TY - CHAP A1 - Fackler, Guido T1 - Zwischen (musikalischem) Widerstand und Propaganda - Jazz im "Dritten Reich" N2 - No abstract available KW - Jazz Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41879 SN - 3-89206-590-X ER - TY - CHAP A1 - Hommers, Wilfried T1 - Zur quantitativen Theorie von Wiedergutmachungskognitionen unter Gewinnung ihrer Merkmale aus der Jurisprudenz N2 - Grundzüge des rechtswissenschaftlichen Gedankenguts zur Schadenswiedergutmachung werden psychologischen Ansätzen dazu gegenübergestellt. Das Ergebnis ist die Feststellung, daß die stimulusbezogene Urteilsrelevanz der Schadenswiedergutmachung nicht in der psychologischen Forschung berücksichtigt wurde. Ein diesbezüglicher Untersuchungsansatz sollte sechs Merkmale besitzen: multifaktoriell, multivariat, Stimulus-Response-vergleichend, quantitativ, ontogenetisch und individual-diagnostisch. Er bildet den Prototyp eines die Moral positiver und negativer Akte umfassenden Ansatzes zur moralischen Urteilsbildung, des ses erste Ergebnisse beschrieben werden. KW - Psychologie KW - Kongress Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43519 ER - TY - CHAP ED - Klein, Wolf Peter ED - Staffeldt, Sven T1 - Zur Geschichte der Fach- und Wissenschaftssprachen. Identität, Differenz, Transfer N2 - Der Band enthält acht Aufsätze zur Geschichte der Fach- und Wissenschaftssprachen. Disziplinär geht es in erster Linie um juristische, balneologische, sprachwissenschaftliche pharmazeutische, medizinische Fach- und Wissenschaftssprachen. Darüber hinaus thematisiert ein Beitrag die Problematik der Fachsprachen im Rahmen der Stadtsprachenforschung, ein weiterer die Sprach- und Textpraxis von Vorlesungen. T3 - WespA. Würzburger elektronische sprachwissenschaftliche Arbeiten - 23 KW - Fachsprache KW - Wissenschaftssprache KW - Geschichte Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-251173 SN - 978-3-945459-40-9 SN - 1864-9238 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Nagel, U. T1 - Zur Funktion des mimischen Ausdrucks - Mimisches Verhalten bei Vorstellungen und Mitteilung N2 - No abstract available Y1 - 1986 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33660 ER - TY - CHAP A1 - Anders, Fritz A1 - Schartl, Manfred A1 - Barnekow, Angelika T1 - Xiphophorus as an in vivo model for studies on oncogenes N2 - The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels. KW - Schwertkärpfling KW - In vivo KW - Onkogen Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86398 ER - TY - CHAP A1 - Heiser, A. A1 - Ulrichs, Karin A1 - Eckstein, V. A1 - Müller-Ruchholtz, W. T1 - Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets N2 - no abstract available Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45479 ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - Was ist Sprechen? - objektive Registrierung des Sprechverhaltens im Alltag mit dem Logoport N2 - No abstract available Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41266 ER - TY - CHAP A1 - Schmitz, Barbara T1 - War, violence and Tyrannicide in the Book of Judith N2 - No abstract available KW - Judit KW - Gewalt KW - Krieg KW - Tyrannenmord KW - Judith KW - Violence KW - War KW - Tyrannicide Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67058 ER - TY - CHAP A1 - Schmitz, Barbara T1 - Vor-Denken und Nach-Denken. Die Funktion der Reden und Gebete im Buch Judit N2 - No abstract available KW - Judit KW - Rede KW - Gebet KW - Judith KW - Prayer KW - Speech
Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-67093 ER - TY - CHAP A1 - Weinert, Franz E. A1 - Knopf, Monika A1 - Schneider, Wolfgang T1 - Von allgemeinen Theorien der Gedächtnisentwicklung zur Analyse spezifischer Lern- und Erinnerungsvorgänge N2 - No abstract available. KW - Lernen KW - Erinnerung Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87578 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Clarke, A. H. T1 - Verlaufsbeobachtungen anhand standardisierter Videoaufzeichnungen bei depressiven Patienten N2 - No abstract available Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33744 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Gaebel, W. T1 - Verhaltensbiologische Aspekte