  - 82
SP  - 255
EP  - 260
ER  - 
TY  - JOUR
A1  - Fiala, Brigitte
A1  - Grunsky, Harald
A1  - Maschwitz, Ulrich
A1  - Linsenmair, Karl Eduard
T1  - Diversity of ant-plant interactions: Protective efficacy in Macaranga species with different degrees of ant-association.
N2  - The pioneer tree Macaranga in SE Asia has developed manyfold associations with ants. The genus comprises all stages of interaction with ants, from facultative relationships to obligate myrmecophytes. Only myrmecophytic Macaranga offer nesting space for ants and are associated with a specific ant partner. The nonmyrmecophytic species are visited by a variety of different ant species which are attracted by extrafloral nectaries (EFN) and food bodies. Transitional Macaranga species like M. hosei are colonized later in their development due to their stem structure. Before the colonization by their specific Crematogaster partner the young plants are visited by different ant species attracted by EFN. These nectaries are reduced and food body production starts as soon as colonization becomes possible. We demonstrated earlier that obligate ant partners can protect their Macaranga plants against herbivore damage and vine cover. In this study we focused on nonspecific interactions and studied M. tanarius and M. hosei, representing a non-myrmecophyte and a transitional species respectively. In ant exclusion experiments both M. tanarius and M. hosei suffered significantly higher mean leaf damage than controls, 37% versus 6% in M. hosei, 16% versus 7% in M. tanarius. M. tanarius offers both EFN and food bodies so that tests for different effects of these two food rewards could be conducted. Plants with food bodies removed but with EFN remaining had the lowest mean increase of herbivore damage of all experimental groups. Main herbivores on M. hosei were mites and caterpillars. Many M. tanarius plants were infested by a shootborer. Both Macaranga species were visited by various ant species. Crematogaster spp. being the most abundant. We found no evidence for any specific relationships. The results of this study strongly support the hypothesis that non-specific, facultative associations with ants can be advantageous for Macaranga plants. Food bodies appear to have lower attractive value for opportunistic ants than EFN and may require a specific dietary adaptation. This is also indicated by the fact that food body production in the transitional M. hosei does not start before stem structure allows a colonization by the obligate Crematogaster species. M. hosei thus benefits from facultative association with a variety of ants until it produces its first domatia and can be colonized by its obligate mutualist.
KW  - Ant-plant interactions ; Herbivory Macaranga ; Mutualism ; Myrmecophytes
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32905
ER  - 
TY  - JOUR
A1  - Schüssler, Ulrich
A1  - Henjes-Kunst, Friedhelm
T1  - Petrographical and Geochronological Investigations on a Garnet-Tourmaline Pegmatite from Ringgold Knoll, Oates Coast, Antarctica
N2  - The Ringgold Knoll pegmatite, a late-stage member of the Granite Harbour Intrusives, crosscuts high-grade Wilson gneisses of the Oates Coast, which forms the westernmost part of the Wilson Terrane at the Pacific end of the Cambro-Ordovician Ross orogenic belt in West Antarctica. The pegmatite mineral assemblage consists of K-feldspar, plagioclase, quartz, garnet (almandinespessartine-pyrope), dark tourmaline (schorl-dravite), muscovite, apatite, monazite, zircon, blue AI-rich tourmaline and dumortierite in order of decreasing abundances. Major, minor and rare earth elements are reported for the greater part of the mineral assemblage. The time of pegmatite emplacement is constrained by Rb-Sr and Sm-Nd isochron ages of 492 ± 8 (2a) Ma and 500 ± 40 (2a) Ma, respectively. High initial 87Sr/86Sr of 0.7315 ± 0.0003 and low E Nd,t of -8.7 ± 1.2 strongly support an origin of the magma from highly evolved crustal source rocks. K-Ar and Ar-Ar model ages of about 470 to 475 Ma for igneous muscovite indicate that the pegmatite together with its wall rocks spent a prolonged period at elevated temperatures before final cooling below about 350 °C. The muscovite dates may give an estimate for the time of exhumation of the Oates Coast crystalline basement along two major late Ross orogenic detachment zones within the Wilson Terrane i.e. the Wilson and the Exiles thrusts (c.f. FLÖTTMANN and KLEINSCHMIDT, 1991).
