TY  - JOUR
A1  - Perra, Alessandra
A1  - Riccardo, Chiara Laura
A1  - De Lorenzo, Valerio
A1  - De Marco, Erika
A1  - Di Natale, Lorenzo
A1  - Kurotschka, Peter Konstantin
A1  - Preti, Antonio
A1  - Carta, Mauro Giovanni
T1  - Fully immersive virtual reality-based cognitive remediation for adults with psychosocial disabilities: a systematic scoping review of methods intervention gaps and meta-analysis of published effectiveness studies
JF  - International Journal of Environmental Research and Public Health
N2  - Background: Cognitive Remediation (CR) programs are effective for the treatment of mental diseases; in recent years, Virtual Reality (VR) rehabilitation tools are increasingly used. This study aimed to systematically review and meta-analyze the published randomized controlled trials that used fully immersive VR tools for CR programs in psychiatric rehabilitation. We also wanted to map currently published CR/VR interventions, their methods components, and their evidence base, including the framework of the development intervention of CR in fully immersive VR. Methods: Level 1 of evidence. This study followed the PRISMA extension for Scoping Reviews and Systematic Review. Three electronic databases (Pubmed, Cochrane Library, Embase) were systematically searched, and studies were included if they met the eligibility criteria: only randomized clinical trials, only studies with fully immersive VR, and only CR for the adult population with mental disorders. Results: We found 4905 (database) plus 7 (manual/citation searching articles) eligible studies. According to inclusion criteria, 11 studies were finally reviewed. Of these, nine included patients with mild cognitive impairment, one with schizophrenia, and one with mild dementia. Most studies used an ecological scenario, with improvement across all cognitive domains. Although eight studies showed significant efficacy of CR/VR, the interventions’ development was poorly described, and few details were given on the interventions’ components. Conclusions: Although CR/VR seems to be effective in clinical and feasibility outcomes, the interventions and their components are not clearly described. This limits the understanding of the effectiveness and undermines their real-world implementation and the establishment of a gold standard for fully immersive VR/CR.
KW  - virtual reality
KW  - cognitive remediation
KW  - mental health
KW  - recovery
KW  - psychiatric rehabilitation
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-304948
SN  - 1660-4601
VL  - 20
IS  - 2
ER  - 
TY  - JOUR
A1  - Perra, Alessandra
A1  - Galetti, Alessia
A1  - Zaccheddu, Rosanna
A1  - Locci, Aurora
A1  - Piludu, Federica
A1  - Preti, Antonio
A1  - Primavera, Diego
A1  - Di Natale, Lorenzo
A1  - Nardi, Antonio Egidio
A1  - Kurotshka, Peter Konstantin
A1  - Cossu, Giulia
A1  - Sancassiani, Federica
A1  - Stella, Giusy
A1  - De Lorenzo, Valerio
A1  - Zreik, Thurayya
A1  - Carta, Mauro Giovanni
T1  - A recovery-oriented program for people with bipolar disorder through virtual reality-based Cognitive Remediation: results of a feasibility randomized clinical trial
JF  - Journal of Clinical Medicine
N2  - Background: Cognitive impairment is a frequent consequence of bipolar disorder (BD) that is difficult to prevent and treat. In addition, the quality of the preliminary evidence on the treatment of BD through Cognitive Remediation (CR) with traditional methods is poor. This study aims to evaluate the feasibility of a CR intervention with fully immersive Virtual Reality (VR) as an additional treatment for BD and offers preliminary data on its efficacy. Methods: Feasibility randomized controlled cross-over clinical study, with experimental condition lasting three months, crossed between two groups. Experimental condition: CR fully immersive VR recovery-oriented program plus conventional care; Control condition: conventional care. The control group began the experimental condition after a three months period of conventional care (waiting list). After the randomization of 50 people with BD diagnosis, the final sample consists of 39 participants in the experimental condition and 25 in the control condition because of dropouts. Results: Acceptability and tolerability of the intervention were good. Compared to the waitlist group, the experimental group reported a significant improvement regarding cognitive functions (memory: p = 0.003; attention: p = 0.002, verbal fluency: p = 0.010, executive function: p = 0.003), depressive symptoms (p = 0.030), emotional awareness (p = 0.007) and biological rhythms (p = 0.029). Conclusions: The results are preliminary and cannot be considered exhaustive due to the small sample size. However, the evidence of efficacy, together with the good acceptability of the intervention, is of interest. These results suggest the need to conduct studies with larger samples that can confirm this data. Trial registration: ClinicalTrialsgov NCT05070065, registered in September 2021
KW  - virtual reality
KW  - Cognitive Remediation
KW  - mental health
KW  - recovery
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-311201
SN  - 2077-0383
VL  - 12
IS  - 6
ER  -