endogener Psychosen N2 - No abstract available KW - Verhaltensbiologie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-73588 ER - TY - CHAP A1 - Ellgring, Johann Heinrich A1 - Scherer, K. R. T1 - Verhaltensanalyse sozialer Interaktion N2 - No abstract available Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43131 ER - TY - CHAP A1 - Schüssler, Ulrich A1 - Oppermann, U. A1 - Seidel, E. A1 - Okrusch, M. A1 - Richter, P. T1 - Vergleichende Untersuchungen an Metabasiten des ostbayerischen Kristallins T1 - Comparative inquiries into the metabasite of the eastern Bavarian crystallines N2 - No abstract available KW - Kontinentales Tiefbohrprogramm Y1 - 1986 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39212 ER - TY - CHAP A1 - Clarke, A. H. A1 - Ellgring, Johann Heinrich T1 - Verfahren zur halbautomatischen Bearbeitung von Videoaufzeichnungen N2 - No abstract available Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33750 ER - TY - CHAP A1 - Hommers, Wilfried T1 - Urteilsbildung : Entwicklung der Informationen-Integration im Urteil N2 - No abstract available KW - Psychologie KW - Kongress Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43497 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - Universal trends and individual differences in memory development N2 - No abstract available. KW - Gedächtnisbildung Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86518 ER - TY - CHAP A1 - Klawitter, Jörg T1 - Umwelt, Mitwelt, Nachwelt im Fokus einer verantworteten Wissenschaft N2 - No abstract available KW - Umweltschutz KW - Kongress KW - Wiesbaden <1985> Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44396 ER - TY - CHAP A1 - Klawitter, Jörg T1 - Umwelt, Mitwelt, Nachwelt im Fokus einer verantworteten Wissenschaft N2 - No abstract available. KW - Umweltschutz Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87040 ER - TY - CHAP A1 - Trendelenburg, M. F. A1 - Franke, Werner W. A1 - Spring, H. A1 - Scheer, Ulrich T1 - Ultrastructure of transcription in the nucleoli of the green algae Acetabularia major and A. mediterranea N2 - No abstract available Y1 - 1975 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33779 ER - TY - CHAP A1 - Ruhe, Ernstpeter T1 - Tristan et Iseut dans l'espace: A propos d'un poème de Pierre Garnier N2 - No abstract available Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34074 ER - TY - CHAP A1 - Eckstein, V. A1 - Ulrichs, Karin A1 - Meincke, G. A1 - Mülller-Ruchholtz, W. T1 - Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45707 ER - TY - CHAP A1 - Scheer, Ulrich A1 - Franke, Werner W. T1 - Transcriptional complexes of nucleolar genes N2 - No abstract available Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41072 ER - TY - CHAP A1 - Rethwilm, Axel A1 - Baunach, Gerald A1 - Mori, Kazuyasu A1 - ter Meulen, Volker T1 - Transactivation of HIV by human spumaretrovirus N2 - To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected. KW - HIV Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86436 ER - TY - CHAP A1 - Abendschein, Robin A1 - Desai, Shital A1 - Astell, Arlene J. T1 - Towards Accessibility Guidelines for the Metaverse : A Synthesis of Recommendations for People Living With Dementia T2 - Conference on Human Factors in Computing Systems (CHI’23) : Workshop "Towards an Inclusive and Accessible Metaverse" N2 - Given the growing interest of corporate stakeholders in Metaverse applications, there is a need to understand accessibility of these technologies for marginalized populations such as people living with dementia to ensure inclusive design of Metaverse applications. We assessed the accessibility of extended reality technology for people living with mild cognitive impairment and dementia to develop accessibility guidelines for these technologies. We used four strategies to synthesize evidence for barriers and facilitators of accessibility: (1) Findings from a non-systematic literature review, (2) guidelines from well-researched technology, (3) exploration of selected mixed reality technologies, and (4) observations from four sessions and video data of people living with dementia using mixed reality technologies. We utilized