TY  - JOUR
A1  - Lee, Marcel
A1  - Eyer, Florian
A1  - Felgenhauer, Norbert
A1  - Klinker, Hartwig H. F.
A1  - Spinner, Christoph D.
T1  - Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient
JF  - AIDS Research and Therapy
N2  - A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay\(^{®}\)) and tenofovir disaproxil fumarate/emtricitabine (Truvada\(^{®}\)) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments.
KW  - integrase inhibitor
KW  - HIV
KW  - AIDS
KW  - suicide attempt
KW  - dolutegravir
KW  - tenofovir disaproxil fumarate
KW  - emtricitabine
KW  - overdose
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-151994
VL  - 12
IS  - 18
ER  -