TY  - JOUR
A1  - McFleder, Rhonda L.
A1  - Makhotkina, Anastasiia
A1  - Groh, Janos
A1  - Keber, Ursula
A1  - Imdahl, Fabian
A1  - Peña Mosca, Josefina
A1  - Peteranderl, Alina
A1  - Wu, Jingjing
A1  - Tabuchi, Sawako
A1  - Hoffmann, Jan
A1  - Karl, Ann-Kathrin
A1  - Pagenstecher, Axel
A1  - Vogel, Jörg
A1  - Beilhack, Andreas
A1  - Koprich, James B.
A1  - Brotchie, Jonathan M.
A1  - Saliba, Antoine-Emmanuel
A1  - Volkmann, Jens
A1  - Ip, Chi Wang
T1  - Brain-to-gut trafficking of alpha-synuclein by CD11c\(^+\) cells in a mouse model of Parkinson’s disease
JF  - Nature Communications
N2  - Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c+ cells. Using single-cell RNA sequencing, we demonstrate that ileal CD11c\(^+\) cells are microglia-like and the same subtype of cells is activated in the brain and ileum of PD mice. Moreover, by utilizing mice expressing the photo-convertible protein, Dendra2, we show that CD11c\(^+\) cells traffic from the brain to the ileum. Together these data provide a mechanism of αSyn trafficking between the brain and gut.
KW  - antigen-presenting cells
KW  - neuroimmunology
KW  - Parkinson's disease
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-357696
VL  - 14
ER  -