template analysis to develop codes and themes towards accessibility guidelines. Future work can validate our preliminary findings by applying them on video recordings or testing them in experiments. KW - CHI Conference KW - Accessibility KW - Metaverse KW - extended reality KW - dementia KW - cognitive impairment KW - Human-centered computing / Access KW - Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Mixed / augmented reality KW - Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Virtual reality KW - Human-centered computing / Human computer interaction (HCI) / Interactiondevices KW - Human-centered computing / Human computerinteraction (HCI) / Interaction techniques Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-320199 UR - https://sites.google.com/view/accessiblemetaverse ER - TY - CHAP A1 - Ruhe, Ernstpeter T1 - Thesen zum Ende der Gattungsgeschichte des höfischen Romans N2 - No abstract available Y1 - 1979 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33626 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - The role of knowledge, strategies, and aptitudes in cognitive Performance: Concluding Comments N2 - No abstract available. KW - Kognitive Entwicklung KW - Begabung Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87190 ER - TY - CHAP A1 - Schneider, Wolfgang A1 - Weinert, Franz E. T1 - The role of knowledge, strategies, and aptitudes in cognitive performance : concluding comments N2 - No abstract available. KW - Intelligenzleistung KW - Wissen KW - Begabung Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86554 ER - TY - CHAP A1 - Kaitschick, J. A1 - Ulrichs, K. A1 - Müller-Ruchholtz, W. T1 - The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization N2 - No abstract available KW - Immunbiologie Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45727 ER - TY - CHAP A1 - Axelrod, V. D. A1 - Gorboulev, Valentin G. A1 - Kutateladze, T. V. A1 - Barciszewski, J. A1 - Bayev, A. A. T1 - The new approach to tRNA primary structure determination : the primary structure of valine tRNA\(^{Val}_{2b}\) N2 - The new combination of TLC and high voltage electrophoresis on cooling plate is described.We have applied this technique to study of primary structure of tRNA.Preliminary sequence of baker's yeast tRNA^Val_2b is described. New approach to preparation of large tRNA fragments is demonstrated. KW - RNS Y1 - 1976 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50920 ER - TY - CHAP A1 - Werner, Rudolf A. A1 - Marcus, Charles A1 - Sheikhbahaei, Sara A1 - Higuchi, Takahiro A1 - Solnes, Lilja B. A1 - Rowe, Steven P. A1 - Buck, Andreas K. A1 - Lapa, Constantin A1 - Javadi, Mehrbod S. T1 - The Impact of Ageing on Dopamine Transporter Imaging T2 - Journal of Nuclear Medicine N2 - No abstract available. KW - Parkinson-Krankheit KW - Parkinson KW - Parkinson Disease KW - DaTscan KW - Ioflupane KW - SPECT KW - molecular imaging KW - ageing Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-162213 UR - http://jnm.snmjournals.org/content/59/supplement_1/1646.abstract SN - 0161-5505 N1 - This research was originally published in JNM. Rudolf A. Werner, Charles Marcus, Sara Sheikhbahaei, Takahiro Higuchi, Lilja B. Solnes, Steven P. Rowe, Andreas K. Buck, Constantin Lapa, Mehrbod S. Javadi. The Impact of Ageing on Dopamine Transporter Imaging. J Nucl Med. May 1, 2018; vol. 59 no. supplement 1:1646. © SNMMI. VL - 59 IS - Supplement No 1 SP - 1646 ER - TY - CHAP A1 - Werner, Rudolf A. A1 - Chen, Xinyu A1 - Hirano, Mitsuru A1 - Nose, Naoko A1 - Lapa, Constantin A1 - Javadi, Mehrbod S. A1 - Higuchi, Takahiro T1 - The Impact of Ageing on [\(^{11}\)C]meta-Hydroxyephedrine Uptake in the Rat Heart T2 - Journal of Nuclear Medicine N2 - No abstract available. KW - Positronen-Emissions-Tomografie KW - moycardial sympathetic innervation KW - Positronen-Emissions-Tomografie KW - positron emission tomography KW - PET KW - 11C-HED KW - hydroxyephedrine KW - ageing Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-162228 UR - http://jnm.snmjournals.org/content/59/supplement_1/100.abstract SN - 0161-5505 VL - 59 IS - Supplement No 1 ER - TY - CHAP A1 - Heiser, A. A1 - Ulrichs, Karin A1 - Eckstein, V. A1 - Müller-Ruchholtz, W. T1 - The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment N2 - No abstract available Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45670 ER - TY - CHAP A1 - Fiala, Brigitte A1 - Federle, W. A1 - Maschwitz, U. A1 - Azarae, Idris T1 - The first myrmecophytic 2-partner-system in the genus Macaranga: The association between Macaranga puncticulata and a Componotus (Colobopsis) in Malaysia N2 - No abstract available KW - Biologie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55144 ER - TY - CHAP A1 - Gotz, R. A1 - Schartl, Manfred T1 - The conservation of neurotrophic factors during vertebrate evolution N2 - No abstract available KW - Physiologische Chemie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61964 ER - TY - CHAP A1 - Fiala, Brigitte A1 - Maschwitz, Ulrich A1 - Tho, Yow Pong T1 - The association between Macaranga trees and ants in South-east Asia N2 - No abstract available KW - Macaranga Y1 - 1991 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54752 ER - TY - CHAP A1 - Schneider, Wolfgang T1 - The "what" and "how" of development: Really two separate research agendas? N2 - No abstract available. KW - Entwicklungspsychologie Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86630 ER - TY - CHAP ED - Middelhoff, Frederike ED - Schönbeck, Sebastian ED - Borgards, Roland ED - Gersdorf, Catrin T1 - Texts, Animals, Environments: Zoopoetics and Ecopoetics N2 - Texts, Animals, Environments. Zoopoetics and Ecopoetics probes the multiple links between ecocriticism and animal studies, assessing the relations between animals, environments and poetics. While ecocriticism usually relies on a relational approach to explore phenomena related to the environment or ecology more broadly, animal studies tends to examine individual or species-specific aspects. As a consequence, ecocriticism concentrates on ecopoetical, animal studies on zoopoetical elements and modes of representation in literature (and the arts more generally). Bringing key concepts of ecocriticism and animal studies into dialogue, the volume explores new ways of thinking about and reading texts, animals, and environments – not as separate entities but as part of the same collective. KW - Ecocriticism KW - Animal Studies KW - Cultural Animal Studies KW - Human-Animal Studies KW - Environmental Humanities KW - Literary Studies KW - Cultural Studies Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-177209 UR - https://www.rombach-verlag.de/buecher/suchergebnis/rombach/buch/details/texts-animals-environments.html SN - 978-3-7930-9928-4 PB - Rombach Druck- und Verlagshaus CY - Freiburg i. Br. ET - 1. Auflage ER - TY - CHAP A1 - Franke, Werner W. A1 - Zentgraf, Hanswalter A1 - Scheer, Ulrich T1 - Supranucleosomal and non-nucleosomal chromatin configurations N2 - A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin? Y1 - 1978 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39447 ER - TY - CHAP A1 - Burschka, Christian A1 - Bringmann, Gerhard A1 - Busse, Holger A1 - Guessregen, Stefan A1 - Schoener, Bernd A1 - Zagst, Rainer T1 - Structure and dynamics of free and metallated benzonaphthopyranones and -pyrans N2 - First calculations of the structures of metal-free and complexed biaryl lactones and their confrrmation by X-ray crystaIlography, the search for the transition states of their heIimerization processes, and the spectroscopic determination of the heIimerization barriers of related cyclic ethers by DNMR are reported. Y1 - 1992 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46858 ER - TY - CHAP A1 - Lutz, Werner K. T1 - Structural characteristics of compounds that can be activated to chemically reactive metabolites: use for a prediction of a carcinogenic potential N2 - Many mutagens and carcinogens act via covalent interaction of metabolic intermediates with DNA in the target cell. This report groups those structural elements which are often found to form the basis for a metabolism to such chemically reactive metabolites. ~mpounds which are chemically reactive per se and which do not require metabolic activation form group 1. Group 2 compri~es of olefins and