TY  - JOUR
A1  - Matthes, Niels
A1  - Diers, Johannes
A1  - Schlegel, Nicolas
A1  - Hankir, Mohammed
A1  - Haubitz, Imme
A1  - Germer, Christoph-Thomas
A1  - Wiegering, Armin
T1  - Validation of MTL30 as a quality indicator for colorectal surgery
JF  - PLoS One
N2  - Background 
Valid indicators are required to measure surgical quality. These ideally should be sensitive and selective while being easy to understand and adjust. We propose here the MTL30 quality indicator which takes into account 30-day mortality, transfer within 30 days, and a length of stay of 30 days as composite markers of an uneventful operative/postoperative course. 

Methods 
Patients documented in the StuDoQ|Colon and StuDoQ|Rectal carcinoma register of the German Society for General and Visceral Surgery (DGAV) were analyzed with regard to the effects of patient and tumor-related risk factors as well as postoperative complications on the MTL30. 

Results 
In univariate analysis, the MTL30 correlated significantly with patient and tumor-related risk factors such as ASA score (p<0.001), age (p<0.001), or UICC stage (p<0.001). There was a high sensitivity for the postoperative occurrence of complications such as re-operations (p<0.001) or subsequent bleeding (p<0.001), as well as a significant correlation with the CDC classification (p<0.001). In multivariate analysis, patient-related risk factors and postoperative complications significantly increased the odds ratio for a positive MTL30. A negative MTL30 showed a high specify for an uneventful operative and postoperative course. 

Conclusion 
The MTL30 is a valid indicator of colorectal surgical quality.
KW  - surgical care
KW  - discharge definition
KW  - definition
KW  - mortality
KW  - pancreatectomy
KW  - complications
KW  - superior
KW  - capture
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-230530
VL  - 15
IS  - 8
ER  - 
TY  - JOUR
A1  - Rychlik, Michael
A1  - Humpf, Hans-Ulrich
A1  - Marko, Doris
A1  - Dänicke, Sven
A1  - Mally, Angela
A1  - Berthiller, Franz
A1  - Klaffke, Horst
A1  - Lorenz, Nicole
T1  - Proposal of a comprehensive definition of modified and other forms of mycotoxins including “masked” mycotoxins
JF  - Mycotoxin Research
N2  - As the term "masked mycotoxins" encompasses only conjugated mycotoxins generated by plants and no other possible forms of mycotoxins and their modifications, we hereby propose for all these forms a systematic definition consisting of four hierarchic levels. The highest level differentiates the free and unmodified forms of mycotoxins from those being matrix-associated and from those being modified in their chemical structure. The following lower levels further differentiate, in particular, "modified mycotoxins" into "biologically modified" and "chemically modified" with all variations of metabolites of the former and dividing the latter into "thermally formed" and "non-thermally formed" ones. To harmonize future scientific wording and subsequent legislation, we suggest that the term "modified mycotoxins" should be used in the future and the term "masked mycotoxins" to be kept for the fraction of biologically modified mycotoxins that were conjugated by plants.
KW  - definition
KW  - mycotoxins
KW  - masked mycotoxins
KW  - modified mycotoxins
KW  - hidden mycotoxins
KW  - mycotoxin derivates
KW  - mycotoxin metabolites
KW  - conjugated mycotoxins
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121240
VL  - 30
IS  - 4
ER  - 
TY  - JOUR
A1  - Groll, J
A1  - Burdick, J A
A1  - Cho, D-W
A1  - Derby, B
A1  - Gelinsky, M
A1  - Heilshorn, S C
A1  - Jüngst, T
A1  - Malda, J
A1  - Mironov, V A
A1  - Nakayama, K
A1  - Ovsianikov, A
A1  - Sun, W
A1  - Takeuchi, S
A1  - Yoo, J J
A1  - Woodfield, T B F
T1  - A definition of bioinks and their distinction from biomaterial inks
JF  - Biofabrication
N2  - Biofabrication aims to fabricate biologically functional products through bioprinting or bioassembly (Groll et al 2016 Biofabrication 8 013001). In biofabrication processes, cells are positioned at defined coordinates in three-dimensional space using automated and computer controlled techniques (Moroni et al 2018 Trends Biotechnol. 36 384–402), usually with the aid of biomaterials that are either (i) directly processed with the cells as suspensions/dispersions, (ii) deposited simultaneously in a separate printing process, or (iii) used as a transient support material. Materials that are suited for biofabrication are often referred to as bioinks and have become an important area of research within the field. In view of this special issue on bioinks, we aim herein to briefly summarize the historic evolution of this term within the field of biofabrication. Furthermore, we propose a simple but general definition of bioinks, and clarify its distinction from biomaterial inks.
KW  - bioink
KW  - biomaterial ink
KW  - definition
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-253993
VL  - 11
IS  - 1
ER  -