N2  - Der Pegmatit vom Ringgold Knoll geh6rt zur spaten Gangfolge der Granite Harbour Intrusionen und durchschlagt hochgradig metamorphe Wilson Gneise der Oates Coast, die den westlichsten Teil des Wilson Terranes am pazifischen Ende des Kambro-Ordovizischen Ross Orogengiirtels in der Westantarktis bildet. Die pegmatitische Mineralparagenese besteht aus Kalifeldspat, Plagioklas, Quarz, almandin-spessartin-pyrop-betontem Granat, dunklem schorl-dravit-betontem Turmalin, Muscovit, Apatit, Monazit, Zirkon, blauem AI-reichem Turmalin und Dumortierit in der Reihenfolge abnehmenden Modalanteils. FUr den groBeren Teil der Minerale wurden Haupt-, Neben- und Seltenerdelemente bestimmt. Der Zeitpunkt der Pegmatitintrusion wird durch Rb-Sr und Sm-Nd Isochronenalter von 492 ± 8 (20") Ma bzw. 500 ± 40 Ma (20") datiert. Ein hohes "SrI" Sr Initialverhaltnis von 0,7315 ± 0,0003 und ein niedriger Wert flir E Nd,t von -8,7 ± 1,2 sprechen deutlich für eine Magmenherkunft von hochdifferenzierten krustalen Ausgangsgesteinen. K-Ar und Ar-Ar Modellalter von etwa 470 bis 475 Ma von magmatischem Muscovit zeigen, daB der Pegmatit und das Nebengestein eine langsame AbkUhlung auf Temperaturen unter etwa 350°C er1ebten. Die Muscovitdaten konnen als eine Zeitmarke gesehen werden fUr die Heraushebung des kristallinen Grundgebirges der Oates Coast entlang der zwei split Ross-orogenen Wilson und Exiles Hauptüberschiebungszonen im Wilson Terrane (FLÖTTMANN und KLElNSCHMlDT 1991).
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31789
ER  - 
TY  - JOUR
A1  - Vortkamp, Andrea
A1  - Gessler, Manfred
A1  - Paslier, D. Le
A1  - Elaswarapu, R.
A1  - Smith, S.
A1  - Grzeschik, Karl-Heinz
T1  - Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region
N2  - Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a VAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30182
ER  - 
TY  - JOUR
A1  - Argos, P.
A1  - Dandekar, Thomas
T1  - Delineating the main chain topology of four-helix bundle proteins using the genetic algorithm and knowledge based on the amino acid sequence alone
N2  - No abstract available
KW  - Proteine
KW  - Strukturanalyse
KW  - Abstandsmessung
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33807
ER  - 
TY  - JOUR
A1  - Linsenmair, Karl Eduard
T1  - Biologische Vielfalt und ökologische Stabilität
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31157
ER  - 
TY  - JOUR
A1  - Gorboulev, Valentin G.
A1  - Akhundova, Aida
A1  - Grzeschik, K.-H.
A1  - Fahrenholz, Falk
T1  - Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus
N2  - The gene encoding the human homologue of the guinea pig uterine bombesm receptor [( 1992) Eur. J. Biochem. 208,405] was isolated from a genomic lambda library by the PCR/homology screening approach. The gene spans more than 4 kb and consists of 3 exons and 2 introns. The deduced amino acid sequence shows about 86% identity to that of guinea pig bombesin receptor. This subtype of bombesin receptor is expressed in the pregnant uterus and in two human tumour cell lines, T47D (ductal breast carcinoma) and A431 (epidermal carcinoma). PCR analysis of genomic DNA from human-mouse cell hybrids allows the cloned gene to be localized to the region q26q28 on chromosome X.
KW  - Bombesin ; Bombesin receptor ; Chromosomal localization
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32572
ER  - 
TY  - JOUR
A1  - Scheer, Ulrich
A1  - Weisenberger, Dieter
T1  - The nucleolus
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-32037
ER  - 
TY  - JOUR
A1  - Schittkowski, K.
A1  - Zillober, Christian
A1  - Zotemantel, R.
T1  - Numerical comparison of nonlinear programming algorithms for structural optimization
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31971
ER  - 
TY  - JOUR
A1  - Dandekar, Thomas
A1  - Argos, Patrick
T1  - Amiloride-sensitive epithelial Na\(^+\) channel is made of three homologous subunits
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29734
ER  -