TY  - JOUR
A1  - Solimando, Antonio G.
A1  - Palumbo, Carmen
A1  - Pragnell, Mary Victoria
A1  - Bittrich, Max
A1  - Argentiero, Antonella
A1  - Krebs, Markus
T1  - Aplastic anemia as a roadmap for bone marrow failure: an overview and a clinical workflow
JF  - International Journal of Molecular Sciences
N2  - In recent years, it has become increasingly apparent that bone marrow (BM) failures and myeloid malignancy predisposition syndromes are characterized by a wide phenotypic spectrum and that these diseases must be considered in the differential diagnosis of children and adults with unexplained hematopoiesis defects. Clinically, hypocellular BM failure still represents a challenge in pathobiology-guided treatment. There are three fundamental topics that emerged from our review of the existing data. An exogenous stressor, an immune defect, and a constitutional genetic defect fuel a vicious cycle of hematopoietic stem cells, immune niches, and stroma compartments. A wide phenotypic spectrum exists for inherited and acquired BM failures and predispositions to myeloid malignancies. In order to effectively manage patients, it is crucial to establish the right diagnosis. New theragnostic windows can be revealed by exploring BM failure pathomechanisms.
KW  - hematopoietic stem cells
KW  - bone marrow immune-microenvironment
KW  - bone marrow failure
KW  - cytopenia
KW  - aplastic anemia
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-290440
SN  - 1422-0067
VL  - 23
IS  - 19
ER  - 
TY  - JOUR
A1  - Solimando, Antonio Giovanni
A1  - Da Vià, Matteo Claudio
A1  - Bolli, Niccolò
A1  - Steinbrunn, Torsten
T1  - The route of the malignant plasma cell in its survival niche: exploring “Multiple Myelomas”
JF  - Cancers
N2  - Growing evidence points to multiple myeloma (MM) and its stromal microenvironment using several mechanisms to subvert effective immune and anti-tumor responses. Recent advances have uncovered the tumor-stromal cell influence in regulating the immune-microenvironment and have envisioned targeting these suppressive pathways to improve therapeutic outcomes. Nevertheless, some subgroups of patients include those with particularly unfavorable prognoses. Biological stratification can be used to categorize patient-, disease- or therapy-related factors, or alternatively, these biological determinants can be included in a dynamic model that customizes a given treatment to a specific patient. Genetic heterogeneity and current knowledge enforce a systematic and comprehensive bench-to-bedside approach. Given the increasing role of cancer stem cells (CSCs) in better characterizing the pathogenesis of solid and hematological malignancies, disease relapse, and drug resistance, identifying and describing CSCs is of paramount importance in the management of MM. Even though the function of CSCs is well-known in other cancer types, their role in MM remains elusive. With this review, we aim to provide an update on MM homing and resilience in the bone marrow micro milieu. These data are particularly interesting for clinicians facing unmet medical needs while designing novel treatment approaches for MM.
KW  - multiple myeloma
KW  - cell of origin
KW  - cancer stem cells
KW  - bone marrow homing
KW  - adhesion molecule
KW  - bone marrow immune-microenvironment
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281728
SN  - 2072-6694
VL  - 14
IS  - 13
ER  -