aromatic hydrocarbons where the oxidation via an epoxide can be responsible for the generation of reactive species. Aromatic amines, hydrazines, and nitrosamirres form group 3 requiring an oxidation of a nitrogen atom or of a carbon atom in alpha position to a nitrosated amine. Group 4 compounds are halogenated hydrocarbons which can either give rise to radicals or can form an ·olefin (group 2) upon dehydrohalogenation. Group 5 compounds depend upon some preceding enzymatic activity either not available in the target cell or acting on positions in the molecule which are not directly involved in the subsequent formation of electrophilic atoms. Examples for each group are taken from the "List of Chemieals and Irrdustrial Processes Associated with Cancer in Humans" as compiled by the International Agency for the Research on Cancer, and it is shown that 91% of the organic carcinogens would have been detected on the basis of structural elements characteristic for group 1-5. As opposed to this very high sensitivity, the specificity ( the true negative fraction) of using this approach as a short-term test for carcinogenicity is shown to be bad because detoxification pathways have so far not been taken into account. These competing processes are so complex, however, that either only very extensive knowledge about pharmacokinetics, stability, and reactivity will be required or that in vivo systems have to be used to predict, on a quantitative basis, the darnage expected on the DNA. DNA-binding experiments in vivo are presented with benzene and toluene to demonstrate one possible way for an experimental assessment and it is shown that the detoxification reaction at the methyl group available only in toluene gives rise to a reduction by at least a factor of forty for the binding to rat liver DNA. This quantitative approach available with DNA-binding tests in vivo, also allows evaluation as to whether reactive metabolites and their DNA binding are always the most important single activities contributing to the overall carcinogenicity of a chemical. With the example of the livertumor inducing hexachlorocyclohexane isomers it is shown that situations will be found where reactive metabolites are formed and DNA binding in vivo is measurable but where this activity cannot be the decisive mode of carcinogenic action. It is concluded that the lack of structural elements known to become potentially reactive does not guarantee the lack of a carcinogenic potential. KW - Toxikologie KW - Structureactivity relationship KW - Reactive intermediates KW - Metabolic activation KW - DNA Binding KW - Covalent binding index KW - Carcinogens KW - Benzene Y1 - 1984 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80105 ER - TY - CHAP A1 - Hommers, Wilfried A1 - Endres, Johann T1 - Strafe und Schadensersatz als multivariater Response Komplex N2 - No abstract available Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-43895 ER - TY - CHAP A1 - Ellgring, Johann Heinrich T1 - Spezifische Signalsysteme in der menschlichen Interaktion N2 - Nonverbal communicative behaviours are associated with affective states in a way specific to the individual. This result emerged from longitudinal studies on depressed patients. From the analysis of various nonverbal behaviours it can be concluded that the depressed state is indicated by nonverbal elements in a logical "or-" rather than "and-connection" or in a hierarchical way. It is maintained that the relationship of psychological relevant states (mood) and nonverbal behaviour needs to be studied by intra-individual comparisons to reveal the specifically close relationships effective in everyday communication. With regard to the pragmatic aspect of communication, elements in the nonverbal signalling system seem to possess different levels of generality. However, from decoding studies it can be shown that even very subtle behavioural differences can be detected by an observer. Thus specific signals can become effective in interaction given a familiarity with the idiosyncratic usage. KW - Psychologie Y1 - 1983 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50212 ER - TY - CHAP A1 - Kohnen, Ralph