TY  - JOUR
A1  - Solimando, Antonio Giovanni
A1  - Da Vià, Matteo Claudio
A1  - Bolli, Niccolò
A1  - Steinbrunn, Torsten
T1  - The route of the malignant plasma cell in its survival niche: exploring “Multiple Myelomas”
JF  - Cancers
N2  - Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Nevertheless, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease- or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach. Given the increasing role of cancer stem cells (CSCs) in better characterizing the pathogenesis of solid and hematological malignancies, disease relapse, and drug resistance, identifying and describing CSCs is of paramount importance in the management of MM. Even though the function of CSCs is well-known in other cancer types, their role in MM remains elusive. With this review, we aim to provide an update on MM homing and resilience in the bone marrow micro milieu. These data are particularly interesting for clinicians facing unmet medical needs while designing novel treatment approaches for MM.
KW  - multiple myeloma
KW  - cell of origin
KW  - cancer stem cells
KW  - bone marrow homing
KW  - adhesion molecule
KW  - bone marrow immune-microenvironment
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281728
SN  - 2072-6694
VL  - 14
IS  - 13
ER  -