A1 - Krüger, Hans-Peter T1 - Soziale Situationen als experimentelle Bedingungen der Pharmakopsychologie N2 - Summary (Social Situations as Experimental Conditions in Psychopharmacology): To reduce a great variability of drug effects in healthy subjects, stress conditions are used often in pharmacopsychology. However, empirical results show that the desired stress effects are failing. This paper suggests to realize social stress Situations as interactions between subjects, expecting higher challenging effects than experimentator-subject-interactions, usually used in experimental designs. Two experimental studies are reported: the call-upsituation and the group-therapy situation. The experimental effects were measured by changes of pulse-frequencies. The results indicate that in the two situations high and low dosages of tranquilizing drugs lead to comparable (and so predictable) effects only, if a Situation is high challenging for the experimental subjects. The call-up situation, which proves performance, challenges male subjects highly. The emotional or social competence demanding group-therapy situation is a high challenging situation for warnen. It is concluded that no situation is stressing a person generally. Depending from personality characteristics, differential stressor effects appear. Consequences for experiments in pharmacopsychology are discussed. KW - Soziale Situation KW - Psychopharmakologie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86041 ER - TY - CHAP A1 - Kurtz, Beth A1 - Schneider, Wolfgang A1 - Borkowski, John G. A1 - Carr, Martha A1 - Turner, Lisa A. T1 - Sources of memory and metamemory development: Societal, parental, and educational influences N2 - This project had two goals: (1) to examine the impact of strategy training on memory performance in German and American children, and (2) to search for environmental correlates of individual differences in cognitive processes. Following pretesting, 437 children were divided into training and control groups, with the former receiving training in clustering strategies. Trained children showed sizable strategy maintenance and transfer effects two weeks and six months later. Parents and teachers completed questionnaires about the teaching of strategies and their attributional beliefs about children's academic successes and failures. The differences in strategie behavior and attributions of German and American children were due, in part, to differences in strategy-enriched environments. KW - Psychologie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50524 ER - TY - CHAP A1 - Zillober, Christian T1 - Sequential convex programming in theory and praxis N2 - In this paper, convex approximation methods, suclt as CONLIN, the method of moving asymptotes (MMA) and a stabilized version of MMA (Sequential Convex Programming), are discussed with respect to their convergence behaviour. In an extensive numerical study they are :finally compared with other well-known optimization methods at 72 examples of sizing problems. Y1 - 1993 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-35513 ER - TY - CHAP A1 - Sagelsdorff, P. A1 - Lutz, Werner K. T1 - Sensitivity of DNA and nucleotides to oxidation by permanganate and hydrogen peroxide N2 - no abstract available KW - Toxikologie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80062 ER - TY - CHAP A1 - Krüger, Hans-Peter T1 - Selbst- und Fremdbeurteilung in Diagnostik und Psychotherapie N2 - No abstract available KW - Klinische Psychologie KW - Psychotherapie Y1 - 1980 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40964 ER - TY - CHAP A1 - Hommers, Wilfried T1 - Schadenswiedergutmachung als entwicklungspsychologische Fragestellung N2 - No abstract available KW - Entwicklungspsychologie / Kongress / Trier <1985> Y1 - 1985 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44031 ER - TY - CHAP A1 - Bossert, Sabine A1 - Meiler, Caroline A1 - Laessle, Reinhold A1 - Ellgring, Heiner A1 - Pirke, Karl-Martin T1 - Responses to visual perception of food in eating disorders N2 - No abstract available KW - Psychologie Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58762 ER -